Mendelspod Podcast

28:08

The Invention of Enzymatic DNA Synthesis with Sylvain...

Mendelspod Podcast ·

2022/03/03

The DNA synthesis space is seeing some real creativity and disruption this past year. One newcomer, in particular, is shaking things up.Sylvain Gariel is the co-founder and chief operating officer of DNA Script, who has recently launched the world’s first benchtop enzymatic DNA synthesizer. In today's show, Sylvain, co-inventor of the new system, tells how he met his co-inventors at a French gas company and came to invent a whole new way of writing DNA. This is a public episode. If you'd like to

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30:25

Akoya Biosciences Launches New Integrated Spatial...

Mendelspod Podcast ·

2022/02/24

Even though Brian McKelligon calls himself a rookie CEO, he comes to the top position at Akoya Biosciences with a veteran’s resume. His path to one of spatial biology’s hottest companies in 2022 worked him up the ranks of some of the top names in life science tools: Affymetrix, Ingenuity, Ion Torrent, and 10X Genomics. Last year Brian led Akoya through an IPO and this year the company has launched a new integrated product line called the Phenocycler-Fusion which they are calling the fastest

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31:11

Harlan Robins on How T-cell Focused COVID Vaccines...

Mendelspod Podcast ·

2022/02/16

Harlan Robins is the Chief Scientific Officer at Adaptive Biotechnologies in Seattle. In 2014, Harlan and his brother Chad co-founded Adaptive as a spinout from the Fred Hutchinson Cancer Center where Harlan had served as the head of computational biology. Adaptive has been developing what they call "immune medicine" mainly in the area of cancer. When the corona virus pandemic hit, they came out with the world’s first T cell-based COVID diagnostic. The test has garnered them a lot of data on T

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39:15

Twist Bioscience: A New Kind of DNA Synthesis Company

Mendelspod Podcast ·

2022/02/10

“DNA is changing everything for the better,” says today’s guest, Emily Leproust, CEO of Twist Bioscience. Twist has emerged at the heart of what a New York Times Magazine write-up recently headlined The Gene Synthesis Revolution. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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37:33

Going High Resolution with 10X Genomics: Michael...

Mendelspod Podcast ·

2022/01/27

Working at the Broad Institute early in his career, Michael Schnall Levin was discovering he was a biologist at heart. He’d begun his studies in physics then done his PhD in mathematics. But he'd wanted “to do math that had an application in the real world.” It was at the Broad that Michael came in contact with the new tools that were revolutionizing biology. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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41:08

George Church and Ben Lamm on the Launch of Colossal...

Mendelspod Podcast ·

2022/01/20

According to scientists, 30,000 species per year are going extinct. That’s 6 an hour, 150 per day. Up to one half of all species could be extinct by 2050. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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47:10

We Might Be the Comeback Kids of the Universe: Chris...

Mendelspod Podcast ·

2021/12/21

Chris Mason is back on the program for our end-of-year special. He’s Professor of Genomics, Physiology, and Biophysics at Weill Cornell School of Medicine and the author of such an outstanding book that we had to have him on the program a second time this year. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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52:34

Invitae and PacBio CEOs Share Details of Clinical...

Mendelspod Podcast ·

2021/12/07

In a joint interview, Sean George, CEO of diagnostics firm, Invitae, and Christian Henry, CEO of sequencing tools company, Pacific Biosciences, say that “it was clear in the first five minutes of a phone call that they shared a vision for doing something big together.”What comes through the interview is that this partnership is built on a big vision: speeding up the adoption of whole genome sequencing into clinical medicine as the preferred method for genetic testing. This is a public episode. If

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23:28

Building on the Knowledge Base of Developer...

Mendelspod Podcast ·

2021/11/30

There are some technologies that become so ubiquitous in biomedical research that their name turns synonymous with their use. This has been the case for the Luminex xMAP platform and multiple biomarker analysis. The product has been applied in just about every area of life sciences including infectious disease, STD, organ transplant rejection, vaccine development, cancer research, immunodeficiency, animal testing, agriculture, and others. (xMAP is a research use only product and not for use in

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28:31

DNA Script Takes DNA Synthesis Back to the Bench with...

Mendelspod Podcast ·

2021/11/17

DNA is a multibillion-dollar industry in 2021 and satisfies many life science applications, including drugs, reagents, siRNA, PCR, diagnostics, synthetic biology, and many others. Enzymatic DNA synthesis, or EDS, is a new approach to manufacturing DNA that is much more efficient and user-friendly and could disrupt the current market. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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29:28

Tumor Evolution in Context with Christina Curtis

Mendelspod Podcast ·

2021/11/11

If one was going to be a cancer researcher, surely one would want to be Christina Curtis. She’s an associate professor of oncology and genetics at Stanford, and she studies tumor evolution. She’s the Darwin of cancer research.Because scientists can’t see human tumors evolve in real life, in Christina's lab she creates what she calls "virtual tumors that recapitulate the size and spatial properties of an actual tumor. And evaluating patient data,” she says, "we have found that metastatic seeding

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44:37

The History of mRNA Vaccines with Elie Dolgin

Mendelspod Podcast ·

2021/11/04

"Scientists have been putting RNA into cells through a lipid delivery system for 44 years,” says Elie Dolgin. “And that’s ultimately the vaccine that has gone into millions of arms.”Elie is the author of a recent piece in Nature magazine, The Tangled History of mRNA Vaccines. He joins us to talk about his quest to uncover the winding journey that led to the cure that is moving the world forward. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus

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29:31

Hundreds of Thousands of Biological Molecules...

Mendelspod Podcast ·

2021/11/02

“Why do plants make a host of chemicals they don’t use? One answer that has always intrigued me is that, unlike us, they can’t walk up and walk away from an environment they don’t like. Evolution has honed this space for over 400 million years.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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27:31

Quantitative Pathology with David Rimm, Yale

Mendelspod Podcast ·

2021/10/25

David Rimm, Professor of Pathology at Yale, was doing spatial biology since before it was called that. He’s known for counting. And he’s been going beyond—beneath?--the model of the cell in biology for years. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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27:26

The State of Comprehensive Genomic Profiling at One...

Mendelspod Podcast ·

2021/10/19

Carlo Bifulco joins us today. He’s an Italian who helped persuade one of America’s largest not-for-profit health systems that providing more genomic information to cancer patients early on was the right thing. With 52 hospitals, over 1,000 physician clinics, more than 120,000 caregivers serving communities across seven states—Alaska, California, Montana, New Mexico, Oregon, Texas, and Washington—Providence and Carlo have quite a task ahead. We ask Carlo what is the state of comprehensive genomic

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25:44

Inside the World of Genome Engineering at Amyris with...

Mendelspod Podcast ·

2021/10/04

If a company knows genome engineering, that would be Emeryville based Amyris, the Bay Area's crown jewel for synthetic biology. Founded back in 2003, the company first worked on creating biofuels from yeast. Today they have retooled their platform to produce a diversified line of consumer products that have not only rewarded their bottom line but point the world to a model of sustainable consumer goods. This is a public episode. If you'd like to discuss this with other subscribers or get access to

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39:51

Clinical Genetics 2021 Highlights: Laura Hercher,...

Mendelspod Podcast ·

2021/09/21

Laura Hercher, host of our sister podcast, The Beagle Has Landed, joins us today to compare notes. Her gig is much more focused on the clinical side of genomics. Genetic counselors are her core audience. Today we do a highlights show looking back over the Beagle's past year. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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30:24

A New Way to Phenotype Life: Chris Mason Talks...

Mendelspod Podcast ·

2021/08/10

Chris Mason, Professor of Physiology and Biophysics and prolific genomics researcher at Weill Cornell Medicine, joins us to talk about what he’s doing with the new generation of spatial biology tools.The first papers we dive into are his work on COVID. Chris says the spatial tools have shown us the ravages of the coronavirus on the body like nothing we’ve seen before, i.e. the tissue damage from the cytokine storms and “the long term perturbations such as seeing cells far apart that were usually

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28:16

The Impact of Spatial Technology on Childhood Cancers...

Mendelspod Podcast ·

2021/08/03

David Steffin is a cancer researcher and physician at Texas Children's whose particular focus is on pediatric cancers. He begins today’s program with some interesting numbers. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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37:06

Robert Green: Newborn Sequencing Is the Goal Here in...

Mendelspod Podcast ·

2021/07/29

"If you go to a scientific meeting, even with the greatest critics, and you ask, how many people in this audience believe that your entire genome will be part of your everyday medical care in fifty years, every person will raise their hand. So the only questions we’re debating are: how do we get there, how soon can we get there, and what evidence base must we have in place before we get there? What’s really exciting to me is getting there sooner rather than later. If we get there 20 years sooner,

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