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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

04:33

🧠 Smart Lipids: ApoB and Lp(a) in the Age of Risk...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/31

🔬 New Insights in Lipidology! 🫀 A landmark study in European Heart Journal (2025) shows that Apolipoprotein B (ApoB) particle count is a more powerful predictor of coronary artery disease than traditional LDL cholesterol. While VLDL particles are more atherogenic per unit, LDL dominates by count — making total ApoB count + Lipoprotein(a) the gold standard for risk assessment. 🧪📊 👩‍⚕️👨‍⚕️ Time to rethink lipid panels and embrace particle-based precision. #Cardiology #Lipidology #ApoB #Lp(a)

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05:09

🧠💡 From Effort to Impact: : Lifestyle Lessons for...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/31

🧠✨ Just read a thought-provoking article in JAMA on the US POINTER trial! Structured lifestyle changes (think 🏃‍♀️🥗🧩) showed modest but real gains in cognition for older adults at risk of dementia. But here’s the twist: even light-touch self-guided changes yielded nearly similar benefits. 🤯 So… 💬 Is intensity always worth the investment? Or can simplicity scale smarter? 🔗 Worth pondering as we shape the future of brain health! #DementiaPrevention #CognitiveHealth #LifestyleMedicine

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04:19

Beyond Cholesterol 🌪️: 🇮🇳🩺: Lp(a)’s Reach in the...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/30

🔬 New Review Alert! 🫀 South Asians face one of the highest global burdens of premature heart disease — and Lp(a) may be the silent culprit. 📈 In a comprehensive JAHA 2025 review, researchers reveal how 25% of South Asians have dangerously elevated Lp(a) levels, doubling their risk of myocardial infarction. 🧬💥 Key takeaways: ✅ Lp(a) is genetically driven & unaffected by lifestyle ✅ Risk is underestimated by standard calculators ✅ Novel therapies (PCSK9i, siRNA, ASOs) are on the horizon ✅

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03:24

🏫 Early Edge, Not Late Armor — Why Brain Aging...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/30

📢 New insights on education & brain aging! 🧠📉 A mega-analysis across 33 countries (170K+ participants, 15K+ MRIs) shows 📚 higher education boosts baseline memory—but doesn’t slow brain aging or cognitive decline over time. ❌🧓 ✅ Early-life traits (like childhood cognition & environment) drive the advantage. 🔗 Education matters—but not in the way we thought. Full story: “Reevaluating the role of education on cognitive decline and brain aging” in Nature Medicine 🧬🌍 #CognitiveHealth

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02:50

📉 “Lp(a) is a Vascular Crystal Ball” 🚷🦿🛣️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/29

🧬 Just dropped: our latest podcast episode 🎙️ dives into Lipoprotein(a) and its powerful role in predicting vascular disease beyond the heart 🫀—including PAD 🦵 and stroke 🧠. 📊 Based on a massive UK Biobank study (n=460K+), high Lp(a) levels (≥150 nmol/L) were linked to: • 18% ↑ risk of PAD • 17% ↑ risk of carotid stenosis • 60% ↑ risk of major limb events ⚠️ Lp(a) is more than a lab value—it’s a Vascular Crystal Ball. #LipoproteinA #PAD #Stroke #VascularMedicine #PrecisionCardiology

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03:09

Dr. RR Baliga’s Philosophical Discourses: Avicenna...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/29

🧠✨ Dive into the mind of Avicenna (Ibn Sina) — the Persian polymath who shaped medicine, metaphysics, and logic for centuries. From the Canon of Medicine to the Book of Healing, his legacy lives on in modern science and thought. 🎓📚 #Philosophy #Medicine #Avicenna

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05:30

Scan. Score. Prevent. 📊🧠💊: A New Era in South Asian...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/28

📢 New Data Drop! 🫀💥 South Asian adults in the U.S. have an earlier and sharper rise in coronary artery calcium (CAC) — a silent marker of heart disease risk! 🇮🇳📊 In a first-of-its-kind study combining MASALA & DILWALE cohorts (n=2,743), 65% of South Asian men and 30% of women had CAC >0 by age 55 — and women catch up fast after menopause. 🚹➡️🚺 📌 Sex-specific CAC percentiles = smarter screening, better prevention. 💡 Time to rethink traditional risk calculators for this high-risk group

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04:04

🍕 Engineered, Addictive, Unregulated — Why...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/28

🚨 New Insights from Nature Medicine 🧠🍕 Can cookies and chips hijack your brain like cocaine? A compelling new article argues that ultra-processed food addiction mirrors classic substance use disorders — down to the cravings, compulsive use, and reward circuit disruption. With GLP-1 drugs bridging obesity and addiction treatment, is it time the DSM-5 recognized food addiction? 🧬 Science says yes. ⚖️ Policy is lagging. 📢 Let’s start the conversation. #FoodAddiction #UltraProcessedFoods

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04:37

Hypertension: Treat Early, Treat All, Save More 💊🌍❤️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/27

🚨 New Hypertension Guidance Alert! 🩺💡 The British & Irish Hypertension Society now recommends treating all adults with sustained BP ≥135/85 mmHg—regardless of CVD risk—and targeting <130/80 mmHg within 6 months. No more waiting for risk scores to rise 📉⏳. This bold, evidence-backed move aligns with global trends 🌍 and aims to end therapeutic inertia for good. Let’s make treatment simpler, safer, and sooner! 💊✅ #Hypertension #Guidelines #PrimaryCare #Cardiology #PublicHealth

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03:10

Neurons in Motion: Run, Repair, Rewire 🏃‍♂️🧠🔧”...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/27

🧠🏃‍♂️ Can running rewire the Alzheimer’s brain? New study in Nature Neuroscience shows how exercise transforms cell-specific gene expression in the dentate gyrus of AD mice! Using single-nucleus RNA-seq, researchers found that voluntary running reversed transcriptional dysregulation in key cell types—especially immature neurons, astrocytes, and microglia. 💡Highlights: ✅ Neurogenesis boosted ✅ Disease-associated microglia reprogrammed ✅ Novel astrocyte subpopulation rescued This could pave

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03:42

💊 Dose, Diabetes & Destiny: The Statin Tradeoff

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/26

🚨 Statins & Diabetes: Dose Matters, But So Does Perspective 💊📉 A 2024 CTT Collaboration meta-analysis of 154,664 participants confirms: ✅ Statins modestly increase risk of diabetes (10% with moderate, 36% with high-intensity) 📈 Small upticks in HbA1c and glucose 🧪 But most new cases were already teetering near the threshold 🩺 Bottom line? Cardiovascular benefits far outweigh the diabetes risk. 💡 It’s a reminder: precision prevention is about balancing risk, not eliminating it. 📚 Ref:

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02:43

🧓🏼 The Aorta Whispers First at age 50: Signals of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/26

🧬 Just explored a groundbreaking 50-year proteomic atlas that charts how our proteins evolve with age across 13 human tissues! 🧠 Key insights? Aging inflection around 50, transcriptome-proteome decoupling, amyloid buildup, and senoproteins like GAS6 & GPNMB driving vascular & systemic aging. 📊 Proteomic clocks, plasma biomarkers, and tissue-specific aging maps may redefine how we measure and manage aging. 🔗 Dive into the protein-powered future of aging science! #Proteomics #AgingResearch

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03:19

“Fat, Fuel, Freedom 🍔🔋❤️” Cardiomyocyte PTP1B...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/25

🧬 New findings from Science Signaling reveal that deleting PTP1B in cardiomyocytes protects the heart from high-fat diet–induced cardiomyopathy! 🛡️❤️ This elegant study shows how **metabolic rewiring—boosting fatty acid oxidation, enhancing AMPK, and preserving mitochondria—**prevents cardiac hypertrophy and dysfunction. 🚫🍔➡️💪💓 Could targeting the PTP1B–PKM2–AMPK–NAD⁺ axis be the future of cardio-metabolic therapy? #Cardiology #Metabolism #HeartFailure #Obesity #PrecisionMedicine #FAO

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03:02

🔬 Triple Threat for Kidneys: RASi, SGLT2i &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/25

🚨 Just in: The 2024 KDIGO guidelines are here to delay CKD progression! 🩺💡 With updated insights on protein intake, SGLT2 inhibitors, and BP targets, this is a must-read for every internist and nephrologist. 🚱💊 Highlights include use of finerenone, combo therapies, and emerging role of GLP-1RAs. 🧬📉 🔗 Dive into the new JAMA summary and elevate your CKD care! #Nephrology #CKD #KDIGO #CardioRenal #PrecisionMedicine

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03:21

7K to Stay OK 🚶‍♀️❤️📊 Why 7000 Steps May Be the Sweet...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/24

🚶‍♀️ How many steps a day keep the doctor away? 📉🧠 A sweeping meta-analysis in The Lancet Public Health reveals that just 7000 steps/day (not 10,000!) can reduce the risk of death, cardiovascular disease, cancer, dementia, diabetes, depression, and falls—with benefits starting as low as 4000 steps. 🩺👟 Every step counts. 🔗 Read more. #PublicHealth #MetaAnalysis #PhysicalActivity #Wearables #HealthOutcomes #StepsToHealth

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03:14

🧓 Old Cells, New Threats & Hidden Mutations Why Age...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/24

🔬 Just explored a brilliant review in Nature Reviews Cancer on how ageing shapes cancer evolution 🧓🧬 From clonal expansions and inflamm-ageing to cutting-edge models like GEMMs, CRISPR, and epithelioids, this article reframes how we study cancer through the lens of time ⏳ 🎧 Check out our latest podcast: “Mutations, Microenvironments & Mortality” — a deep dive into ageing, adaptation, and malignancy #CancerResearch #AgeingBiology #Geroscience #Oncology #ClonalEvolution #PrecisionMedicine

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08:01

🧬 Genes, Hearts, and Hope: Precision Therapies for...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/23

🚨 New Podcast Alert! 🎙️ 🧬 “Genes, Hearts, and Hope: Precision Therapies for Cardiomyopathy” is LIVE! From sarcomeres to splicing, from fibrosis to fixable mutations—this episode unpacks cutting-edge treatments like myosin modulators 🧪, gene therapy 🧠, and antisense oligonucleotides 💉. If you’re a cardiologist, geneticist, or just curious about the future of heart care ❤️—this one’s for you. 🎧 Tune in, share, and let’s rethink cardiomyopathy together! #Cardiomyopathy #PrecisionMedicine

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03:40

Polygenic Power, Predictive Precision, Population...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/23

📢 Just read a landmark study in Nature Medicine—over 5 million participants across ancestries! 🧬 The new multi-ancestry polygenic risk score (PRS-CSx) predicts BMI & obesity from early life to adulthood 🌍👶📈. Strong implications for personalized prevention, though disparities persist in African ancestry populations ⚖️. Precision meets public health—time to rethink obesity prediction. #Genomics #Obesity #PrecisionMedicine #PRS #GWAS #HealthEquity 🧠💡

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05:12

🔍 Elevated but Innocent: Cracking the Troponin Code

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/22

🔬🫀 When Troponin Lies: A Case of Macrotroponin 🧪❗ We’ve all seen elevated troponins trigger cath lab calls—but what if the numbers don’t add up? This fascinating case from EHJ Case Reports reveals how an IgG–troponin T complex (macrotroponin) mimicked an acute coronary syndrome in a patient with a structurally normal heart and clean coronaries. 📈 Persistently high cTnT 🧪 Normal cTnI 🧫 Confirmed macrotroponin via SDS-PAGE + immunoblotting 🤝 Biochemistry + Clinical Team = Diagnostic Clarity

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03:36

Dr. RR Baliga’s Philosophical Discourses: Al-Farabi...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/07/22

🎓 Dive into the profound legacy of Abu Nasr al-Farabi—the “Second Master” after Aristotle 🧠🎼 From logic to music, metaphysics to political philosophy, his thought shaped both East & West. 🕌🌍 #Philosophy #IslamicPhilosophy #AlFarabi #Neoplatonism #KnowledgeIsPower #WisdomWednesday ✨📚

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