x

75% of people globally want unbiased news (Pew Research) but are concerned they're not getting that.

Get balanced coverage with Symby. See how stories are covered across diverse outlets and spot when one side covers a story the other skips.

PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

04:22

🔌 Power Heist in the Tumor: Neurons Fuel Cancer Spread

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/30

🚨 New insights from cancer neuroscience! 🧠🧬 A groundbreaking Nature study reveals that cancer cells can steal mitochondria from nearby neurons via tunneling nanotubes — supercharging their metabolism, stemness, and metastatic potential 🌪️💥 Using a clever tool called MitoTRACER, researchers traced this “mitochondrial hijack” across cancers (breast, prostate, melanoma) and showed that recipient cells were more likely to seed distant metastases — especially in the brain 🧳🧠 🧪 Targeting this

en

05:13

🧠💡 Memory Matters: A Cardiologist’s Guide to...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/29

🧠💓 Cognitive decline and cardiovascular disease often go hand in hand — but they don’t have to spiral together. In our latest breakdown, we explore how cardiologists can detect, manage, and even improve cognitive impairment through smart risk factor control, lifestyle changes, and a multidisciplinary approach. From MoCA to memantine, TAVR to team-based care — it’s time to connect the mind and the heart. 📊 Evidence-based strategies 🩺 Practical tools for clinicians 💡 Insights from JACC’s

en

04:11

Adjuvants & Alzheimer’s: A Shot at Prevention 💥🧬🧠

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/29

🧠💉 Can vaccines protect the mind? New research suggests that AS01-adjuvanted vaccines like Shingrix and Arexvy may reduce the risk of dementia—possibly by stimulating immune pathways like IFN-γ and TLR4, not just by preventing infection. 📊 In a large US-based EHR study, those who received the RSV or shingles vaccine had a significantly lower 18-month dementia risk than flu-vaccinated peers. 🔬 The common thread? The AS01 adjuvant. 🛡️ Could this be a new frontier in neuroprotection? Let’s

en

04:26

💉 Pump, 📉 Pressure, ⚡ Power: Inside the STEMI Shock...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/28

New Insights from the DanGer Shock Trial! 🫀💡 Can early left ventricular unloading with a microaxial flow pump (mAFP) save lives in STEMI-related cardiogenic shock? This compelling substudy shows that mAFP not only boosts cardiac output and power, but also reduces pulmonary pressures—all while using less pharmacologic support. 📉💊 🧪 Native CO improved steadily over 48 hours, hinting at myocardial recovery. 📊 PAC data gives us a front-row seat to the physiology behind the survival curves. 🔬

en

03:43

🌐 ACHIEVE-1 Decoded: Efficacy & Safety of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/28

🚨 New Breakthrough in Type 2 Diabetes Care! 💊🧬 The ACHIEVE-1 trial shows that Orforglipron, a once-daily oral, nonpeptide GLP-1 receptor agonist, delivers significant reductions in HbA1c and body weight—without injections and with minimal restrictions! 🌍📉 👨‍⚕️ 559 patients across 5 countries ⏱️ 40 weeks, 3 dosing arms (3, 12, 36 mg) 📊 HbA1c ↓ by up to 1.48%, weight ↓ up to 7.6% ✅ No severe hypoglycemia 📌 Mild GI side effects during dose titration This is a potential gamechanger for early

en

04:54

Frailty as a Cardiovascular Compass 🧭📉🩻

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/27

🚨 Frailty matters — even in the cath lab! 🧓🫀 A new NCDR registry analysis of 1.3M+ older adults shows a clear gradient: as frailty increases, so do complications, mortality, and procedural risks during PCI. Severely frail patients faced a striking 20.3% in-hospital mortality and >50% mortality with cardiogenic shock. 🧠 It’s time to treat frailty as a vital sign — embedded in our workflow, guiding shared decisions, and shaping post-PCI care. 📊 Let’s bring team-based, geriatric-informed

en

07:00

🧬 Amylin & GLP-1: Double Agents for Weight Loss &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/27

🚨 Major breakthrough in obesity pharmacotherapy! The REDEFINE-1 & REDEFINE-2 trials show that once-weekly CagriSema (Cagrilintide + Semaglutide) delivers up to 20% weight loss in people with obesity—and significant glycemic improvements in those with type 2 diabetes. 💉📉 🌍 Global, double-blind RCTs ⚖️ >90% lost ≥5% body weight 🩺 SBP ↓, QoL ↑, prediabetes reversed in 88% ⚠️ GI side effects common but mostly mild 💡 CagriSema is redefining the weight loss frontier—with dual satiety and metabolic

en

04:23

🌲 Burning Risk: How Wildfires Ignite Heart Failure 📉

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/26

🔥 New Study Alert! 🩺 Wildfire smoke isn’t just a respiratory threat — it’s taking a toll on the heart, especially in older adults. 📊 A nationwide Medicare cohort (~22M) shows that long-term exposure to wildfire-specific PM2.5 is linked to significantly higher heart failure risk — more so than urban pollution. 📍 Vulnerable groups — women, Medicaid-eligible individuals, and low-income communities — face the highest burden. 🌫️ Tiny particles. Massive impact. 📚 Read the study: Hao et al,

en

06:10

🧬 Amylin & GLP-1: Double Agents for Weight Loss (Part 1)

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/26

🧠💊 Appetite Meets Its Match: The Amylin Advantage” In this episode of Got Knowledge Doc, we explore how amylin, the lesser-known hormone co-secreted with insulin, is making a comeback — this time as part of a dual receptor strategy with GLP-1. 💡 Learn how amylin: 🧠 Activates brainstem satiety centers ⏳ Delays gastric emptying 📉 Suppresses glucagon 🔁 Synergizes with GLP-1 & leptin We break down the science behind amycretin, the first oral dual GLP-1/amylin agonist, and what

en

04:43

⏱️🩸 Timing is Brain: Early DOACs in Atrial Fibrillation

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/25

🧠💉 When should you start anticoagulation after an ischaemic stroke in atrial fibrillation? The CATALYST meta-analysis may have the answer! 📊 5,441 patients from 4 RCTs ⏱️ Early DOAC (≤4 days) reduced recurrent stroke risk at 30 days ⚖️ No increased bleeding, even in moderate stroke severity 🚫 But patients with PH2 or very severe strokes were excluded Individual Participant Data Meta-Analysis allowed detailed subgroup analysis and minimized bias 💡 Clinical Takeaway: In most mild-to-moderate

en

03:18

🧠 Restore, Regulate, Reimagine Type 1 Diabetes

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/25

🚨 Breakthrough in Type 1 Diabetes! 🧬💉 A new study in NEJM shows that zimislecel, a fully differentiated stem cell–derived islet therapy, restored insulin production and led to insulin independence in 83% of participants! ✅ 📉 HbA1c dropped, 📈 time-in-range soared to 93%, and ⚖️ glucose variability was dramatically reduced. This marks a major step toward curing—not just managing—Type 1 diabetes. 🔬 Precision science. 💪 Real-world impact. 🌍 Hope for millions. #Type1Diabetes

en

03:48

🧘‍♂️📉 Fitness on the Floor: Predicting Death with a Sit

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/24

🧘‍♂️ How Well Can You Sit and Rise from the Floor? 🪑⬆️ That simple motion might say more about your longevity than you think. A 12-year study of 4,282 adults found that lower Sit–Rise Test (SRT) scores predicted 3.8x higher natural death and 6x higher cardiovascular death rates. 😱 ✅ No equipment ✅ Under 2 minutes ✅ Predicts survival Why aren’t we using this more in routine clinical exams? 🩺 💡 If you score a 10, your 10-year survival is 97%. Score 0–4? It drops to 73%. 🔍 Let’s rethink

en

02:38

Dr. RR Baliga’s Philosophical Discourses: Aristotle...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/24

Aristotle (384–322 BC), a Greek philosopher and polymath, founded the Peripatetic school and Lyceum in Athens. His extensive works spanned diverse fields, including logic, ethics, politics, biology, and metaphysics, profoundly influencing Western thought, science, and philosophy.

en

04:23

⚡Gatekeepers of Strength: Allopurinol, Calcium & the...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/23

⚡Gatekeepers of Strength: Allopurinol, Calcium & the RyR Revolution”! Did you know that an old gout drug might hold the key to reversing age-related muscle weakness and heart failure? Using cryo-EM, researchers found that allopurinol and xanthine derivatives directly activate ryanodine receptors—calcium channels essential for muscle contraction. 💡 This could change how we think about cardiac therapeutics and sarcopenia. Tune in for the full story—explained for med students, researchers, and

en

05:24

🧠🔥 Flame Within the Brain: Neuroinflammation Decoded

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/23

🧠🔥 Neuroinflammation: The Common Flame in MS, Stroke, Alzheimer’s & Parkinson’s Why do microglia flip from guardians to arsonists? How does immune cell infiltration differ between MS and AD? And which CNS-penetrant therapies show the most promise in dousing the inflammatory fire? In our latest Got Knowledge Doc podcast, we decode the science behind neuroinflammation, explore treatment frontiers like BTK inhibitors and TREM2 agonists, and highlight key clinical insights for neurologists and

en

06:00

EF Up, Risk Still On 📈🧠⚠️: Understanding the Fragile...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/22

🔬💓 New Insights on HFimpEF 💓🔬 Heart Failure with Improved Ejection Fraction (HFimpEF) is no longer just a transition phase—it’s a distinct, dynamic phenotype with its own risks and management needs. From biomarkers and imaging to the latest trials like PROSPER-HF and FINEARTS-HF, we’re entering an era of more personalized care for these patients. 📈 Better EF ≠ Complete Recovery. 💊 Continued GDMT, careful ICD decisions, and ongoing surveillance are key. Let’s discuss: Are we ready to

en

02:28

🧠 🎛️💡 Master Control: Is the Brain Orchestrating Aging?

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/22

🧠 Is your brain orchestrating how fast you age? New insights suggest that aging isn’t just about wear and tear—it may be centrally coordinated by the brain through molecules like GDF15, responding to stress, senescence, and energy demands. 💬 Fascinating findings from Nature (June 2025) show how psychological stress accelerates aging at a cellular level—and how lifestyle interventions like exercise may help reverse it. 👇 How are you integrating brain–body science into your approach to aging

en

06:07

💊❤️🔥Obesity:- Hormones, Hearts, and Hope; The...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/21

“Obesity Rx 💊❤️🔥: Hormones, Hearts, and Hope” The 2025 ACC guidance reframes obesity as a chronic disease—with precision therapies like GLP-1/GIP agonists now essential in cardiology. We explore NuSH therapies (semaglutide, tirzepatide), the latest trial data, clinical thresholds for risk reduction, and practical steps for de-stigmatizing care. 👉 Tune in if you’re ready to treat obesity like the cardiovascular disease it truly is. #Cardiology #ObesityMedicine #GLP1 #Tirzepatide #NuSH #MASLD

en

03:48

🥗🧬💊 “Eat Less or Pop a Pill? Rapamycin vs. Metformin

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/21

🔬 New meta-analysis alert! 🧪 Researchers compared rapamycin and metformin to dietary restriction across 167 studies in 8 vertebrate species. 📈 Key finding: Rapamycin mirrors dietary restriction’s longevity benefits—but metformin falls short. ⚠️ High heterogeneity and species bias remind us: translation to human health still needs careful navigation. 🧠 Full of insights for aging science, pharmacology, and precision medicine! #LongevityScience #Rapamycin #AgingResearch #MetaAnalysis

en

05:42

🫀 Cells, Senescence, and Survival: How the Heart Ages

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/06/20

🫀 The Heart Ages—But Can We Intervene? New insights from Nature Reviews Cardiology highlight how endothelial dysfunction, inflammageing, CHIP, and senescence-associated secretory phenotypes (SASP) drive cardiovascular ageing. Promising interventions—from gerotherapeutic diets and exercise to NAD+ boosters, senolytics, and ACBP neutralization—may help delay decline and promote resilience. 💡 Can we target the biology of ageing to extend cardiovascular healthspan, not just lifespan? 👇 Join the

en

779 results

Similar Podcasts

Classic Radio Science Fiction

solgoodmedia.com

Mission to Mars

Inception Point Ai

The 365 Days of Astronomy

365DaysOfAstronomy.org

Creek Devil

william Jevning

UFO Chronicles Podcast

Nik Hunter