Mendelspod Podcast

67:42

End-of-Decade Review, What's Next? with Nathan and Laura

Mendelspod Podcast ·

2019/12/27

It's our special look back over the entire decade which has Nathan and Laura firing on all fours. Not only do we discover their genomic highlights of the last ten years--ups and downs-- they also pull out their special "future glasses" and come up with a provocative list for the next ten. You don't want to miss this.But first, we do cover December and that kerfuffle over the George Church dating app. And the genomics of income--really? Did you go for that?Theral, Nathan, and Laura for an

en

50:21

Ewan Birney on Race, UK Genomics

Mendelspod Podcast ·

2019/12/17

Our end-of-year special guest is one of the U.K.’s top genomicists, Ewan Birney, Co-Director of the European Bioinformatics Institute at EMBL. He is also the non-Executive Director for Genomics England. Ewan's perhaps best known for his work with the ENCODE consortium. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

en

50:47

November 2019 with Nathan and Laura: Happy Birthday...

Mendelspod Podcast ·

2019/12/02

The gene edited babies, Lulu and Nana, turn one. Laura Hercher says it feels like it’s been five years. Nathan says, “Happy Birthday.”Along with our genomics headline party this month, we also discuss a comment that came in from our last show which leads us to the question, can we discuss science without discussing politics?It’s Nathan, Laura and Theral for almost a full hour sifting through November’s news. This is a public episode. If you'd like to discuss this with other subscribers or get

en

32:44

Learning from the Field's Mistakes, Ancestry.com...

Mendelspod Podcast ·

2019/11/26

Just in time for Black Friday, Ancestry.com has launched new health testing. Thanksgiving week (the company calls the shopping holidays the “Turkey Five”) has been kind to what is the largest DNA testing company in the world. Back in 2017, their ancestry test competed with the Instapot for Amazon’s top sellers on the biggest shopping day of the year. To date Ancestry has sold over 15 million DNA tests. This is a public episode. If you'd like to discuss this with other subscribers or get access

en

44:19

The Gene Edited Babies Saga - A Year Later with Hank...

Mendelspod Podcast ·

2019/11/22

On November 25th, 2018, the world was shocked to find out a Chinese scientist, He Jiankui, had edited the germline of twin girls-and the twins had been born. Many in the scientific community remember that Sunday afternoon well as the story broke on MIT's Tech Review, "EXCLUSIVE: Chinese scientists are creating CRISPR babies."Today’s guest can even tell you what he had for dinner that Sunday and just what was his reaction. "Holy S**t!" This is a public episode. If you'd like to discuss this with

en

31:16

Improving Quantitative Evidence for Genetic Tests:...

Mendelspod Podcast ·

2019/11/14

Warning: the first part of this story can sound quite typical. Three co-founders with backgrounds in genomics and AI found a Stanford spinout. Their goal: to bring the tools of AI and computational modeling to unlock the medical secrets of the genome and deliver those to patients. They call this company, Jungla—Spanish for “jungle”—naming not only their adventure, but the whole problem. Then things get interesting. This is a public episode. If you'd like to discuss this with other subscribers

en

33:31

The Meteoric Rise of Twist Bioscience and the Wild...

Mendelspod Podcast ·

2019/11/07

In 2013 Twist Bioscience was a newcomer to a market that most of us thought was saturated, cornered, commoditized—that of synthetic DNA. But Emily Leproust and her co-founders saw something different. They saw "a big market with unhappy customers.” Today, with a radically disruptive technology, they are market dominant. Twist is a publicly traded company whose stock has doubled already once since they IPOd last year. Imagine, a DNA synthesis company going public! And then seeing their stock

en

59:18

October 2019 Review with Nathan and Laura: Prime...

Mendelspod Podcast ·

2019/11/01

Our Halloween show this year summarizing October’s genomics news has more tricks and treats than spooks and scares. It’s Nathan and Laura back to sift through a big month of happenings from the cool CRISPR upgrade to Inscripta’s bold move in gene editing to Ancestry.com’s shift into health testing.It’s all here, right now, on Mendelspod. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

en

42:56

Should We Increase Panel Testing for All Breast...

Mendelspod Podcast ·

2019/10/24

It’s a hot question in the field today. Recently several studies arguing for increased testing for all breast cancer patients have been published in leading oncology journals.Peter Beitsch is a breast cancer surgeon in Dallas Texas and co-author of one such study in the Journal of Clinical Oncology. He says that NCCN guidelines were created when tests were much more expensive and in an outdated context and that many patients are going under-diagnosed today. This is a public episode. If you'd

en

39:16

Genomics Going from a Passive to an Active Science:...

Mendelspod Podcast ·

2019/10/22

Not many people have had quite the same view on the genomics revolution as John Stuelpnagel. He co-founded Illumina, Ariosa, and Fabric Genomics (formerly Omicia). And he’s the Chairman of Fabric, 10X Genomics, and Inscripta. And not all had the foresight John did that biology would turn out to be so complex.John is our guest today to preview and describe what he calls the new “writing” phase of genomics, which he says is already underway. This is a public episode. If you'd like to discuss this

en

36:23

Why Isn’t Personalized Medicine Being Mentioned by...

Mendelspod Podcast ·

2019/10/15

Ed Abrahams has a message for Nancy Pelosi about HR 3. That’s the new bill in the House to reduce drug pricing.Ed is the President of the Personalized Medicine Coalition, an advocacy organization in Washington representing our industry which will soon announce a new caucus in congress devoted to personalized medicine. Ed joins us today and says to Pelosi, there’s a better way, a more American way to reduce drug costs. This is a public episode. If you'd like to discuss this with other subscribers

en

25:49

Karen Miga on the Next Era of Genomics

Mendelspod Podcast ·

2019/10/07

"Welcome to the era of T2T genomics,” tweeted UCSC’s Karen Miga on August 16th of this year. Then she linked to a paper on bioRxiv that begins:"After nearly two decades of improvements, the current human reference genome (GRCh38) is the most accurate and complete vertebrate genome ever produced. However, no one chromosome has been finished end to end, and hundreds of unresolved gaps persist.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus

en

56:54

September 2019 Review with Nathan and Laura: Same-Sex...

Mendelspod Podcast ·

2019/10/01

After the summer break, Nathan and Laura, stir from their beach slumbers, to again offer their anything but sleepy opinions on the latest genomics headlines. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

en

29:39

We Can See Tumor Heterogeneity. Now What? We Ask...

Mendelspod Podcast ·

2019/09/17

Cathy Smith counts herself among the Gleevec Generation after the landmark targeted cancer therapy. She’s an optimist who believes in the possibilities of precision medicine.“We are outsmarting cancer,” she says.Cathy is an Assistant Professor of Hematology/Oncology at UCSF where she is also an MD treating patients. Her area of expertise is in acute myeloid leukemia or AML. She joins us today to discuss a recent group paper and collaboration using new technology to track and monitor cancer

en

23:13

Hallelujah! A Universal Flu Preventative and Therapy...

Mendelspod Podcast ·

2019/09/12

As another summer winds down, another flu season approaches. Yuuuk. When will we be able to stop living in fear of that crowded plane flight in winter months or waking up congested and wondering . . . dreading, “am I coming down with a cold?”Yes, we get that annual flu vaccine shot, but each year we still get the bug. Until now, a real universal flu vaccine has eluded drug makers, and having the flu goes on being just part of life. But it doesn't have to be. This is a public episode. If you'd

en

40:11

'The Movement:' John Cumbers Previews the Rapidly...

Mendelspod Podcast ·

2019/09/03

Synthetic biology is experiencing a second renaissance and the place to be this October 1-3 is at the SynBioBeta conference in San Francisco.For those of you who are going, today’s show is your preview. For those of you who need a nudge, just listen to what conference founder, John Cumbers, has conjured up in this biggest and most diverse lineup yet. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

en

29:22

Anya Prince on Our Current Vulnerability to Genetic...

Mendelspod Podcast ·

2019/08/13

Some Americans still resist genetic testing for fear they will be discriminated against by insurance companies. Why?in 2008, Congress passed GINA, the Genetic Information Nondiscrimination Act, to protect us from insurance companies choosing to include us or not for policies based on the genes we came with. Then in 2010, Congress passed the ACA, or Affordable Care Act, and with it protection against preexisting conditions. This includes genetic predispositions. This is a public episode. If

en

32:13

Do Long Reads Hold Answers for Alzheimer’s? with Mark...

Mendelspod Podcast ·

2019/08/01

It’s the kind of plot that makes great science.There are genes that have been hiding in plain sight, undetected until now. They’ve gone unseen, that is, by short read sequencing. Today’s guest and his colleagues call them “camouflage genes,” and a couple in particular may play functional roles in Alzheimer’s disease.Mark Ebbert is an Assistant Professor of Neuroscience at the Mayo Clinic where he is using long read sequencing technology and computational biology to study neurodegenerative

en

25:05

With Nanopore Sensing Beyond Sequencing, Ontera Takes...

Mendelspod Podcast ·

2019/07/25

We’ve interviewed several CEOs over the years since the Theranos fiasco who avoided any mention of the blighted company whenever the comparison came up. But today’s guest, Murielle Thinard McLane, the CEO of Ontera, jumped at the chance before Theral could get to it."Some people might say, well that's the Theranos model. They (Theranos) didn't get it wrong. The demand for a fast, comprehensive point-of-care solution near the patient is there. Where they got it wrong is that you need a technology

en

41:31

Mark Chaisson on Two New Structural Variation Papers

Mendelspod Podcast ·

2019/07/17

If you’re not on the long read sequencing train, you’re not landing in the world of genomics.A new paper out begins, "Structural variants contribute greater diversity at the nucleotide level between two human genomes than another form of genetic variation.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

en

All Episodes

Similar Podcasts

Mendelspod Podcast

Theral Timpson

DMCN Journal

John Wiley & Sons Ltd

汪诘：科学有故事（主打）

科学有故事

天方烨谈

基因频道

Homesteading and Permaculture by Paul Wheaton

paul wheaton