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PODCAST

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

science life sciences

All Episodes

00:16:01

️ 56: Neuronal Immunoproteasome — A Metabolic Trigger...

Base by Base ·

2025/06/26

️ Episode 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis In this episode of Base by Base, we examine the transformative findings of Woo et al. (2025) in Cell, revealing how inflammation reshapes neuronal proteostasis. Under interferon-γ–driven stress, neurons incorporate the immunoproteasome subunit PSMB8 into their core proteasome, profoundly impairing catalytic function. This shift undermines

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00:15:59

🎙️ 56: Neuronal Immunoproteasome — A Metabolic...

Base by Base ·

2025/06/26

🎙️ Episode 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis🧬 In this episode of Base by Base, we examine the transformative findings of Woo et al. (2025) in Cell, revealing how inflammation reshapes neuronal proteostasis. Under interferon-γ–driven stress, neurons incorporate the immunoproteasome subunit PSMB8 into their core proteasome, profoundly impairing catalytic function. This shift undermines the degradation of the glycolytic

en-us

00:14:33

🎙️ 55: Denisovan DNA in Dental Calculus — Linking...

Base by Base ·

2025/06/25

🎙️ Episode 55: Denisovan DNA in Dental Calculus — Linking Morphology and Genetics in a 146,000-Year-Old Hominin🦴 In this episode of Base by Base, we delve into a groundbreaking study by Fu et al. (2025) published in Cell, which reports the first successful retrieval of hominin mitochondrial DNA from dental calculus on the Harbin cranium, dated to over 146,000 years ago. Through targeted enrichment and high-throughput sequencing, the team recovered endogenous mtDNA fragments despite extensive

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00:14:34

️ 55: Denisovan DNA in Dental Calculus — Linking...

Base by Base ·

2025/06/25

️ Episode 55: Denisovan DNA in Dental Calculus — Linking Morphology and Genetics in a 146,000-Year-Old Hominin In this episode of Base by Base, we delve into a groundbreaking study by Fu et al. (2025) published in Cell, which reports the first successful retrieval of hominin mitochondrial DNA from dental calculus on the Harbin cranium, dated to over 146,000 years ago. Through targeted enrichment and high-throughput sequencing, the team recovered

en-us

00:18:50

️ 54: Temporal Immune Landscapes — A Multi-Omic Lens...

Base by Base ·

2025/06/24

️ Episode 54: Temporal Immune Landscapes — A Multi-Omic Lens on COVID-19 in End-Stage Kidney Disease In this new Base by Base episode we unpack a 2025 Cell Genomics study by Stephenson et al. that followed 61 haemodialysis patients through two waves of the pandemic. Using single-cell multi-omics (CITE-seq, VDJ-seq) across 580 000 immune cells, the team captured how SARS-CoV-2 reshapes the blood compartment over time, why some patients spiral into critical

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00:18:49

🎙️ 54: Temporal Immune Landscapes — A Multi-Omic Lens...

Base by Base ·

2025/06/24

🎙️ Episode 54: Temporal Immune Landscapes — A Multi-Omic Lens on COVID-19 in End-Stage Kidney Disease🧬 In this new Base by Base episode we unpack a 2025 Cell Genomics study by Stephenson et al. that followed 61 haemodialysis patients through two waves of the pandemic. Using single-cell multi-omics (CITE-seq, VDJ-seq) across 580 000 immune cells, the team captured how SARS-CoV-2 reshapes the blood compartment over time, why some patients spiral into critical illness, and how routine dexamethasone

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00:17:13

️ 53: Weighing the Evidence — A Systematic Review of...

Base by Base ·

2025/06/23

️ Episode 53: Weighing the Evidence — A Systematic Review of Polygenic Risk Score Economic Evaluations In this episode of Base by Base, we explore the systematic review by Siena et al. (2025) in The American Journal of Human Genetics, which examines the methods used to quantify the costs and benefits of polygenic risk–based strategies in clinical practice. The authors conducted a comprehensive search of PubMed, Web of Science, and Scopus, identifying 24

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00:17:12

🎙️ 53: Weighing the Evidence — A Systematic Review of...

Base by Base ·

2025/06/23

🎙️ Episode 53: Weighing the Evidence — A Systematic Review of Polygenic Risk Score Economic Evaluations🧬 In this episode of Base by Base, we explore the systematic review by Siena et al. (2025) in The American Journal of Human Genetics, which examines the methods used to quantify the costs and benefits of polygenic risk–based strategies in clinical practice. The authors conducted a comprehensive search of PubMed, Web of Science, and Scopus, identifying 24 full economic evaluations—predominantly

en-us

00:16:42

🎙️ 52: Human Genetic Variation Reveals FCRL3 as a...

Base by Base ·

2025/06/22

🎙️ Episode 52: Human Genetic Variation Reveals FCRL3 as a Lymphocyte Receptor for Yersinia pestis🧬 In this episode of Base by Base, we dive into a cellular genome-wide association study (GWAS) of nearly 1,000 lymphoblastoid cell lines published by Keener et al. (2025) in Cell Genomics, which uncovers Fc receptor-like 3 (FCRL3) as a previously unrecognized surface receptor that mediates attachment and invasion of Yersinia pestis into human B cells. Employing the Hi-HOST platform, the authors

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00:16:43

️ 52: Human Genetic Variation Reveals FCRL3 as a...

Base by Base ·

2025/06/22

️ Episode 52: Human Genetic Variation Reveals FCRL3 as a Lymphocyte Receptor for Yersinia pestis In this episode of Base by Base, we dive into a cellular genome-wide association study (GWAS) of nearly 1,000 lymphoblastoid cell lines published by Keener et al. (2025) in Cell Genomics, which uncovers Fc receptor-like 3 (FCRL3) as a previously unrecognized surface receptor that mediates attachment and invasion of Yersinia pestis into human B cells. Employing

en-us

00:17:38

️ 51: Diagnosing the Undiagnosed — A Phenotype-Driven...

Base by Base ·

2025/06/21

️ Episode 51: Diagnosing the Undiagnosed — A Phenotype-Driven Pipeline for Mitochondrial DNA Discovery In this episode of Base by Base, we dive into a powerful phenotype-guided strategy to uncover mitochondrial DNA (mtDNA) diseases in large-scale rare disease cohorts. Ratnaike et al. (2025), publishing in The American Journal of Human Genetics, present the results of a systematic reanalysis of 10,157 exome and genome datasets from the European Solve-RD

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00:17:37

🎙️ 51: Diagnosing the Undiagnosed — A...

Base by Base ·

2025/06/21

🎙️ Episode 51: Diagnosing the Undiagnosed — A Phenotype-Driven Pipeline for Mitochondrial DNA Discovery🧬 In this episode of Base by Base, we dive into a powerful phenotype-guided strategy to uncover mitochondrial DNA (mtDNA) diseases in large-scale rare disease cohorts. Ratnaike et al. (2025), publishing in The American Journal of Human Genetics, present the results of a systematic reanalysis of 10,157 exome and genome datasets from the European Solve-RD project, applying a semi-automated pipeline

en-us

00:17:56

🎙️ 50: The Microbiome for Clinicians — Bridging...

Base by Base ·

2025/06/19

🎙️ Episode 50: The Microbiome for Clinicians — Bridging Research and Practice🧬 In this episode of Base by Base, we explore a Perspective article by Porcari et al. (2025) in Cell titled “The microbiome for clinicians,” which examines the current disconnect between microbiome research and its implementation in medical practice, and outlines a strategic roadmap to overcome the barriers preventing its clinical adoption. 🔍 Key Highlights:The authors categorize translational barriers into biological

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00:17:57

️ 50: The Microbiome for Clinicians — Bridging...

Base by Base ·

2025/06/19

️ Episode 50: The Microbiome for Clinicians — Bridging Research and Practice In this episode of Base by Base, we explore a Perspective article by Porcari et al. (2025) in Cell titled “The microbiome for clinicians,” which examines the current disconnect between microbiome research and its implementation in medical practice, and outlines a strategic roadmap to overcome the barriers preventing its clinical adoption. Key Highlights:The authors categorize

en-us

00:22:59

️ 49: Chitin as a Reservoir for Horizontal Gene...

Base by Base ·

2025/06/18

️ Episode 49: Chitin as a Reservoir for Horizontal Gene Transfer — Environmental DNA Adsorption and Natural Transformation in Vibrio cholerae In this episode of Base by Base, we explore the study by Holt et al. (2025) in Proceedings of the National Academy of Sciences, which uncovers how extracellular DNA from the marine environment binds to chitin surfaces and becomes accessible to Vibrio cholerae for natural transformation. Through the use of

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00:22:58

🎙️ 49: Chitin as a Reservoir for Horizontal Gene...

Base by Base ·

2025/06/18

🎙️ Episode 49: Chitin as a Reservoir for Horizontal Gene Transfer — Environmental DNA Adsorption and Natural Transformation in Vibrio cholerae🧬 In this episode of Base by Base, we explore the study by Holt et al. (2025) in Proceedings of the National Academy of Sciences, which uncovers how extracellular DNA from the marine environment binds to chitin surfaces and becomes accessible to Vibrio cholerae for natural transformation. Through the use of microfluidic flow chambers mimicking realistic

en-us

00:16:10

🎙️ 48: Mainstreaming Genetic Testing — A Conceptual...

Base by Base ·

2025/06/16

🎙️ Episode 48: Mainstreaming Genetic Testing — A Conceptual Framework for Expanding Genomic Medicine🧬 In this episode of Base by Base, we explore an important policy and practice shift presented by Mackley et al. (2025) in Genetics in Medicine. The authors propose a conceptual framework for the mainstreaming of clinical genetic testing, addressing the increasing demand for genomic services across medicine and the limited growth of the clinical genetics workforce. By redefining how genetic testing

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00:16:11

️ 48: Mainstreaming Genetic Testing — A Conceptual...

Base by Base ·

2025/06/16

️ Episode 48: Mainstreaming Genetic Testing — A Conceptual Framework for Expanding Genomic Medicine In this episode of Base by Base, we explore an important policy and practice shift presented by Mackley et al. (2025) in Genetics in Medicine. The authors propose a conceptual framework for the mainstreaming of clinical genetic testing, addressing the increasing demand for genomic services across medicine and the limited growth of the clinical genetics

en-us

00:22:38

️ 47: Selectivity and Promiscuity — Decoding the...

Base by Base ·

2025/06/16

️ Episode 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network In this episode of Base by Base, we explore a systems-level framework unveiled by Kleist et al. (2025) in Cell, which dissects how selectivity and promiscuity arise in the intricate network of human chemokine-GPCR interactions. By combining structural biology, evolutionary conservation, and machine learning, the study reveals the molecular grammar that encodes receptor

en-us

00:22:37

🎙️ 47: Selectivity and Promiscuity — Decoding the...

Base by Base ·

2025/06/16

🎙️ Episode 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network🧬 In this episode of Base by Base, we explore a systems-level framework unveiled by Kleist et al. (2025) in Cell, which dissects how selectivity and promiscuity arise in the intricate network of human chemokine-GPCR interactions. By combining structural biology, evolutionary conservation, and machine learning, the study reveals the molecular grammar that encodes receptor specificity and versatility across immune

en-us

452 results

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