x

75% of people globally want unbiased news (Pew Research) but are concerned they're not getting that.

Get balanced coverage with Symby. See how stories are covered across diverse outlets and spot when one side covers a story the other skips.

PODCAST

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

science life sciences

All Episodes

00:21:27

247: Genome graphs reveal structural variation in M....

Base by Base ·

2026/01/02

️ Episode 247: Genome graphs reveal structural variation in M. tuberculosis In this episode of PaperCast Base by Base, we explore Long-read assemblies and a pangenome reference graph uncover widespread structural variants that shape Mycobacterium tuberculosis evolution and contribute to drug resistance Study Highlights:The authors built an M. tuberculosis pangenome reference graph from 859 high-quality long-read assemblies and identified 3,077 unique

en-us

00:16:44

246: SV2A structural pharmacology and allosteric...

Base by Base ·

2026/01/01

️ Episode 246: SV2A structural pharmacology and allosteric occlusion In this episode of PaperCast Base by Base, we explore High-resolution cryo-EM structures of human SV2A reveal that orthosteric ligands induce an occluded MFS conformation and a secondary allosteric pocket modulates ligand binding Study Highlights:The authors report sub-3 Å cryo-EM structures of human SV2A in the apo state and in complexes with levetiracetam, UCB-J, padsevonil, and the

en-us

00:16:44

246: SV2A structural pharmacology and allosteric...

Base by Base ·

2026/01/01

️ Episode 246: SV2A structural pharmacology and allosteric occlusion In this episode of PaperCast Base by Base, we explore High-resolution cryo-EM structures of human SV2A reveal that orthosteric ligands induce an occluded MFS conformation and a secondary allosteric pocket modulates ligand binding Study Highlights:The authors report sub-3 Å cryo-EM structures of human SV2A in the apo state and in complexes with levetiracetam, UCB-J, padsevonil, and the

en-us

00:19:10

245: Benchmarking DNA foundation models

Base by Base ·

2025/12/31

️ Episode 245: Benchmarking DNA foundation models In this episode of PaperCast Base by Base, we explore A comprehensive, unbiased benchmark compares five DNA foundation models across 57 datasets and multiple tasks, finding mean token embeddings improve classification and that model strengths vary by task and pre-training. Study Highlights:The study evaluated DNABERT-2, NT-v2, HyenaDNA, Caduceus-Ph, and GROVER on 57 datasets spanning sequence

en-us

00:19:10

245: Benchmarking DNA foundation models

Base by Base ·

2025/12/31

️ Episode 245: Benchmarking DNA foundation models In this episode of PaperCast Base by Base, we explore A comprehensive, unbiased benchmark compares five DNA foundation models across 57 datasets and multiple tasks, finding mean token embeddings improve classification and that model strengths vary by task and pre-training. Study Highlights:The study evaluated DNABERT-2, NT-v2, HyenaDNA, Caduceus-Ph, and GROVER on 57 datasets spanning sequence

en-us

00:17:38

244: NEK7 couples SDHB to preserve mitochondrial...

Base by Base ·

2025/12/30

️ Episode 244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis In this episode of PaperCast Base by Base, we explore Mitochondrial NEK7 is imported via MTS peptides, binds SDHB to stabilize complex II conformation, prevent reverse electron transport and ROS, and thereby protects against spontaneous and experimentally induced liver fibrosis Study Highlights:NEK7 localizes to hepatocyte mitochondria through two

en-us

00:17:38

244: NEK7 couples SDHB to preserve mitochondrial...

Base by Base ·

2025/12/30

️ Episode 244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis In this episode of PaperCast Base by Base, we explore Mitochondrial NEK7 is imported via MTS peptides, binds SDHB to stabilize complex II conformation, prevent reverse electron transport and ROS, and thereby protects against spontaneous and experimentally induced liver fibrosis Study Highlights:NEK7 localizes to hepatocyte mitochondria through two

en-us

00:17:41

243: Genome-wide UVB GxE study finds 162 vitamin D...

Base by Base ·

2025/12/29

️ Episode 243: Genome-wide UVB GxE study finds 162 vitamin D variants In this episode of PaperCast Base by Base, we explore A GWIS of 338,977 UK Biobank White British participants using a cumulative weighted ambient UVB measure identified 307 independent loci for 25-hydroxyvitamin D, including 162 novel variants Study Highlights:The study linked a cumulative and weighted ambient UVB (CW-D-UVB) dose from TEMIS to each participant’s residence and blood

en-us

00:17:41

243: Genome-wide UVB GxE study finds 162 vitamin D...

Base by Base ·

2025/12/29

️ Episode 243: Genome-wide UVB GxE study finds 162 vitamin D variants In this episode of PaperCast Base by Base, we explore A GWIS of 338,977 UK Biobank White British participants using a cumulative weighted ambient UVB measure identified 307 independent loci for 25-hydroxyvitamin D, including 162 novel variants Study Highlights:The study linked a cumulative and weighted ambient UVB (CW-D-UVB) dose from TEMIS to each participant’s residence and blood

en-us

00:17:40

242: AAV9-fcMISv2 gene therapy prevents pregnancy in...

Base by Base ·

2025/12/28

️ Episode 242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats In this episode of PaperCast Base by Base, we explore A single intramuscular injection of an AAV9 vector encoding feline anti‑Müllerian hormone (fcMISv2) in prepubertal kittens produced sustained supraphysiological AMH, was well tolerated, and prevented breeding‑induced ovulation and pregnancy in adult females Study Highlights:Twelve 2–3 month-old kittens received a single IM dose

en-us

00:18:36

241: Wagyu T2T reveals a cattle X neocentromere

Base by Base ·

2025/12/27

️ Episode 241: Wagyu T2T reveals a cattle X neocentromere In this episode of PaperCast Base by Base, we explore A telomere-to-telomere Wagyu assembly uncovers a natural neocentromere on the cattle X formed by inverted repeats and transposable element expansion, adds hundreds of new genes, and improves variant discovery Study Highlights:The UOA_Wagyu_1 haplotype-resolved assembly includes a complete X chromosome and four T2T autosomes, adding 431 Mb

en-us

00:18:46

240: CYFIP1 controls cortical axon development by...

Base by Base ·

2025/12/26

️ Episode 240: CYFIP1 controls cortical axon development by modulating calcium In this episode of PaperCast Base by Base, we explore Reduction of CYFIP1 delays callosal axon growth and arborization by lowering intracellular calcium and impairing mitochondrial function Study Highlights:In vivo, Cyfip1+/- mice show delayed callosal axon growth at P5 and reduced axonal branching during P15 arborization that normalizes by P30. Cyfip1+/- cortical neurons have

en-us

00:18:46

240: CYFIP1 controls cortical axon development by...

Base by Base ·

2025/12/26

️ Episode 240: CYFIP1 controls cortical axon development by modulating calcium In this episode of PaperCast Base by Base, we explore Reduction of CYFIP1 delays callosal axon growth and arborization by lowering intracellular calcium and impairing mitochondrial function Study Highlights:In vivo, Cyfip1+/- mice show delayed callosal axon growth at P5 and reduced axonal branching during P15 arborization that normalizes by P30. Cyfip1+/- cortical neurons have

en-us

00:19:21

239: Genomic Adaptations of the Svalbard Reindeer

Base by Base ·

2025/12/25

️ Episode 239: Genomic Adaptations of the Svalbard Reindeer In this episode of PaperCast Base by Base, we explore Comparative whole-genome analyses identify 150 differentiated genomic regions and candidate genes linked to fat metabolism, energy conservation, cold tolerance, reduced body size, fur morphology, and circadian rhythm that likely underpin Svalbard reindeer adaptation to the High Arctic Study Highlights:The authors sequenced and analyzed 62

en-us

00:19:21

239: Genomic Adaptations of the Svalbard Reindeer

Base by Base ·

2025/12/25

️ Episode 239: Genomic Adaptations of the Svalbard Reindeer In this episode of PaperCast Base by Base, we explore Comparative whole-genome analyses identify 150 differentiated genomic regions and candidate genes linked to fat metabolism, energy conservation, cold tolerance, reduced body size, fur morphology, and circadian rhythm that likely underpin Svalbard reindeer adaptation to the High Arctic Study Highlights:The authors sequenced and analyzed 62

en-us

00:18:14

238: Germline polymorphisms shape antibody light...

Base by Base ·

2025/12/24

️ Episode 238: Germline polymorphisms shape antibody light chain repertoires In this episode of PaperCast Base by Base, we explore Long-read sequencing of IGK and IGL paired with AIRR-seq shows that common germline SNVs, SVs, and alleles drive inter-individual differences in light chain gene usage and CDR3 properties Study Highlights:The authors combined targeted long-read genomic sequencing of IGK and IGL in 177 donors with matched AIRR-seq (IGK n=164,

en-us

00:18:14

238: Germline polymorphisms shape antibody light...

Base by Base ·

2025/12/24

️ Episode 238: Germline polymorphisms shape antibody light chain repertoires In this episode of PaperCast Base by Base, we explore Long-read sequencing of IGK and IGL paired with AIRR-seq shows that common germline SNVs, SVs, and alleles drive inter-individual differences in light chain gene usage and CDR3 properties Study Highlights:The authors combined targeted long-read genomic sequencing of IGK and IGL in 177 donors with matched AIRR-seq (IGK n=164,

en-us

00:20:00

237: Tracing enteric pathogens in Africa with...

Base by Base ·

2025/12/23

️ Episode 237: Tracing enteric pathogens in Africa with metagenomics and WGS In this episode of PaperCast Base by Base, we explore This study combines whole-genome sequencing and metagenomics to map the diversity, abundance, and genomic relationships of enteric foodborne pathogens across human, animal, food and environmental samples in four African LMICs Study Highlights:The project sampled 3,417 items across Ethiopia, Mozambique, Nigeria and Tanzania

en-us

00:20:00

237: Tracing enteric pathogens in Africa with...

Base by Base ·

2025/12/23

️ Episode 237: Tracing enteric pathogens in Africa with metagenomics and WGS In this episode of PaperCast Base by Base, we explore This study combines whole-genome sequencing and metagenomics to map the diversity, abundance, and genomic relationships of enteric foodborne pathogens across human, animal, food and environmental samples in four African LMICs Study Highlights:The project sampled 3,417 items across Ethiopia, Mozambique, Nigeria and Tanzania

en-us

00:19:54

236: XPD translocation and genetic disease etiology

Base by Base ·

2025/12/22

️ Episode 236: XPD translocation and genetic disease etiology In this episode of PaperCast Base by Base, we explore Computational modeling reveals how ATP-driven conformational cycles of the XPD helicase drive directional 5′→3′ translocation on single-stranded DNA and how mutations disrupt this process to cause disease Study Highlights:The authors combined molecular dynamics, partial nudged elastic band path optimization, transition path sampling, and

en-us

391 results

Similar Podcasts

Classic Radio Science Fiction

solgoodmedia.com

Mission to Mars

Inception Point Ai

The 365 Days of Astronomy

365DaysOfAstronomy.org

Creek Devil

william Jevning

UFO Chronicles Podcast

Nik Hunter