Mendelspod Podcast

23:50

A Seqster Preview with Founder Ardy Arianpour

Mendelspod Podcast ·

2018/08/16

As long as we’ve been doing clinical genetics, the goal has been to marry up the genetic data with phenotypic data in the electronic medical records. This has been achieved with some success and with a few of the best genetic markers at some of the leading healthcare providers: Geisinger, Rady Children's, Brigham and Women’s—to name a few. But it hasn’t happened at scale, at least not in this country. Some of the national health services around the world are making the dream more of a reality,

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31:13

Detective Stories from the Genomic War Room with...

Mendelspod Podcast ·

2018/07/26

A book like this only comes around once in a while—one never knows from which corner. This time it was written by the CTO of a next gen sequencing data analytics company.“Every one of these cases was intense. It was just so fascinating that I had to put it down in a book and tell the story. There’s so much in biology that boggles your mind and makes you wonder.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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27:44

Should Biobanking Come Under CLIA? Shannon McCall, Duke

Mendelspod Podcast ·

2018/07/17

When former President Obama’s team released the paperwork for what’s become the All of Us Research Program, in the part about biobanking, the wording specified that the biobanks applying for the grants be “CLIA compliant.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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15:24

Pharma Stepping Up, Footing the Bill for Genetic...

Mendelspod Podcast ·

2018/06/12

It seems to be human nature to value and pay up to hundreds of thousands of dollars for a little white pill that we can drop on the floor--and granted, can do wonders for us, but we want to pay nothing or very little to be told what is wrong with us so that we might know which little white pill to use in the first place. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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26:59

Are We Asking Too Much of Genomics in Cancer...

Mendelspod Podcast ·

2018/06/07

It’s a question we’ve asked on the program before. Are we over relying on the genomics route getting us to biomedical research paradise? Should we be putting more eggs in other baskets?After combing through lots of clinical trials data, Tony Letai of Dana Farber and the Broad, found that a majority of cancer patients have not benefited from precision medicine. On today’s show he says we need to rethink our approach to cancer research and treatment. This is a public episode. If you'd like to

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25:07

I Won’t Rest Until We Have Quality Standards in Place...

Mendelspod Podcast ·

2018/06/05

She’s a force of nature, and she’s back on Mendelspod. A decade ago, Carolyn Compton was hired by the NCI to solve a problem that has plagued the world of not just cancer research, but all of biomedical research. To this day, there are no standards in place for the acquisition, collection, storage, and delivery of human biological samples used for research. The leader of the NIH has acknowledged that this is a major part of biology’s non-reproducibility problem. This is a public episode. If you'd

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28:59

May 2018 with Nathan and Laura: The Free Exome,...

Mendelspod Podcast ·

2018/06/01

Nathan Pearson and Laura Hercher are back for a look over a busy month of headlines.May took us into the era of the free genome as Geisinger planted the genomic medicine flag on an even higher peak. And did you know California was keeping a genetic database for every baby born?Meh. . . says Laura. Every state does it. Old news.And mosaicism is old scientific news, says Nathan, but he likes the way Carl Zimmer brings it to light in a new book. Nathan and Laura then go above and beyond with their

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23:03

Has Diagnostic Testing Plateaued? Alka Chaubey,...

Mendelspod Podcast ·

2018/05/24

If you’ve been in the field of genetic testing then you know about the Greenwood Genetic Center. With an address on Mendel Circle in Greenwood, South Carolina, this non profit diagnostic testing laboratory has basically written the book on diagnosing and understanding genetic disorders. Chances are, too, that you know the director of their cytogenetics lab and our guest today, Alka Chaubey. Her hunger for meeting new people and learning new science is matched only by her desire to share the

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58:43

A New Way for DTC? Nathan Pearson, Root Deep Insight

Mendelspod Podcast ·

2018/05/17

You know him, but do you know what he does for a day job?Over the past two years, Nathan Pearson has dazzled us with his broad knowledge of the genomics space on our regular monthly reviews. Today we’re talking to Nathan about his new company that he soft launched last December, Root Deep Insight, a venture into what he calls “direct-to-lay folk genetics.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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36:18

Genetic Testing in the Age of Trump: Hank Greely,...

Mendelspod Podcast ·

2018/05/10

"In a world turned upside down, this is an area where I don’t think he’s had much effect. I don’t think he knows how to spell “DNA.”"So begins Hank Greely in today’s interview on genetic testing in the age of Trump. Hank is a Professor of Law and, by courtesy, Professor of Genetics at Stanford. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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34:39

Genetic Testing is Dead, Long Live Genetic Testing:...

Mendelspod Podcast ·

2018/05/03

A few years ago they were the new kid on the block, and now they are a leader of mainstream genetic testing. Last year their revenue and profit were significantly up.And yet in today’s interview, CEO Sean George does not sound like someone sitting back on his laurels. In fact, he says his business model has got to change. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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27:46

April 2018 with Nathan and Laura: Golden State Killer...

Mendelspod Podcast ·

2018/05/01

After decades on the loose, it’s cool the cops finally caught him. But is it cool how they caught him?Nathan Pearson and Laura Hercher are back for April’s headlines. AACR had some more good news about Keytruda, and we take a look at the cancer prediction space.DNA Day, the first cannabis based therapy to be recommended for FDA approval, the Zuckerberg hearing—there’s lots in here today. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes,

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19:45

Liquid Biopsy for Infectious Disease with Mickey...

Mendelspod Podcast ·

2018/04/24

Sequencing goes to the world of infectious disease. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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23:24

Nanopore Sequencing and the Future of Cancer Research...

Mendelspod Podcast ·

2018/04/18

We can all recognize that PacBio has laid down the railroad tracks in the frontier of long read sequencing. What many are asking is just how close on their caboose is Oxford Nanopore? And just what exactly will be the differences between the two technologies?Chia-Lin Wei is the Director of Genome Technologies at the Jackson Laboratories. When we called her up for today’s interview to talk about how she is using nanopore sequencing, she said, “I’ve been using nanopore for years, why the interest

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26:56

A New Method for Long Reads: Hanlee Ji of Stanford on...

Mendelspod Podcast ·

2018/04/10

Hanlee Ji is the Senior Associate Director of the Stanford Genome Technology Center as well as an oncologist at Stanford. He’s also a clinical geneticist. In other words, he doesn’t need to take off his glasses and spin around in a phone booth to be able to do about everything.“I was in fellowship for a long time,” he says in todays interview. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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18:09

March 2018 in Genomics with Nathan & Laura: DTC BRCA...

Mendelspod Podcast ·

2018/04/01

23andMe steals the headlines yet again.“If somebody is worried about breast cancer susceptibility in their family, they should certainly not be using this test.”That’s our monthly commentator and genetic counselor, Laura Hercher, talking about BRCA going DTC. But wait a minute. Then she says the test could be good in some instances. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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23:32

With More Tools in the Box, Lon Cardon Says We’re in...

Mendelspod Podcast ·

2018/03/21

“I think the field has just really come to life over the last five or seven years. We’ve got all this sequence data. We’ve got the population data. We’ve got gene editing. I’ve been at this thirty plus years, and we haven’t had a culmination of technology and data like this before. I think everyone has to be excited in some way or other.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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27:45

Personalized Medicine in the Trump Era with Edward...

Mendelspod Podcast ·

2018/03/15

The Personalized Medicine Coalition advocates for a wide group of constituents, including scientists, health care providers, entrepreneurs, payers, and patients. Which is why we’ve often wondered how the organization can be absolutely clear in their priorities.Today, PMC President Edward Abrahams joins us to answer that question. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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34:12

Eric Schadt and Sema4 Try the Consumer Model with...

Mendelspod Podcast ·

2018/03/06

"We like to refer to it as consumer initiated, but physician supervised,” says Eric Schadt today when asked if his new test is direct-to-consumer.Eric is the Dean for Precision Medicine at the Icahn School of Medicine at Mount Sinai in New York and since 2016 has served as CEO of Sema4, a spinoff that he founded out of the Mount Sinai Health System. Sema4 launched a newborn screening panel, Sema4 Natalis, in February of this year covering over 190 disorders. This is a public episode. If you'd like

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16:42

February 2018 in Genomics with Nathan & Laura:...

Mendelspod Podcast ·

2018/03/01

Booking 26 million viewers, the voice of Warren buffet, the endorsements of Olympians Joey Cheek and Tara Lipinski—this company was going for the gold with their ads during the Olympics this year. Of course, we’re talking of the direct-to-consumer genetic testing company, 23andMe. What was the take of our monthly commentators, Nathan Pearson of Root and Laura Hercher of Sarah Lawrence College?Also, for all the doomsday predictions, has Donald Trump been any worse after one year for our industry

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