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PODCAST

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

science life sciences

All Episodes

00:22:37

🎙️ 47: Selectivity and Promiscuity — Decoding the...

Base by Base ·

2025/06/16

🎙️ Episode 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network🧬 In this episode of Base by Base, we explore a systems-level framework unveiled by Kleist et al. (2025) in Cell, which dissects how selectivity and promiscuity arise in the intricate network of human chemokine-GPCR interactions. By combining structural biology, evolutionary conservation, and machine learning, the study reveals the molecular grammar that encodes receptor specificity and versatility across immune

en-us

00:22:38

️ 47: Selectivity and Promiscuity — Decoding the...

Base by Base ·

2025/06/16

️ Episode 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network In this episode of Base by Base, we explore a systems-level framework unveiled by Kleist et al. (2025) in Cell, which dissects how selectivity and promiscuity arise in the intricate network of human chemokine-GPCR interactions. By combining structural biology, evolutionary conservation, and machine learning, the study reveals the molecular grammar that encodes receptor

en-us

00:20:34

️ 46: Pan-Epitranscriptomic Control — How tRNA and...

Base by Base ·

2025/06/14

️ Episode 46: Pan-Epitranscriptomic Control — How tRNA and m6A Interact to Regulate mRNA Decay In this episode of Base by Base, we delve into a landmark study by Linder et al. (2025), published in Cell, which uncovers a molecular interaction between two layers of RNA modifications — m6A in mRNA and mcm5s2U in tRNA — that tunes mRNA stability in a codon-specific and translation-dependent manner. The authors present a compelling model where tRNA

en-us

00:20:33

🎙️ 46: Pan-Epitranscriptomic Control — How tRNA and...

Base by Base ·

2025/06/14

🎙️ Episode 46: Pan-Epitranscriptomic Control — How tRNA and m6A Interact to Regulate mRNA Decay🧬 In this episode of Base by Base, we delve into a landmark study by Linder et al. (2025), published in Cell, which uncovers a molecular interaction between two layers of RNA modifications — m6A in mRNA and mcm5s2U in tRNA — that tunes mRNA stability in a codon-specific and translation-dependent manner. The authors present a compelling model where tRNA modifications actively influence the functional

en-us

00:20:53

️ 45: Probing Nucleolar Mechanics — RNA-Dependent...

Base by Base ·

2025/06/12

️ Episode 45: Probing Nucleolar Mechanics — RNA-Dependent Viscoelasticity of Nucleolar Subcompartments In this episode of Base por Base, we delve into a groundbreaking study by Cheng et al. (2025) in PNAS that employs micropipette aspiration to directly measure the material properties of nucleoli within living Xenopus laevis oocytes. By aspirating these large, transcriptionally active condensates, the authors distinguish the Newtonian, liquid-like

en-us

00:20:52

🎙️ 45: Probing Nucleolar Mechanics — RNA-Dependent...

Base by Base ·

2025/06/12

🎙️ Episode 45: Probing Nucleolar Mechanics — RNA-Dependent Viscoelasticity of Nucleolar Subcompartments🧬 In this episode of Base por Base, we delve into a groundbreaking study by Cheng et al. (2025) in PNAS that employs micropipette aspiration to directly measure the material properties of nucleoli within living Xenopus laevis oocytes. By aspirating these large, transcriptionally active condensates, the authors distinguish the Newtonian, liquid-like behavior of the granular component (GC) from the

en-us

00:19:00

🎙️ 44: Proofreading Precision — Unveiling the Cryo-EM...

Base by Base ·

2025/06/12

🎙️ Episode 44: Proofreading Precision — Unveiling the Cryo-EM Mechanism of Human DNA Polymerase ε Holoenzyme🧬 In this episode of Base per Base, we delve into a groundbreaking study by Wang et al. (2025) in PNAS that illuminates the molecular choreography of the human leading-strand DNA polymerase ε (Polε) holoenzyme during mismatch proofreading. By combining in situ mismatch generation with high-resolution cryo-electron microscopy, the research captures authentic intermediates of the Polε–PCNA

en-us

00:19:02

️ 44: Proofreading Precision — Unveiling the Cryo-EM...

Base by Base ·

2025/06/12

️ Episode 44: Proofreading Precision — Unveiling the Cryo-EM Mechanism of Human DNA Polymerase ε Holoenzyme In this episode of Base per Base, we delve into a groundbreaking study by Wang et al. (2025) in PNAS that illuminates the molecular choreography of the human leading-strand DNA polymerase ε (Polε) holoenzyme during mismatch proofreading. By combining in situ mismatch generation with high-resolution cryo-electron microscopy, the research captures

en-us

00:19:32

🎙️ 43: Personalized Molecular Signatures of Insulin...

Base by Base ·

2025/06/11

🎙️ Episode 43: Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes🧬 In this episode of Base by Base, we explore the groundbreaking work by Kjærgaard et al. (2025) in Cell, where cutting-edge proteomics and phosphoproteomics were applied to skeletal muscle biopsies from over 120 participants with normal glucose tolerance or type 2 diabetes. By combining hyperinsulinemic-euglycemic clamps with deep in vivo phenotyping, the study maps fasting and insulin-stimulated protein and

en-us

00:19:33

️ 43: Personalized Molecular Signatures of Insulin...

Base by Base ·

2025/06/11

️ Episode 43: Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes In this episode of Base by Base, we explore the groundbreaking work by Kjærgaard et al. (2025) in Cell, where cutting-edge proteomics and phosphoproteomics were applied to skeletal muscle biopsies from over 120 participants with normal glucose tolerance or type 2 diabetes. By combining hyperinsulinemic-euglycemic clamps with deep in vivo phenotyping, the study maps

en-us

00:23:34

🎙️ 42: Amino Acids Catalyse RNA Formation — Unlocking...

Base by Base ·

2025/06/11

🎙️ Episode 42: Amino Acids Catalyse RNA Formation — Unlocking Prebiotic Cross-Catalysis🧬 In this episode of Base por Base, we delve into the groundbreaking 2025 Nature Communications study by Rout et al., which uncovers how simple amino acids, under ambient alkaline dry conditions, act as potent acid-base catalysts to drive non-enzymatic RNA oligomerisation from ribonucleoside-2′,3′-cyclic phosphates .🔍 Principais destaques:Amino acids elevate RNA oligomer yields by more than 100-fold at pH

en-us

00:23:35

️ 42: Amino Acids Catalyse RNA Formation — Unlocking...

Base by Base ·

2025/06/11

️ Episode 42: Amino Acids Catalyse RNA Formation — Unlocking Prebiotic Cross-Catalysis In this episode of Base por Base, we delve into the groundbreaking 2025 Nature Communications study by Rout et al., which uncovers how simple amino acids, under ambient alkaline dry conditions, act as potent acid-base catalysts to drive non-enzymatic RNA oligomerisation from ribonucleoside-2′,3′-cyclic phosphates . Principais destaques:Amino acids elevate RNA oligomer

en-us

00:18:43

️ 41: Public Preferences for Genomic Newborn...

Base by Base ·

2025/06/10

️ Episode 41: Public Preferences for Genomic Newborn Screening in Australia — Insights from Discrete Choice Experiments In this episode of Base by Base, we discuss a landmark study by Peters et al. (2025) in The American Journal of Human Genetics, which surveyed 2,509 members of the Australian public to uncover how people value and would like to see genomic newborn screening (gNBS) implemented . Highlights of the Study: Through two discrete choice

en-us

00:18:42

🎙️ 41: Public Preferences for Genomic Newborn...

Base by Base ·

2025/06/10

🎙️ Episode 41: Public Preferences for Genomic Newborn Screening in Australia — Insights from Discrete Choice Experiments🧬 In this episode of Base by Base, we discuss a landmark study by Peters et al. (2025) in The American Journal of Human Genetics, which surveyed 2,509 members of the Australian public to uncover how people value and would like to see genomic newborn screening (gNBS) implemented .🔍 Highlights of the Study: Through two discrete choice experiments, the authors demonstrated that

en-us

00:17:43

️ 40: Lysosomal Proton Leak — Uncovering SLC7A11’s...

Base by Base ·

2025/06/09

️ Episode 40: Lysosomal Proton Leak — Uncovering SLC7A11’s Role as an Unconventional H⁺ Transit Pathway In this episode of Base by Base, we delve into a revealing study by Zhou et al. (2025) in Cell that identifies SLC7A11—long known for its function in redox homeostasis and ferroptosis—as a slow H⁺ transporter embedded in lysosomal membranes. Through a combination of CRISPR knockouts, pharmacological inhibition, ratiometric pH imaging, and assays on

en-us

00:17:42

🎙️ 40: Lysosomal Proton Leak — Uncovering SLC7A11’s...

Base by Base ·

2025/06/09

🎙️ Episode 40: Lysosomal Proton Leak — Uncovering SLC7A11’s Role as an Unconventional H⁺ Transit Pathway🧬 In this episode of Base by Base, we delve into a revealing study by Zhou et al. (2025) in Cell that identifies SLC7A11—long known for its function in redox homeostasis and ferroptosis—as a slow H⁺ transporter embedded in lysosomal membranes. Through a combination of CRISPR knockouts, pharmacological inhibition, ratiometric pH imaging, and assays on isolated lysosomes, the authors demonstrate

en-us

00:19:14

🎙️ 39: Whole-Genome Polygenic Score Inference — Fast...

Base by Base ·

2025/06/07

🎙️ Episode 39: Whole-Genome Polygenic Score Inference — Fast and Memory-Efficient Algorithms for Scalable PRS🧬 In this episode of Base by Base, we dive into the methodological breakthroughs of Zabad et al. (2025) in The American Journal of Human Genetics, where the authors introduce an updated variational inference framework (VIPRS v0.1) and novel data structures that together enable polygenic risk score computation across tens of millions of variants with dramatically reduced runtime and memory

en-us

00:19:15

️ 39: Whole-Genome Polygenic Score Inference — Fast...

Base by Base ·

2025/06/07

️ Episode 39: Whole-Genome Polygenic Score Inference — Fast and Memory-Efficient Algorithms for Scalable PRS In this episode of Base by Base, we dive into the methodological breakthroughs of Zabad et al. (2025) in The American Journal of Human Genetics, where the authors introduce an updated variational inference framework (VIPRS v0.1) and novel data structures that together enable polygenic risk score computation across tens of millions of variants with

en-us

00:20:28

🎙️ 38: Viral Journeys — Tracing the Ancestral Bat...

Base by Base ·

2025/06/07

🎙️ Episode 38: The Recency and Geographical Origins of Bat Viruses Ancestral to SARS-CoV and SARS-CoV-2🧬 In this episode of Base by Base, we delve into a landmark study by Pekar et al. (2025) in Cell that harnesses recombination-aware phylogenetic and spatial analyses to trace how the closest bat coronavirus ancestors of SARS-CoV-1 and SARS-CoV-2 circulated mere years before spilling over into humans. By dissecting non-recombinant genomic segments and applying tailored molecular clock models, the

en-us

00:20:29

️ 38: Viral Journeys — Tracing the Ancestral Bat...

Base by Base ·

2025/06/07

️ Episode 38: The Recency and Geographical Origins of Bat Viruses Ancestral to SARS-CoV and SARS-CoV-2 In this episode of Base by Base, we delve into a landmark study by Pekar et al. (2025) in Cell that harnesses recombination-aware phylogenetic and spatial analyses to trace how the closest bat coronavirus ancestors of SARS-CoV-1 and SARS-CoV-2 circulated mere years before spilling over into humans. By dissecting non-recombinant genomic segments and

en-us

454 results

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