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PODCAST

The Optispan Podcast with Matt Kaeberlein

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that

science

All Episodes

01:18:28

Siim Land: Biohacking Longevity, Health Span Truths &...

The Optispan Podcast with Matt Kaeberlein ·

2025/04/17

Subscribe to our channel: https://www.youtube.com/@optispanBiohacking expert Siim Land joins Matt Kaeberlein to discuss optimizing health span with science-based lifestyle tips (diet, exercise, sleep), key biomarkers, and navigating longevity misinformation & biological age clock hype.0:00 Introduction: Meet Siim Land2:41 Defining Longevity: Health Span vs Lifespan4:31 The Longevity Escape Velocity Debate12:21 Navigating Longevity Hype, Misinformation & Credibility28:56 Biohacking Case

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00:16:12

The Science of Aging Well: "A Practical Approach to...

The Optispan Podcast with Matt Kaeberlein ·

2025/04/15

Subscribe to our channel: https://www.youtube.com/@optispanSign up for the Optispan Newsletter: https://www.optispan.life/Read or get your copy of Matt's Scientific American Article: https://www.scientificamerican.com/custom-media/healthspan/In this episode, Dr. Matt Kaeberlein reads and discusses his insightful article, "A Practical Approach to HealthSpan Medicine," featured in the Scientific American special issue "HealthSpan: The Science of Aging Well."Discover the future of healthcare focused on

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00:56:38

Longevity Experts Discuss Their Health Advice &...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/27

Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein is joined by Dr. Marcus Ranney and Dr. Brian Kennedy, leading experts in longevity science. Recorded at the Rise for Aging Conference in Bangalore, India, they discuss India’s growing role in longevity research, the impact of AI in aging and healthcare, and unique health challenges in India, such as diet, diabetes, and metabolic health. They also explore innovative healthcare solutions, including digital health records,

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01:00:35

Brain Aging & Alzheimer’s Prevention: The Future of...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/18

Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Christin Glorioso, founder of NeuroAge Therapeutics, explore groundbreaking advancements in brain aging and Alzheimer's prevention. Learn how cutting-edge brain age testing—combining MRI, cognitive assessments, blood biomarkers, and genetics—can predict Alzheimer’s risk decades in advance. Discover the impact of lifestyle factors like diet, exercise, and sleep on cognitive decline, plus the latest in

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01:15:32

Gut Health: Science-Backed Tips For Leaky Gut, IBS, &...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/13

Subscribe to our channel: https://www.youtube.com/@optispanDr. Matt Kaeberlein & Dr. Mary Pardee sit down to discuss insights on gut health, digestion, and common GI issues like IBS and constipation. This video covers practical approaches to improving gut function, debunking myths, and identifying effective solutions for long-term wellness, all while attempting to separate fact from fiction in the world of gut health.0:00 - Introduction to Gut Health & Microbiome1:47 - IBS and Digestive

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00:14:33

The Truth About Biological Age Tests | 104

The Optispan Podcast with Matt Kaeberlein ·

2025/03/11

Subscribe to our channel: https://www.youtube.com/@optispanMatt Kaeberlein dives into the controversial world of biological age tests. Many direct-to-consumer tests claim to measure your biological age, but are they accurate or useful? Based on extensive research and clinical experience, we uncover why these tests are statistically meaningless, lack regulatory validation, and fail to provide actionable health insights. Instead, we highlight proven biomarkers that actually contribute to longevity and

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00:55:07

Dr. Kevin White: Concierge Medicine & Its Impacts On...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/06

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, we dive into concierge medicine, how it differs from traditional primary care, and why more people are opting for personalized healthcare. Dr. Kevin White shares insights on longevity medicine, proactive health strategies, and the benefits of direct physician access. We discuss the costs, the role of insurance, advanced diagnostics, and the future of AI in concierge medicine.0:00 - Intro & Concierge Medicine Overview3:15

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00:50:54

Dr. Kevin White: Concierge Medicine & Its Impacts On...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/06

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, we dive into concierge medicine, how it differs from traditional primary care, and why more people are opting for personalized healthcare. Dr. Kevin White shares insights on longevity medicine, proactive health strategies, and the benefits of direct physician access. We discuss the costs, the role of insurance, advanced diagnostics, and the future of AI in concierge medicine.0:00 - Intro & Concierge Medicine Overview3:15

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00:42:42

Thomas Delauer: NEW Nutrition, Exercise, and Mindset...

The Optispan Podcast with Matt Kaeberlein ·

2025/03/04

Subscribe to our channel: https://www.youtube.com/@optispanThomas DeLauer & I (Dr. Matt Kaeberlein) discusses his evolving perspectives on nutrition, exercise, and health optimization. Thomas shares how his views on insulin, low-carb diets, and fructose have shifted, his approach to training for strength and longevity, and the importance of sleep, emotional well-being, and recovery. Delauer also touches on peptides, supplements, and wearable tech, providing valuable takeaways for those looking

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00:21:21

My Biggest Health & Longevity Breakthroughs at 54 | 101

The Optispan Podcast with Matt Kaeberlein ·

2025/02/27

Subscribe to our channel: https://www.youtube.com/@optispanI share the top health and longevity strategies that have transformed my energy, fitness, and well-being at 54 - From hormone optimization (TRT) and resistance training to diet improvements, alcohol reduction, and preventative diagnostics.0:00 - Reflections on Turning 54 & Longevity Mindset1:42 - Hormone Optimization: The Biggest Game-Changer3:28 - Diet & Alcohol Reduction: Key Health Improvements4:56 - Exercise & Resistance

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01:31:13

Dr. Greg Fahy: Thymus Regeneration & Boosting The...

The Optispan Podcast with Matt Kaeberlein ·

2025/02/25

Subscribe to our channel: https://www.youtube.com/@optispanDr. Greg Fahy discusses his groundbreaking research on thymus regeneration, immune system rejuvenation, and the role of growth hormone, DHEA, and metformin in reversing aging-related immune decline. He explains the TRIM protocol, the impact of thymic involution on longevity, and the potential for improving vaccine response and overall health. This conversation explores immune function, senescent cell clearance, and epigenetic aging

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00:58:44

The Benefits Of Testosterone Replacement Therapy...

The Optispan Podcast with Matt Kaeberlein ·

2025/02/20

Subscribe to our channel: https://www.youtube.com/@optispanIs testosterone therapy right for you? In this episode, Matt Kaeberlein & Kevin White explore the benefits, risks, and misconceptions of testosterone replacement therapy (TRT). Learn about low testosterone symptoms, when to get tested, and the differences between primary and secondary hypogonadism. We also cover treatment options like injections, creams, and Clomid, plus the impact on heart health, longevity, and mental well-being.0:00 -

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00:42:12

The Effects of Rapamycin on APOE4 Carriers & Brain...

The Optispan Podcast with Matt Kaeberlein ·

2025/02/11

Subscribe to our channel: https://www.youtube.com/@optispanIn this video we discuss current studies relating to Rapamycin use and it's effects on brain function, specifically for APOE4 carriers. This data may (or may not) provide evidence to support the claim that Rapamycin can be beneficial for those with the APOE4 variant.0:00 - Introduction1:58 - Should APOE4 Carriers Take Rapamycin? 3:30 - What is APOE and APOE4? 13:06 - Why Knowing Your APOE Status Matters 15:03 - The Case for Rapamycin

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01:00:50

Crypto-Powered Science: How Blockchain & DAOs Are...

The Optispan Podcast with Matt Kaeberlein ·

2025/02/06

Subscribe to our channel: https://www.youtube.com/@optispanIn this video I sit down with the COO of Molecule AG, Benji Leibowitz, to discuss how blockchain and cryptocurrency can be applied to intellectual property (IP) in biotech research, particularly in funding longevity studies. The discussion covers concepts like DAOs (Decentralized Autonomous Organizations), tokenized intellectual property, and how this model might revolutionize scientific collaboration and fundraising. 0:00 What is

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01:17:45

Peter Attia: Training, Eating & Optimizing To Live...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/23

Subscribe to our channel: https://www.youtube.com/@optispanIn this video I sit down with Dr. Peter Attia to explore strategies for improving healthspan and lifespan, focusing on practical interventions like exercise, nutrition, and emerging therapies. Topics we discuss include defining healthspan (physical, cognitive, and emotional health), the benefits of purposeful exercise, and prioritizing dietary factors (what, when, and how much to eat). Our discussion also addresses nuanced views on

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00:21:46

These Supplements Help Dogs Live Longer?

The Optispan Podcast with Matt Kaeberlein ·

2025/01/16

Subscribe to our channel: https://www.youtube.com/@optispanIn this video of Longevity this Week, Matt, Nick, and Mitchell sit down to discuss longevity supplements for pets, scientific evidence backing them, supplement industry ethics, and broader implications in the longevity field. 0:00 - Introduction to Longevity Supplements for Pets 0:16 - Supplement Ingredients 1:30 - Evaluating Scientific Evidence 4:18 - Ethical Concerns in the Supplement Industry 7:20 - Potential Risks of Unproven

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00:26:22

Aging "Hotspot" Found in Brain? Hypochondriacs Don't...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/14

Subscribe to our channel: https://www.youtube.com/@optispanWe explore the psychological and health implications of hypochondriasis, especially in the context of biological age testing and wearables. We then delve into how anxiety and fixation on health metrics can influence behavior and potentially exacerbate health risks. This discussion transitions to a groundbreaking study on brain aging from the Allen Institute, highlighting insights from single-cell transcriptomics, particularly inflammation

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00:38:31

Correcting the Record on Past Videos: Biological Age...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/09

Subscribe to our channel: https://www.youtube.com/@optispanMatt & Nick cover past episode fixes, address audience comments, and share updates about the channel and what you can expect to see from the channel moving forward into the New Year. 00:00 Intro & Setting New Years Goals 07:34 Full body MRI's 11:55 DrugAge Database 1:17:22 Biological Age Tests 1:29:38 Matt Talking Too Much? 1:32:17 Podcast Guests 1:35:08 Scott Carney Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob

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01:38:48

LIVE AMA: Longevity Scientists Answer Your Health &...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/02

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, Matt and Brian Kennedy delve into the potential benefits and side effects of interventions like Rapamycin, the role of biomarkers, and optimal approaches to enhancing healthspan and cognitive function. Together they highlight the challenges of supplement use, aging research methodologies, and regulatory hurdles like the FDA’s stance on aging. They address emerging ideas such as leveraging AI for aging research, the

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00:46:08

My Review of Peter Attia’s AMA: What I Agree &...

The Optispan Podcast with Matt Kaeberlein ·

2025/01/02

Subscribe to our channel: https://www.youtube.com/@optispan In this episode, Matt shares his thoughts on Peter Attia's AMA , exploring areas of agreement and differing perspectives on health and longevity. Topics include the significance of grip strength, biomarkers for health assessment, exercise strategies while traveling, and advancements in longevity research like Klotho and GLP-1 agonists. Matt also discusses the role of AI in healthcare and addresses concerns about direct-to-consumer

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