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PODCAST

The Optispan Podcast with Matt Kaeberlein

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that

science

All Episodes

00:45:27

Everything I do for Healthspan (and why I skip THESE...

The Optispan Podcast with Matt Kaeberlein ·

2026/01/10

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/As we close out 2025, I'm sharing a comprehensive and honest review of my personal health optimization protocol. I break down the exact lifestyle habits, supplements, and medications I use daily, and just as importantly, which popular ones I avoid and why.I detail the massive impact of my "Four Pillars" and explain the thought process behind each item in my regimen,

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01:03:17

This Viral "Whorebath" Test Is Not What You Think It Is

The Optispan Podcast with Matt Kaeberlein ·

2026/01/08

Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/They call it the "whorebath" test. 🛁 We call it a massive misunderstanding of science.ing biological age tests.In this episode, Dr. Matt cuts through the noise to explain what ageing clocks actually are, what they measure, and more importantly, what they DON'T. You'll learn why that $500 direct-to-consumer test is likely giving you meaningless noise, why seeing a drop in your

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01:11:33

Preventive Failure: How Modern Healthcare Misses...

The Optispan Podcast with Matt Kaeberlein ·

2026/01/07

Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join Matt and Dr. Nicole (Nicki) Byrne, Clinic Director at Optispan, for a deep dive into preventative Healthspan Medicine. In this episode, they discuss why traditional reactive healthcare is failing us, what true preventative care looks like, and the comprehensive, data-driven approach used at Optispan to catch risks early and optimize long-term health. From advanced diagnostics to lifestyle

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00:50:02

6 Months on TRT Changed My Body (THIS Is My Takeaway)

The Optispan Podcast with Matt Kaeberlein ·

2025/12/13

This is an AMA episode where Dr Matt answers the pressing questions audience had. In this episode, Matt shares candid updates on his TRT journey and physique, debates rapamycin protocols vs. extreme fasting, and separates the scary headlines from the science on microplastics and "magic" mushrooms. Plus: why he wakes up at 4:30 AM, the truth about HBOT, and a surprising update on his books.Timestamps0:00 Intro1:00 Is Matt Still Taking Rapamycin?6:09 Best Time of Day to Take Rapamycin8:29

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00:53:00

The Dangerous Truth About The Peptide Craze (I Tried It)

The Optispan Podcast with Matt Kaeberlein ·

2025/12/06

This podcast episode is part three of a travel series where Matt recounts his recent trips to longevity and healthspan conferences in Geneva, Chicago, and Mauritius. He shares his experiences with jet lag, workouts, and the contrasting cultures of these events, from the more "alternative medicine" feel of the Geneva summit to the more scientifically-grounded Mauritius conference. A major theme is his critique of the current state of the longevity field, where he advocates for

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01:09:01

New Discovery: This Molecule Could Beat Rapamycin in...

The Optispan Podcast with Matt Kaeberlein ·

2025/11/29

Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Dive into the future of longevity research with Dr. Ben Blue, CEO of Ora Biomedical. We explore how Ora's high-throughput "Wormbot" platform is conducting the world's largest unbiased search for longevity interventions, moving beyond the narrow focus on established pathways like mTOR.In this episode, we discuss:• The ambitious Million Molecule Challenge and why it could revolutionize the field.•

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00:06:04

Matt's Thanksgiving Message

The Optispan Podcast with Matt Kaeberlein ·

2025/11/27

Happy thanksgiving from the Optispan Team!

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02:07:38

Longevity Problem: 70% Of All Deaths Are Caused By...

The Optispan Podcast with Matt Kaeberlein ·

2025/11/25

Longevity scientist Dr. Andrew Steele sits down with Dr. Matt Kaeberlein to make the provocative case that aging should be treated as humanity's greatest challenge, even bigger than climate change. In this deep conversation, they explore why two-thirds of all deaths are caused by aging, the cutting-edge science that's already extending healthy lifespan in animals, and what it would really mean to add decades of vitality to human life. From CRISPR gene therapies to senescent cell clearance,

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00:58:42

Scientist Reacts: Why Megadosing Creatine Is A Waste...

The Optispan Podcast with Matt Kaeberlein ·

2025/11/22

Creatine is being called a "cognitive super-drug" that feels like "speed without the speed." Influencers are telling you to mega-dose 20 grams a day for brain power, bone health, and more. But what does the science actually say?In this episode, we go beyond the hype and fact-check the wildest creatine claims taking over the internet. I break down the real evidence on mega-dosing, and put the cognitive benefits to the testI react to clips from Paul Saladino, Jeff Cavalier, Rhonda

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01:33:18

We'll Pay $101 Million If You Prove You Can Reverse...

The Optispan Podcast with Matt Kaeberlein ·

2025/11/18

Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join me for a fascinating conversation with Dr. Jamie Justice, Executive Director of the $101 Million XPRIZE Healthspan. In this podcast, we discuss the world of longevity science, from the ambitious goals of this global competition to the lessons learned from the stalled TAME trial.Dr. Justice explains how the XPRIZE is structured to find real-world solutions to extend human

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01:13:00

Dr. Stanfield Mortgaged His House For $150k To Prove...

The Optispan Podcast with Matt Kaeberlein ·

2025/11/11

In this in-depth conversation, Dr. Brad Stanfield sits down with Dr Matt Kaeberlein to discuss his journey from a primary care physician in New Zealand to a leading voice in the evidence-based longevity space. We cover the launch and philosophy behind his YouTube channel, the challenges and exciting results of his self-funded rapamycin clinical trial, and his critical perspective on supplements, medical guidelines, and the future of aging research.Dr. Stanfield provides a unique clinician's

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00:09:43

Don't Fall For This Scam: Matt's Deepfake PSA

The Optispan Podcast with Matt Kaeberlein ·

2025/11/06

Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical

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00:42:23

You Might Have The Heart Attack Gene. Here Are The Signs

The Optispan Podcast with Matt Kaeberlein ·

2025/11/04

Joel Jamison is back for another deep dive, and this episode is packed with actionable insights, personal health revelations, and answers to your burning questions. We cover everything from the legitimacy of new health tech to Joel's ongoing journey with a shocking calcium score and what he's doing about it.If you have a family history of heart disease, use wearable tech, or are just focused on optimizing your health and longevity, this conversation is for you.TIMESTAMPS:00:00:00 -

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01:47:39

The $40 Cure They Don't Want You to Know About

The Optispan Podcast with Matt Kaeberlein ·

2025/10/28

In this podcast, I sit down with Dr. Jon Berner to explore two of the most promising yet misunderstood therapeutic agents: Lithium and Rapamycin.We begin with a groundbreaking discussion on Lithium, moving far beyond its traditional use in psychiatry. We break down the recent landmark study in Nature that positions lithium as a potential powerhouse for combating Alzheimer's disease, delve into the different salts (orotate vs. carbonate), and discuss who might benefit, who should be cautious, and

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01:48:07

Longevity Lie: Doctor Reveals Why Anti-Aging...

The Optispan Podcast with Matt Kaeberlein ·

2025/10/22

Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join me for an in-depth conversation with Dr. Alex and Dr. Jan from the YEARS Healthspan Clinic in Berlin. They pull back the curtain on what a truly evidence-based, scientific approach to longevity medicine looks like, moving beyond the hype and "snake oil" to focus on rigorous diagnostics, personalized interventions, and the critical collection of high-quality data.In this episode,

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01:26:12

Blood Cleaning: Cuts Age Biomarkers 2.6 Years in 90...

The Optispan Podcast with Matt Kaeberlein ·

2025/10/21

Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Ever heard of a medical procedure that’s been called an “oil change for your blood”?In this episode, I sit down with Dr. Brad Younggren to explore Therapeutic Plasma Exchange (TPE), a cutting-edge intervention that just might help extend healthspan, reduce biological age, and even clear hidden toxins like microplastics.We discuss the fascinating science behind TPE, from the famous parabiosis

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00:53:35

Doctor Reveals: The Dark Side of the Longevity Industry

The Optispan Podcast with Matt Kaeberlein ·

2025/10/15

Just back from the tour of the longevity world! In this episode, we discuss my recent travels to two major conferences: the high-end Longevity Investors Conference in Gstaad, Switzerland, and the academic GJAM Conference in Jena, Germany.We unpack the stark contrasts between these two worlds, from the venues and treatment of attendees to the fundamental divides in how people perceive and practice "longevity." I share my key takeaways on the growing chasm between real science and snake oil,

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01:30:15

Why 400+ Alzheimer's Drugs Failed (Here's What Works)

The Optispan Podcast with Matt Kaeberlein ·

2025/10/05

Alzheimer’s is often talked about but rarely understood in full. For decades, most research has focused on amyloid plaques, but what if that’s only part of the story? In this deep-dive, Dr. Cory, from the Institute for Systems Biology explains a new way of looking at Alzheimer’s: It is not simply a plaque problem, but as a breakdown in the brain’s “debris management” system, especially how it handles cholesterol. This perspective connects the dots between genes like ApoE4, the role of microglia, and

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01:00:32

Female Biohacker: Why Women Need Different Longevity...

The Optispan Podcast with Matt Kaeberlein ·

2025/09/30

Ever wondered how simple, consistent practices can transform your health? In this episode, Kayla Barnes shares her personal journey from growing up on a standard diet to discovering the science-backed habits that help manage toxin exposure, support heart and brain health, and reduce stress.She talks about:• How her environment affected her toxin levels and what helped bring them down• The surprising benefits of sauna and why long-term practices matter• The early health choices that set her up for

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01:23:38

AI Medicine: ChatGPT Reads Blood Tests Faster Than...

The Optispan Podcast with Matt Kaeberlein ·

2025/09/23

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Most people take supplements without ever checking if their body actually needs them. Is that smart… or just expensive guesswork?In this podcast, Dr. Matt Kaeberlein sits down with Ryan Ware to unpack the truth about supplements, the rise of AI in medicine, and how people are consuming health information today. From internet “gurus” to tools like ChatGPT, they explore where people

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