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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

03:37

📅🔍🧠: A Natural Experiment Reveals Dementia-Slowing...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/06

🚀 New insights from Cell shine a light on an unexpected ally in the fight against cognitive decline. A natural experiment from Wales shows that the shingles (herpes zoster) vaccine doesn't just prevent viral reactivation—it may also reduce new mild cognitive impairment and lower dementia-related mortality over long-term follow-up. 🔍 Using a strict birthday-based eligibility cutoff, the study provides causal evidence—rare in population dementia research—that vaccination may slow disease across its

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04:56

Covid, RSV, Influenza: The 2025–26 NEJM Update 🧬🔥📊

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/05

📘 New NEJM Evidence for the 2025–26 Vaccine Season is out—and it delivers clarity at a time we need it most. The systematic review of 511 studies shows strong, consistent protection against hospitalization from Covid-19, RSV, and Influenza, with reassuring safety profiles across age groups. 💉🛡️ Key insights: improved VE for updated Covid-19 strains, high efficacy of maternal RSV vaccination and nirsevimab for infants, and solid influenza performance. 📊👶 A valuable guide for clinicians,

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05:46

Winning Against HFrEF 🥇💓🛠 Diagnose Early. Treat with...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/04

New Lancet Seminar on heart failure with reduced ejection fraction. 💓📘, this videocast walks listeners through the essentials of diagnosis, natriuretic peptides, imaging pathways, and the four foundational therapies shaping modern heart failure care. It's a clear, evidence-driven journey—designed to inform, clarify, and elevate bedside practice. Tune in to explore the science, the strategy, and the future of treating HFrEF. 🫀🔬✨ 🫀🔬✨

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06:20

Seeing CAD Clearly 🔍❤️: Plaque, Perfusion, Prognosis 📸💓📈

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/03

🔍💓 Chronic Coronary Artery Disease: Seeing What Matters Before It Hurts Just finished reviewing the 2025 Lancet paper on contemporary non-invasive imaging for chronic CAD, and the message is striking: how we see the heart shapes how well we save it. From CT angiography that unmasks non-obstructive plaque 🖥️➡️🫀 to stress PET/CMR that maps true ischemia under load 💨📊, multimodality imaging is redefining diagnosis, risk, and long-term outcomes. The evidence is clear: better imaging leads to

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03:25

Dr RR Baliga's Philosophical Discourses: David Hume...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/02

Exploring David Hume 🧠✨ Just revisited David Hume's extraordinary contributions to modern thought — a reminder of how deeply empiricism, skepticism, and the science of human nature shape our intellectual world. His insights on causation, the limits of reason, and the power of moral sentiment continue to resonate across philosophy, psychology, economics, and evidence-based decision-making. 🌍📚 Hume challenges us to look closely, question boldly, and reason with humility — a timeless guide for

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04:42

Heart Failure Rising 📈 | Risks Rewired 🔄 | America's...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/12/01

The U.S. heart failure landscape is transforming—and fast. 🫀📊 A new JACC analysis reveals a 35-year shift from ischemic to metabolic drivers of heart failure, with obesity, dysglycemia, and chronic kidney disease rising sharply, even as blood pressure, cholesterol, smoking, and myocardial infarction decline. 📉⚖️ These trends demand a new generation of HF trials—more inclusive, prevention-focused, metabolism-centered, and designed to capture outcomes beyond cardiovascular death. 🚀🧬 A

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03:20

Clocks, Clues, and Clarity ⏳🔬🧠 — Decoding...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/30

🧬⏳ New Insights into Organ-Specific Aging! 🧠❤️🩺 Just explored a remarkable Nature Aging study showing how organ-specific proteomic clocks can forecast disease, cognitive decline, and even longevity with impressive precision. These clocks—built from >2,900 plasma proteins—reveal that the brain, kidney, and arteries age on their own timelines, each carrying unique clues about future health. What struck me most is how brain aging outperforms traditional risk markers, predicting dementia even

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04:29

Vaccines. Viruses. Vital Signs. 💉🦠❤️ Adult...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/29

Respiratory vaccines are not just infection-fighters—they're cardiovascular protectors. 💉🫀 The 2025 JACC Consensus reminds us that influenza, pneumococcal, COVID-19, RSV, and zoster vaccines reduce MI, HF decompensation, hospitalizations, and death in our most vulnerable patients. As clinicians, we hold the power to translate evidence into prevention: strong recommendations, simple pathways, and clear conversations can save lives long before interventions do. 🌟 Vaccinate to protect the heart

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03:02

Sun, Skin, Survival 🌞🧬🛡️ – The Modern Landscape of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/29

The latest JAMA article on keratinocyte carcinomas 🌞—a timely reminder that BCC and cSCC remain the world's most common cancers, with more than 5.4 million cases annually in the US alone . The review highlights essential updates in epidemiology, high-risk features, prevention, and evidence-based management, especially the role of sun protection, actinic keratosis treatment, and risk-stratified surgical care 🔬⚕️. A great resource for clinicians committed to early detection, thoughtful treatment,

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04:48

Food In, Fire Out 🍽️🔥—The Leukotriene Story 🧬

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/28

🚨 Food Anaphylaxis: New Mechanisms Unveiled 🍽️🧬 A superb NEJM review highlights how cysteinyl leukotrienes act as gatekeepers in the gut—opening antigen passages, expanding mast cells, and amplifying the risk of oral anaphylaxis. The work elegantly bridges basic lipid biology with real-world food allergy challenges, and points toward new preventive strategies beyond current IgE-based therapies. 🔍 A must-read for clinicians, scientists, and anyone navigating severe food allergies.

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05:07

Cannabis: Promise, Peril, and Practice 🌿⚖️🧭

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/27

🌿 What does the evidence really say about medical cannabis? A new JAMA review highlights a clear message: cannabis helps few conditions—and harms may outweigh benefits for many. 📉 Small benefit for nausea ⚡ Moderate benefit for select pediatric seizures 💊 Limited evidence for pain, insomnia, or psychiatric use ❤️ Risks rise with high-potency products, especially for heart and mental health. 🧭 Clinicians: guide with evidence, screen carefully, use lowest-risk options.

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03:56

Dengue Blocked, Viral Load Dropped, Hope...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/27

Thrilled to see a major step forward in dengue prevention! 🦟💊 A new NEJM study reports that daily mosnodenvir, a first-in-class antiviral targeting the NS3–NS4B interaction, significantly reduced DENV-3 viral load and prevented infection in a controlled human challenge model. 📉🧬 It's early, but the results offer real hope for a long-awaited oral dengue prophylaxis—with encouraging safety, strong PK, and dose-dependent efficacy. 🚀🌍 Exciting moment for global infectious-disease innovation and

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04:46

Storms, Syncope, Survival 🌩️😵‍💫❤️ — Long QT Syndrome...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/26

Delighted to share a concise update on the latest NEJM review of Long QT Syndrome 🫀📘 — a masterful synthesis by Schwartz & Crotti that reframes how we recognize risk, personalize therapy, and prevent sudden death in this genetically mediated disorder. The piece highlights ion-channel biology, gene-specific triggers, the impact of modifier genes, and the effectiveness of a tiered therapeutic approach including beta-blockers, mexiletine, and left cardiac sympathetic denervation ⚡️🧬🛡️. For

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03:15

Dr RR Baliga's Philosophical Discourses: Gottfried...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/25

🧠✨ Leibniz: Harmony, Logic, and the Birth of the Digital Mind Celebrating Gottfried Wilhelm Leibniz — the mathematician-philosopher who co-created calculus, invented binary arithmetic, and envisioned a world stitched together by pre-established harmony. His Monadology reads like proto-systems theory, and his binary system is the quiet ancestor of every computer we use today. For clinicians and scientists, his legacy whispers: 🔹 Seek the sufficient reason behind every pattern 🔹 Value multiple

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05:15

Genes, Environment, Development 🧬🌿🧠— A 2025...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/24

🧬 New insights into autism: A 2025 JCI Viewpoint highlights how hundreds of genes, polygenic risk, and specific environmental factors converge during fetal brain development to shape autism likelihood. 🧠 Early biomarkers—from infant MRI and ERPs to machine-learning models using EHR data—are accelerating earlier, more tailored interventions. 🌱 Advances in gene therapy, IGF-1 pathways, and proteomics offer emerging therapeutic possibilities. 🤝 Centering autistic voices remains essential as

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04:58

Numbness • Nerves • Nuance 🦶⚡🧠 — Decoding Peripheral...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/23

🔍 Peripheral Neuropathy: What Clinicians Should Know 🧠⚡ Peripheral neuropathy affects ~1% of adults worldwide, with diabetes accounting for more than half of all cases. The JAMA review highlights why length-dependent patterns dominate, how metabolic stress injures long axons first, and why sensory symptoms outpace motor loss. Evidence-based evaluation still begins with glucose testing, vitamin B12 with methylmalonic acid, and serum protein electrophoresis. First-line therapies for neuropathic

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05:12

Stroke Risk, Stent Benefit, Surgical Uncertainty 🧠✨🔧

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/22

New NEJM insights on asymptomatic carotid stenosis 🧠🔍 The CREST-2 trials offer a landmark update: intensive medical therapy remains the cornerstone, while carotid stenting shows selective benefit when performed by expert operators. Endarterectomy, however, provides no significant advantage over modern medical management. With stricter blood-pressure and LDL targets, plus expanding use of PCSK9 inhibitors, the future of stroke prevention is increasingly precision-driven, medically optimized,

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06:26

UPFs, Diets, Disease: The Global Drift 🍔➡️🌍➡️⚠️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/21

The new Lancet Series on ultra-processed foods offers a striking insight: as UPFs rise globally, traditional whole-food diets decline—bringing nutrient imbalance, overeating, toxic exposures, and hyper-palatable formulations that quietly reshape health trajectories. 🍔➡️⚠️ Across more than 100 prospective studies and multiple trials, higher UPF intake consistently links to obesity, type 2 diabetes, cardiovascular disease, kidney disease, depression, and higher all-cause mortality. 📉🩺 The

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04:50

Groceries, Guidance, Gains 🛒📞📉 — How DASH Delivery...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/20

Home-delivered DASH-patterned groceries paired with dietitian counseling meaningfully lowered blood pressure and LDL cholesterol among Black adults living in food deserts 🥗📉—as demonstrated in the GoFresh randomized trial (JAMA). An accompanying editorial highlights why future "food-as-medicine" programs must prioritize underconsumed, health-promoting foods and align with modern evidence favoring higher-fat DASH/Mediterranean patterns 🌱🫒. A powerful reminder: the right groceries can be

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04:57

Hemodialysis, Cardiovascular Burden, Therapeutic Hope...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/11/19

🩺 New insights in hemodialysis care. A major New England Journal of Medicine study reports that daily supplementation with long-chain omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) led to a 43% reduction in serious cardiovascular events among adults receiving maintenance hemodialysis. 🐟💙 In a population where traditional cardioprotective therapies often fall short, these findings open a fresh path for investigation — and perhaps, future practice. 📉🔬 A confirmatory trial

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