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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

06:14

🧩 Matching RCTs to Reality: The Impella Data from Japan

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/15

🚨 Real-World vs RCT? Only 1 in 3 patients with AMI-related cardiogenic shock in Japan met the 🔬 DanGer trial criteria for Impella use. The J-PVAD registry (🇯🇵, n=3975) reveals a stark ⚖️ reality: eligibility matters, and survival varies! 🫀 Time to align practice with precision. 📖 Read the full European Heart Journal study for clinical pearls and caveats. #Impella #CardiogenicShock #DanGer #JPVAD #EHJ #MCS #RCTvsRealWorld

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05:11

📚 Learn. Use. Lead. A Clinician’s Guide to the GenAI...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/15

🚨 New Era in Medicine! 🩺🤖 JAMA Internal Medicine highlights how Generative AI (GenAI) is reshaping clinical workflows—from AI scribes 📝 to diagnostic copilots 🧠. Physicians must prompt wisely, partner smartly, and practice responsibly. A must-read to stay ahead! 💡📈 #GenerativeAI #DigitalHealth #MedicalEducation #JAMA 🔗 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2840192

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05:11

🥑⚔️🧫 Immunity Meets Metabolism: The Fat-Absorption...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/14

🧠✨ New Science Perspective unpacks a “tripartite alliance” between TH17 cells, IL-22 cytokine signaling, and enterocytes in regulating fat absorption! 🥑🧫 Loss of Aster-A in T cells boosts IL-22, suppressing intestinal lipid uptake—a striking example of immune-metabolic crosstalk with implications for obesity and malabsorption. 🔬🛡️ 📘 Science, Oct 2025 #Immunometabolism #GutImmunity #LipidAbsorption #ObesityResearch #PrecisionNutrition #TCells #IL22

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05:25

Dr RR Baliga's Philosophical Discourses: Tulsidas...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/14

🌸 Tulsidas (1511–1623 CE): India’s Poet of Devotion and Duty ✨ Bridging East and West, Tulsidas transformed spiritual thought much like Dante, Milton, and Luther did in Europe. His Ramcharitmanas made divine wisdom accessible to all, blending poetry, psychology, and ethics. 🌏 A timeless voice for compassion, virtue, and inner transformation — reminding us that love is the highest law. 💫 #Tulsidas #Ramcharitmanas #Philosophy #Leadership #Spirituality #CulturalBridge #Wisdom

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09:35

Delay, Dose, Duration ⏳: The Triple Threat of LDL-C |...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/13

🧬💊 How long is too long to wait on statins? Two new studies reveal a powerful truth: ⏳ It’s not just how high your LDL is—but how long you’ve had it. 🔻 Delayed statin initiation (⏰ >6 months) after detecting high LDL-C is linked with increased risk of MI and stroke. 📆 Enter “Cholesterol-Years”—a concept akin to pack-years for smoking: the longer the LDL exposure, the higher the ASCVD risk. 🚨 Early cholesterol hurts more than late cholesterol. 🛠️ Statins can help—but early action is

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02:57

Biomarkers, Big Data & Biology: Mapping the Plasma...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/13

🧬 New Era in Blood-Based Biomarkers! 🩸 A pan-disease atlas of the circulating proteome across 59 diseases and 8,262 individuals reveals powerful insights into age, sex, BMI, and disease-specific protein signatures. 💡 Highlights: 🔹 Over 5,400 proteins profiled using Olink 🔹 Longitudinal stability of wellness proteome 🔹 Machine learning predicts biological age (R² = 0.85) 🔹 Shared vs disease-specific profiles across conditions 🔹 Early signals in cancers like lung and ovarian 🎯 📍 Explore

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05:22

🧬 The Double-Edged Blade of Antithrombotic Therapy in...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/12

🫀 New insights from EUROMACS registry! The latest JACC study explores the delicate ⚖️ trade-off between bleeding 🩸 and ischemic 🧠 events in LVAD patients. While HM3 reduces thrombotic risks, bleeding remains the dominant threat. Time to rethink the “one-size-fits-all” anticoagulation 🧪. Personalized strategies like LD-DOACs & lower INR targets may be the next frontier 🚀. Editorial call to action included! 📘 #Cardiology #LVAD #PrecisionMedicine #JACC #HM3 #BleedingRisk #Anticoagulation 👉

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04:31

MGUS Under the Microscope 🔬: From Screening to...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/12

🧬 New NEJM Review Alert! MGUS — once “undetermined,” now clinically significant. This comprehensive update by Rajkumar & Kumar reveals how asymptomatic plasma clones may drive renal (MGRS) and neurologic (MGNS) damage 🧠🩺 even without cancer. 🔬 Dive into new diagnostic pathways, risk models (iSTOPMM), and why “watch and wait” no longer fits for all. 📚 A must-read for nephrologists, hematologists, and internists. #MGUS #MGRS #MGNS #NEJM #Myeloma #PlasmaCellDisorders #MedicalEducation

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05:12

💊Baxdrostat, Blood Pressure, Breakthrough! New Hope...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/11

🚨 New NEJM Study Alert! 🧬💊 Baxdrostat, a selective aldosterone synthase inhibitor, shows significant BP reduction in patients with resistant & uncontrolled hypertension despite RAAS blockade and diuretic therapy. ✅ SBP ↓ ~9–10 mmHg at 12 weeks 🧂 Targets salt-retaining physiology ⚖️ Well-tolerated: early mild hyperkalemia & hyponatremia 🔁 Durable effect even after withdrawal A promising step toward precision therapy in tough-to-treat hypertension! 📖 Read more: NEJM Aug 2025 | BaxHTN Trial

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05:53

UPFs: 🥤Processed, Packaged, Perilous?

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/11

📣 New in NEJM: Ultraprocessed Food on an Ultrafast Track 🥫⚡️ Are ultraprocessed foods (UPFs) really the villains of modern nutrition? 🤔 This thought-provoking piece critiques the Nova classification system 🧂📊 and urges caution before reshaping national dietary policy around it. From 🍟 glycemic spikes to 🧪 questionable additives, the debate is rich — but the evidence? Still cooking. 🔬🍽️ 💡 Worth a read for clinicians, policymakers, and food thinkers alike. #NutritionScience #UPF

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05:39

💔 Vulnerable Hearts. ⚠️ Hidden Risks. ⛑️ Wearable...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/10

🚨 New insights from the SCD-PROTECT Study! 🫀 In a nationwide German cohort of 19,598 patients with newly diagnosed NICM or MI/CAD, early use of the Wearable Cardioverter-Defibrillator (WCD) offered critical protection during the high-risk window of guideline-directed therapy initiation. 📉 Most shocks occurred in the first 200 days 📈 >50% improved LVEF beyond ICD threshold 🛡️ WCD = early shield + risk stratification tool Let’s rethink how we protect vulnerable hearts ❤️‍🔥 #Cardiology #SCD

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09:03

Hypothyroidism: Slowed Metabolism 🐢, Silent Symptoms...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/10

📢 New JAMA Review Alert! 🦋 Hypothyroidism remains a silent disruptor of health — often underrecognized, yet linked with fatigue 😴, weight gain ⚖️, cardiovascular disease ❤️, and reproductive health challenges 🤰. This latest JAMA clinical review underscores: ✅ Autoimmunity (Hashimoto thyroiditis) as the leading cause ✅ Lifelong levothyroxine 💊 as first-line therapy ✅ The dangers of both over- and undertreatment ⚖️ ✅ When to screen, test, and refer 👩‍⚕️ A must-read for clinicians,

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06:48

📲 Wearables Speak: A Minute of Vigrous Activity Is...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/09

🚶‍♀️🏃‍♂️⏱️ Not all movement minutes are created equal! A major Nature Communications study using data from 73,000+ UK Biobank participants wearing accelerometers found: 1 minute of vigorous activity (VPA) = up to 9 mins moderate (MPA) or 94+ mins light (LPA) for reducing mortality, CVD, diabetes, and cancer risk. This rewrites the old 1:2 rule and urges updates to global guidelines and wearable health metrics. 📲 Time to upgrade from steps to science. #NatureCommunications #Wearables

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05:56

Hippocampus: Ripples 🌊, Riddles 🤔, Revelations ✨

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/09

Hidden Horns 🐏, Silent Signals ⚡, New Memories 🧠 A new Science review reframes the hippocampus beyond the classic trisynaptic loop. Once-overlooked regions like CA2, fasciola cinereum, and indusium griseum — along with enigmatic signals such as small irregular activity (SIA) and dentate spikes (DS) — emerge as crucial for social memory, novelty detection, and arousal states. Far from “junk activity,” these dynamics expand our map of hippocampal computation with deep clinical implications.

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04:34

🧭 Mapping the Large Vessel Vasculitis Landscape:...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/08

🚨 Just read the latest Lancet 2025 Seminar on Large-Vessel Vasculitis – a must-read for anyone tracking 🔍 Giant Cell Arteritis, 💥 Takayasu Arteritis, and 🧬 Isolated Aortitis. From 🚑 clinical phenotypes to 🧠 imaging advances and 🎯 targeted biologics like tocilizumab and JAK inhibitors, this article bridges inflammation with innovation. 📸 Vascular imaging, 🔬 immunopathology, and 🧪 new therapies—essential insights for rheumatology, cardiology & internal medicine teams. 📖 Read it, teach it,

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06:44

🧪 Gut Check: Sweeteners, Bugs & Body Weight

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/08

🍬 Can sweeteners help you stay slim? A new 1-year multicenter RCT in Nature Metabolism shows that replacing sugar with sweeteners & sweetness enhancers supports modest weight loss maintenance ⚖️ and beneficial gut microbiota shifts 🦠—with no adverse cardiometabolic effects 💓. 🚫 Less sugar, ✔️ better weight control, 🧬 smarter microbiota. The future of precision nutrition may be sweet after all! 🔗 #NatureMetabolism #Obesity #Microbiome #Sweeteners #RCT #WeightLoss #NutritionScience

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05:08

🧬 Blocking TGF-β, Boosting Function, Sotatercept’s...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/07

🚨 Just out in NEJM! In the Phase 3 HYPERION trial, adding sotatercept early in pulmonary arterial hypertension (PAH) slashed clinical worsening risk by 76% vs placebo (HR 0.24, P<0.001) 💉🫁 💡 Benefits appeared after just 3 doses, with improved 6-min walk, NT-proBNP, and risk scores. Most AEs were mild (epistaxis, telangiectasia). 📊 A game-changer in early PAH therapy. NNT = 5 over 12 months. 🔗 #Cardiology #PulmonaryHypertension #Sotatercept #NEJM #PrecisionMedicine #ClinicalTrials

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03:44

Dr RR Baliga's Philosophical Discourses: Wang...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/07

🌏 Wang Yangming (1472–1529) — the great Neo-Confucian philosopher-general of the Ming dynasty — taught that true knowledge and right action are one. 🧠💡 His School of Mind emphasized moral intuition, self-cultivation, and compassionate action — insights that still inspire clinicians to align thought, empathy, and care. ❤️‍🩹✨

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05:36

Steps, Scores, and SDGs 🚶‍♀️🧮🎯: Charting Africa’s...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/06

🌍 Cardiovascular Health in Africa: Insights from WHO STEPS 💓📊 A landmark JAMA Cardiology study analyzed 73,000+ adults across 22 African countries (2003–2022). Findings are sobering: ✅ Only 1 in 4 achieved ideal cardiovascular health. ⚠️ Diet, physical inactivity, and uncontrolled blood pressure remain critical gaps. 👩 Women and those with less education had lower odds of good heart health. 📉 No improvement seen over 2 decades. An accompanying editorial urges: 🎯 Reframe the focus from risk

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08:02

🌕🩸🧠 Menstrual Rhythms: Meddlesome Moon & Meandering...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/10/06

🩸🌕🧠 Menstrual Rhythms: Meddlesome Moon & Meandering Minds Two compelling studies—one from Science Advances and another from BMJ Mental Health—reveal how lunar phases may influence menstrual cycles, and how hormonal rhythms shape psychiatric symptoms. It’s time we treat the menstrual cycle as a vital sign in mental health, not an afterthought. 🔁 From gravitational pull to emotional flux, the moon–mind connection deserves deeper attention. #Psychiatry #Chronobiology #WomenInScience

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