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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

05:29

Rotator Cuff Tears 🦴 Ubiquitous, Incidental, Misleading

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/18

🦴 Rotator cuff "tears" are nearly universal after age 40. In a population-based Finnish study (n=602), 99% had ≥1 MRI abnormality — including 96% of asymptomatic shoulders. Even full-thickness tears were usually silent, and adjusted analyses eliminated differences between painful and painless shoulders . Lesson? After 40, imaging abnormalities are common — causality is not. Treat function. Treat symptoms. Treat patients — not scans.

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04:42

Dr RR Baliga's Philosophical Discourses: Aurobindo...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/17

Sri Aurobindo (1872–1950) lived two extraordinary lives in one lifetime — revolutionary nationalist and visionary yogi. From the Alipore trial to the quietude of Pondicherry, he shifted the conversation from political freedom to inner evolution. His Integral Yoga proposed something radical: not escape from the world, but transformation of it — a movement from mind to "Supermind," from human to supramental consciousness. The Life Divine, The Synthesis of Yoga, and Savitri remain profound

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06:05

Chronic lymphedema may not just be about fluid. It...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/16

Chronic lymphoedema may not just be about fluid. It may be about cholesterol. 🧬 In human tissue and translational mouse models, impaired lymphatic drainage led to excess dermal cholesterol deposition, adipocyte dysfunction, fibrosis, and swelling — even when plasma cholesterol was normal. Clearing tissue cholesterol with cyclodextrin restored lymphatic architecture and reduced oedema. Clear the cholesterol. Restore the flow

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06:57

Disrupt. Rewire. Heal. The New Clinical Promise of...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/15

Psychedelic medicine is moving from the margins to mainstream neuroscience. 🧠✨ A recent Nature Medicine review synthesizes the biology behind the renaissance: 5-HT2A signaling, acute brain desynchronization, and a subacute plasticity window driven by BDNF–TrkB pathways. The promise is real — rapid effects in depression, PTSD, and addiction — but so are the challenges: expectancy, unblinding, scalability, and safety. Entropy. Plasticity. Psychiatry. 🔬 A field worth watching — carefully,

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10:50

Statins: Facts, Fears, Findings 💊

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/14

Are statins as risky as labels suggest? 📊 In a 154,664-patient individual-participant meta-analysis of 23 double-blind RCTs, only 4 of 66 listed adverse effects were confirmed — mainly small, dose-related liver enzyme elevations. No causal signal for cognitive decline, depression, sleep disturbance, neuropathy, or kidney injury. Absolute excess risks were tiny (<0.1% per year). Cardiovascular benefit still overwhelmingly outweighs risk. Evidence matters. 💡

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06:09

IgA Nephropathy: Pathogenesis, Progression, Precision...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/13

IgA nephropathy remains the most common immune-mediated glomerular disease worldwide — and up to 50% of patients may progress to kidney failure within a decade. 🧬 The 2025 KDIGO guidance emphasizes early biopsy (proteinuria ≥0.5 g/day), tight BP control (<120/70), renin-angiotensin system inhibition, SGLT2 inhibitors, and targeted therapies such as budesonide and complement inhibition. Proteinuria remains the key modifiable driver. Precision nephrology is here — and measurable. 🩺📉

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09:04

RNA to Receptors. 🔬 Practical Innovations in Blood...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/12

Genes. Glands. Vessels. 💊 Hypertension therapy is entering a new era. The latest Lancet review highlights RNA-based silencing of angiotensinogen, selective aldosterone synthase inhibition, non-steroidal mineralocorticoid receptor antagonists, endothelin receptor blockade, and natriuretic peptide enhancement. These therapies move beyond ACE inhibitors and ARBs toward durable, mechanism-driven blood pressure control—especially for resistant hypertension and multimorbidity. The future may not be

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03:56

☕➡️🧠 From Coffee Cup to Cortex

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/11

☕🧠 Can your daily coffee protect your brain? In a JAMA study of 131,821 adults followed for up to 43 years, moderate caffeinated coffee and tea intake was associated with a lower risk of dementia and modestly better cognition. The sweet spot: 2–3 cups of coffee or 1–2 cups of tea per day. Notably, decaffeinated coffee showed no benefit. A compelling population-level prevention signal—simple habits, long horizons, meaningful impact.

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03:35

Dr RR Baliga's Philosophical Discourses: Bertrand...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/10

Bertrand Russell showed that clear thinking is a moral act 🧠✨ As a founder of analytic philosophy, he taught us to question assumptions, sharpen language, and let logic guide both ideas and action 📐📘 From Principia Mathematica to public debates on freedom and peace, Russell reminds us that clarity, courage, and doubt belong together 🕊️📚

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04:19

🩸 Prick. Dry. Detect: A Scalable Blood Test for...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/09

🧠🩸 A finger-prick may change how we detect Alzheimer's disease. A new Nature Medicine study shows that dried capillary blood spots can reliably measure key Alzheimer's biomarkers—p-tau217, GFAP, and neurofilament light—with strong concordance to venous plasma and cerebrospinal fluid results. 📊 In the DROP-AD multicenter study (7 sites, 337 participants), capillary p-tau217 correlated strongly with plasma (r≈0.74) and predicted amyloid pathology with good accuracy (AUC ≈0.86). 🚀 Why this

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06:46

Genes, CAD Risk, Destiny 🧬

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/08

🧬 Why Coronary Artery Disease Runs in Families Coronary artery disease is not just lifestyle—it is deeply genetic. Rare monogenic disorders like familial hypercholesterolemia and hundreds of common variants together shape lifelong risk, with polygenic risk scores identifying individuals whose inherited risk rivals traditional factors 🫀. The good news: genetic risk is modifiable. Early LDL lowering, healthy lifestyles, and precision prevention deliver the greatest benefit in those at highest

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04:47

🔮 Forecasting the Uncertain: Mortality, Bleeding, and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/07

🧬⚖️ Cancer and Acute Coronary Syndromes: Precision Where It Matters Most As cancer survival improves, more patients live long enough to face acute coronary syndromes (ACS)—often with competing risks of death, bleeding, and ischaemia. Yet these patients have been largely excluded from ACS trials, leaving clinicians to navigate uncertainty. A landmark Lancet study introduces ONCO-ACS, the first cancer-specific, externally validated risk tool that simultaneously predicts 6-month mortality, major

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05:20

Faster. Colder. Smarter: REUP and the New Era of DCD...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/06

🫀 Rethinking DCD Heart Transplantation A new JAMA Original Investigation reports encouraging early outcomes using rapid recovery with extended ultraoxygenated preservation (REUP) for donation after circulatory death (DCD) heart transplantation—without donor heart reanimation or machine perfusion. 🔬 In a 24-patient case series, REUP achieved 96% 30-day survival, low primary graft dysfunction (4%), and minimal early rejection, even with older donors and prolonged ischemic times. ⚖️ By avoiding

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05:45

⏰ Timing the Tumor: Circadian Clocks in Cancer...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/05

⏰🧬 Timing matters in cancer. A superb JCI Review, Rhythms of risk: the intersection of clocks, cancer, and chronotherapy, shows how circadian clocks regulate cell cycle, DNA repair, metabolism, immunity, hypoxia, and even metastasis—and how circadian disruption (e.g., night-shift work) can reshape cancer risk and treatment response. ⚖️💊 The takeaway: clock biology is context-specific, and aligning therapy with circadian phase may enhance efficacy while reducing toxicity—an underused lever in

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16:55

Residual Risk in CAD: What Remains, Why It Matters,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/04

🫀 Residual Risk in Coronary Artery Disease Even after "optimal" therapy, many patients remain at risk. Why? Because atherosclerosis is more than LDL—it's thrombosis 🩸, inflammation 🔥, and metabolism ⚖️ working in concert. This FAQ-based slide deck distills contemporary insights on residual thrombotic, lipid, metabolic, and inflammatory risk, and highlights emerging therapies—from dual-pathway inhibition 💊 to GLP-1 receptor agonists 🧬 and colchicine—that help close the gap between treatment

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06:17

Dr RR Baliga's Philosophical Discourses: Swami...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/03

Swami Vivekananda reminded the world that spiritual strength and social service are inseparable 🕉️🔥 From Chicago in 1893 to India's national awakening, his message was simple yet radical: each soul is potentially divine—and serving humanity is serving the Divine 🌍🤝 More than a monk or philosopher, Vivekananda remains a timeless call to courage, compassion, and inner awakening ✨📚

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03:17

🫀 Sense. 🧠 Signal. 🛡️ Scar. A Heart–Brain–Immune Loop...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/02

🫀🧠🛡️ Sense. Signal. Scar. A striking Cell study reframes myocardial infarction as a systems disease, not a heart-only event. Using single-cell and spatial transcriptomics in murine MI, the authors identify a triple-node heart–brain–immune loop: TRPV1-positive vagal sensory neurons (injury sensing) → hypothalamic paraventricular nucleus AT1aR neurons (central integration) → superior cervical ganglion IL-1β signaling (sympathetic–immune effector arm). Intervening at any node improved ejection

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06:49

👉 Urge. Move. Repeat: The Modern Story of Restless...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/02/01

🦵🌙 Restless Legs Syndrome: more than a sleep complaint RLS affects ~3% of adults and is frequently missed or misdiagnosed as insomnia or anxiety. The latest evidence underscores three practical shifts: think iron (even when "normal"), choose gabapentinoids first, and beware dopaminergic augmentation. For internists and frontline clinicians, recognizing RLS early can meaningfully improve sleep, mood, and quality of life—and may even reduce downstream cardiovascular risk. 🧠🩺💤

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05:58

⚙️ The Operating System of Cancer: Hallmarks,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/31

🧠🩺 Why cancers behave the way they do—and why treatments fail For internists, cancer is not just an oncologic diagnosis but a systems disease: driven by dysregulated growth, immune evasion, metabolic reprogramming, inflammation, and adaptive resistance. The Hallmarks of Cancer framework offers a unifying clinical lens—explaining recurrence, cachexia, immunotherapy variability, and late relapse—without drowning us in molecular minutiae. Understanding how tumors survive stress, therapy, and time

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08:09

🕔🏃‍♂️ Five Minutes More, Fewer Funerals

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2026/01/30

📟🪑🏃‍♂️ A striking accelerometer-based analysis in The Lancet suggests that small, realistic behavior shifts could translate into meaningful mortality gains at the population level. For the least active adults, +5 minutes/day of moderate-to-vigorous physical activity (MVPA) was associated with preventing ~6% of deaths; applying a similar increase broadly (excluding the most active) could prevent ~10%. Reducing sedentary time by 30 minutes/day was associated with preventing ~3% (high-risk) to ~7%

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