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PODCAST

The Orange Pill Podcast

The Orange Pill Podcast 🎙️ Your go-to source for the latest in the dietary supplement and natural health product industry! Brought to you by KGK Science, a global leader in clinical research and regulatory consulting, this podcast delivers: ✔️ Breaking industry news and trends ✔️ Educational insights and practical takeaways ✔️ Discussions on cutting-edge research ✔️ Landmark cases and notable events shaping the field Join us as we bridge the gap between science, regulation, and everyday impact.

health & fitness nutrition

All Episodes

30:18

Episode 32: Efficacy of Probiotic Supplementation for...

The Orange Pill Podcast ·

2025/06/17

In this episode, we explore the findings of a newly published clinical trial investigating the impact of an 84-day probiotic regimen on gut and mental health in older adults aged 50–85 who experience occasional constipation. The probiotic blend—Lactiplantibacillus plantarum strains KABP031 and KABP032 (marketed as INNERIM™)—was tested in a randomized, double-blind, placebo-controlled study to evaluate its efficacy and safety.The results are significant: - Participants taking the probiotic showed

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19:04

Episode 31: Determining Whether Human Research...

The Orange Pill Podcast ·

2025/06/12

The FDA’s guidelines on when human research studies require an Investigational New Drug (IND) application can be a maze for researchers and sponsors. In this episode, we break it all down for you: from the broad definition of "drugs" under the FD&C Act to exemptions in clinical investigations. We discuss the core criteria that help you determine if your research falls under the IND requirements and how to avoid common pitfalls.Whether you’re working with new compounds, marketed drugs, or even

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34:42

Episode 30: Review of the FDA Bioresearch Monitoring...

The Orange Pill Podcast ·

2025/06/10

The FDA’s Bioresearch Monitoring (BIMO) program is more than just inspections—it's a regulatory safeguard for the rights and welfare of clinical trial participants and the integrity of data used to support FDA submissions. In this episode, we break down the scope and function of the BIMO program, explore common findings during inspections, and discuss practical strategies for maintaining continuous inspection readiness.Learn how sponsors, CROs, investigators, IRBs, and testing labs can stay ahead

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34:20

Episode 29: A GOOD IDEA for Better Blood Sugar

The Orange Pill Podcast ·

2025/06/05

In today's episode, we explore a clinically studied nutritional supplement drink made with five amino acids and chromium — shown to reduce post-meal blood sugar levels by up to 25%. We break down the research, the claims, and what it could mean for metabolic health, diabetes prevention, and the supplement industry as a whole.

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53:27

Episode 28: Natural Relief- The Science Behind...

The Orange Pill Podcast ·

2025/06/03

In this episode, we unpack a fascinating clinical trial conducted by KGK Science for LifeSeasons Inc., evaluating the natural health product Relieve-R (formerly Pain Bloc-R) as an alternative for occasional pain relief and inflammation.Published in the journal Nutrients, this randomized, double-blind, placebo-controlled crossover study compared Relieve-R to acetaminophen and placebo across three 7-day supplementation periods. The results? Relieve-R significantly reduced pain severity

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17:21

Episode 27: A Novel trial design by KGK Science on...

The Orange Pill Podcast ·

2025/05/29

In this episode, we explore an innovative clinical trial by KGK Science evaluating Unigen’s UP446, a natural health ingredient composed of Acacia catechu and Scutellaria baicalensis. Designed as a randomized, triple-blind, placebo-controlled study, this trial used a human vaccine model to assess immune response following influenza vaccination. We discuss the implications of this design, the significance of the findings, and how UP446 may play a vital role in supporting respiratory

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11:13

Episode 26- FDA Continues to Allow Companies to Use...

The Orange Pill Podcast ·

2025/05/27

In this episode on the Orange Pill Podcast, we tackle a long-standing regulatory loophole: piggybacking on NDI submissions. While companies like Natural Alternatives International (NAI) invest in proper safety and regulatory filings, like their recent successful NDI notification for CarnoSyn® beta-alanine, authored by the regulatory team at KGK Science, others sidestep the process entirely.The FDA’s lack of enforcement has allowed un-notified, and in many cases counterfeit or imported ingredients,

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16:07

Episode 25: MAHA Commission Report – Big Beautiful...

The Orange Pill Podcast ·

2025/05/22

The MAHA Commission Report is expected to be released today—and it’s already making waves. In this special pre-release episode, we explore what to expect from the report, and how it could reshape conversations around policy, governance, and the future.As the noise ramps up, we give you the context and clarity you’ll need to navigate the headlines. From structural insights to potential implications, we break it all down before the official release lands. Get ahead of the narrative. Tune in now.

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11:35

Episode 24: Nestle Launches Salmon Oil Supplement...

The Orange Pill Podcast ·

2025/05/20

In this episode, we explore Nestlé’s U.S. debut of a salmon oil supplement under the Garden of Life brand, featuring OmeGo — a unique whole fish extract by Hofseth Biocare. We break down what makes this omega-3 product stand out in a crowded market, the role of sustainability and full-spectrum benefits, and how KGK Science supported Hofseth in obtaining the crucial NDI status that paved the way for this launch. Tune in for an inside look at the intersection of innovation, regulatory success, and

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08:52

Episode 23: Sustainability: The Future of the Dietary...

The Orange Pill Podcast ·

2025/05/15

As consumer demand grows for clean, conscious products, the supplement industry is being called to evolve.In this episode, we explore the many ways companies can engage in sustainable sourcing and production—from eco-friendly packaging and ethical ingredient procurement to promoting responsible consumer practices. Learn how reducing plastic waste, sourcing local or organic ingredients, and embracing circularity can help your brand lead the change—and why it’s no longer optional.

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13:13

Episode 22: Pollen Extracts for Female Urinary...

The Orange Pill Podcast ·

2025/05/13

In this episode, we explore how flower pollen extracts are being studied as a potential solution for urinary incontinence in women. We break down the latest clinical evidence from a newly published trial in Current Urology, conducted by KGK Science and sponsored by Graminex®.We’ll discuss: The impact of urinary incontinence on daily life How flower pollen extracts may support urinary health Key findings from the clinical trial What this means for the future of women’s health and

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14:15

Episode 21: The Sleep Secret Hidden in Corn Leaves

The Orange Pill Podcast ·

2025/05/08

We are back with a deep dive into the world of sleep — and why melatonin may not be the long-term solution we’ve all been promised.In this episode we cover: Why melatonin is widely used in hospitals, yet many still struggle to sleep What makes sleep so critical to overall health The growing global demand for new, effective sleep supplements A look at Maizinol®, a natural sleep aid derived from corn leaves, clinically shown to improve REM sleep, reduce sleep latency, and extend overall sleep

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13:04

Episode 20: History of the US Food Supply : Before...

The Orange Pill Podcast ·

2025/05/06

In this episode, we uncover the shocking state of America’s food supply before the FDA — from toxic milk to candy laced with arsenic — and explore how those chaotic beginnings shaped the future of food, supplements, and regulation.

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10:47

Episode 19: KGK Science and Nimble Science:...

The Orange Pill Podcast ·

2025/05/01

In this episode of the Orange Pill Podcast, we talk about the exciting new partnership between KGK Science and Nimble Science. Learn how this collaboration is set to redefine gastrointestinal (GI) health research through the integration of SIMBA™, a novel ingestible capsule that collects high-quality gut samples—without invasive procedures.

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10:17

Episode 18: RFK Jr.'s FDA Food Safety Agenda

The Orange Pill Podcast ·

2025/04/29

In this episode, we dive into U.S. presidential candidate Robert F. Kennedy Jr.’s provocative vision for the future of food regulation. RFK Jr. is calling for nothing short of a revolution—taking aim at food chemicals, plastics, and the FDA’s current approach to food safety.We unpack his stance on rethinking Generally Recognized as Safe (GRAS) determinations, his plan to reform the FDA’s oversight of food additives and endocrine disruptors, and what this could mean for food manufacturers,

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16:11

Episode 17: Yeast Postbiotic Effect On Cold And Flu...

The Orange Pill Podcast ·

2025/04/24

In this episode, we unpack a compelling clinical study conducted by KGK Science for Cargill on the impact of EpiCor® postbiotic supplementation in children. Learn how a daily gummy dose of this yeast-derived ingredient significantly reduced cold and flu symptoms, limited the need for medication, and offered a safe, science-backed immune support option for kids aged 4 to 12. Plus, we explore why this study is a milestone in both postbiotic and gummy supplement research.

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14:02

Episode 16: New Vitamin D Meta Analysis Study Shows...

The Orange Pill Podcast ·

2025/04/22

In this episode, we dive into a recent Lancet meta-analysis that questions vitamin D’s effectiveness in preventing acute respiratory infections. What does the data actually say, and how should consumers respond? We also explore promising new findings from Pediatric Research on EpiCor, a postbiotic that may reduce cold and flu symptom severity in children. KGK Science contributed to this important study—hear what the results mean for immune health innovation and the supplement industry at large.

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11:18

Episode 15: Upcoming Trends in 2025 for the Dietary...

The Orange Pill Podcast ·

2025/04/17

In this forward-looking episode, we explore the major shifts on the horizon for the dietary supplement and nutraceuticals sector in 2025. Expect a transformation driven by sustainability, science, and personalization. We cover: The rise of plant-based and functional ingredients Personalized nutrition through genomics and AI Regulatory updates on GRAS and novel ingredients The role of eco-conscious practices and clean-label demands Digital health tech and real-time supplement

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13:53

Episode 14: Disturbing New Trend in CRO Research- Use...

The Orange Pill Podcast ·

2025/04/15

In this episode, we explore a growing issue in nutraceutical clinical research: the misuse of predicted margins to gloss over incomplete data in virtual trials. When predictive models are used in place of raw results—without validation or transparency—scientific rigor is compromised. We break down what predicted margins are, when they should (and shouldn’t) be used, and how this impacts regulatory credibility.

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12:19

Episode 13: FDA's Final Rule for 'Healthy'

The Orange Pill Podcast ·

2025/04/10

In this episode, we explore the FDA’s newly finalized definition of “healthy” for food labeling — a major regulatory update released in December 2024. The goal? To bring food labels in line with today’s nutrition science and help consumers make better choices. We unpack what’s changed, why it matters, and how these new rules will impact how companies across both the supplement and conventional food spaces position their products moving forward.

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72 results

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