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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

01:08:04

PhD at MIT: The Longevity Molecule That Reverses...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/19

Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements,

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00:59:50

Still Fasting in 2025? Here’s How to Make It Work...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/15

How do you activate your body’s natural repair system? How can you hack stem cells for faster recovery, brain optimization, and peak human performance? This episode reveals how to trigger stem cell release, direct them to the right tissues, and stack biohacking tools for maximum regeneration. You’ll learn science-backed strategies for boosting mitochondria, enhancing neuroplasticity, and extending longevity through targeted supplements, fasting, and functional medicine techniques.Watch this

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00:52:09

How to Make Life-Changing Decisions Without Fear –...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/14

How do you make tough decisions? How do you make them without fear or lying? This episode shows you how unresolved emotions disrupt decision-making, relationships, and functioning in peak brain performance. You’ll learn tips to rewire your nervous system for decision making, optimizing emotional intelligence, and regulating your body for high-level clarity, energy, and resilience. Discover biohacking techniques that use emotional release and somatic awareness to boost mitochondria, activate

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00:58:58

The New Poisons Lurking Around You – Save Your...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/12

Toxins you cannot see are damaging your health, wrecking your metabolism, and quietly accelerating aging. This episode reveals how to detect the new poisons lurking in your home, how they sabotage mitochondria and brain optimization, and the biohacking fixes that restore longevity, energy, and human performance. You’ll learn actionable strategies you can implement right away, from functional medicine detox protocols to supplements that protect your nervous system and upgrade

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00:59:39

Jim Kwik: What I Take to Biohack Brain Speed and...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/08

Jim Kwik joins Host Dave Asprey to reveal the exact nootropics, brain hacks, and biohacking routines he used to recover from traumatic brain injuries and unlock peak cognitive performance.

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01:38:53

Why I Inject a “Female Hormone” 3x a Week (Nootropic...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/07

What if the most powerful upgrades for brain energy, metabolism, and drive aren’t in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you’ll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHostDave Aspreysits down withJay CampbellandHunter Williams,

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01:04:20

Top 5 Dopamine Boosting Biohacks for Superhuman...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/05

Ready to learn about the secret compounds, molecules, nootropics, and stacks that Big Pharma doesn’t want you to know about?This episode is packed with the exact dopamine-boosting compounds, stacks, and biohacking protocols that top performers are using to supercharge human performance, brain optimization, and long-term resilience.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Lucas Aoun, Australia’s leading

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00:47:04

Protein vs. Plants: The 50g-a-Meal Biohacking Rule :...

The Human Upgrade: Biohacking for Longevity &... ·

2025/08/01

This episode of The Human Upgrade with Host Dave Asprey and Dr. Gabrielle Lyon reveals why eating 50 grams of high-quality animal protein per meal is the most overlooked biohacking strategy for reversing muscle loss, boosting metabolism, and extending longevity.

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00:54:05

The Air Force Uses This Mind-Bending Sound Biohack —...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/31

This episode reveals how military-grade sound frequencies can rapidly shift your mental state, enhance neuroplasticity, and accelerate brain optimization.You’ll learn how to hack your nervous system using real-time biometric data, how frequency compositions are changing functional medicine, and why sound is emerging as one of the most powerful tools for human performance and longevity.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave

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00:59:15

How To change ANY Habit In 63 Seconds (No Willpower...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/29

You’ve been lied to about how long it takes to change a habit.This episode reveals a powerful, science-backed method to rewire your brain in just 63 seconds—without relying on willpower. You’ll discover how to use the 63-second window to interrupt destructive thought loops and how true habit change requires 63-day habit formation, not the popularized 21-day myth.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with

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00:59:12

Who Should Take Herbal Ecstasy Supplements? (The...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/25

What is Herbal Ecstasy—and why does it matter? This might be one of the most insane episodes we’ve ever recorded, and we had to bring it back because the story is too wild, too relevant, and too packed with real lessons in biohacking, brain optimization, and supplement hacking to miss. Host Dave Asprey sits down with Shaahin Cheyene, the renegade teenage entrepreneur who built a billion-dollar supplement empire before he could legally drink. As the creator of Herbal Ecstasy, Shaahin hacked

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01:10:55

Boost Brain Power by 25% WITHOUT a Pill (Brain...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/24

You’re leaving brainpower on the table, and this episode shows you how to reclaim it.Learn how to boost cognitive performance by 25% without relying on pills, stimulants, or gimmicks. Host Dave Asprey sits down with global finance expert and cross-cultural thinker Richard Conrad to explore how your cultural programming shapes your biology, metabolism, neuroplasticity, and even your ability to reach peak human performance.Watch this episode on YouTube for the full video

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00:54:24

The Biohacking Tool That Will Change the World...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/22

This may be the most cutting-edge life extension technology you’ll hear about for decades. You’ll discover how mitochondrial transfusion, rejuvenation, and repair could reverse biological aging, supercharge your metabolism, and radically extend healthspan—all by upgrading the cellular energy systems that power every function in your body. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with inventor and tech

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00:46:00

The Fastest-Acting Nootropic I’ve Ever Used : 1303

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/18

What if one spray could upgrade your brain, protect your mitochondria, and outperform IV therapy and liposomal supplements?In this episode, you’ll discover the breakthrough science behindtopical glutathione delivery that uses your skin’swater channelsto raiseintracellular glutathionelevels in just 60 seconds. Learn how this powerful antioxidant works at the cellular level to reduceoxidative stress, supportmitochondrial function, and drive real improvements inbrain health,emotional

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00:53:57

Why Big Pharma Hates Nitric Oxide (And How to Use It...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/17

If you care about longevity, brain optimization, sexual performance, or metabolism, this molecule changes everything.Host Dave Asprey sits down with nitric oxide pioneer Dr. Nathan Bryan to reveal why this overlooked molecule controls your blood flow, mitochondrial energy, neuroplasticity, insulin response, and even your libido. You’ll learn how nitric oxide acts as a master switch for human performance and why the medical system has ignored it for decades.Watch this episode on YouTube for

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00:49:51

Easy Oxygen Hacking for Mitochondria (The 15-Minute...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/15

Supercharge your mitochondria, slash inflammation, and boost energy with one of the most overlooked hacks in human performance. This episode reveals how just 15 minutes of oxygen-based exercise can radically improve metabolism, brain optimization, and even reverse chronic conditions, without expensive gear or endless protocols.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Brad Pitzele, founder of One

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00:57:25

Facelifts, Breast Implants, and the REAL Fix for...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/10

Wrinkles are just the surface. This episode reveals what’s really happening beneath your skin and how to reverse it using stem cells, regenerative medicine, and the most advanced techniques in plastic surgery and aging. You’ll learn how to improve facial skin tightening, reduce inflammation, and trigger deep skin rejuvenation with stem cells, red light therapy, and targeted procedures that actually work.Watch this episode on YouTube for the full video

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01:17:52

Superintelligence, Transhumanism & Biohacking in 2027...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/08

Superintelligence is coming faster than anyone predicted. In this episode, you’ll learn how to upgrade your biology, brain, and consciousness beforeAI and transhumanismreshape the future of health. Host Dave Asprey sits down withSoren Gordhamer, founder ofWisdom 2.0, to explore whatsuperintelligence in 2027means for your mind, body, and soul.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRSoren has spent decades at the intersection of

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00:30:41

Why I Add Creatine to My Coffee Every Morning (And...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/03

Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey breaks down the myths and truths about creatine,

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00:57:09

Death, Legacy & the Philosophy of Longevity — with...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/01

What if death isn’t inevitable but a solvable problem? This episode explores how biohacking is reshaping our understanding of mortality, legacy, and the limits of human performance. You’ll learn why some of today’s top thinkers are treating longevity as both a science and a spiritual movement, and how this shift affects your brain, your mitochondria, and your entire approach to life.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave

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