Mendelspod Podcast

28:26

With 50 Million Users, Is Academia.edu Speeding Up...

Mendelspod Podcast ·

2017/04/18

Today we follow up with Richard Price, the founder and CEO of the most popular social sharing site for the academic sector, Academia.edu. When we talked to Richard almost five years ago, the site had 1.5 million users, mostly academics sharing their own papers so that their peers had access without any paywalls. Today the site boasts over 50 million users and serves as a laboratory for the future of academic publishing. This is a public episode. If you'd like to discuss this with other

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21:22

How to Improve Lab Tests in the Absence of FDA...

Mendelspod Podcast ·

2017/04/13

Rubbing shoulders at molecular medicine conferences these days one senses a sigh of relief when you talk about laboratory developed tests (LDTs). With the FDA’s decision to put regulation on hold coupled with the expected confirmation of Scott Gottlieb as FDA commissioner, those in the lab testing business seem to be confidently settling back to the status quo. And those who were arguing that all we need is a “beefed up” CLIA to hold labs to better testing standards don’t appear to be motivated to

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18:50

Known for Medical Devices, 116 Yr Old BD Makes a Bold...

Mendelspod Podcast ·

2017/04/05

Talk to someone who attended this year’s AGBT, and you’ll know the big buzz was about single cell genomics. One of the exciting new platforms came from a new player in the genomics space and yet from a very old company. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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20:41

Proposed NIH Cuts, Undermining GINA, and Game...

Mendelspod Podcast ·

2017/03/31

The largest cut to NIH budget ever, rolling back genetic non-discriminatory law—the bad news continues to roll from Washington. But there was great news this month as well. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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19:23

Art in the Lab (Falling in Love with Bacteria)

Mendelspod Podcast ·

2017/03/28

Today’s guest makes time to create beauty in the lab. Memo Berkmen is a bacterial artist along with being a staff scientist at New England Bio Labs. He and his colleague, Maria Penil, were the winners of the American Society for Microbiology’s agar art contest in 2015. Their felicitous relationship with the unseen, often unnoticed, world of ancient organisms fills us with wonder and inspiration.----- This is a public episode. If you'd like to discuss this with other subscribers or get access to

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27:29

Flint Whistleblower Says Today's Science Is to Blame...

Mendelspod Podcast ·

2017/03/16

Marc Edwards is telling a different story than the one most of us have been reading and hearing lately. But then he’s used to it.Marc was the engineer from Virginia Tech who was called one day in September, 2015, by a resident of Flint, Michigan. A Ms Lee Ann Walters wanted Marc to check out her water. When Marc and his team got to Flint they uncovered super high levels of lead in the potable water, with over 100,000 people exposed to high lead levels and 12,000 people with lead poisoning. You

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24:12

The Story of Geisinger and Doing Genomic Medicine at...

Mendelspod Podcast ·

2017/03/08

Mike Murray and the crew over at Geisinger are making the implementation of genomic medicine look down right easy.In today’s interview, Mike explains GenomeFIRST Medicine, a program at the Geisinger Health System in Pennsylvania to offer care “that is based on an individual’s DNA sequence.” The healthcare provider boasts its own biobank and has partnered up with Regeneron’s Genome Center to offer exome screening to self selected patients. As of DNA Day last year, April 25th 2016, 100,000 recruits

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23:33

In-Situ Sequencing, CRISPR Patents, and Racist Milk...

Mendelspod Podcast ·

2017/03/01

Commentators Nathan Pearson and Laura Hercher join us to look back on February’s genomics headlines.Beginning this time with science, Nathan says we should be expecting great things from new in-situ sequencing. Laura found it encouraging that the National Academy of Sciences shifted to be more in support of genome editing. Theral asks what life forms are left to sequence for the Earth BioGenome Project? This is a public episode. If you'd like to discuss this with other subscribers or get access to

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18:52

New Pocket Size Nanopore Device Could Revolutionize...

Mendelspod Podcast ·

2017/02/20

First of all, watch the video below.A Santa Cruz company is now previewing a nanopore device that could be a major disruptor in molecular testing. The device is the size of a glucometer and could take all kinds of testing—perhaps someday even cancer-tracking liquid biopsies—into the home with its ease of use and ability to work with thousands of different assays. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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21:36

By Changing a Basic Lab Step, Acoustic Liquid...

Mendelspod Podcast ·

2017/02/13

Freeman Dyson famously said, “the great advances in science usually result from new tools rather than from new doctrine.”Today we talk with Mark Fischer-Colbrie, CEO of Labcyte, a company which has made some waves--literally-- in the life sciences by changing a very fundamental laboratory procedure: liquid transfer. For some years now, Labcyte has been selling machines that move liquid around with sound. By eliminating the need for pipette tips and other “solid” surfaces, the machines guarantee

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25:40

Many Biologists Today Don’t Have Enough Computer...

Mendelspod Podcast ·

2017/02/09

Moray Campbell was for all intents and purposes an accomplished and successful cancer biologist at the renowned Roswell Park Cancer Center. Then one day he woke up and realized he was becoming irrelevant. He was a traditionally trained wet lab biologist who was getting left behind by computer science. Any scientist must keep up with their field, but this was different. A few conferences and journals--reading the news everyday was not going to be enough. Facing reality, Moray enrolled in a

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25:48

Cardiologists Love Genomics: Euan Ashley, Stanford

Mendelspod Podcast ·

2017/02/07

Euan Ashley is one of the big names in genomic medicine that has been missing from our guest list. We’re happy to correct that today.In 2010, he led the team who did the first clinical interpretation of a human genome--that of his Stanford colleague, Steve Quake. Since then Euan, an MD PhD, has been driving to make the use of new genomic tools and discoveries a routine part of medicine at Stanford, particularly in his own discipline of cardiology.A regular speaker on the conference circuit, Euan

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20:04

Scientists vs Trump: January 2017 with Nathan and Laura

Mendelspod Podcast ·

2017/02/02

As we look back at January’s headlines with our two regular commentators, Nathan and Laura, the question becomes: How much should we ignore the fire raging across America to focus on the science?Speaking of Trump's new immigration order and the very real threat of a "brain drain," Nathan tells of his own personal time doing research in Iran, commending scientists there and the many Iranian scientists here. But he says Iran has already announced they're going to retaliate. This is a public episode

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21:09

Want to Stop Smoking? Start with Epigenetic Biomarker...

Mendelspod Podcast ·

2017/01/31

Why are there no viable psychiatric genetic tests, we ask today’s guest.Rob Philibert is a geneticist and psychiatrist working at the University of Iowa. He admits at the outset of today’s interview that the field of psychiatric genetics is in a “quandary.”“The results are not matching the hype,” he says. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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20:26

When an Exome Test Is Part of the Therapy and Not a...

Mendelspod Podcast ·

2017/01/24

Podcast brought to you by: Slone Partners - Providing the leaders that shape the clinical trials space. About six years ago there was a wave of genome interpretation startups getting their first rounds of funding. One of them was Personalis, a company founded by a well known group of Stanford geneticists and bioinformaticians. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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24:11

People Told Us It Was Impossible: UCSC’s Mark Akeson...

Mendelspod Podcast ·

2017/01/18

Mark Akeson has been working on nanopore sequencing at UC Santa Cruz’s biophysics lab for twenty years. Up until the past few years with the launch of Oxford Nanopore’s sequencers, that work was mostly the methodical toil of the quiet inventor.Today it is quite ordinary to see a sequencer the size of your wallet being taken out into the field for DNA work. But for years, the naysayers dominated.“Back in the day, the skeptics outnumbered the proponents 99 to 1,” Mark says in today’s show. This is a

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28:24

When Long Reads are Double the Price of Short Reads,...

Mendelspod Podcast ·

2017/01/12

Each year at this time, sequencing tools leader, Illumina, generates another round of sequencing buzz in the industry, this year by announcing the $100 genome is around the corner with their latest boxes. But more and more, people are asking just what they will get with that $100. Indeed, what do they get today with a $1,500 genome?Illumina sells short read sequencing technology which is unable to characterize much of the human genome, particularly complex regions which are responsible for many of

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25:18

Genomics in 2016: Nathan and Laura Name Their Top...

Mendelspod Podcast ·

2016/12/28

From new CRISPR trials in humans to mitochondrial transfer therapy, from the spinout by Illumina of two new genomics health companies to the complete and utter failure of Theranos, from the approval by the FDA of GM mosquitos to the FDA giving up on LDT regulation as a result of the election, the genomics headlines of 2016 didn’t fail to dazzle, deliver, and disappoint.Hear which stories our regular commentators, Laura Hercher and Nathan Pearson, chose as their top and also most underreported of the

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32:00

Hank Greely on “The End of Sex" and Other Stuff

Mendelspod Podcast ·

2016/12/22

Each year at this time we bring on a guest who is somewhat out of the way of our normal lineup, for example, a science fiction writer or a philosopher. Today Theral interviews a law professor who loves to philosophize and write about the impact of biotechnology on our lives now and in the near future. His newest book out this year, “The End of Sex and the Future of Human Reproduction,” is another comprehensive and provocative example of what has made Stanford’s Hank Greely such an in-demand

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23:16

How to Scale Cancer Genomics, with Marco Marra, UBC

Mendelspod Podcast ·

2016/12/06

Back in 2009 at the annual AGBT meeting for sequencing, Marco Marra presented one of the first cases of cancer treatment using whole genome sequencing.We caught up with Marco at his office at the University of British Columbia where he heads the Department of Medical Genetics. Marco also directs the Genome Sciences Center which is part of a very special organization called the BC Cancer Agency. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus

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