x

75% of people globally want unbiased news (Pew Research) but are concerned they're not getting that.

Get balanced coverage with Symby. See how stories are covered across diverse outlets and spot when one side covers a story the other skips.

PODCAST

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

science life sciences

All Episodes

00:25:14

️ 18: Bi-allelic UGGT1 Variants Define a Distinct...

Base by Base ·

2025/05/13

️ Episode 18: Bi-allelic UGGT1 Variants Define a Distinct Congenital Disorder of Glycosylation In this episode of PaperCast Base by Base, we explore the identification of bi-allelic variants in the UGGT1 gene as the cause of a novel congenital disorder of glycosylation characterized by neurodevelopmental impairment, seizures, dysmorphic features, and multiorgan involvement within the broader landscape of gene–disease associations and variant

en-us

00:25:13

🎙️ Episode 18: Network Causality — A New Bayesian...

Base by Base ·

2025/05/13

🎙️ Episode 18: Network Causality — A New Bayesian Model for Multivariable Mendelian Randomization🧬 In this episode of Base by Base, we examine the methodological breakthrough presented by Liu et al. (2025) in Nature Communications. The authors introduce BayesMRnet, a Bayesian causal graphical model designed to perform joint Mendelian randomization (MR) across multiple exposures and outcomes. By leveraging genome-wide association study (GWAS) data, BayesMRnet constructs directed acyclic graphs

en-us

00:20:18

️ 17: The Structure of Human Sweetness — Cryo-EM of...

Base by Base ·

2025/05/13

️ Episode 17: The Structure of Human Sweetness — Cryo-EM of the TAS1R2+TAS1R3 Sweet Taste Receptor In this episode of Base por Base, we explore a landmark cryo-electron microscopy study by Juen et al. (2025) published in Cell, which reveals the high-resolution structure of the human sweet taste receptor heterodimer TAS1R2+TAS1R3 bound to the artificial sweeteners sucralose and aspartame, providing the first detailed view of how a single receptor

en-us

00:20:17

🎙️ Episode 17: The Structure of Human Sweetness —...

Base by Base ·

2025/05/13

🎙️ Episode 17: The Structure of Human Sweetness — Cryo-EM of the TAS1R2+TAS1R3 Sweet Taste Receptor🧬 In this episode of Base por Base, we explore a landmark cryo-electron microscopy study by Juen et al. (2025) published in Cell, which reveals the high-resolution structure of the human sweet taste receptor heterodimer TAS1R2+TAS1R3 bound to the artificial sweeteners sucralose and aspartame, providing the first detailed view of how a single receptor recognizes a diverse array of sweet compounds.🔍

en-us

00:15:52

️ 16: Equity in Focus: Building a Truly Global...

Base by Base ·

2025/04/25

️ Episode 16: Equity in Focus: Building a Truly Global Genomic Landscape In this episode of Base by Base, we address one of the most pressing issues in human genomics: the need to close the ancestral data gap. Published in Cell Genomics, this commentary by Ana Luiza Arruda, Andrew Morris, and Eleftheria Zeggini calls attention to how genomic medicine remains disproportionately centered on individuals of European ancestry—jeopardizing its promise of

en-us

00:13:04

🎙️ Episode 16: Equity in Focus: Building a Truly...

Base by Base ·

2025/04/25

🎙️ Episode 16: Equity in Focus: Building a Truly Global Genomic Landscape🧬 In this episode of Base by Base, we address one of the most pressing issues in human genomics: the need to close the ancestral data gap. Published in Cell Genomics, this commentary by Ana Luiza Arruda, Andrew Morris, and Eleftheria Zeggini calls attention to how genomic medicine remains disproportionately centered on individuals of European ancestry—jeopardizing its promise of precision health for all.The authors highlight

en-us

00:35:32

🎙️ Episode 15: What Makes Us Human? Genetics from...

Base by Base ·

2025/04/25

🎙️ Episode 15: What Makes Us Human? Genetics from Neandertals to Now🧬 In this episode of Base by Base, we travel back in time—over 600,000 years—to explore the genomic storylines of Neandertals, Denisovans, and modern humans. Published in Cell by Hugo Zeberg, Mattias Jakobsson, and Nobel Laureate Svante Pääbo, this comprehensive review deciphers the evolutionary divergences that defined—and continue to define—our species.By comparing high-quality genomes from extinct and extant human lineages, the

en-us

00:20:07

️ 15: What Makes Us Human? Genetics from Neandertals...

Base by Base ·

2025/04/25

️ Episode 15: What Makes Us Human? Genetics from Neandertals to Now In this episode of Base by Base, we travel back in time—over 600,000 years—to explore the genomic storylines of Neandertals, Denisovans, and modern humans. Published in Cell by Hugo Zeberg, Mattias Jakobsson, and Nobel Laureate Svante Pääbo, this comprehensive review deciphers the evolutionary divergences that defined—and continue to define—our species.By comparing high-quality genomes

en-us

00:25:44

️ 14: Beyond the Genome - Societal Value of National...

Base by Base ·

2025/04/25

️ Episode 14: Beyond the Genome: Societal Value of National Genomics Programmes In this episode of Base by Base, we discuss a thought-provoking report published in the European Journal of Human Genetics that tackles a crucial yet underexplored question: what is the actual value of large-scale national genomic programmes for society?Led by Ruth Horn, Angeliki Kerasidou, Jennifer Merchant and the UK-FR+GENE consortium, this multidisciplinary workshop

en-us

00:19:14

🎙️ Episode 14: Beyond the Genome - Societal Value of...

Base by Base ·

2025/04/25

🎙️ Episode 14: Beyond the Genome: Societal Value of National Genomics Programmes🧬 In this episode of Base by Base, we discuss a thought-provoking report published in the European Journal of Human Genetics that tackles a crucial yet underexplored question: what is the actual value of large-scale national genomic programmes for society?Led by Ruth Horn, Angeliki Kerasidou, Jennifer Merchant and the UK-FR+GENE consortium, this multidisciplinary workshop brought together ethicists, geneticists,

en-us

00:13:45

🎙️ Episode 13: Decoding De Novo: A Multigenerational...

Base by Base ·

2025/04/25

🎙️ Episode 13: Decoding De Novo: A Multigenerational Benchmark for Human Mutation Rates🧬 In this episode of Base by Base, we explore a monumental study published in Nature that redefines how we understand human de novo mutation (DNM) rates. By sequencing 28 individuals across four generations from the CEPH 1463 family with five complementary technologies, this study delivers the most complete pedigree reference to date.Led by Porubsky and colleagues, the research team used a mix of short- and

en-us

00:19:34

️ 13: Decoding De Novo: A Multigenerational Benchmark...

Base by Base ·

2025/04/25

️ Episode 13: Decoding De Novo: A Multigenerational Benchmark for Human Mutation Rates In this episode of Base by Base, we explore a monumental study published in Nature that redefines how we understand human de novo mutation (DNM) rates. By sequencing 28 individuals across four generations from the CEPH 1463 family with five complementary technologies, this study delivers the most complete pedigree reference to date.Led by Porubsky and colleagues, the

en-us

00:17:33

🎙️ Episode 12: Repairing the Blueprint: Insights from...

Base by Base ·

2025/04/19

🎙️ Episode 12: Repairing the Blueprint: Insights from MUTYH Structure and Cancer-Associated Variants🧬 In this episode of Base by Base, we explore a pivotal study published in Nature Communications that reveals the structural and functional secrets of the human MUTYH DNA glycosylase. This landmark work provides the first crystal structure of human MUTYH bound to DNA, illuminating how its [4Fe-4S] cluster cofactor allosterically connects to the catalytic site — a critical feature for maintaining

en-us

00:16:28

️ 12: Repairing the Blueprint: Insights from MUTYH...

Base by Base ·

2025/04/19

️ Episode 12: Repairing the Blueprint: Insights from MUTYH Structure and Cancer-Associated Variants In this episode of Base by Base, we explore a pivotal study published in Nature Communications that reveals the structural and functional secrets of the human MUTYH DNA glycosylase. This landmark work provides the first crystal structure of human MUTYH bound to DNA, illuminating how its [4Fe-4S] cluster cofactor allosterically connects to the catalytic site

en-us

00:19:15

️ 11: Targeting Mitochondria: A Therapeutic Strategy...

Base by Base ·

2025/04/19

️ Episode 11: Targeting Mitochondria: A Therapeutic Strategy for Dnmt3a-Mutant Clonal Hematopoiesis In this episode of Base by Base, we dive into a compelling study published in Nature Communications that reveals a novel therapeutic vulnerability in clonal hematopoiesis driven by DNMT3A mutations. The research identifies elevated mitochondrial membrane potential (Δψm) as a selective weakness in mutant hematopoietic stem and progenitor cells (HSPCs),

en-us

00:10:39

🎙️ Episode 11: Targeting Mitochondria: A Therapeutic...

Base by Base ·

2025/04/19

🎙️ Episode 11: Targeting Mitochondria: A Therapeutic Strategy for Dnmt3a-Mutant Clonal Hematopoiesis🧬 In this episode of Base by Base, we dive into a compelling study published in Nature Communications that reveals a novel therapeutic vulnerability in clonal hematopoiesis driven by DNMT3A mutations. The research identifies elevated mitochondrial membrane potential (Δψm) as a selective weakness in mutant hematopoietic stem and progenitor cells (HSPCs), paving the way for targeted interventions.Led

en-us

00:19:38

️ 10: Targeting the Genome: Guidelines for Antisense...

Base by Base ·

2025/04/18

️ Episode 10: Targeting the Genome: Guidelines for Antisense Oligonucleotide Therapy Eligibility In this episode of Base by Base, we explore a transformative study published in The American Journal of Human Genetics that introduces the N1C VARIANT guidelines — a consensus framework for evaluating the eligibility of pathogenic DNA variants for antisense oligonucleotide (ASO) therapies. This pioneering effort addresses a critical gap for rare genetic

en-us

00:14:51

🎙️ Episode 10: Targeting the Genome: Guidelines for...

Base by Base ·

2025/04/18

🎙️ Episode 10: Targeting the Genome: Guidelines for Antisense Oligonucleotide Therapy Eligibility🧬 In this episode of Base by Base, we explore a transformative study published in The American Journal of Human Genetics that introduces the N1C VARIANT guidelines — a consensus framework for evaluating the eligibility of pathogenic DNA variants for antisense oligonucleotide (ASO) therapies. This pioneering effort addresses a critical gap for rare genetic diseases, where individualized treatments are

en-us

00:18:45

🎙️ Episode 9: Unraveling Complexity: A Bayesian...

Base by Base ·

2025/04/18

🎙️ Episode 9: Unraveling Complexity: A Bayesian Graphical Model for Joint Mendelian Randomization🧬 In this episode of Base by Base, we explore a groundbreaking study published in The American Journal of Human Genetics that introduces MrDAG, a Bayesian causal graphical model designed to jointly analyze multiple exposures and outcomes in Mendelian randomization (MR) studies. This innovative approach overcomes the limitations of traditional MR methods, offering a deeper understanding of complex

en-us

00:20:34

️ 9: Unraveling Complexity: A Bayesian Graphical...

Base by Base ·

2025/04/18

️ Episode 9: Unraveling Complexity: A Bayesian Graphical Model for Joint Mendelian Randomization In this episode of Base by Base, we explore a groundbreaking study published in The American Journal of Human Genetics that introduces MrDAG, a Bayesian causal graphical model designed to jointly analyze multiple exposures and outcomes in Mendelian randomization (MR) studies. This innovative approach overcomes the limitations of traditional MR methods,

en-us

456 results

Similar Podcasts

Classic Radio Science Fiction

solgoodmedia.com

Mission to Mars

Inception Point Ai

The 365 Days of Astronomy

365DaysOfAstronomy.org

Creek Devil

william Jevning

UFO Chronicles Podcast

Nik Hunter