Mendelspod Podcast

21:10

Defending the Value of Biotech Innovation in...

Mendelspod Podcast ·

2015/10/09

Earlier this year, the California Life Sciences Association (CLSA) launched, becoming the first statewide policy and advocacy group for biotech. The new nonprofit, a merger between BayBio and the California Healthcare Institute, is led by CEO Sara Radcliffe, former Executive VP of Health at the international Biotechnology Industry Organization (BIO) in Washington. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit

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23:30

Long Read Sequencing Dramatically Improves Blood...

Mendelspod Podcast ·

2015/10/06

One of the popular questions on the program this past year is how those doing sequencing decide between the quality of Pacific Bioscience's long reads and the cheaper short read technology, such as that of Illumina or Thermo Fisher. Today’s guest provides the most clear and dramatic answer yet: use the PacBio system exclusively. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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28:17

The World of DIY Genomics with K T Pickard

Mendelspod Podcast ·

2015/10/01

K Thomas Pickard is not at all into sports cars. So when he hit midlife crisis, it wasn’t a Porsche or a golf club membership that would reenergize his quiet moments. Nope. K T got his genome sequenced. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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30:01

Sequencing in Space: Chris Mason, Cornell

Mendelspod Podcast ·

2015/09/24

The last time we talked with Chris Mason of Weill Cornell Medical College the Supreme Court had just decided the controversial Myriad gene patent case. How forever ago two years can seem. Since then Chris has swabbed and sequenced the microbiome of New York City and began the project of sequencing in space.His favorite research this year has been to longitudinally profile the genome, epigenome, transcriptome, metabolome and microbiome of identical twins, one in space and one on earth. This is a

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26:19

Is the Future of Biology a Return to Chemistry?...

Mendelspod Podcast ·

2015/09/22

Classes for the school year begin this week at Stanford University. New to the faculty is Carolyn Bertozzi, an American chemist who made her name across the bay at Berkeley and was wooed to Stanford by a chance to do research and teach chemistry in a new interdisciplinary institute known as ChEM-H. The institute will bring chemists, engineers, biologists and medical doctors together to understand life at a chemical level. We’ve often heard of biology and engineering institutes, or bringing bio

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28:56

Going Beyond the $1,000 Genome with Mark Gerstein

Mendelspod Podcast ·

2015/09/17

Though recent guests at Mendelspod say we're not quite to the $1,000 genome, we're close enough to use that benchmark in genomics discussions. But what are we getting for that almost $1,000?Mark Gerstein is the co-director of the Yale Computational Biology and Bioinformatics program where he focuses on better annotation of the human genome and better ways to mine big genomics data. He has played a big role in some of the large genomics initiatives since the first human genome project, including

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30:18

Creating the Foundation of Genomics: Marc Salit, NIST

Mendelspod Podcast ·

2015/09/10

What is a human genome? Well it’s the three billion letters of our DNA. But how is it measured? How do we know when we have it accurately represented?These are questions that will have to be answered as precision medicine takes hold; for we must have defined standards that will be the basis for regulatory policy, commerce, and better research. These are also the questions that are foremost on the mind of today’s guest. This is a public episode. If you'd like to discuss this with other

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24:20

Still Unhappy with FDA’s Plan to Regulate LDTs,...

Mendelspod Podcast ·

2015/09/08

It's no secret that America's molecular testing laboratories by and large are worried that the FDA's plan to regulate laboratory developed tests, or LDTs, will severely harm patients. Now they have a new proposal which they are taking directly to Capitol Hill.Roger Klein is the Medical Director of Molecular Oncology at the Cleveland Clinic. He’s also serving as the spokesperson for the Association for Molecular Pathology (AMP) on the controversial topic of regulating LDTs. This is a public episode

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25:13

A Diagnostic Success Story with Alka Chaubey,...

Mendelspod Podcast ·

2015/09/03

Diagnostics can be a tough business. The FDA is making a strong push to bring more oversight. Obtaining reimbursement can be outright Sisyphean. And clinicians are slow on the uptake. All of which makes today’s story so good. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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21:11

With Two New Easy-to-Use Sequencing Instruments,...

Mendelspod Podcast ·

2015/09/01

The race to the $1,000 genome has been full of breathtaking advances, one after the other. But is next gen sequencing reaching maturity? Will there be that many more significant innovations? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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4:28

Here's Looking at Euclid

Mendelspod Podcast ·

2015/08/28

A slow week in life science left us scratching our heads about the purpose of some new studies.The first, a major project to study the microbes in about 1,200 homes appeared under headlines such as this from Tech Times, "Household Bacteria Can Reveal Volumes about Home Residents." Volumes? Really?A second study claimed that we are less successful at biomedical research today because life expectancy is not going up at the same rate as the growth in funding or the increasing number of scientists.

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24:54

Is This the Future of Clinical Trials for Cancer?...

Mendelspod Podcast ·

2015/08/27

It’s taken some time, but the NCI is finally sponsoring a big time clinical trial for cancer where the patients are organized by the genomic pathway that defines their cancer rather than the organ type. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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21:10

Brian Kennedy and Aubrey de Grey on their Converging...

Mendelspod Podcast ·

2015/08/25

Last week we attended the 2015 Rejuvenation Biotechnology Conference where we heard about the latest developments in aging research.We were fortunate enough to sit down with two of the major figures in the field of aging research, Aubrey de Grey, CSO of the SENS Research Foundation and Brian Kennedy, CEO of the Buck Institute for Research on Aging. Brian and Aubrey have gone about their work in different ways but say that their approaches are now converging as the momentum behind aging research

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5:10

The Business of Aging and Three Reasons Why the FDA...

Mendelspod Podcast ·

2015/08/21

We're back in the office after a fabulous vacation, and ready to have some fun. It's Friday, and time for Gene and Tonic.Yes, we celebrate the news this week that women have their own sex pill. And we make our best guesses as to why the FDA's drug approval rate is up in the stratosphere. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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32:49

New York Genome Center’s Nathan Pearson on Public...

Mendelspod Podcast ·

2015/08/19

Nathan Pearson, formerly a genome scientist at Ingenuity and Knome, has been doing public outreach for genomics at the New York Genome Center for about a year now. In today’s interview, Nathan says he always wanted to be able to speak directly to the larger public about the great science he’s been involved in. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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7:30

Tim Triche on Using Arrays for Cancer Research

Mendelspod Podcast ·

2015/07/31

We recently interviewed cancer researcher Tim Triche from Children's Hospital Los Angeles. Tim had two main points: First, microarrays are still a very valuable tool for research and for the clinic. Second, there are perhaps more answers for cancer research to be found in the non-coding portion of the genome than in the genes.Here, we've compiled Tim's comments on the staying power of arrays. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus

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23:27

Thermo’s Chris Linthwaite on Sequencing the Ebola...

Mendelspod Podcast ·

2015/07/28

Major outbreaks of deadly viruses, such as the recent spread of Ebola in Northern Africa, are nothing new on planet earth. What is new is the technology that we are using to identify, track, and contain such plagues. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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22:27

A Tool to Strengthen the Voice of Science in Online...

Mendelspod Podcast ·

2015/07/23

Emmanuel Vincent is the founder of Climate Feedback, a project which includes a new tool for scientists to comment directly on climate science news. The tool is a plugin which can be downloaded for free and gives a viewer real time access to the feedback of scientists on a particular online article. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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22:26

Father of Child with Rare Disease Says Science Equals...

Mendelspod Podcast ·

2015/07/21

Matt Might came knocking on the door of genomic medicine out of pure necessity. After a four year diagnostic odyssey that led them to Duke University, Matt and his wife, Cristina, finally found out through exome sequencing that their son, Bertrand, was suffering from a rare disease known as NGLY1 deficiency. That was three years ago. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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26:29

Bina CEO Details Secret to Success in NGS Informatics

Mendelspod Podcast ·

2015/07/17

Last year, pharma giant Roche went on a buying spree, picking up one company after another. In December, when it was announced they had bought out Bina Technologies, many of us were playing catch up. Who is Bina, and how do they fit in the overall bioinformatics space? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mendelspod.com/subscribe

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