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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

02:38

SUMMIT Trial: Tirzepatide in Heart Failure due to...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/19

The SUMMIT trial investigated tirzepatide, a dual GIP and GLP-1 receptor agonist, in 731 patients with HFpEF and obesity. This randomized, placebo-controlled study found that tirzepatide reduced heart failure-related events (HR 0.62, P=0.026) and significantly improved quality of life (KCCQ-CSS +19.5 vs. +12.7, P<0.001). However, cardiovascular mortality was not significantly different. Gastrointestinal side effects led to a 6.3% discontinuation rate. The findings suggest a potential role for

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04:27

Dr. RR Baliga’s Philosophical Snippets: Kanada...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/18

Summary on Kaṇāda Kaṇāda, also known as Ulūka or Kashyapa, was an ancient Indian natural philosopher and the founder of the Vaisheshika school of Indian philosophy. He is often regarded as the earliest proponent of atomism in the world, proposing that the universe is composed of indivisible, eternal atoms (paramanu), which combine in various ways to form different substances. His ideas were recorded in the seminal text Vaiśeṣika Sūtra, which outlined a realistic and pluralistic ontology.

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02:17

Risedronate 💊: A New Hope for Genetic Cardiomyopathy ❤️

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/17

The study investigates the K210del mutation in genetic cardiomyopathy, which impairs myocardial contractility due to calcium discoordination in the troponin complex. Using a structure-based drug repurposing approach, researchers identified risedronate, an FDA-approved bisphosphonate, as a structural corrector that restores the calcium-binding domain’s normal configuration. Experiments with patient-derived iPSC cardiomyocytes and a mouse model demonstrated that risedronate normalized calcium

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04:47

Early Intervention in Asymptomatic Aortic Stenosis?

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/17

Recent randomized trials, including EARLY TAVR, AVATAR, RECOVERY, and EVOLVED, suggest benefits of early aortic valve replacement (AVR) in asymptomatic severe aortic stenosis (AS). Early AVR reduces stroke, heart failure hospitalizations, and cardiovascular events, with a trend toward improved survival. The data support shifting from clinical surveillance to early intervention?

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02:23

The EVOLVED Trial - Early Intervention in Patients...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/17

The EVOLVED trial investigated whether early aortic valve intervention could improve outcomes in asymptomatic patients with severe aortic stenosis and myocardial fibrosis. The randomized, multicenter study of 224 patients found no significant difference in all-cause mortality or unplanned aortic stenosis-related hospitalizations between early intervention and guideline-directed conservative management. However, early intervention was associated with lower rates of NYHA class II-IV symptoms and fewer

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02:20

Cold-Related Deaths

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/16

Summary: Cold-Related Deaths in the US (1999–2022) 1. Overview and Trends • Cold-related deaths more than doubled over the study period. • 40,079 deaths recorded; age-adjusted mortality rate (AAMR) rose from 0.44 (1999) to 0.92 (2022) per 100,000 population (109% increase). • A significant upward trend began in 2017, with an annual percentage change (APC) of 12.1%. 2. Demographic Insights • Age: Mortality was highest among individuals aged ≥75 years (4.23/100,000 in 2022). • Largest Increase: Adults

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02:47

Abelacimab versus Rivaroxaban in Patients with Atrial...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/16

The AZALEA–TIMI 71 trial compared abelacimab, a monoclonal antibody targeting factor XI, with rivaroxaban in atrial fibrillation patients at moderate-to-high stroke risk. 🚨 New study: Abelacimab vs. Rivaroxaban in AFib 📊 ✅ 62-69% lower bleeding risk than rivaroxaban ✅ 5x lower GI bleeding ⚠️ Slightly higher ischemic stroke rates A promising safer anticoagulant? 🔬 More data needed! #CardioTwitter #CardioEd #MedEd Abelacimab significantly reduced bleeding compared to rivaroxaban (HR: 0.38 for 150

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02:51

Transcatheter Tricuspid Edge-to-Edge Repair is a...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/15

The Tri.Fr Randomized Clinical Trial evaluated the efficacy of Transcatheter Edge-to-Edge Repair (T-TEER) + Optimized Medical Therapy (OMT) versus OMT alone in 300 patients with severe, symptomatic tricuspid regurgitation (TR) across 24 centers in France and Belgium. At 1-year follow-up, 74.1% of patients in the T-TEER group improved, compared to 40.6% in the OMT-alone group (P < .001). T-TEER significantly reduced TR severity, improved NYHA class, patient global assessment (PGA), and Kansas City

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02:52

New studies link aircraft noise to serious health...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/14

Three studies examined the health impacts of aircraft noise exposure. The Heathrow Study (2023) found that nighttime aircraft noise increased cardiovascular events, particularly between 22:00–23:00 and 04:30–06:00, likely due to sleep disturbance and stress-related mechanisms. 🚨 New studies link aircraft noise to serious health risks! 🛩️🔊 📌 Nighttime noise boosts heart disease risk 🫀 📌 Increases cognitive decline & dementia risk 🧠 📌 Alters heart structure, raising cardiac event risk 💔

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02:09

Fatigue in Air Traffic Control

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/13

🚨 Air traffic controllers face severe fatigue due to the 2-2-1 shift system, causing sleep loss, cognitive impairment & safety risks. 🛑 FAA & NATCA now plan to replace it with a safer schedule to enhance aviation safety. ✈️ #Fatigue #AviationSafety #ATC The 2-2-1 shift system in air traffic control (ATC) compresses five shifts into four days, leading to severe fatigue due to counterclockwise rotation and insufficient rest periods. The FAA’s 2024 study found that this schedule causes sleep

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02:31

Continuation vs. Interruption of Oral Anticoagulation...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/12

The POPular PAUSE TAVI trial investigated whether continuing or interrupting oral anticoagulation during transcatheter aortic valve implantation (TAVI) affected clinical outcomes. The randomized, open-label, noninferiority study included 858 patients and assessed a composite primary outcome of cardiovascular death, stroke, myocardial infarction, major vascular complications, or major bleeding at 30 days. The trial found that continuation was not noninferior to interruption, with higher bleeding risk

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05:59

Dr. RR Baliga’s Philosophical Snippets: Six orthodox...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/11

The six orthodox Indian schools of philosophy—Nyaya, Vaisheshika, Samkhya, Yoga, Mimamsa, and Vedanta—offer valuable insights into the mind-body connection, ethics, logic, and holistic well-being. Understanding these systems can benefit healthcare providers and patients in promoting mental, emotional, and physical health.

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02:54

Transcatheter Aortic Valve Implantation (TAVI) and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/11

The TCW Trial compared TAVI + FFR-guided PCI versus SAVR + CABG in patients with severe aortic stenosis and complex coronary artery disease. This multicenter, randomized controlled trial included 172 patients aged ≥70 years. At 1 year, the primary composite endpoint (death, MI, stroke, revascularization, valve reintervention, or major bleeding) was significantly lower in the TAVI + PCI group (4%) compared to SAVR + CABG (23%), meeting both noninferiority and superiority criteria. The study

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02:48

Vascular Access for Cardiac Arrest

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/10

🚑 New studies on #OHCA: No significant survival benefit of intraosseous (IO) over IV access. IV remains the preferred route, with IO as backup. #EmergencyMedicine #CPR #CardiacArrest These 2 randomized clinical trials compared intraosseous (IO) vs. IV vascular access in out-of-hospital cardiac arrest (OHCA). The first study (Denmark) found no significant difference in return of spontaneous circulation (ROSC), 30-day survival, or neurological outcomes between IO and IV access. The second study (UK)

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02:49

Evolocumab shows strong benefits in older adults...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/09

🚨 New study: Evolocumab shows strong CV benefits in older adults (≥75 yrs) with ASCVD! 📉 Lower LDL-C, reduced events (HR: 0.79, NNT: 19), & no major safety concerns. Time to rethink lipid guidelines for seniors? 🔬💙 #Cardiology #LipidLowering #Evolocumab

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02:58

Novel Therapeutics for Reduction of Lipoprotein (a)

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/08

Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. Traditional lipid-lowering therapies have minimal impact on Lp(a), necessitating novel treatments. Zerlasiran, a small-interfering RNA (siRNA), significantly reduces Lp(a) (~85%) by inhibiting hepatic apolipoprotein(a) synthesis via subcutaneous injection. Muvalaplin, an oral small-molecule inhibitor, prevents Lp(a) particle formation, reducing levels by up to

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03:00

Wear Red Day: Women’s Heart Health & Hidden Risk Factors

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/07

1. NEJM Article (2024): A 30-year study of 27,939 U.S. women found that high-sensitivity CRP, LDL cholesterol, and lipoprotein(a) independently predicted cardiovascular risk. Higher levels of these biomarkers increased the risk of major cardiovascular events, emphasizing the need for early screening and prevention in women. 2. BrJSportsMed Article (2024): A study of 13,018 women found that even 1–3 minutes/day of vigorous intermittent lifestyle physical activity (VILPA) significantly reduced

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02:04

Micro and Nanoplastics in the Brain and Atheromas !!!!!

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/06

1. “Bioaccumulation of Microplastics in Decedent Human Brains” (Nature Medicine, 2024) This study confirms the presence of microplastics and nanoplastics (MNPs) in human brain tissue, particularly the frontal cortex. Researchers used pyrolysis gas chromatography-mass spectrometry (Py-GC/MS) and electron microscopy to analyze postmortem samples, finding polyethylene (PE) as the dominant plastic type. Brain tissue exhibited significantly higher plastic concentrations than the liver or kidney, with

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04:53

Dr. RR Baliga’s Philosophical Snippets: Kapila...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/02/04

Kapila: Founder of Samkhya Philosophy Kapila (7th–6th century BCE) is regarded as the founder of the Samkhya school, one of the six orthodox systems of Hindu philosophy. Known for his rational and dualistic approach, he emphasized the distinction between Purusha (consciousness) and Prakriti (matter). His teachings are captured in the Samkhya Sutras and the Bhagavata Purana, where he elaborated on metaphysics, self-realization, and liberation from suffering. Kapila’s influence extends to Hinduism,

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10:42

10-year outcomes from the SCOT- HEART Study--Lancet

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/01/31

Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT- HEART randomised controlled trial in Scotland Michelle C Williams, Ryan Wereski, Christopher Tuck, Philip D Adamson, Anoop S V Shah, Edwin J R van Beek, Giles Roditi, Colin Berry,Nicholas Boon, Marcus Flather, Steff Lewis, John Norrie, Adam D Timmis, Nicholas L Mills, Marc R Dweck, David E Newby, on behalf of theSCOT-HEART Investigators* Summary Background The Scottish Computed Tomography

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