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PODCAST

The Optispan Podcast with Matt Kaeberlein

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that

science

All Episodes

01:16:01

Longevity Scientists Answer 30 MORE of Your Health &...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/24

Subscribe to our channel: https://www.youtube.com/@optispanIn this Q&A, Matt and Brian Kennedy cover a range of topics on caloric restriction, lifespan studies, interventions like rapamycin, and the importance of control groups in research. They critique the validity of certain longevity claims, discusses the complexities of aging mechanisms, and questions the effectiveness of supplements. The conversation also touches on dietary impacts, the role of exercise, and the significance of

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01:27:55

MEGA Q&A: We Answer 30 of Your Health & Longevity...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/19

Subscribe to our channel: https://www.youtube.com/@optispan In this Part 1 episode, Matt and Brian Kennedy cover various aspects of aging research, including the connection between the immune system and aging, the role of inflammation, the potential of supplements and wearables in healthspan, and insights on longevity interventions. They also discuss the challenges in the field regarding clinical practices, the influence of AI on aging research, and personal experiences with health

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00:29:29

I Got a Full Body MRI: IS IT WORTH IT? I Share My...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/17

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode of the Optispan Podcast, Matt Kaeberlein shares his experience of undergoing a whole body MRI, discussing its potential as a screening and preventative tool for health optimization. He covers the benefits and drawbacks of whole body MRIs, shares specific details about his experience with the provider Ezra, and reflects on his results, emphasizing the importance of having quality follow-up care. Kaeberlein concludes with

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00:46:57

Understanding Women's Hormonal Health, Hormonal...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/12

In the final installment of this three-part series, Matt and Kim Celmer explore the essential topic of hormonal health for women, highlighting its impact on both overt and silent symptoms of hormonal changes. Celmer offers practical advice for initiating meaningful conversations with healthcare providers about hormone levels with both diving into the intricacies of hormone replacement therapy (HRT)—what it is, how it works, and its potential benefits and risks. Addressing public concerns, they

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00:14:47

Longevity Scientist On Ethan Klein's "Revolutionary...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/10

Subscribe to our channel: https://www.youtube.com/@optispanMatt Kaeberlein & Nick Arapis discuss the potential of new drugs aimed at extending the lifespan of dogs and cats. The conversation highlights recent advancements, including Loyal’s injection-based treatment targeting the IGF-1 hormone, which may add years to a dog’s life. They also address misconceptions regarding claims about cat lifespan extensions, emphasizing the lack of scientific backing for such assertions. The episode

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00:50:48

Epigenetic & Glycan Age Tests Results: Are Biological...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/05

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode of the Optisan Podcast, Dr. George Sutphin discusses biological age tests, focusing on epigenetic and glycan age assessments. The conversation explores the accuracy, relevance, and implications of these tests for understanding biological versus chronological age. Key topics include the limitations of current biomarkers, the impact of lifestyle on aging metrics, and the challenges of interpreting results. The discussion

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01:07:49

Cold Plunge & Brown Fat, Different Types of Stress,...

The Optispan Podcast with Matt Kaeberlein ·

2024/12/03

Subscribe to our channel: https://www.youtube.com/@optispan In this episode with our guest Dr. Thomas Seager, we delve into the transformative power of cold plunge therapy and its profound effects on resilience and longevity. We explore real-life case studies, including lessons learned from infrastructure failures like Hurricane Katrina and the Oroville Dam crisis. Discover how psychological resilience shapes our responses to stress, the importance of hormesis in health, and the role of brown fat

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00:40:03

Bryan Johnson Stopped Taking THIS & It DOESN'T Make...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/28

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01:00:28

Doctor of Naturopathy: Microbiome & SIBO,...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/26

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00:37:49

I Took 4 Different Biological Age Tests & Compared...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/21

Subscribe to our channel: https://www.youtube.com/@optispanRelated Episode(s):Biological Age & what it REALLY means | 9 - Longevity Science #3: https://youtu.be/DcxgEwQKx8Q?si=y1iF4RviJc0n__gW In this deep dive, Matt examines the growing trend of direct-to-consumer biological (epigenetic) age testing kits, exploring their purpose, popularity, and limitations. He outlines his experimental design to evaluate the accuracy and precision of these tests, addressing important questions about what

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00:46:35

Dr Seager: Rethinking Health for Longevity | 81

The Optispan Podcast with Matt Kaeberlein ·

2024/11/19

Subscribe to our channel: https://www.youtube.com/@optispanIn this episode, Matt sits down with Thomas Seager, an associate professor at Arizona State University (ASU), to explore the challenges and future directions of healthcare. Drawing from his background in environmental engineering and public health, Thomas discusses the pressing health issues affecting longevity in Americans and a potential shift from a reactive healthcare model to one that emphasizes proactive health management. Together,

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00:49:12

Death, Grief, & Purpose from a Longevity Science...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/14

Subscribe to our channel: https://www.youtube.com/@optispan Grief: one of the most profound emotions humanity shares; a universal experience that transcends time, culture, and place; a phenomenon as ancient as human existence. Grief is as intrinsic to the human experience as joy or hope, and no one escapes it—to grieve is to be human. In this episode, Matt and Nick discuss their recent personal experiences with grief and loss. Matt lost his German Shepherd Dobby to degenerative myelopathy, while

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00:34:45

Nutrition Myths, Gut Fixes, Natural Health Tips from...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/07

Subscribe to our channel: https://www.youtube.com/@optispan Related episode: People are GETTING THIS WRONG about Supplements & My Supplement List: https://www.youtube.com/watch?v=_UXk_ynCNUs In this episode, Matt sits down with naturopathic doctor and primary care provider Kim Celmer to discuss the distinct approach naturopathic doctors (NDs) bring to patient care, addressing common misconceptions about complementary and alternative treatment modalities and explaining how NDs treat prevalent

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00:25:29

We are Keeping People Sick Longer - We Need Medicine...

The Optispan Podcast with Matt Kaeberlein ·

2024/11/05

Subscribe to our channel: https://www.youtube.com/@optispanRelated episode: Defining "Healthspan" & its role in LIVING LONGER: https://www.youtube.com/watch?v=cI6CNFeBl88 Author and physician Peter Attia popularized the concept of "Medicine 3.0", the third in a series of distinct phases—Medicine 1.0 and Medicine 2.0 included—that describe the evolution of medicine as we know it. In this episode, Matt takes us through these phases and proposes a "Medicine 4.0" as the best next step beyond

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00:35:01

The Probability of Us Living to Be Much Older? | 77

The Optispan Podcast with Matt Kaeberlein ·

2024/10/31

Subscribe to our channel: https://www.youtube.com/@optispanHow much longer might humans live? This question has fascinated scientists, philosophers, and dreamers for centuries. The average human lifespan has already increased dramatically over the past hundred years thanks to advances in medicine, public health, and technology, and the prospect of radically extending human life remains one of humanity’s most compelling frontiers. A recent paper published in the scientific journal Nature Aging

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00:45:55

Longevity Scientist Answers Burning Questions About...

The Optispan Podcast with Matt Kaeberlein ·

2024/10/30

Subscribe to our channel: https://www.youtube.com/@optispanHere's another Ask Matt Anything episode, with questions from Nick for Matt about topics ranging from the nitty-gritty of bloodwork and workout schedules to bigger-picture questions about upper limits to human lifespan, issues with the US healthcare system, and incentives for food companies to prioritize healthy options. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the

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01:02:32

Brain Repair: The Ketamine Combo Treatment for...

The Optispan Podcast with Matt Kaeberlein ·

2024/10/24

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Brain Disorder Expert: Tackling Alzheimer's & Other Brain Disorders with LITHIUM: https://www.youtube.com/watch?v=ebj-3MuAKRs Check out Woodinville Psychiatric: https://www.woodinvillepsychiatric.com/ Matt and psychiatrist Jon Berner discussed the potential of rapamycin and ketamine for treating severe depression and chronic pain, focusing on their impact on microglia and brain inflammation. They touch on how

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00:31:15

GLP-1 Agonists Could Delay Aging? Scientist Weighs-In

The Optispan Podcast with Matt Kaeberlein ·

2024/10/22

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00:37:23

Anti-Aging Enthusiasts are Taking this Pill to Extend...

The Optispan Podcast with Matt Kaeberlein ·

2024/10/17

Subscribe to our channel: https://www.youtube.com/@optispan Check out the New York Times article: https://www.nytimes.com/2024/09/24/well/live/rapamycin-aging-longevity-benefits-risks.html Related episodes: “Zombie” Senescent cells may play HUGE role in LIVING LONGER, Here's How: https://www.youtube.com/watch?v=-H6cDIl6pgo NEW PEARL Trial Results: Your Questions Answered on Aging with Rapamycin for Longevity: https://www.youtube.com/watch?v=JUAXqSSnXzo Matt and Nick discuss a recent New York

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00:52:45

Brain Disorder Expert: Preventing Alzheimer's & Brain...

The Optispan Podcast with Matt Kaeberlein ·

2024/10/15

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