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PODCAST

The Orange Pill Podcast

The Orange Pill Podcast 🎙️ Your go-to source for the latest in the dietary supplement and natural health product industry! Brought to you by KGK Science, a global leader in clinical research and regulatory consulting, this podcast delivers: ✔️ Breaking industry news and trends ✔️ Educational insights and practical takeaways ✔️ Discussions on cutting-edge research ✔️ Landmark cases and notable events shaping the field Join us as we bridge the gap between science, regulation, and everyday impact.

health & fitness nutrition

All Episodes

14:15

Episode 21: The Sleep Secret Hidden in Corn Leaves

The Orange Pill Podcast ·

2025/05/08

We are back with a deep dive into the world of sleep — and why melatonin may not be the long-term solution we’ve all been promised.In this episode we cover: Why melatonin is widely used in hospitals, yet many still struggle to sleep What makes sleep so critical to overall health The growing global demand for new, effective sleep supplements A look at Maizinol®, a natural sleep aid derived from corn leaves, clinically shown to improve REM sleep, reduce sleep latency, and extend overall sleep

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13:04

Episode 20: History of the US Food Supply : Before...

The Orange Pill Podcast ·

2025/05/06

In this episode, we uncover the shocking state of America’s food supply before the FDA — from toxic milk to candy laced with arsenic — and explore how those chaotic beginnings shaped the future of food, supplements, and regulation.

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10:47

Episode 19: KGK Science and Nimble Science:...

The Orange Pill Podcast ·

2025/05/01

In this episode of the Orange Pill Podcast, we talk about the exciting new partnership between KGK Science and Nimble Science. Learn how this collaboration is set to redefine gastrointestinal (GI) health research through the integration of SIMBA™, a novel ingestible capsule that collects high-quality gut samples—without invasive procedures.

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10:17

Episode 18: RFK Jr.'s FDA Food Safety Agenda

The Orange Pill Podcast ·

2025/04/29

In this episode, we dive into U.S. presidential candidate Robert F. Kennedy Jr.’s provocative vision for the future of food regulation. RFK Jr. is calling for nothing short of a revolution—taking aim at food chemicals, plastics, and the FDA’s current approach to food safety.We unpack his stance on rethinking Generally Recognized as Safe (GRAS) determinations, his plan to reform the FDA’s oversight of food additives and endocrine disruptors, and what this could mean for food manufacturers,

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16:11

Episode 17: Yeast Postbiotic Effect On Cold And Flu...

The Orange Pill Podcast ·

2025/04/24

In this episode, we unpack a compelling clinical study conducted by KGK Science for Cargill on the impact of EpiCor® postbiotic supplementation in children. Learn how a daily gummy dose of this yeast-derived ingredient significantly reduced cold and flu symptoms, limited the need for medication, and offered a safe, science-backed immune support option for kids aged 4 to 12. Plus, we explore why this study is a milestone in both postbiotic and gummy supplement research.

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14:02

Episode 16: New Vitamin D Meta Analysis Study Shows...

The Orange Pill Podcast ·

2025/04/22

In this episode, we dive into a recent Lancet meta-analysis that questions vitamin D’s effectiveness in preventing acute respiratory infections. What does the data actually say, and how should consumers respond? We also explore promising new findings from Pediatric Research on EpiCor, a postbiotic that may reduce cold and flu symptom severity in children. KGK Science contributed to this important study—hear what the results mean for immune health innovation and the supplement industry at large.

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11:18

Episode 15: Upcoming Trends in 2025 for the Dietary...

The Orange Pill Podcast ·

2025/04/17

In this forward-looking episode, we explore the major shifts on the horizon for the dietary supplement and nutraceuticals sector in 2025. Expect a transformation driven by sustainability, science, and personalization. We cover: The rise of plant-based and functional ingredients Personalized nutrition through genomics and AI Regulatory updates on GRAS and novel ingredients The role of eco-conscious practices and clean-label demands Digital health tech and real-time supplement

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13:53

Episode 14: Disturbing New Trend in CRO Research- Use...

The Orange Pill Podcast ·

2025/04/15

In this episode, we explore a growing issue in nutraceutical clinical research: the misuse of predicted margins to gloss over incomplete data in virtual trials. When predictive models are used in place of raw results—without validation or transparency—scientific rigor is compromised. We break down what predicted margins are, when they should (and shouldn’t) be used, and how this impacts regulatory credibility.

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12:19

Episode 13: FDA's Final Rule for 'Healthy'

The Orange Pill Podcast ·

2025/04/10

In this episode, we explore the FDA’s newly finalized definition of “healthy” for food labeling — a major regulatory update released in December 2024. The goal? To bring food labels in line with today’s nutrition science and help consumers make better choices. We unpack what’s changed, why it matters, and how these new rules will impact how companies across both the supplement and conventional food spaces position their products moving forward.

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18:59

Episode 12: Benefits of Fava Beans on Resistance...

The Orange Pill Podcast ·

2025/04/08

In this episode, we discuss a new clinical trial conducted by KGK Science and published in the British Medical Journal of Nutrition, Prevention and Health. This randomised, double-blind, placebo-controlled study evaluated how supplementation with a fava bean protein supplement impacts human strength and endurance when combined with resistance training.

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30:44

Episode 11: Virtual Trials for Dietary Supplements...

The Orange Pill Podcast ·

2025/04/02

In this episode of the Orange Pill Podcast, we explore the growing trend of virtual clinical trials in the dietary supplement and conventional food industries. Learn how these innovative trial designs are making research more accessible, efficient, and data-driven.

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18:16

Episode 10: Update of Kennedy Reform of FDA Operations

The Orange Pill Podcast ·

2025/03/26

In this episode of the Orange Pill Podcast, we explore the evolving landscape of federal health agencies under the leadership of Secretary Robert Kennedy Jr. We’ll take a closer look at the potential reforms he aims to implement at the FDA and how these changes could impact the industry. From Kennedy's well-documented policy positions to recent initiatives by the Trump administration and the latest developments at HHS, we’re unpacking it all.

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12:50

Episode 9: The Science of Brain Supplements - Part 2

The Orange Pill Podcast ·

2025/03/19

In this episode of The Orange Pill Podcast, we continue our deep dive into cognitive health, exploring the science behind brain supplements and how they support memory, focus, and overall mental clarity. Tune in now for expert insights and practical takeaways!

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16:16

Episode 8: Supplements for Brain Health - Part 1

The Orange Pill Podcast ·

2025/03/12

In this episode, we dive into groundbreaking research on cognitive health, exploring a clinical study conducted at KGK Science on Neuriva, a leading brain health supplement. Learn how it impacts cognitive performance in healthy adults with self-perceived memory concerns—delivering insights you won’t want to miss! Tune in for the science, and what it means for your brain health.

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17:40

Episode 7: Exploring The Science, Benefits,...

The Orange Pill Podcast ·

2025/03/05

In this episode, we unravel the fascinating world of GLP-1 agonists—widely known for their role in diabetes and weight management—and their potential as functional food ingredients. From scientific breakthroughs to real-world applications and regulatory hurdles, this discussion offers a comprehensive look at what the future may hold for these powerful metabolic modulators.

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20:11

Episode 6: Science of Plant-Based Protein (Pea...

The Orange Pill Podcast ·

2025/02/26

Could plant-based protein be just as effective as whey for muscle growth? In this episode, we break down a clinical trial conducted by KGK Science for Roquette, comparing pea protein and whey protein head-to-head. We discuss the findings, what they mean for athletes and fitness enthusiasts, and whether plant-based proteins are ready to take over the supplement industry.

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19:54

Episode 5: The Science of Collagen Supplements

The Orange Pill Podcast ·

2025/02/19

In Episode 5, we explore the science behind collagen supplements, including a KGK Science clinical trial on marine collagen from Vinh Wellness, published in the Journal of Cosmetic Dermatology. Tune in to discover what the research says about collagen’s impact on skin hydration, elasticity, and wrinkle reduction—and whether your supplement is really doing what it claims!

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25:03

Episode 4: How Dietary Supplements Became Regulated -...

The Orange Pill Podcast ·

2025/02/12

In this episode, we continue our deep dive into the evolution of dietary supplement regulations. From the passage of DSHEA in 1994 to the introduction of cGMPs, health claim requirements, and the enforcement actions that shaped the industry, we explore how FDA oversight has developed over the years. We also discuss pivotal legal cases, the impact of the Bioterrorism Act, and the increasing role of clinical trials in substantiating supplement claims.

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11:20

Episode 3: How Dietary Supplements Became Regulated -...

The Orange Pill Podcast ·

2025/02/05

In Part 2 of "How Supplements Became Regulated in the US" on the Orange Pill Podcast, the focus is on the Dietary Supplement Health and Education Act (DSHEA) of 1994, led by Senators Orrin Hatch and Tom Harkin. This legislation established the framework for dietary supplements, defining ingredients and directing the FDA to create NDI Guidance and GMP regulations. In Part 3, we will delve into federal legislation and rules that enhanced FDA compliance enforcement in the dietary supplement

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19:00

Episode 2: How Dietary Supplements Became Regulated -...

The Orange Pill Podcast ·

2025/01/29

Many believe dietary supplements aren't regulated, but they are. This podcast's Part I explores the history of their regulation in the US, from the 1960s Vitamin and Mineral Regulations to the NLEA of 1990 for labeling and the 1994 Dietary Supplement Health and Education Act. Stay tuned for future episodes detailing this fascinating journey.

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