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PODCAST

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

science life sciences

All Episodes

00:19:55

229: Inhibiting PCBP2 condensates in Alzheimer’s

Base by Base ·

2025/12/15

️Episode 229: Inhibiting PCBP2 condensates in Alzheimer’s In this episode of PaperCast Base by Base, we explore Elevated PCBP2 forms liquid-like condensates that sequester mitochondrial and RNA-binding proteins, stabilize BACE1 mRNA, and promote amyloid pathology while the small molecule CN-0928 reduces PCBP2 via INTS1 to lower Aβ and improve cognition in AD models Study Highlights:PCBP2 protein is increased in AD patient brains and AD mouse models and

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00:19:55

229: Inhibiting PCBP2 condensates in Alzheimer’s

Base by Base ·

2025/12/15

️ Episode 229: Inhibiting PCBP2 condensates in Alzheimer’s In this episode of PaperCast Base by Base, we explore Elevated PCBP2 forms liquid-like condensates that sequester mitochondrial and RNA-binding proteins, stabilize BACE1 mRNA, and promote amyloid pathology while the small molecule CN-0928 reduces PCBP2 via INTS1 to lower Aβ and improve cognition in AD models Study Highlights:PCBP2 protein is increased in AD patient brains and AD mouse models and

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00:18:02

228: Two non-competing H3N2 stem antibodies reveal...

Base by Base ·

2025/12/14

️ Episode 228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity In this episode of PaperCast Base by Base, we explore Structural and functional characterization of two group 2 H3 HA stem antibodies, 2F02 and AG2-G02, shows distinct non-overlapping epitopes, protection in mice, and antigenic changes driven by HA2 position 32 that limit AG2-G02 binding Study Highlights:Cryo-EM structures show 2F02 targets the central stem epitope while

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00:16:21

227: 1q gain enables rescue of aneuploid hESCs during...

Base by Base ·

2025/12/13

️ Episode 227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation In this episode of PaperCast Base by Base, we explore This study shows that spontaneous RPE differentiation eliminates most aneuploid human pluripotent stem cells but permits expansion of cells with chromosome 1q gains when they are co-cultured with wild-type cells Study Highlights:Large-scale single-cell genomics revealed pervasive low-grade mosaicism in genetically

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00:16:09

226: FGF4 protects podocytes in diabetic kidney disease

Base by Base ·

2025/12/12

️ Episode 226: FGF4 protects podocytes in diabetic kidney disease In this episode of PaperCast Base by Base, we explore This study shows that podocyte-derived FGF4 is reduced in DKD and that recombinant FGF4 preserves podocyte survival and glomerular function in diabetic models via FGFR1-AMPK-FOXO1 signaling Study Highlights:FGF4 expression is downregulated in kidneys from DKD patients and diabetic mouse models and localizes predominantly to podocytes

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00:16:09

226: FGF4 protects podocytes in diabetic kidney disease

Base by Base ·

2025/12/12

️ Episode 226: FGF4 protects podocytes in diabetic kidney disease In this episode of PaperCast Base by Base, we explore This study shows that podocyte-derived FGF4 is reduced in DKD and that recombinant FGF4 preserves podocyte survival and glomerular function in diabetic models via FGFR1-AMPK-FOXO1 signaling Study Highlights:FGF4 expression is downregulated in kidneys from DKD patients and diabetic mouse models and localizes predominantly to podocytes

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00:17:13

225: VRK-1 and BAF-1 release meiotic chromosomes

Base by Base ·

2025/12/10

️ Episode 225: VRK-1 and BAF-1 release meiotic chromosomes In this episode of PaperCast Base by Base, we explore VRK-1 phosphorylates BAF-1 to remove chromatin from the nuclear periphery during early meiotic prophase in C. elegans, and failure of this step impairs pairing and synapsis and generates heritable genome lesions Study Highlights:The authors used an auxin-inducible VRK-1 depletion system and genetic perturbations to show that VRK-1

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00:17:13

225: VRK-1 and BAF-1 release meiotic chromosomes

Base by Base ·

2025/12/10

️ Episode 225: VRK-1 and BAF-1 release meiotic chromosomes In this episode of PaperCast Base by Base, we explore VRK-1 phosphorylates BAF-1 to remove chromatin from the nuclear periphery during early meiotic prophase in C. elegans, and failure of this step impairs pairing and synapsis and generates heritable genome lesions Study Highlights:The authors used an auxin-inducible VRK-1 depletion system and genetic perturbations to show that VRK-1

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00:18:41

224: AntennAlive — wireless in-body sensing with...

Base by Base ·

2025/12/10

️ Episode 224: AntennAlive — wireless in-body sensing with engineered bacteria In this episode of PaperCast Base by Base, we explore A bio-hybrid, battery-free implant converts engineered bacterial activity into microwave backscatter signals by controlled degradation of a biodegradable antenna Study Highlights:The AntennAlive system uses a magnesium split-ring passive implant antenna coupled with genetically engineered Escherichia coli that accelerate

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00:18:41

224: AntennAlive — wireless in-body sensing with...

Base by Base ·

2025/12/10

️ Episode 224: AntennAlive — wireless in-body sensing with engineered bacteria In this episode of PaperCast Base by Base, we explore A bio-hybrid, battery-free implant converts engineered bacterial activity into microwave backscatter signals by controlled degradation of a biodegradable antenna Study Highlights:The AntennAlive system uses a magnesium split-ring passive implant antenna coupled with genetically engineered Escherichia coli that accelerate

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00:16:26

223: Torsion Regulates DNA Replication Stalling and...

Base by Base ·

2025/12/09

️ Episode 223: Torsion Regulates DNA Replication Stalling and Restart In this episode of PaperCast Base by Base, we explore New single-molecule angular optical trap assays reveal that DNA torsion directly controls T7 replisome stalling and reactivation Study Highlights:A high-resolution, label-free angular optical trap (AOT) assay was developed to track T7 replisome-driven DNA rotation and torsional slowing in real time. The combined helicase–DNA

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00:16:26

223: Torsion Regulates DNA Replication Stalling and...

Base by Base ·

2025/12/09

️ Episode 223: Torsion Regulates DNA Replication Stalling and Restart In this episode of PaperCast Base by Base, we explore New single-molecule angular optical trap assays reveal that DNA torsion directly controls T7 replisome stalling and reactivation Study Highlights:A high-resolution, label-free angular optical trap (AOT) assay was developed to track T7 replisome-driven DNA rotation and torsional slowing in real time. The combined helicase–DNA

en-us

00:17:57

222: snaR-A hijacks splicing to drive proliferation

Base by Base ·

2025/12/08

️ Episode 222: snaR-A hijacks splicing to drive proliferation In this episode of PaperCast Base by Base, we explore This episode examines how the cancer-associated Pol III transcript snaR-A binds core splicing factors, localizes near nuclear speckles, perturbs U2-dependent splicing to increase intron retention, and promotes cell proliferation linked to poorer patient outcomes Study Highlights:Proteomic pull-downs and CLIP analyses reveal snaR-A

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00:20:23

221: Allele-resolved nanopore tour of the human...

Base by Base ·

2025/12/07

️ Episode 221: Allele-resolved nanopore tour of the human placental methylome In this episode of PaperCast Base by Base, we explore Using phased long-read nanopore and short-read sequencing across eight trios, the study maps allele-specific DNA methylation and transcription in female human placentas, identifies hundreds of DMRs and novel imprinted genes, and reports somatic placental variants Study Highlights:The authors combined >20x Oxford Nanopore

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00:15:48

220: The AML cellular state space reveals NPM1 immune...

Base by Base ·

2025/12/06

️Episode 220: The AML cellular state space reveals NPM1 immune evasion subtypes In this episode of PaperCast Base by Base, we explore Single-cell and bulk sequencing of 120 AML cases reveal two NPM1-mutated subtypes with distinct immune evasion mechanisms and divergent responses to hematopoietic stem cell transplantation Study Highlights:Bulk RNA-seq profiles are strongly confounded by variable mature cell-type signatures that can conceal subtype-specific

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00:15:48

220: The AML cellular state space reveals NPM1 immune...

Base by Base ·

2025/12/06

️Episode 220: The AML cellular state space reveals NPM1 immune evasion subtypes In this episode of PaperCast Base by Base, we explore Single-cell and bulk sequencing of 120 AML cases reveal two NPM1-mutated subtypes with distinct immune evasion mechanisms and divergent responses to hematopoietic stem cell transplantation Study Highlights:Bulk RNA-seq profiles are strongly confounded by variable mature cell-type signatures that can conceal subtype-specific

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00:16:41

219: Multi-omic mapping of lipid dysregulation in...

Base by Base ·

2025/12/05

️Episode 219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain In this episode of PaperCast Base by Base, we explore Targeted multi-region lipidomics with proteomic and mitochondrial data reveals region- and stage-specific lipid alterations in Parkinson’s disease that converge on mitochondrial dysfunction Study Highlights: The study quantified 146 lipid species across eight anatomically distinct post-mortem brain regions in controls and mid-

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00:19:37

218: SIM1 and the multi-ancestry genomics of erectile...

Base by Base ·

2025/12/04

️Episode 218: SIM1 and the multi-ancestry genomics of erectile dysfunction In this episode of PaperCast Base by Base, we explore A large multi-ancestry GWAS meta-analysis identifies a dominant SIM1-linked locus and multiple genetic connections between electronic health record-defined erectile dysfunction and cardiometabolic, psychiatric, and substance-use traits Study Highlights: Meta-analysis of 913,194 European and 125,315 African ancestry individuals

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00:19:37

218: SIM1 and the multi-ancestry genomics of erectile...

Base by Base ·

2025/12/04

️Episode 218: SIM1 and the multi-ancestry genomics of erectile dysfunction In this episode of PaperCast Base by Base, we explore A large multi-ancestry GWAS meta-analysis identifies a dominant SIM1-linked locus and multiple genetic connections between electronic health record-defined erectile dysfunction and cardiometabolic, psychiatric, and substance-use traits Study Highlights: Meta-analysis of 913,194 European and 125,315 African ancestry individuals

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00:17:47

217: Multiscale triads of meiotic crossover patterning

Base by Base ·

2025/12/03

️Episode 217: Multiscale triads of meiotic crossover patterning In this episode of PaperCast Base by Base, we explore FFT and inverse-FFT analysis of Zip3/Zip2, Hop1 and Zip1 on yeast pachytene chromosomes reveals two interdigitated tiers of evenly spaced protein triads that correspond to canonical and minority crossovers and are differentially regulated by Pch2/TRIP13 Study Highlights: Quantitative fluorescence profiles and Fourier analysis identify two

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