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PODCAST

What"s Your Problem?

iHeartPodcasts and Pushkin Industries

Every week on What"s Your Problem?, former Planet Money host Jacob Goldstein talks withentrepreneurs and engineerstackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What"s Your Problem? learns from the thinkers and doers trying to make our future

technology entrepreneurship

All Episodes

47:00

The AI Pioneer Developing New Kinds of Medicine

What"s Your Problem? ·

2025/07/17

Jakob Uszkoreit is the CEO and co-founder of Inceptive, a biotech start-up. He’s also a co-author of “Attention is All You Need,” the paper that created transformer models. Today, transformers power chatbots like ChatGPT and Claude. They’ve also led to breakthroughs in everything from generating images to predicting the structure of proteins. On today’s show, Jakob talks about the invention of transformer models. And he discusses how he’s using those models to try

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42:55

A Billion-Dollar Bet on Carbon Removal

What"s Your Problem? ·

2025/07/10

Nan Ransohoff is the head of climate at Stripe. The company is known mainly for facilitating online payments, but it’s become a key driver of the nascent carbon-removal industry. On today’s show, Nan explains how she used a clever economic idea to get companies to spend $1 billion on carbon removal. And she talks about the different approaches startups are pursuing to pull carbon dioxide out of the atmosphere.See omnystudio.com/listener for privacy information.

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35:11

Giving Old Batteries New Life

What"s Your Problem? ·

2025/07/03

Megan O’Connor is the co-founder and CEO of Nth Cycle. Megan’s problem is this: How do you create a new system that can both refine the raw metals we need for new batteries and recycle metal from old batteries?See omnystudio.com/listener for privacy information.

en-US

40:53

Engineering the Future of Fusion

What"s Your Problem? ·

2025/06/26

Getting energy from nuclear fusion has been a dream for decades; it would be cheap, abundant, and safer than today’s nuclear fission reactors. Billions of dollars have flowed into fusion startups in recent years, but reliable, economic fusion power may still be decades away.Greg Piefer is the founder of a fusion company called Shine, where he’s pursuing a different path. Rather than go straight to fusion as a source of energy, he’s using fusion to pursue more profitable markets

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32:59

Can Robots Fix Recycling?

What"s Your Problem? ·

2025/06/19

Recycling plants take in a huge amount of random (and occasionally hazardous) stuff, which they then have to turn into reliable outputs that their customers will buy. That’s why Rebecca Hu Thrams calls recycling “the most demented form of manufacturing on the planet.” Rebecca is the co-founder of Glacier, and her problem is this: Can you use AI and robots to make recycling a somewhat less demented business? Get early, ad-free access to episodes of What's Your Problem? by

en-US

38:58

Warlords, Espionage, and Disinformation | Introducing...

What"s Your Problem? ·

2025/06/17

In 2020, the Financial Times exposed a 2 billion euro fraud at Wirecard, a high-flying German fintech. Many thought that was the end of the story. But for reporter Sam Jones, it was just the beginning. This season on Hot Money: Agent of Chaos, from Pushkin Industries and the Financial Times, Jones investigates Wirecard’s chief operating officer who vanished just as Wirecard collapsed. And turned out to also be a Russian spy. Here’s episode 1. Listen to Hot Money: Agent of Chaos wherever

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43:28

Inside the Mind of an AI Model

What"s Your Problem? ·

2025/06/12

AI might be the most consequential advancement in the world right now. But – astonishingly – no one fully understands what’s going on inside AI models. Josh Batson is a research scientist at Anthropic, the AI company behind Claude, one of the world’s leading language models. Josh’s problem is this: How do we learn how AI works? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers

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37:18

Teaching Robots How to Do Everything

What"s Your Problem? ·

2025/06/05

AI is better than humans at a lot of things, but physical tasks – even seemingly simple ones like folding a shirt – routinely stump AI-powered robots. Chelsea Finn is a professor at Stanford and the co-founder of Physical Intelligence. Chelsea's problem is this: Can you build an AI model that can teach any robot to do any task, anywhere? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can

en-US

38:19

Making a Universal Flu Vaccine

What"s Your Problem? ·

2025/05/29

Jacob Glanville is the founder and CEO of Centivax. Jacob’s problem is this: Can you create a vaccine that protects people against almost all strains of flu – even strains that haven’t evolved yet? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple:

en-US

36:16

Teaching Computers to Smell

What"s Your Problem? ·

2025/05/22

Alex Wiltschko got obsessed with perfume when he was 12 years old. He grew up to be an AI researcher at Google. Then he started Osmo, a company that fused his job at Google with his childhood obsession: Osmo is using AI to teach computers to smell.The company is getting into the perfume business, and it plans eventually to use scent to diagnose disease and detect security risks. Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm

en-US

25:39

China’s Race to Dominate: Listen to Global Tech Wars

What"s Your Problem? ·

2025/05/01

For decades, China’s economic rise has been symbolized by its unstoppable force of low-cost manufacturing. Now, it’s the leading country in cutting-edge industries like artificial intelligence, electric vehicles, surveillance technology, and more. In Global Tech Wars, Financial Times’ veteran journalist James Kynge analyzes China’s rapid technological ascent and what it means for the future. Enjoy this preview of Global Tech Wars: China’s Race to Dominate. If you like

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45:42

Can a Chatbot Treat Depression?

What"s Your Problem? ·

2025/04/24

Nick Jacobson and his team at Dartmouth medical school spent over 100,000 hours trying to build an AI chatbot that can serve as a safe, effective therapist. After a few false starts, they seem to be on to something.Note: This episode contains references to self harm. Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all

en-US

47:03

Will AI Radically Change the World by 2027?... from...

What"s Your Problem? ·

2025/04/23

This week, Nate and Maria discuss AI 2027, a new report from the AI Futures Project that lays out some pretty doom-y scenarios for our near-term AI future. They talk about how likely humans are to be misled by rogue AI, and whether current conflicts between the US and China will affect the way this all unfolds. Plus, Nate talks about the feedback he gave the AI 2027 writers after reading an early draft of their forecast, and reveals what he sees as the report’s central flaw. Enjoy this episode

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41:17

Is the Future of Flight Supersonic?

What"s Your Problem? ·

2025/04/17

Blake Scholl is the founder and CEO of Boom Supersonic. Blake's problem is this: Can you build a commercial airplane that flies faster than the speed of sound – and that makes economic sense? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin shows. Subscribe on Apple: apple.co/pushkinSubscribe on Pushkin:

en-US

25:20

The Secrets of Silk

What"s Your Problem? ·

2025/04/10

Fiorenzo Omenetto is a professor of biomedical engineering at Tufts University and the director of Silklab. Fiorenzo's problem is this: How do you turn a material people have been using for thousands of years into useful, cutting edge tools that improve everything from vaccine delivery to food waste? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive

en-US

33:14

Infiltrating an International Ransomware Gang

What"s Your Problem? ·

2025/04/08

A few years ago, a ransomware gang called LockBit rose from obscurity to extort over $100 million from organizations around the world. A security strategist named Jon DiMaggio wanted to understand how the organization worked. So he used the techniques of World War II-era spycraft to make contact with the hackers.On today’s show, Jon tells the story of LockBit – from the way it borrowed techniques from mainstream companies to market itself and attract talent, to the response from

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55:09

Preparing for the Future of War

What"s Your Problem? ·

2025/04/03

Christopher Kirchhoff helped launch a Defense Department office that aimed to bring Silicon Valley technology to the US military. Christopher’s problem is this: How can the giant bureaucracy that is the US military keep up with technological change? Get early, ad-free access to episodes of What's Your Problem? by subscribing to Pushkin+ on Apple Podcasts or Pushkin.fm. Pushkin+ subscribers can access ad-free episodes, full audiobooks, exclusive binges, and bonus content for all Pushkin

en-US

27:56

Stopping HIV Without a Vaccine

What"s Your Problem? ·

2025/03/13

Jared Baeten is senior vice president in virology at Gilead Sciences. Jared's problem is this: In a world without a vaccine, how do you make a medicine that people will actually take to help prevent HIV?There’s already a daily pill that reduces the risk of getting HIV, but a majority of people who are at high risk are unwilling or unable to take it.So Jared and his colleagues are developing a new drug, lenacapivir, designed to be given as a shot once every six months. Note: The views and

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49:26

Harnessing the Heat Deep Beneath Our Feet

What"s Your Problem? ·

2025/03/06

Carlos Araque is the co-founder and CEO of Quaise Energy. Carlos' problem is this: How do you make drilling for geothermal energy as routine, widespread, and profitable as drilling for oil or gas? The answer involves digging deeper into the Earth than anyone has ever dug before.See omnystudio.com/listener for privacy information.

en-US

29:11

The Brain Implant That Could Change Medicine

What"s Your Problem? ·

2025/02/27

Ben Rapoport is the co-founder and CSO of Precision Neuroscience. Ben's problem is this: Can you build a device that allows a paralyzed person to use a computer with only their thoughts – without damaging their brain?See omnystudio.com/listener for privacy information.

en-US

224 results

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