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PODCAST

What"s Your Problem?

iHeartPodcasts and Pushkin Industries

Every week on What"s Your Problem?, former Planet Money host Jacob Goldstein talks withentrepreneurs and engineerstackling the biggest challenges at the forefront of technology. How do you make a trip to space as routine as a plane flight? How do you turn solar energy into clean fuel? How do you use AI to stop deadly infections before they spread? We hear a lot these days about how the world is getting worse. What"s Your Problem? learns from the thinkers and doers trying to make our future

technology entrepreneurship

All Episodes

40:34

Growing New Livers to Save Lives

What"s Your Problem? ·

2026/03/19

Michael Hufford is the co-founder and CEO of LyGenesis, a company working on a new treatment for end stage liver disease. Michael’s problem is this: How do grow a new liver inside the body of a sick patient? In this episode, Michael explains: The liver's unique power of regeneration The organ transplant crisis and how regeneration can help The science behind using lymph nodes to grow new organs The status of LyGenesis’ human trials The future of regenerative medicine Learn more: Check

en-US

28:17

Introducing Rapid Response: Logitech's CEO treats AI...

What"s Your Problem? ·

2026/03/16

Today, we’re sharing an episode of the Rapid Response podcast. Rapid Response features candid conversations with today’s top business leaders navigating real-time challenges. In this episode, Logitech may be known for keyboards, webcams, and gaming gear—but CEO Hanneke Faber is pushing the company to go AI-first. She joins Bob Safian to talk about leading a global hardware brand through a major technological shift, including experimenting with an AI “board member” to

en-US

41:54

Can the US Break China's Grip on Rare Earths?

What"s Your Problem? ·

2026/03/12

Rare earth elements are inside pretty much everything with an on-off switch: Phones, laptops, cars. Even missiles. And China controls the world’s supply of components made from rare earths. David Abraham is the author of the book “The Elements of Power: Gadgets, Guns, and the Struggle for a Sustainable Future in the Rare Metal Age.” David’s problem is this: What should the US do about China's chokehold on the rare earth supply chain? According to Abraham, the current US

en-US

40:03

How Quantum Computers Could Change the World

What"s Your Problem? ·

2026/03/05

Ben Bloom is the co-founder and CEO of Atom Computing, a company building quantum computers out of individual atoms. Ben’s problem is this: How do you build a quantum computer that is actually useful for everything from discovering new medicines to building better batteries? In this episode, Ben explains: The practical applications of quantum computers Atom Computing’s approach using individual neutral atoms as qubits The key engineering challenge of scaling while maintaining accuracy

en-US

48:58

Fighting Wildfires from Space

What"s Your Problem? ·

2026/02/26

Jonny Dyer is the founder and CEO of a satellite company called Muon Space. The company’s first big project is a satellite constellation called FireSat. Jonny’s problem is this: How do you capture data from space to help manage wildfires around the world in near-real time? In this episode, Jonny explains: How smartphone tech inspired smaller, cheaper satellites. Why fighting wildfires is still shockingly primitive. Why China does not distinguish between commercial and military

en-US

39:13

The Killer We Refused to See

What"s Your Problem? ·

2026/02/19

After bacteria were discovered, it took scientists 200 years to figure out that they cause disease. If scientists had made the link sooner, hundreds of millions of lives could have been saved. In his recent book So Very Small, Tom Levenson, a professor of science writing at MIT, tells the amazing story of germ theory, and argues that our worldview can prevent us from seeing what is right in front of us – even when lives are at stake.See omnystudio.com/listener for privacy information.

en-US

54:16

The Startup Run by AI Agents

What"s Your Problem? ·

2026/02/12

Evan Ratliff co-founded a publishing startup in 2011. Now he hosts a podcast called Shell Game. In the latest season of the show, Evan creates a company run by AI agents. The project is absurdly funny – Evan calls it an office satire – but it also illuminates the power and limits of AI agents.See omnystudio.com/listener for privacy information.

en-US

33:47

Can AI Help Solve Alzheimer’s?

What"s Your Problem? ·

2026/02/05

Patrick Hsu is the co-founder of Arc Institute, which is integrating AI models and biological research. Patrick’s problem is this: How can you use AI to make biological research more efficient – and ultimately to find cures for Alzheimer’s and other complex diseases?See omnystudio.com/listener for privacy information.

en-US

32:54

The New Science of Preventing Heart Attacks

What"s Your Problem? ·

2026/01/29

In recent decades, medical research has fundamentally changed how we think about heart disease. This fresh understanding has opened up new ways to prevent heart attacks. Eric Topol is a cardiologist and the founder of the Scripps Research Translational Institute in San Diego. Eric’s problem is this: How can doctors use recent technological developments to do a better job at preventing heart attacks?See omnystudio.com/listener for privacy information.

en-US

40:58

From Solar Pumps to Everything: Building a Market...

What"s Your Problem? ·

2026/01/22

Samir Ibrahim is the co-founder and CEO of SunCulture. When he started the company, he thought he was solving a simple problem: How do you sell solar-powered pumps to help poor farmers irrigate their land? It turned out, he was working on something much bigger: How do you help poor farmers get richer, and create a giant new market from scratch?See omnystudio.com/listener for privacy information.

en-US

34:22

Mass-Producing Stem Cells to Cure Disease

What"s Your Problem? ·

2026/01/15

Nabiha Saklayen is the co-founder and CEO of Cellino. Nabiha’s problem is this: How can you make personalized stem cell therapies quickly and cheaply? Induced pluripotent stem cells, or IPSCs, have shown tremendous promise as treatments for illnesses like Parkinson’s, leukemia, and heart disease. On today’s show, Nabiha explains why IPSC manufacturing is still mostly done by hand, how her background in physics and lasers led her into biology, and what it takes to try and build

en-US

39:39

From Kill Switch: The Glassholes Are Back

What"s Your Problem? ·

2025/12/25

Today, we're sharing an episode of a show that explores the problems that new technology is creating and how we navigate living in the future. It's called Kill Switch, and it's hosted by Pulitzer Prize-winning journalist, Dexter Thomas. The episode you're about to hear is about the latest in wearable tech—stuff like smart glasses, pendants, watches and rings. After the implosion of Google Glass back in 2013, which faced backlash and ridicule, we’re now readily embracing wearables

en-US

43:21

Building a Self-Driving Tractor to Change the Future...

What"s Your Problem? ·

2025/12/18

Please take our survey https://tinyurl.com/wyplistenersurveyabout the show! Tell us what you want to hear, and what would make it better. Tim Bucher is a farmer, and the founder and CEO of Agtonomy. Tim's problem is this: How do you build an autonomous tractor that can work for specialty crops like grapes, olives, apples, and almonds?On today’s show, Tim explains what makes certain farming processes so difficult to automate, and how autonomy may soon change how we eat.See

en-US

35:53

We’re Going to Need a Better Boat

What"s Your Problem? ·

2025/12/11

Mitch Lee is the co-founder and CEO of Arc Boats. Mitch's problem is this: How do you build competitively priced electric boats?On today’s show, Mitch explains why water makes electrification so hard, the techno-economic puzzle of building giant battery packs, and how Arc’s high-end wake sport boat opened the door for a new generation of hybrid-electric tugboats.See omnystudio.com/listener for privacy information.

en-US

47:42

How to Experience the Joy of Giving Right Now: A...

What"s Your Problem? ·

2025/12/02

According to the science, it really is better to give than receive. Donating a dollar; sharing a kind word or lending someone a hand changes lives, but can also hugely boost your happiness. So we're teaming up with other podcasts from Hidden Brain to Revisionist History to ask you to give to a charity helping some of the poorest people around. We're calling it #PodsFightPoverty. Go to givedirectly.org/happinesslab right now and give whatever you can. And the first $500,000 we donate will be

en-US

32:11

The Big Short Companion from Against the Rules: How...

What"s Your Problem? ·

2025/11/25

We’re sharing another podcast we think you’ll enjoy, The Big Short Companion from Against the Rules, hosted by fellow Pushkin podcast host Michael Lewis. The Big Short is now 15 years old and to mark the occasion, Lewis narrated a new audiobook version of The Big Short and is looking back on how the 2008 financial crisis still affects the world today. To make sense of Wall Street’s hangover from the crash described in The Big Short, Lewis calls up Matt Levine, author of the Money

en-US

45:14

The App Where Strangers Lend Each Other Money

What"s Your Problem? ·

2025/11/20

Nina Mohanty is the founder and CEO of Bloom Money. Nina’s problem is this: How do you build an app to help immigrants manage their money? On today’s show, Nina talks about bringing a saving and lending practice into the 21st century, navigating regulators who’ve never seen anything like it, and what global traditions can teach us about the future of money.See omnystudio.com/listener for privacy information.

en-US

49:42

Introducing Business History: The Edison Invention...

What"s Your Problem? ·

2025/11/18

What's Your Problem? host Jacob Goldstein has a new show: Business History. How did Hitler’s favorite car become synonymous with hippies? What got Thomas Edison tangled up with the electric chair? Did someone murder the guy who invented the movies? On Business History, Jacob and fellow former Planet Money host Robert Smith examine the surprising stories of businesses big and small and find out what you can learn from those who founded them.In this episode: The inventor that transformed America

en-US

34:07

Using Sound Waves to Destroy Tumors

What"s Your Problem? ·

2025/11/13

Mike Blue is the CEO of HistoSonics. The company recently developed a device that uses ultrasound to destroy tumors.On today’s show, Mike talks about how a garage-built prototype became an FDA-approved machine; changing the company’s story after a failed clinical trial; and why he loves being a salesman but hates most sales pitches.See omnystudio.com/listener for privacy information.

en-US

44:00

From Desert Robots to Driverless Trucks

What"s Your Problem? ·

2025/11/06

Chris Urmson is the co-founder and CEO of Aurora, a company trying to bring autonomous driving to commercial trucking.Chris led a team at the 2004 DARPA challenge that launched the autonomous vehicle industry. Then he held a senior role at Google’s self-driving car project, which later became Waymo.On the show today, he talks about the long arc of autonomous driving, why he left Google, and the future of autonomous trucking.See omnystudio.com/listener for privacy information.

en-US

197 results

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