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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

41:39

Making Whole Genome Sequencing the Universal Genetic...

Mendelspod Podcast ·

2025/08/28

Today we sit down with renowned geneticist David Ledbetter, whose pioneering work helped uncover the chromosomal basis of Prader-Willi, Angelman, and Miller-Dieker syndromes. He served as Chief Scientific Officer at Geisinger, where he led the MyCode Community Health Initiative—one of the largest population genomic screening programs in the world. Now, he's bringing his decades of experience to bear on a bold new initiative: the Institute for Pediatric Rare Diseases at Florida State

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36:14

Remembering Atul Butte with Marina Sirota, Chirag...

Mendelspod Podcast ·

2025/08/21

In this special tribute episode, Mendelspod honors the life and legacy of Dr. Atul Butte (1969-2025), a towering figure in big data and precision medicine who passed away earlier this year. Atul was more than a pioneer in translational bioinformatics—he was a mentor, a builder, and a boundless source of ideas. He sought to “lift all boats in the harbor.”Joining the conversation are three scientists who worked closely with him and continue to carry forward his vision:* Dr. Marina Sirota, UCSF

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5:21

The Age of Digital Pathology with Andy Beck, PathAI

Mendelspod Podcast ·

2025/08/14

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comMost cancer biomarkers aren’t found in your DNA—they’re found on a microscope slide. And according to Dr. Andy Beck, CEO and co-founder of PathAI, that slide is undergoing a digital transformation.In this episode, Andy takes us behind the scenes of modern pathology to reveal how AI is reshaping not only cancer diagnostics but also drug development. From…

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36:09

What’s New for Regulatory Informatics in the Age of...

Mendelspod Podcast ·

2025/08/05

In this episode of Mendelspod, we’re joined by Raju Rayavarapu, bioinformatician at DNAnexus and former FDA data specialist, to discuss how regulatory science is adapting to the age of AI, big data, and cloud platforms.* 0:00 How has AI changed regulatory informatics?* 4:15 KISS* 12:50 On standards* 25:00 So nothing new about AI? The juicy question of the interview* 32:45 Raju’s life: good days and bad nightsDespite the buzz around AI, Raju insists the fundamentals haven’t changed much. “It still

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4:58

From Illumina to Advocacy: Mike Kreitzinger on the...

Mendelspod Podcast ·

2025/07/31

This is a free preview of a paid episode. To hear more, visit www.mendelspod.com“Genomics works. Don’t be scared of it.” That’s the message from Mike Kreitzinger, a longtime Illumina leader now advising the Institute for Pediatric Rare Disease at Florida State University and stepping into a broader role as a genomics advocate.In this episode, Mike gives us an inside look at Florida’s newly funded Sunshine Genetics Act, which includ…

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24:34

Amplifying the Expert: Jing Gao on Illumina's...

Mendelspod Podcast ·

2025/07/30

Illumina’s new interpretation software, Illumina Connected Insights, signals a turning point in oncology genomics—where sequencing power meets end-to-end clinical utility. On this episode of Mendelspod, host Theral Timpson sits down with Jing Gao, VP of Software Engineering at Illumina, to explore how the company is extending its leadership from sequencers to software.“We’ve moved from offering modular tools to building full-stack solutions,” Jing explains. “Connected Insights is about taking raw

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4:55

The End of Animal Testing? Vivodyne Scales Human...

Mendelspod Podcast ·

2025/07/24

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comCan we finally replace animal testing in drug development—and still know a drug is safe and effective?That’s the provocative question at the heart of this episode, as we sit down with Andrei Georgescu, co-founder and CEO of Vivodyne. The company is developing robotic, AI-enabled systems for growing living, biopsy-like human tissues that can be used to t…

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26:03

How Liquid Biopsy Is Becoming Standard of Care with...

Mendelspod Podcast ·

2025/07/23

In this episode of Mendelspod, Theral welcomes Dr. Rita Shaknovich, Chief Medical Officer in Agilent’s Life Sciences and Diagnostics group, for a high-level and deeply insightful look at where liquid biopsy technology stands today.With her background in hematopathology and molecular diagnostics, Rita brings clarity to a field that has long promised transformation—and is now delivering. “It’s not the future anymore. It’s actually here,” she says. Liquid biopsy has moved beyond the buzzword phase and

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27:48

Tracking GMOs in the Gene Editing Era: Frédéric...

Mendelspod Podcast ·

2025/07/17

In this episode of Mendelspod, Theral speaks with Frédéric Debode, Scientific Director at CRA-W in Wallonia, Belgium, about the evolving landscape of GMO detection in the age of gene editing. From early work in real-time PCR to the latest in next-gen sequencing and target enrichment, Debode has been on the front lines of tracking genetically modified organisms—often when the modifications leave almost no trace.What’s at stake? In Europe, labeling GMOs is not just a policy—it’s the law. Debode

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35:44

From Discovery to Translation: Bruker's Bold New Play...

Mendelspod Podcast ·

2025/07/10

“We’re going to be rewriting the textbooks on how tissues work.”In this compelling reunion with spatial biology pioneer Joe Beechem and a first-time visit from Oliver Braubach, we explore the rapid evolution of spatial technologies at Bruker, a legacy instrumentation company newly resurgent in the spatial space. Following Bruker’s acquisition of Nanostring and Canopy, the company has emerged as a unifying platform where whole-transcriptome discovery meets translational assay development—under one

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4:53

Tagomics Wins NHS Grant, Unveils De-Methylation...

Mendelspod Podcast ·

2025/07/01

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIn this episode of Mendelspod, Theral sits down with Rob Neely, co-founder and CSO at Tagomics, to discuss how his company is fusing genomics, epigenomics, and fragmentomics into a single, assumption-free assay for early cancer detection. The conversation begins with breaking news: Tagomics has just received a new grant from the UK’s Innovation Agency a…

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4:21

From Paris to the Pentagon: Sophie Peresson Maps...

Mendelspod Podcast ·

2025/06/12

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIn this premium episode of Mendelspod, we’re joined by one of the few people speaking clearly and globally about biosecurity in the era of synthetic biology and AI: Sophie Peresson.A consultant and leader in responsible innovation, Sophie brings an unusually broad and grounded perspective. With experience spanning international law and governance, she p…

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4:26

From Mitochondria to Protein Degradation: Mike...

Mendelspod Podcast ·

2025/06/05

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comAs artificial intelligence continues to influence the life sciences, some researchers are questioning not just what it can predict, but what it can explain. On this episode, Mike Kiebish, VP of Platform and Translational Sciences at BPGbio, discusses the company’s “biology-first” approach to drug discovery—one that begins not with models or literature, …

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31:29

The Grammar of RNA: Gavin Knott on Gene Editing and...

Mendelspod Podcast ·

2025/05/29

In this episode of Mendelspod, we plunge into the shape-shifting world of RNA with Dr. Gavin Knott, associate professor at Monash University and alum of Jennifer Doudna’s lab. Knott is part of a new generation of researchers setting structural biology ablaze with AI, decoding RNA-guided systems and expanding the CRISPR toolbox far beyond its original scope.Knott introduces the listener to RNA not just as code, but as living language. He discusses how AI now allows scientists to see molecules in 3D

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4:19

The Third Way: Christian Schafmeister’s Spiroligomer...

Mendelspod Podcast ·

2025/05/22

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comFor decades, drug discovery has followed two main roads: small molecules that can slip into cells but often lack precision, and biologics that offer specificity but struggle with delivery and manufacturing. In this episode, Christian Schafmeister introduces us to a third path: spiroligomers—synthetic, fused-ring molecules designed to combine the best of…

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21:34

Can Math and AI Replace Some Biology in Drug...

Mendelspod Podcast ·

2025/05/15

What if drug design didn’t depend on pre-existing biological data? In this episode of Mendelspod, Theral sits down with Aridni Shah, co-founder and CEO of Immunito AI, a Bengaluru-based biotech startup reinventing how we develop antibody therapies. Shah and her team are using artificial intelligence to design antibodies from scratch, bypassing traditional animal-based and data-heavy methods. “We no longer need to rely on pre-existing data,” she explains. “We’ve gone to the fundamental atomic level

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4:12

$10 Genome, $8 Coffee: Rethinking the Economics of...

Mendelspod Podcast ·

2025/05/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comYes, the Trump economy has been tough on life science tools—but according to today’s guest, the business model was failing us anyway. It’s time to go back to rethinking the basics.Today we’re joined by Stephane Budel, founding partner at DeciBio, one of the leading market research and consulting firms focused on life science tools and precision medicine…

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4:54

Quantum Scale: A New Era for Single-Cell Analysis...

Mendelspod Podcast ·

2025/05/08

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comOn today’s episode of Mendelspod, Theral sits down with Giovanna Prout, CEO of Scale Biosciences, to explore a how the company is achieving new orders of magnitude of scale in the single cell space."In the past, single cell was one cell per well—maybe 96 cells per experiment," Prout explains. "Now, with our Quantum Scale platform, we can scale from 85,…

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42:06

Building Intuition at the Nanoscale: Steve McCloskey...

Mendelspod Podcast ·

2025/05/01

What if you could step inside a molecule? On today’s episode of Mendelspod, we talk with Steve McCloskey, founder and CEO of Nanome, the company bringing virtual reality into the world of drug discovery and molecular modeling. A former nanoengineering student at UC San Diego and a self-described futurist, Steve founded Nanome to create what he calls the "ultimate scientific interface"—a way for scientists not just to visualize molecules, but to interact with them naturally in 3D space.* 0:00 The

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5:03

Beyond the $100 Genome--the Everyday Sequencing...

Mendelspod Podcast ·

2025/04/29

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comWait! What? Sequencing as a service?That was the reaction when Mark Budde first set out to upend a basic ritual in molecular biology—confirmation Sanger sequencing—with his company Plasmidsaurus. You’ve heard it many times: Illumina machines sequence around 80% of the bases in the world. But as Mark points out in today’s interview, it’s not 80% of th…

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562 results

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