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PODCAST

The Synthesis of Wellness®

Chloe Porter is dedicated to health research and optimization. She is the host of The Synthesis of Wellness ® Podcast; an engineer; and an acclaimed health science speaker, expert, and best-selling author known for her deep dives into gastrointestinal function, functional health, and health optimization.

health & fitness alternative health

All Episodes

00:23:50

141. The Role that Gut-Microbiome Metabolites,...

The Synthesis of Wellness® ·

2024/09/20

In this episode, we dive into how short-chain fatty acids (SCFAs), particularly butyrate, and tryptophan metabolites support the gut-immune axis by promoting regulatory T cell differentiation, strengthening the intestinal barrier, and enhancing antimicrobial defenses through IL-22 signaling. We break down how butyrate can improve immune tolerance as well as epithelial integrity, aiding in the prevention of chronic inflammatory responses. We also detail practical ways to support butyrate levels and

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00:20:55

140. Gastrointestinal Mucus & Its Role in Combating...

The Synthesis of Wellness® ·

2024/09/13

In this episode, we explore the crucial role of the protective mucus layer in maintaining intestinal lining integrity, highlighting how it shields the epithelial cells from harmful substances and supports overall digestive function. We dive into the components and functions of mucins, goblet cells, and secretory IgA, explaining their contributions to gut immunity and barrier integrity. Additionally, we discuss strategies for supporting mucus production centered around butyrate, N-acetyl glucosamine,

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00:19:59

139. Neuroanatomy of Sleep | Understanding the...

The Synthesis of Wellness® ·

2024/09/06

In this episode, we explore the neuroanatomical and molecular mechanisms underlying sleep regulation, focusing on the interplay between the suprachiasmatic nucleus, brain stem, and pineal gland in maintaining circadian rhythms. We dive into the biochemical pathways involving neurotransmitters such as GABA and hormones like melatonin, elucidating their synthesis and role in sleep-wake transitions. Further, the discussion extends to practical strategies, emphasizing the influence of light exposure on

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00:23:37

138. Pathogenicity of Candida Overgrowth |...

The Synthesis of Wellness® ·

2024/08/30

In today's episode, we explore the complex interactions between Candida and the gastrointestinal tract, examining how this fungus can transition from harmless commensal to pathogenic state that disrupts gut barrier functions. We dive into Candida's ability to undermine mucosal integrity through the production of candidalysin and other virulence factors like secreted aspartyl proteases, which specifically target and degrade tight junction proteins such as claudins and occludins. We'll

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00:28:19

137. Supporting Brain Health & Cognitive Function by...

The Synthesis of Wellness® ·

2024/08/23

In today's episode, we dive into the crucial roles that gut-derived microbial metabolites, particularly short-chain fatty acids and tryptophan metabolites, play in supporting the health of neurons and glial cells, ultimately promoting cognitive function. We explore how enhancing the body’s natural production of these metabolites through a healthy gut microbiome and how strategic supplementation can both benefit brain health. The discussion includes detailed insights into the cellular mechanisms

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00:25:12

136. Borrelia (Lyme) & The Brain - Neurological...

The Synthesis of Wellness® ·

2024/08/16

In this episode, we delve into the complexities of how Borrelia burgdorferi, the bacterium responsible for Lyme disease, impacts the brain, leading to neuroinflammation and a spectrum of neurological symptoms. We'll explore the pathophysiology of Borrelia's interaction with the brain's blood-brain barrier, its evasion of the immune system, and the direct effects on neural cells. Additionally, we'll discuss specific neurological symptoms and manifestations.Topics: 1. Introduction

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01:07:41

135. Harnessing the Power of Astaxanthin with the...

The Synthesis of Wellness® ·

2024/08/14

We are so honored to be joined by Dave Watumull. Dave has more than twenty years of experience in the development and commercialization of astaxanthin—a safe and powerful, naturally-occurring molecule with important health and longevity benefits. He is the Co-founder and CEO of AX3 Life, the consumer health company behind the breakthrough product, AX3® Bio-Pure Astaxanthin. He is also the COO of Cardax, a life sciences business focused on advancing pharmaceutical and nutraceutical applications of

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00:18:50

134. Combatting Intestinal Dysbiosis Using the Power...

The Synthesis of Wellness® ·

2024/08/09

In this episode, we dive into the incredible role of T4D-Myoviridae bacteriophages in targeting Escherichia coli strains, highlighting their unique contractile tail structures that facilitate precise DNA injection into host cells. We explore the specific interactions between phage tail fibers and bacterial lipopolysaccharide receptors, illustrating the phage’s lock-and-key mechanism crucial for selective bacterial lysis. This discussion extends into the implications for combatting SIBO and enhancing

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00:22:00

133. HLA Gene Variants & Their Impact on the Immune...

The Synthesis of Wellness® ·

2024/08/02

In this episode, we dive into the critical role of HLA gene variants, such as HLA-DRB1, and their profound impact on immune system function, particularly focusing on their significance in conditions like Lyme disease and mold toxicity. We'll explore how variations in these HLA genes, like the HLA-DRB1*0401 allele, influence the body's ability to recognize and respond to pathogens, potentially leading to chronic symptoms. The discussion will also cover HLA gene variant testing and how it can

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00:18:22

132. Bartonella (Lyme Co-Infection) - Pathology of...

The Synthesis of Wellness® ·

2024/07/26

In this episode, we dive into the complexities of Bartonella, a genus of gram-negative, facultative intracellular bacteria known for its ability to evade the immune system and persist in host cells such as endothelial cells and erythrocytes. We explore the specific pathogenesis mechanisms of Bartonella henselae, including its interaction with cell adhesion molecules which facilitate its intracellular entry and survival. Additionally, we discuss the clinical manifestations and epidemiological

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00:22:30

131. Focusing on Neuroprotection & Reducing...

The Synthesis of Wellness® ·

2024/07/19

In this episode, we explore the intricacies of neuronal communication, delving into how neurons transmit signals through synaptic connections using neurotransmitters like glutamate and GABA. We also examine the effects of neurotoxins, such as heavy metals and environmental pollutants, on these critical synaptic pathways, leading to cognitive and neurological impairments. Lastly, we discuss neuroprotective strategies to mitigate neurotoxin exposure and promote optimal brain health.Topics: 1

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00:23:11

130. Mast Cell Activation Syndrome - Discussing How...

The Synthesis of Wellness® ·

2024/07/12

In this episode, we explore the role of probiotics in managing histamine levels and mast cell activation syndrome (MCAS), particularly in the context of rebuilding the gut microbiome. We discuss which probiotic strains could contribute to symptoms (in the short term) due to their histamine-producing properties, such as Lactobacillus casei and Lactobacillus reuteri, and we highlight beneficial strains that degrade histamine, including Lactobacillus plantarum. Topics: 1. Introduction to Histamine

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00:54:03

129. The Power of Authentic Turkey Tail Mushrooms:...

The Synthesis of Wellness® ·

2024/07/10

Today we are diving into the world of natural turkey tail mushroom supplements. I am excited to introduce our special guest, the founder and owner of Tremetes, LLC. Our guest today brings nearly two decades of broad commercial experience with some of the world’s leading global life science companies. With extensive knowledge across multiple therapeutic areas such as diabetes, cardiovascular and metabolic diseases, and oncology, he has a profound understanding of the healthcare landscape. This

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00:23:14

128. Psychobiotics - How Microbial Metabolites...

The Synthesis of Wellness® ·

2024/07/05

This episode dives into the emerging concept of psychobiotics, exploring how these live (probiotic) microorganisms can positively impact mental health by interacting with the gut-brain axis. We'll provide an in-depth look at the anatomy of the gut lining and the enteric nervous system, explaining how these pathways facilitate communication between the gut and the brain. Additionally, we'll spotlight the psychobiotic Bifidobacterium longum 1714, detailing its mechanisms and benefits for

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00:24:54

127. Microplastics & Nanoplastics - How They Impact...

The Synthesis of Wellness® ·

2024/06/28

In this episode, we explore the science behind microplastics (MPs) and nanoplastics (NPs), focusing on their effects on the liver and gut microbiome. We'll examine how these particles can disrupt cellular functions in hepatocytes, leading to oxidative stress and inflammation, and we will also discuss recent research findings related to MP exposure and gut dysbiosis. We will finish by addressing several strategies to reduce exposure.Topics: 1. Introduction - Introduction to microplastics (MPs)

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01:02:04

126. Broad-Spectrum Micronutrient Supplements to...

The Synthesis of Wellness® ·

2024/06/26

We are honored to have Cory Rasmussen and Dallin Hardy from Hardy Nutritionals on the podcast. Cory oversees the company's financial activities, including strategy, accounting, and reporting. Dallin, a research scientist, focuses on nutraceutical product development, consulting health professionals on micronutrients, and collaborating on research in integrative psychiatry.We'll explore how broad-spectrum micronutrient supplements can support mental health while also diving into some amazing

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00:23:59

125. ApoE Gene Variants & Alzheimer's Disease - What...

The Synthesis of Wellness® ·

2024/06/21

In today's episode, we dive into the APOE4 gene variant and its significant role in neurodegeneration, particularly Alzheimer's disease. We'll start by exploring the basics of the APOE gene, its expression in the liver and brain, and how it impacts lipid metabolism. Finally, we'll discuss the specific challenges faced by APOE4 carriers and offer practical strategies, including lifestyle changes and supplements, to help combat neurodegeneration and support brain health.Topics: 1

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00:26:29

124. Methylation - MTHFR Gene Variants,...

The Synthesis of Wellness® ·

2024/06/14

In this episode, we dive into the critical process of methylation and its significance in detoxification, mood regulation, and overall cellular function. We explain the step-by-step conversion of dietary folate to its active form and how gene mutations can impair this process, leading to reduced SAMe levels, high homocysteine, and various health issues. Finally, we discuss practical strategies to support methylation through dietary choices and targeted supplementation.Topics: 1. Introduction -

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00:23:24

123. Babesia (Lyme Co-infection) Part 2 -...

The Synthesis of Wellness® ·

2024/06/07

In this part 2 episode, we dive into the pathology and symptoms of Babesiosis, exploring how the Babesia parasite infects red blood cells and evades the immune system. We discuss various labs and biomarkers to look out for. We then address various treatment protocols featuring anti-malarials including herbal supplements such as artemisinin and cryptolepis, and proteolytic enzymes like lumbrokinase and nattokinase. Additionally, we cover the use of methylene blue and its impact on Babesia

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00:22:41

122. Babesia (Lyme Co-infection) - Pathology of the...

The Synthesis of Wellness® ·

2024/05/31

In this episode, we explore the intricacies of Babesia and Babesiosis, exploring how this protozoan parasite infects red blood cells and evades the immune system. We discuss the various pathological effects of the infection, including impaired blood flow, tissue ischemia, and multi-organ dysfunction syndrome. Additionally, we cover common symptoms, relevant bloodwork indicators, and an overview of anti-malarial herbs/supplements and other strategies often employed in cases of Babesia. Topics:

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201 results

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