PODCAST

Immune

Vincent Racaniello

A podcast about the body"s defenders against disease.

science life sciences

All Episodes

01:23:00

Immune 59: Forks in the road: Th17 cells with Mandy...

Immune ·

2022/08/19

At Cornell University in Ithaca, NY, Mandy joins Immune to discuss her career and her research on understanding how Th17 cells develop and are influenced to be ‘good’ or ‘bad’ in their function. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Mandy McGeachy Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Th17 cytokines in health and disease (Immunity) Time stamps by Jolene. Thanks! Music by Steve

01:17:22

Immune 58: Gut B cells awry in ulcerative colitis

Immune ·

2022/08/03

Immune explains a study of three cohorts of patients with ulcerative colitis which finds major perturbations within the mucosal B cell compartment, highlighting a potential role for these cells in disease pathogenesis. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Gut B cell dysbiosis in ulcerative colitis (Nat Med) Time stamps by Jolene. Thanks! Music by

01:27:40

Immune 57: Bacteria, the new cure for wounds?

Immune ·

2022/06/30

Immune reviews data showing that in mice, skin bacteria activate keratinocytes to stimulate hair follicle regeneration and wound healing. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Bacteria induce skin regeneration via IL-1beta (Cell Host Microbe) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your

01:15:00

Immune 56: Flip flops on the thymic beach with Al Singer

Immune ·

2022/06/01

Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Guest: Al Singer Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode T cell FlipFlop mice reveal lineage determination (Nat Immunol) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo

01:09:17

Immune 55: Cells that suck at their job

Immune ·

2022/05/03

Immune reveals a CD8+ regulatory subset of T cell subset that suppress pathogenic T cells and are active in autoimmune diseases and infectious diseases including COVID-19. Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode KIR+CD8+ regulatory T cells (Science) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your

01:28:04

Immune 54: Asthma and aging

Immune ·

2022/04/06

Immune explains how aging influences chronic outcomes of respiratory viral infection through regulation of the alveolar macrophage compartment and type 2 inflammatory responses to viruse Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Age-dependent reduction in asthmatic pathology (J Immune) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image

01:20:25

Immune 53: Dendritic cell robbers

Immune ·

2022/02/21

Immune reveals that marginal zone B cells steal complexes of MHC and complement C3 from dendritic cells for antigen presentation to T cells. Hosts: Vincent Racaniello, Cynthia Leifer, and Brianne Barker Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Trogocytosis in Immune 18 B cells steal from dendritic cells (Science) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology

01:13:33

Immune 52: B cell boot camp with Gabriel Victora

Immune ·

2022/01/29

Gabriel Victora joins Immune to review how high affinity antibodies are produced in the germinal centers of secondary lymphoid tissues. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Gabriel Victora Subscribe (free): Apple Podcasts, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Concerto in B (TWiV 161) Visualizing antibody affinity maturation (Science) Restricted B cell clonality after boosting (Cell) Time stamps by Jolene

01:03:23

Immune 51: Teenage NINJA mice with Nikhil Joshi

Immune ·

2021/12/22

Nikhil Joshi joins Immune to discuss the creation of NINJA mice that synthesize neoantigens to enable the study of endogenous antigen-specific naïve T cell responses in disease and infection. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Nikhil Joshi Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Creation of NINJA mice (Nature Biotech) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo

01:21:25

Immune 50: Red blood cells are immune sentinels

Immune ·

2021/11/11

Immune reviews evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake by macrophages and innate immune activation. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode DNA binding to TLR9 on red blood cells (Sci Transl Med) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your

01:34:20

Immune 49: I fell in love with worms with Keke Fairfax

Immune ·

2021/10/13

Keke Fairfax joins Immune to discuss the work from her laboratory on understanding how maternal schistosomiasis impairs IL-4 production and B cell expansion in offspring, and modulation of macrophage immunometabolism by helminths. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Keke Fairfax Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Maternal schistosomiasis impairs offspring immunity (PloS Path)

01:14:56

Immune 48: Environmental enteric dysfunction with...

Immune ·

2021/09/13

Tim Hand joins Immune to discuss the work from his laboratory showing that environmental enteric dysfunction, a disease caused by chronic malnutrition and infection, and which is associated with reduced growth and oral vaccine failure, is controlled by an increase in intestinal regulatory T cells. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Timothy Hand Click arrow to play Download Immune 48 (43 MB .mp3, 71 min) Subscribe (free): iTunes, Google

01:10:51

Immune 47: Trapping viruses in NETs

Immune ·

2021/08/23

The immune professors discuss neutrophil extracellular traps, and how IgA-virus immune complexes potentiate this process through Fc receptors on neutrophils. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Antiviral IgA potentiates NETosis (PNAS) Letters read on Immune 47 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical

01:10:37

Immune 46: Bats don't STING like a bee

Immune ·

2021/07/27

Immune explore the observation that bat cells display dampened STING-dependent interferon activation, suggesting why bats might have a unique capacity to harbor many viruses. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Dampened STING in bats (Cell Host Micr) Lessons from bat defenses (Nature) Bat immune systems (Front Immune) Bats protected from genotoxic

01:23:52

Immune 45: Immune messages

Immune ·

2021/06/16

On this episode of Immune, we answer listener questions about CAR-Macs, complement and COVID-19, sleep and the immune system, caving and the immune system, germinal centers, COVID-19 vaccines and much more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Letters read on Immune 45 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen

01:12:12

Immune 44: Got IgA on the brain

Immune ·

2021/05/17

On this episode of Immune, IgA-producing plasma cells mobilized from the gut play an unexpected role in suppressing neuroinflammation. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Intestinal IgA regulates neuroinflammation (Cell) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments

01:18:53

Immune 43: CAR-NK and CAR-MAC, thinking outside the...

Immune ·

2021/03/24

On this episode of Immune, Cindy provides an update on CAR-T cell therapy of cancers and introduces two new approaches that utilize NK cells and macrophages and their use in treating solid tumors. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CAR-T cell therapy on Immune 4 Recent CAR-T cell advances (Nat Rev Cancer) Status of CAR-T cell therapy (CancerConnect)

01:11:23

Immune 42: Evolution of SARS-CoV-2 antibody immunity...

Immune ·

2021/02/13

Christian joins Immune to discuss the humoral memory response in a cohort of 87 individuals 1.3 and 6.2 months after infection with SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Christian Gaebler Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Evolution of antibody immunity to SARS-CoV-2 (Nature) Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical Send

01:23:00

Immune 41: Zebrafish immunology with Madina Wane

Immune ·

2021/01/25

Madina joins Immune to explain how the immune system of zebrafish gills compares to its functional counterpart in mammals, the lungs, and to discuss a zebrafish model for understanding olfactory loss during COVID-19. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Madina Wane Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Black in Immuno (YouTube) Cytokines and gill homeostasis (J Immune) Zebrafish

01:35:18

Immune 40: COVID-19 nuances

Immune ·

2020/12/30

Immune reminisces about a year in COVID-19 immunology, Steph’s receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Immune response during common cold CoV infection (Epidem Infect) Summary of

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Immune

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