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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

01:10:55

Boost Brain Power by 25% WITHOUT a Pill (Brain...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/24

You’re leaving brainpower on the table, and this episode shows you how to reclaim it.Learn how to boost cognitive performance by 25% without relying on pills, stimulants, or gimmicks. Host Dave Asprey sits down with global finance expert and cross-cultural thinker Richard Conrad to explore how your cultural programming shapes your biology, metabolism, neuroplasticity, and even your ability to reach peak human performance.Watch this episode on YouTube for the full video

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00:54:24

The Biohacking Tool That Will Change the World...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/22

This may be the most cutting-edge life extension technology you’ll hear about for decades. You’ll discover how mitochondrial transfusion, rejuvenation, and repair could reverse biological aging, supercharge your metabolism, and radically extend healthspan—all by upgrading the cellular energy systems that power every function in your body. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with inventor and tech

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00:46:00

The Fastest-Acting Nootropic I’ve Ever Used : 1303

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/18

What if one spray could upgrade your brain, protect your mitochondria, and outperform IV therapy and liposomal supplements?In this episode, you’ll discover the breakthrough science behindtopical glutathione delivery that uses your skin’swater channelsto raiseintracellular glutathionelevels in just 60 seconds. Learn how this powerful antioxidant works at the cellular level to reduceoxidative stress, supportmitochondrial function, and drive real improvements inbrain health,emotional

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00:53:57

Why Big Pharma Hates Nitric Oxide (And How to Use It...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/17

If you care about longevity, brain optimization, sexual performance, or metabolism, this molecule changes everything.Host Dave Asprey sits down with nitric oxide pioneer Dr. Nathan Bryan to reveal why this overlooked molecule controls your blood flow, mitochondrial energy, neuroplasticity, insulin response, and even your libido. You’ll learn how nitric oxide acts as a master switch for human performance and why the medical system has ignored it for decades.Watch this episode on YouTube for

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00:49:51

Easy Oxygen Hacking for Mitochondria (The 15-Minute...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/15

Supercharge your mitochondria, slash inflammation, and boost energy with one of the most overlooked hacks in human performance. This episode reveals how just 15 minutes of oxygen-based exercise can radically improve metabolism, brain optimization, and even reverse chronic conditions, without expensive gear or endless protocols.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Brad Pitzele, founder of One

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00:57:25

Facelifts, Breast Implants, and the REAL Fix for...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/10

Wrinkles are just the surface. This episode reveals what’s really happening beneath your skin and how to reverse it using stem cells, regenerative medicine, and the most advanced techniques in plastic surgery and aging. You’ll learn how to improve facial skin tightening, reduce inflammation, and trigger deep skin rejuvenation with stem cells, red light therapy, and targeted procedures that actually work.Watch this episode on YouTube for the full video

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01:17:52

Superintelligence, Transhumanism & Biohacking in 2027...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/08

Superintelligence is coming faster than anyone predicted. In this episode, you’ll learn how to upgrade your biology, brain, and consciousness beforeAI and transhumanismreshape the future of health. Host Dave Asprey sits down withSoren Gordhamer, founder ofWisdom 2.0, to explore whatsuperintelligence in 2027means for your mind, body, and soul.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRSoren has spent decades at the intersection of

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00:30:41

Why I Add Creatine to My Coffee Every Morning (And...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/03

Creatine isn’t just for bodybuilders. It’s one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey breaks down the myths and truths about creatine,

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00:57:09

Death, Legacy & the Philosophy of Longevity — with...

The Human Upgrade: Biohacking for Longevity &... ·

2025/07/01

What if death isn’t inevitable but a solvable problem? This episode explores how biohacking is reshaping our understanding of mortality, legacy, and the limits of human performance. You’ll learn why some of today’s top thinkers are treating longevity as both a science and a spiritual movement, and how this shift affects your brain, your mitochondria, and your entire approach to life.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave

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00:45:39

Fix What’s Making You Feel Old—From Joints to...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/27

You feel stiff, tired, or older than you should—and this episode shows you how to reverse it. Learn how to fix joint pain, restore youthful movement, and upgrade your longevity by hacking the hidden causes of early aging like mitochondrial dysfunction, leaky gut, and chronic inflammation.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Dr. Gregory Kelly, SVP of Product Development at Qualia Life and a leading

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01:06:15

The Ultimate Guide to a Metabolism That Burns Fat...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/26

93% of people are metabolically unhealthy, and it’s not because they’re lazy or eating too much fat. It’s because their bodies forgot how to burn fat at all. This episode gives you a complete roadmap to reboot your metabolism, escape the sugar-burning trap, and reignite your fat-burning engine for good.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down withBen Azadi, functional health expert, best-selling author

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00:49:23

Why Your Workouts Aren’t Giving You a Summer Body —...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/24

You’re working out, eating clean, and still not getting the results you want. This episode reveals the real reason your fitness isn’t translating to the summer body you’re chasing and what to do instead.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with performance-driven entrepreneur and former Army RangerNick Bare, founder of Bare Performance Nutrition and theGo One Moremovement. With over a decade of

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01:05:01

The Plants That Reverse Aging And Block Daily Toxins...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/19

Your everyday habits might be accelerating aging, and this episode reveals what to do instead. You’ll learn how specific plants trigger powerful longevity pathways and how to eliminate the hidden toxins disrupting your hormones, brain, mitochondria, and overall health. This is a masterclass in biohacking from two experts who’ve spent decades researching how to upgrade the human body.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave

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01:08:34

The Anti-Aging Skincare Trends That Are DAMAGING Your...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/17

Your anti-aging skincare routine might be secretly aging you faster. In this episode, you’ll uncover how trending skincare products including vitamin C serums, harsh exfoliants, and blue light therapies can damage your skin’s mitochondria, accelerate senescence, and trigger systemic inflammation. You’ll learn how to reverse this damage, support cellular repair, and choose smarter formulations that work with your biology for long-term skin and brain health.Watch this episode on YouTube for

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00:43:21

Why Most Supplements Are a WASTE of Money (And What...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/13

Most supplements don’t work, and this episode reveals why. You’ll learn how to stop wasting money on “expensive pee,” how to spot marketing lies on labels, and which ingredients actually move the needle for energy, focus, and longevity.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Jeff Boyd, founder of MTE and a leader in the new wave of performance supplements. With a background in data-driven wellness and

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00:53:28

Can Injectable MDMA Become the Next Biohack in 2026?...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/12

Psychedelic therapy is on the verge of reshaping mental health, trauma healing, and human consciousness. This episode reveals what’s really happening behind the scenes at the FDA, inside pharmaceutical companies, and within the global movement to legalize MDMA-assisted therapy.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down withRick Doblin, PhD, the legendary founder of MAPS and one of the most influential figures

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01:05:58

Should You Eat Dirt? The “Healthy” Foods Destroying...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/10

You’ve been told to eat clean, but what if your “healthy” foods are wrecking your gut, crushing your hormones, and aging you faster? This episode exposes the nutrient-depleted truth behind modern diets, soil erosion, and why regenerative farming might be the key to reversing chronic disease, boostingmitochondria, and rebuilding your biology from the ground up.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Dr

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00:52:54

How 5G Affects Brainwaves (and the New Science to Fix...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/05

Your brain is under constant assault from devices you use every day. This episode reveals the hidden effects of 5G on brain function, cognitive performance, and nervous system stress, along with the science-backed method that neutralizes the damage.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Aspreysits down with Philipp Samor von Holtzendorff-Fehling, founder of Quantum Upgrade and a former VP at T-Mobile, to explore

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01:22:37

Mark Sisson: The Japanese Walking Hack That...

The Human Upgrade: Biohacking for Longevity &... ·

2025/06/03

Most people think 10,000 steps a day is the gold standard for health, but it’s outdated, inefficient, and often damaging. In this episode, you’ll discover a smarter, faster way to walk for longevity, fat burning, and total body resilience.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down withMark Sisson, bestselling author, primal health pioneer, and founder of Primal Kitchen. With over 40 years at the forefront of

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01:15:05

60 Days Alone in Antarctica: Amputation, Frostbite,...

The Human Upgrade: Biohacking for Longevity &... ·

2025/05/29

Akshay Nanavati returns to share how 60 days alone in Antarctica, dragging a 420-pound sled, became a radical experiment in pain, PTSD healing, spiritual transcendence, and the biology of human resilience.

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