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PODCAST

The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade,Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee -has redefined what’s possible for the human mind and body. After more than a thousand episodes ofBulletproof Radio, he’s taking it to the next level withThe Human Upgrade™- a masterclass inbiohacking, longevity, and performance optimization.Each episode explorescutting-edge science, advanced technology, and proven biohacksto help youupgrade your energy, focus, metabolism, and resilience.You’ll

health & fitness self-improvement

All Episodes

01:02:24

Your Organic Protein Powder Is Slowly Killing You :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/31

Most people buying "clean" supplements are unknowingly loading their bodies with heavy metals, rancid fish oil, and glyphosate, even inside products labeled organic and healthy. This episode breaks down exactly what the supplement industry refuses to tellyou andgives you the tools to stop poisoning yourself every morning.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Grab a discount onPuoriProducts by

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00:15:26

This Legal Sleep Powder Beats Melatonin Every Time :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/29

A step-by-step breakdown of the exact brain states, amino acids, and light environment changes that separate people who fall asleep easily from people who lie awake staring at the ceiling.

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00:31:10

I Injected Stem Cells Into My Penis (Here's What...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/27

The most advanced stem cell clinic on the planet just figured out how to upgrade your brain like hardware, and Dave went to Costa Rica to be one of the first to try it.

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00:57:31

Arthur Brooks | Why Your Life Has No Meaning : 1438

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/26

The neuroscience of why optimizing your body means nothing if you're starving the half of your brain responsible for meaning, consciousness, and everything that makes life worth living.

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00:55:36

This Popular Fat Loss Shortcut Destroys Your Youth :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/24

Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actuallyis.Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRGet 20% off your next purchase ofOMNi-BiOTiCwith code ‘Dave20’ at:https://omnibioticlife.com/In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science

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00:21:08

Give Me 21 Minutes And I'll Give You Perfect Vision...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/22

Your eyes have a built-in nightly repair cycle that most people unknowingly disrupt, and by adopting seven simple daily habits — including red light therapy, blueberries, cold exposure, grounding, distance viewing, deliberate blinking, and aligning with natural light cycles — you can reactivate that self-healing switch and restore or preserve your vision naturally.

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00:12:36

SNL Roasts MAHA, Pistachios Slap, ChatGPT Doctor...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/20

SNL, pistachios, AI doctors, your microbiome's architecture, colon cancer under 50, and a measles comeback — this week's news is a masterclass in why the assumptions you haven't questioned yet are the most dangerous ones.

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01:01:20

Here's Why You Still Feel Like Sh*t After Doing...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/19

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy

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00:58:56

Hair Regrowth, Pain Relief, and Altered States — The...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/17

What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has everencountered.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Get $250 off from The Light System by using

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00:16:47

This Nobel Prize Discovery Reverses Aging In 72 Hours...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/15

A Nobel Prize-winning discovery reveals that triggering autophagy — your body's built-in cellular repair switch — through strategic 72-hour fasting can reverse biological aging, sharpen the brain, and regenerate tissues from the inside out.

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00:12:34

Your Telomeres Are a Lie, Bats Beat Aging, Sleep Meds...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/13

Your sleep tracker might be lying to you, bats are breaking the telomere model, a cheap kitchen seed is flattening glucose spikes, the first real longevity supplement trial just dropped hard data, carbon monoxide is quietly spiking in homes across the country, and fat plus carbs around your workout might actually be the move.

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01:03:19

Your Penis Is a Longevity Organ (Here's How to Hack...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/12

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Dr. Justin Houman, a nationally recognizedurologistand Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman

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00:57:57

AI Expert Says: Humans Are Just Mystical Meat Robots...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/10

What if understanding how AI thinks could reveal uncomfortable truths about how your own brain works, and give you powerful tools to make smarter decisions, resist manipulation, and upgrade your cognition at the root level?-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Tom Griffiths, the Henry R. Luce Professor of Information Technology, Consciousness, and Culture in the Departments of Psychology and

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00:09:42

How I Finally FIXED My Terrible Sleep After 18 Years ...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/08

In this video, I break down why light exposure, not just sleep duration, controls your circadian rhythm, energy, and recovery.

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00:11:31

WW3 Doomscrolling, 5 Minute Sleep Hack, Diet Wars,...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/06

Your genes don't decide your fate — this week Dave breaks down five research-backed stories on how diet, daily habits, amino acid biology, and even your news feed are quietly shaping how fast you age.

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00:56:09

Your Brain Is 0.5% Plastic (Here’s How to Flush It) :...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/05

Microplastics are everywhere from teabags to synthetic clothing, accumulating in your brain and disrupting hormones, but simple detox strategies and Josephine Musco's innovative tea strips can help you reduce exposure and remove what's already in your body.

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00:53:16

Why Are Hackers Microdosing “Sex Drugs” Now? : 1425

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/03

Most doctors treat the average patient. But you are not average, and this episode gives you the precision medicine blueprint to treat yourself like the individual you are, using multi-omictesting, biohacking technology, and longevity science tooptimizeevery layer of your biology.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPRHost Dave Asprey sits down with Dr. Anil Bajnath, a Board-Certified Family Physician, author of The Longevity

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00:14:50

A-List Celebrities' Anti-Aging Hack to Look 30 At 50...

The Human Upgrade: Biohacking for Longevity &... ·

2026/03/01

Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.

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00:09:22

Mexican Cartel Biohacking, Google Anti-Aging...

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/27

This week, Host Dave Asprey breaks down the first real human age reversal trials, DeepMind’s closed-door AI drug engine, the global gray market peptide boom, the return of measles, and how 2026 health policy shifts could quietly shape access to the next generation of longevity tools.

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01:00:34

The Secret to Staying DANGEROUS After 50 : 1422

The Human Upgrade: Biohacking for Longevity &... ·

2026/02/26

Peptides can change how you heal, lean out, build muscle, and age, but only if you stop taking influencer advice and start thinking like a scientist.-Watch this episode on YouTube for the full video experience:https://www.youtube.com/@DaveAspreyBPR-Get a discount fromBIOLONGEVITY LABS by using code ‘Dave’ at:https://biolongevitylabs.com/Host Dave Asprey sits down with Josh Felber and Jay Campbell for a deep, practical conversation on what peptidesactually are, how they work in the body, and

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