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PODCAST

The Optispan Podcast with Matt Kaeberlein

Optispan is a vision for what health should be. The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good. We believe that the current practice of medicine is disease care, not health care. We believe that

science

All Episodes

00:12:05

Don't Drink Your Coffee First Thing in the Morning?

The Optispan Podcast with Matt Kaeberlein ·

2024/10/10

Subscribe to our channel: https://www.youtube.com/@optispanCheck out the study on caffeine and cortisol secretion: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2257922/?__hstc=3584879.1bb630f9cde2cb5f07430159d50a3c91.1522713601929.1522713601930.1522713601931.1&__hssc=3584879.1.1522713601932&__hsfp=1773666937 Check out James Hoffman's views on delaying caffeine intake in the morning: https://www.youtube.com/watch?v=yCJr49GU9yY Coffee: one of the world's most popular beverages, a

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00:14:36

Metformin Decelerates Aging Clocks & Slows Brain...

The Optispan Podcast with Matt Kaeberlein ·

2024/10/08

Subscribe to our channel: https://www.youtube.com/@optispan Check out the paper: https://www.sciencedirect.com/science/article/pii/S0092867424009140?casa_token=6qa0LtsLh8QAAAAA:Iid3EX1qav1JTfkO5Skj787iUo6bJjD4dAgjvK_2ix5JirSEakRCc92m_W0G5CgNdLZR-RT4B4Q In September 2024, the scientific journal Cell published a paper suggesting that metformin slows the pace of biological aging in male primates. Metformin is an FDA-approved prescription medication commonly used to treat type 2 diabetes by improving

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00:21:16

Does Plant Protein Slow Your Aging? | 69 - Longevity...

The Optispan Podcast with Matt Kaeberlein ·

2024/10/03

Subscribe to our channel: https://www.youtube.com/@optispanWe recently came across a study published in the European Journal of Nutrition that examined the relationship between plant and animal protein intake and measures of biological aging. The study, which uses data from the UK Biobank, a long-term database of biological data from half a million participants in the United Kingdom, found that a higher plant protein intake correlates inversely with biological aging. Matt takes us through the

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00:55:18

The Dog Aging Project that aims at Helping Dogs Live...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/26

Subscribe to our channel: https://www.youtube.com/@optispanMore about the Dog Aging Project: https://dogagingproject.org/ The Dog Aging Institute: https://dogaginginstitute.org Enroll your dog in the Dog Aging Project: https://redcap.dogagingproject.org/surveys/?s=DYYDHK8HAP We get lots of feedback and questions about the Dog Aging Project (DAP) from viewers, so we wanted to provide an update about how the project is going as well as some context. In this episode, Matt dives into the

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00:21:35

You Should Focus on THESE 4 Things for Your Health &...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/24

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Current Healthcare ISN'T CUTTING IT: How Optispan is REVOLUTIONIZING it: https://www.youtube.com/watch?v=yc2kiKsm-Z0 Aging Expert Explains How Healthcare got it ALL WRONG: https://www.youtube.com/watch?v=PAEx-5CdX94 Your health doesn't need to be complicated. With so much conflicting information out there, it's easy to feel overwhelmed and unsure of what truly works. At the Optispan Podcast, we focus on

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00:55:16

NEW PEARL Trial Results: Your Questions Answered on...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/19

Subscribe to our channel: https://www.youtube.com/@optispan Check out the PEARL trial webinar with Dr. Z of AgelessRx, Oliver Medvedik of Genspace, and Matt Kaeberlein: https://www.youtube.com/watch?v=dEXBFlQOTf4&t=1217s Check out the preprint discussing PEARL trial results after one year: https://www.medrxiv.org/content/10.1101/2024.08.21.24312372v1 Check out the PEARL trial listing: https://clinicaltrials.gov/study/NCT04488601 The AgelessRx-sponsored Participatory Evaluation of Aging with

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01:45:31

Mike Mutzel on Choosing YOUR Supplements, Cholesterol...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/17

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00:58:30

This Study Says IL-11 Inhibitor Drug May Extend...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/12

Subscribe to our channel: https://www.youtube.com/@optispanCheck out the paper: https://www.nature.com/articles/s41586-024-07701-9.pdf Related episodes: The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY A recent paper demonstrating that injecting older mice with an anti-IL-11 drug extended their median lifespan made a splash in the geroscience community this summer. IL-11 is a proinflammatory cytokine that plays a role in regulating

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00:19:13

Trametinib & Rapamycin = Greater Effect on Lifespan?...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/10

Subscribe to our channel: https://www.youtube.com/@optispan Check out paper #1 on IL-11 signaling: https://www.nature.com/articles/s41586-024-07701-9.pdf Check out paper #2 on combination trametinib/rapamycin treatment: https://www.biorxiv.org/content/biorxiv/early/2024/07/25/2024.07.25.605097.full.pdf Related episodes: An introduction to the study of RAPAMYCIN: https://www.youtube.com/watch?v=czx_-DqnnrQ&t=1s In this episode, Matt discusses two recent mouse lifespan studies: one focused

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01:06:57

Matt Kaeberlein reflects on "David Sinclair’s...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/05

Subscribe to our channel: https://www.youtube.com/@optispan Check out Scott Carney's channel: https://www.youtube.com/@sgcarney Related episodes: The True Story of David Sinclair's Longevity Lie: https://www.youtube.com/watch?v=xQrXs7CxIjk DON'T Take Resveratrol Until You Watch This Video: https://youtu.be/MmIBdqsQYfw Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ In

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00:24:57

Does NMN Actually Increase VO2 MAX? | 61 - Longevity...

The Optispan Podcast with Matt Kaeberlein ·

2024/09/03

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA Supplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN" https://youtu.be/OgsfIUfuyqk NAD+ boosters are supplements designed to enhance levels of nicotinamide adenine dinucleotide (NAD+), a central coenzyme found in all living cells and involved in innumerable biochemical reactions that include DNA

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01:36:01

The Horribly Under-Researched Science of Menopause,...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/27

Subscribe to our channel: https://www.youtube.com/@optispanCheck out Productive Health: https://productivehealth.org/ Check out the Garrison Lab: https://garrisonlab.com/ We had a great time hosting Dr. Jennifer Garrison from the Buck Institute for Research on Aging to talk about her areas of expertise: reproductive aging and neuropeptide signaling. Jennifer and Matt go over the fascinating and chronically under-researched science of menopause, misconceptions about hormone replacement therapy,

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00:25:55

Trying Cold Plunge & Sauna w/ Mike Mutzel (Risks &...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/22

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Scientists Discuss Longevity Interventions & Optimisms: https://youtu.be/Itx1FvJfDXc This summer, Matt and Nick visited MYOXCIENCE Nutrition founder and content creator Mike Mutzel at his home to give saunas and cold plunges a try. In this episode, they share their personal experiences with both, noting the mental and physical effects they experienced during and afterward, and emphasize the importance of

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00:43:48

Responding to Comments that Disagree with Us on...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/15

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Comparing Bryan Johnson's RAPAMYCIN DATA: INTERESTING RESULTS: https://youtu.be/1-ZKzfQDQYk Why Drinking a Banana Smoothie IS the Same as Eating a Banana: https://youtu.be/Dg7S33-75_E Supplement Industry Secrets: What They Aren't Telling You About NAD+ & NMN: https://youtu.be/OgsfIUfuyqk Scientists Discuss Longevity Interventions & Optimisms: https://youtu.be/Itx1FvJfDXc Scientists Debate How to Live

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00:37:17

Scientist Reacts to Greg Doucette's Controversial...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/13

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: Why DEXA Scans Are NOT the HOLY GRAIL of BODYFAT Testing - Science Explained: https://www.youtube.com/watch?v=2Gg4Jm5KS1Y Are DEXA scans ACCURATE? What YOU NEED to KNOW: https://youtu.be/SsDJZMlM1ko The UNEXPECTED Ozempic Weight Loss Body Scan Results (DEXA): https://youtu.be/C_Z7qPVRA5M Coach, bodybuilder, and powerlifter Greg Doucette published a video on his Youtube channel discussing what he sees as the

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00:32:38

Most Longevity Experts Don't Tell You This About...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/08

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Biological Age & what it REALLY means: https://youtu.be/DcxgEwQKx8Q The Surprising Way Body Size Relates to Lifespan: https://youtu.be/Fjh6WbkZkvw The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ Depending on how you look at them, aging genes are genes whose expression changes in a

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02:20:57

Scientists Debate How to Live Longer & Longevity...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/07

Subscribe to our channel: https://www.youtube.com/@optispanCheck out the Brenner lab: https://brennerlab.net Related episodes: The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY Matt and City of Hope Alfred E. Mann Family Foundation Chair of Diabetes and Cancer Metabolism Charles Brenner have had several public disagreements on social media. We love a good conversation between two distinguished scientists whose views may not entirely

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00:18:52

This Company's New Longevity Senolytic Drug & The...

The Optispan Podcast with Matt Kaeberlein ·

2024/08/01

Subscribe to our channel: https://www.youtube.com/@optispanCheck out Vertical Longevity Pharma: https://vertical-longevity-pharma.com/ Matt recently attended the 52nd annual meeting of the American Aging Association (AGE) in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the geroscience field. His last guest from the AGE meeting is David Scieszka, a longevity entrepreneur with a unique background that includes work as a PsyOps specialist for the US Army

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00:36:43

A Longevity Breakthrough w/ Yamanaka Factor...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/30

Subscribe to our channel: https://www.youtube.com/@optispanRelated episodes: You Can Live Longer!: https://www.aspenideas.org/sessions/you-can-live-longer Estriol Shown to Increase Lifespan as Winner of Intervention Testing Program: https://youtu.be/1DQEuT0dtWk The Best Strategies for Living Longer RANKED: Longevity Tier List: https://youtu.be/41WUYgEkQeA Reversing Biological Age: Have we finally found the answer?: https://youtu.be/ivP3QTyQ2d4 In June 2024, the Aspen Ideas Festival held a

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00:49:05

The Benefits of Protein Restriction, How Protein...

The Optispan Podcast with Matt Kaeberlein ·

2024/07/25

Subscribe to our channel: https://www.youtube.com/@optispanCheck out Cristal's page at USC: https://gero.usc.edu/faculty/cristal-m-hill-phd/ Matt recently attended the 52nd annual meeting of the American Aging Association in Madison, Wisconsin and met with several people doing fascinating work in or adjacent to the geroscience field. One of these was Cristal Hill. Cristal is an Assistant Professor of Gerontology at the University of Southern California Leonard Davis School of Gerontology,

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