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PODCAST

Dr RR Baliga"s "Got Knowledge Doc" Podkast

Dr RR Baliga, MD, MBA

"Got Knowledge Doc" Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each

science natural sciences

All Episodes

03:28

💥 Force, Fibroblasts & 🫀 Failure

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/25

🚨 New Insights in Dilated Cardiomyopathy (DCM)! 🫀 Fibroblasts aren’t just bystanders — they’re mechanical rheostats shaping disease severity. 🧬 This groundbreaking study shows that blocking p38 signaling halts fibrosis, boosts contractility, and may redefine how we treat DCM. 💥 🧠 Think beyond myocytes. Think collective cell behavior. 🧪 Read the full paper in Science: “Preventing Hypocontractility-Induced Fibroblast Expansion Alleviates DCM” #Cardiology #HeartFailure #Fibrosis #ECM

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07:03

🧠 Dysreflexia Decoded & Pressure Rebooted: Circuits,...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/25

🚨 New frontier in #NeuroRehab & #BioelectronicMedicine! Just explored two groundbreaking studies on autonomic dysreflexia and implantable neurostimulation in spinal cord injury (SCI) 🧠💥 ⚡ One reveals the neuronal circuitry driving dangerous BP spikes 🔌 The other shows how epidural stimulation at T11–L1 can restore BP within 2 minutes 💡 Together, they mark a paradigm shift—from managing symptoms to rewiring circuits. #SCI #SpinalCordInjury #Neuroscience #CardiovascularHealth

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04:58

🫀 Coronary Artery Bypass Blues: Does Lower LDL-C Save...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/24

🫀 NEWTON-CABG Trial: Can intensive LDL-C lowering prevent vein graft failure after CABG? 💉 Evolocumab slashed LDL-C by ~50%, but did not improve SVG patency at 2 years. Why? Timing is everything. 🧠 Early SVG failure = thrombosis & hyperplasia—not classic atherosclerosis. LDL-C ≠ magic bullet here. #Cardiology #CABG #LDL #PCSK9 #Evolocumab #CardioTrials #Lipids #HeartHealth #GraftPatency #ClinicalResearch #JACC #TheLancet #SurgeryMeetsPrevention

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07:11

From Rest to Reset: 🛌 The Motor Theory &...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/24

🧠💤 Why do we sleep? A groundbreaking Neuron article explores this timeless question through a bold new lens: 🛌 The Motor Theory & Catecholamine Hypothesis of Sleep. Instead of a single “sleep center,” 🧬 sleep emerges from distributed motor control circuits regulating both somatic & autonomic activity. And the “why”? 😴 Suppressing dopamine, noradrenaline & adrenaline may be key to healing our brain, body, & immune system. 📉 Sleep isn’t passive—it’s active neural choreography for recovery

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04:53

Culprit, Complete, or Cautious? 🔧❤️🕰️”: Decoding...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/23

🚨 New insights from the Lancet! 🚑 In the OPTION–STEMI trial, immediate multivessel PCI during the index procedure failed to show non-inferiority compared to staged revascularisation in STEMI patients with multivessel disease. 🧠 Key takeaway? Timing matters. ⚠️ Higher risk in those with heart failure (Killip II/III) 💡 Safer strategy: staged PCI for high-risk patients 📊 Fractional flow reserve, procedural MI, and guideline implications all in focus. A must-read for interventionalists &

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04:28

Dr RR Baliga's Philosophical Discourses: Thomas...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/23

✨ St. Thomas Aquinas (1225–1274) — Dominican friar, philosopher & theologian — is among the most influential thinkers in Western tradition. 📖 His Summa Theologica shaped Catholic theology, blending Aristotle’s philosophy with Christian faith. 🕊️ Known as the Doctor Angelicus, he championed faith & reason, natural law ⚖️, and virtue ethics 💡— principles that still guide philosophy, theology, and even modern healthcare ethics 🏥. 🌍 #Philosophy #Theology #Healthcare #Leadership #Wisdom

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07:54

Squeezing the Heart Failure Curve: Risk, Reward, and...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/22

🚨 New Podcast Drop! 🎙️ “VICTOR, Vericiguat, and Victory?” unpacks the Lancet trilogy — the VICTOR trial, pooled analysis, and expert commentary 🧠📊💊. We explore Vericiguat’s evolving role across the heart failure spectrum 💓📉 and what it means for clinical care in HFrEF patients. 📚 Trials discussed: VICTOR, VICTORIA 🎧 Tune in for insights on risk-based treatment effects, NT-proBNP thresholds, and more! #HeartFailure #Vericiguat #HFrEF #Lancet #Cardiology #RCT #NTproBNP #Podcast

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03:17

🎨 Art, Health & Hope: Preventing noncommunicable...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/21

🎭 Just explored a landmark Nature Medicine review on how the arts can prevent noncommunicable diseases (NCDs) across 27 countries! 🎨 From dance and drama to gardening and storytelling, arts-based interventions improved physical activity, diet, and mental well-being—especially in underserved communities. 📊 A must-read for anyone interested in health equity, cultural relevance, and community-led innovation in public health. 👇 Dive into the power of creativity for prevention! #NCDs #ArtsInHealth

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03:25

🌍 Obesity, Orals, Outcomes: Rewriting the GLP-1 Script

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/21

💊 Orforglipron: A new era in obesity treatment? In the ATTAIN-1 trial, this oral, nonpeptide GLP-1 receptor agonist delivered up to 11.2% weight loss over 72 weeks—with significant drops in waist circumference, triglycerides, and blood pressure 📉🌡️ 🔥 Nearly 1 in 5 patients lost ≥20% body weight 💡 A promising alternative to injectable therapies Accessible. Effective. Oral. 👉 A game-changer for global obesity care? #Obesity #GLP1 #Orforglipron #WeightLoss #CardiometabolicHealth #NEJM

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07:08

HCM in Two Acts 🎭: Aficamten, Mavacamten & Dueling...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/20

🚨 New Podcast Drop! 🎙️ “Myosin, Metrics & Momentum 🧬📈🫀” dives into 3 landmark NEJM articles on Aficamten vs Mavacamten in hypertrophic cardiomyopathy. We decode: 🔹 MAPLE-HCM (obstructive HCM) 🔹 ODYSSEY-HCM (nonobstructive HCM) 🔹 Expert editorial insights on PROs, EF, & trial design 🎯 Learn what matters: peak VO₂ vs PROs, safety signals, and the road ahead in precision cardiomyopathy care. 🎧 Tune in and share! #HCM #CardioTwitter #NEJM #HeartFailure #MyosinInhibitors #Podcast

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04:12

🧬 Science, Slimming, and Semaglutide Redefining...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/20

💊 New Hope in a Pill for Obesity? The 71-week OASIS 4 trial shows that oral semaglutide 25 mg led to a 13.6% weight loss, improved physical function, and reversed prediabetes in 71% of cases—all without injections. 📉 Effective. 🧬 Metabolically beneficial. 📦 Orally delivered. #ObesityCare #GLP1 #Semaglutide #NEJM #DigitalHealth #Cardiometabolic

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03:23

🌞 Sun, Skin & Science: The Bright Side of Exposure

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/20

☀️ Walking on Sunshine? Rethinking Our Relationship with the Sun! 🧴🧬 New research—spotlighted in The Economist (Sep 20, 2025)—challenges old assumptions: Could moderate sun exposure reduce cardiovascular mortality? ❤️📉 From nitric oxide to vitamin D, this FAQ explores the science, nuance, and shifting global guidelines. Let’s talk melanin, mortality, and medicine! 🌍💡 #Sunlight #CardiovascularHealth #TheEconomist #PublicHealth #MedicalEducation

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04:46

🫀 Cardiogenic Shock Survival: Impella’s Decade-Long...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/18

🚨 Cardiogenic Shock—A Decade Later The DanGer Shock Trial shows that patients with STEMI and shock treated with the Impella CP microaxial flow pump lived 600 more days over 10 years vs standard care alone. 📉 Mortality: 52.5% vs 68.8% (HR 0.70) 🛠️ Despite higher adverse events, the survival benefit endured a full decade. 📊 This changes how we think about long-term outcomes in mechanical support. 🔗 Time to revisit your shock protocols? #DanGerShock #Impella #CardiogenicShock #STEMI

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07:06

💓 Genes, Gradients, and Game-Changers: FAQs on...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/17

🧠 Hypertrophic Cardiomyopathy — A Masterclass from Eugene Braunwald 🧬 📌 Just published in NEJM (Aug 2025): a sweeping, state-of-the-art review on HCM — from Teare’s first autopsy to myosin inhibitors, AI diagnostics, and gene therapy. 💥 Clinical insights, historical depth, trial data (EXPLORER-HCM, SEQUOIA-HCM, VALOR-HCM), and future-facing advances—all distilled into one must-read. 📉 SCD prevention, 🫀 LVOT obstruction, 🧪 MYBPC3/MYH7 mutations, 🧬 proteomics, and more. 🔗 Essential

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04:42

🔬 Silence APOC3, Slash Triglycerides, A New Era in...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/16

🚨 New NEJM Study on Olezarsen 🚨 In patients with moderate hypertriglyceridemia and elevated cardiovascular risk, monthly subcutaneous olezarsen reduced triglycerides by over 60% at 6 months! 📉💥 ✅ Significant drops in APOC3, VLDL, remnant & non-HDL cholesterol ✅ No rise in LDL-C ✅ Well-tolerated with mild injection-site reactions 🔬 APOC3 inhibition emerges as a game-changer in lipidology. 📖 ESSENCE–TIMI 73b Trial | Funded by Ionis Pharmaceuticals #Cardiology #LipidLowering

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03:24

Dr RR Baliga's Philosophical Discourses: Dogen...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/16

🌸 Dōgen Zenji (1200–1253), founder of the Sōtō Zen school in Japan, taught that true practice lies in zazen—“just sitting” 🧘‍♂️—where enlightenment and practice are inseparable. His Shōbōgenzō continues to inspire mindfulness & presence today. ⏳✨ #Zen #Mindfulness

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05:11

NSTEMI: 📉 Less Ischemia, Less Reintervention

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/05

🚨 New Evidence in NSTEMI Care! 🫀 The SLIM Trial shows that FFR-guided complete revascularization during the index procedure in patients with NSTEMI and multivessel disease significantly reduces death, MI, stroke, and repeat PCI compared to culprit-only PCI. 🎯 Key win? Fewer revascularizations, better outcomes — physiology beats anatomy again. 📚 Published in JAMA, presented at #ESC2025 🔗 Read more: https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.16189 #Cardiology #NSTEMI

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06:04

Real-World Rx 💊, Real Results 📉: GLP-1 Agents Slash...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/05

💥 Practice-Changing Evidence in HFpEF! 💥 In a real-world cohort of 97,000+ patients with obesity & type 2 diabetes, semaglutide and tirzepatide reduced risk of heart failure hospitalization or death by over 40% 📉 ⚖️ No meaningful difference between the two agents. 🧠 Findings reinforce STEP-HFpEF & SUMMIT trials and highlight GLP-1 therapies’ expanding role in cardiometabolic HFpEF 🫀 #Cardiology #HFpEF #GLP1 #Semaglutide #Tirzepatide #T2DM #RealWorldEvidence #JAMA #HeartFailure

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03:20

The AMALFI AF Screening Trial-📈 Atrial Fibrillation...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/04

📢 Just read the #AMALFI trial in JAMA 📰 — a landmark remote RCT of AF screening using 14-day ECG patches mailed to older adults at stroke risk 📦🫀. At 2.5 years, the patch group had a modestly higher AF detection rate (6.8% vs 5.4%, p=0.03) and increased anticoagulation use 💊🧠. Stroke rates were similar ⚖️. 🎯 Key takeaway: Remote, mail-based AF screening is feasible and nudges diagnosis rates — but will it move the needle on outcomes? #AFib #StrokePrevention #RemoteMonitoring #ECG

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05:14

🛑 AFib Gone, OAC Gone? ALONE-AF Challenges Lifelong...

Dr RR Baliga"s "Got Knowledge Doc" Podkast ·

2025/09/04

🚨 New Trial Alert 🚨 Can we safely stop anticoagulation after AF ablation? The ALONE-AF Trial 🫀 suggests yes—in selected patients with no AF recurrence, stopping DOACs reduced major bleeding 🌟 without increasing stroke risk 🧠. 📉 0.3% vs 2.2% for the composite outcome (P = .02) 📍 Carefully monitored, low-risk patients may benefit most. 📝 Editorial: Recommends shared decision-making 🤝 & individualized rhythm monitoring. 📚 A potential shift in post-ablation care. 🔗 #AFib

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