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PODCAST

Mendelspod Podcast

Offering a front row seat to the Century of Biology, veteran podcast host Theral Timpson interviews the who"s who in genomics and genomic medicine. www.mendelspod.com

science & medicine natural sciences

All Episodes

37:50

What Next for LDTs? A Conversation with Sarah Overton...

Mendelspod Podcast ·

2025/04/22

Just weeks before the FDA’s sweeping rule to regulate laboratory-developed tests (LDTs) was set to take effect, a federal court struck it down. What does this mean for the field of precision medicine and for labs themselves? There are have been those on the side of regulation arguing its importance for reimbursement. Yet many, such as the plaintiffs in this case, the ACLA and AMP, have argued that FDA regulation could stifle innovation in a new field and even force labs to shut down. Today we

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26:46

AI’s Quiet Revolution in the Pharma Supply Chain with...

Mendelspod Podcast ·

2025/04/17

In today’s show, Theral is joined by Chris Petersen, Chief Technology Officer at Scientist.com, a company sometimes called the "Amazon for science"—though with a great deal more complexity. Chris pulls back the curtain on how AI is transforming the research services marketplace and offers a rare look into how AI is already reshaping the infrastructure of pharma and biotech.Calling this the "tinkering phase" of AI, Chris likens the current moment to the early days of the web—when best practices were

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25:24

We've Been Misclassifying Childhood AML for Years:...

Mendelspod Podcast ·

2025/04/15

In today’s program, we continue our series on disease subtyping with Dr. Jeffery Klco, a pediatric pathologist and researcher at St. Jude Children’s Research Hospital. Dr. Klco joins us to discuss groundbreaking work recently published in Nature Genetics, which redefines the genomic landscape of childhood acute myeloid leukemia (AML).Klco and his team have identified twelve novel molecular subtypes of pediatric AML—some driven by genetic alterations that had long gone undetected by standard

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40:41

Aaron Viny: A 21-Year Leukemia Survivor on the...

Mendelspod Podcast ·

2025/04/10

Dr. Aaron Viny, oncologist and researcher at Columbia University, begins today’s conversation with a personal milestone—he’s now been leukemia-free for 21 years. This experience gives his work on cancer a powerful human dimension that comes through in his interview with Theral today—not only in his dedication to patient care, but in his boundary-pushing research on the epigenetic roots of cancer.Dr. Viny’s research focuses on the epigenetic architecture of hematologic malignancies, exploring how

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29:33

Toward Disease Sub-typing with Ben Busby, DNAnexus

Mendelspod Podcast ·

2025/04/03

We’re happy to welcome back Ben Busby, Principal Scientist at DNAnexus, to dive deeper into the evolving world of disease subtyping and multi-omic data sets. Building on our previous conversation with Busby about the genomic data ecosystem, we explore the shift from single-cause disease models to multifaceted approaches that incorporate genomics, proteomics, imaging, and more."We’re no longer in a world where we’re doing genomics or imaging or proteomics," he explains. "These things are all coming

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37:36

Synthetic Biology Ready for Its ChatGPT Moment: A...

Mendelspod Podcast ·

2025/04/01

John Cumbers, founder of SynBioBeta, joins Theral for our annual look ahead at the field of synthetic biology and the upcoming SynBioBeta 2025 conference, happening May 6–9 in San Jose. It's obviously a big year for AI, and synthetic biology is no exception. As John puts it, “Biology and AI coming together represents a huge opportunity for us to be able to understand biology and then ultimately engineer biology.” This year’s conference features a strong emphasis on AI's role in scaling and

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24:01

Beyond the Parts List: Chris Mason and Simon...

Mendelspod Podcast ·

2025/03/27

Today Theral is joined by returning guests Chris Mason of Weill Cornell Medicine and Simon Fredriksson, CEO of Pixelgen Technologies, for a deep dive into the emerging field of cell surface proteomics and its power to illuminate both space biology and cancer research.Chris Mason shares new insights from his work on the Space Omics and Medical Atlas (SOMA), the largest collection of astronaut health data to date. His latest findings confirm that space is more than a hostile environment—it’s a

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38:51

DNA Is Still Where It's At: Christian Henry, CEO of...

Mendelspod Podcast ·

2025/03/20

In our last episode, we explored the growing shift from genomics to multi-omics. But for Pacific Biosciences CEO Christian Henry, the foundation of discovery remains clear: “DNA is still where it’s at.” PacBio is doubling down on long-read sequencing, committed to delivering on its promise of accuracy and completeness.2024 marks a “watershed year” for PacBio, with the launch of the Vega system—a benchtop long-read sequencer at an unprecedented $169,000 price point—alongside major advancements in

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8:02

A New Sequencing Technology Has Entered the World:...

Mendelspod Podcast ·

2025/03/13

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIt’s time for our annual deep dive into sequencing—no, wait—multi-omics! Back on the show is our resident sequencing guru, Keith Robison, scientist at Ginkgo Bioworks and author of the OmicsOmics blog. Keith is our all time return champion, and as always, he brings technical experience alongside the storytelling instincts of a seasoned journalist.Keith …

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21:29

Unlocking the Future of Forensic Genetics with Mirna...

Mendelspod Podcast ·

2025/03/06

This week on Mendelspod, as we celebrate International Women’s Day, we’re spotlighting groundbreaking contributions from women in science. Our guest, Dr. Mirna Ghemrawi, is at the forefront of forensic genetics, where DNA analysis meets the pursuit of justice. As Associate Director at the Center for Forensic Science Research and Education, Ghemrawi applies next-gen sequencing and AI to some of the most challenging questions in forensic biology.Originally from Lebanon, Ghemrawi’s path to forensic

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33:48

Public Science in Peril: Hank Greely of Stanford on...

Mendelspod Podcast ·

2025/03/04

In this urgent and unflinching conversation, Stanford law professor Hank Greely returns to Mendelspod to address the mounting threats of the Trump administration to public science funding and the institutions that regulate medicine. As the NIH faces existential challenges and the FDA comes under fire, Greely lays out a compelling case for why government-supported research remains essential—not just for innovation, but for maintaining a functional society.“Research is like fishing,” Greely explains

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31:55

Breaking the ‘Undruggable’ Barrier with AI and...

Mendelspod Podcast ·

2025/02/27

For decades, drug developers have struggled with so-called "undruggable" proteins—those regions of the proteome that evade traditional small molecules and antibodies. But Aikium, led by Eswar Iyer, could be changing the game. In today’s show, Iyer, a prolific scientist with over 100 patents and a background in George Church’s lab, shares how his company is tackling one of the toughest challenges in therapeutics.At the heart of Aikium’s approach is Yotta-ML2, an AI-powered wet lab platform that

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40:11

"They're not cutting a branch. They're cutting the...

Mendelspod Podcast ·

2025/02/10

Today Theral talks with Laura Hercher, Director of Research for Human Genetics at Sarah Lawrence College, about the growing political assault on diversity, equity, and inclusion (DEI) initiatives in scientific research. With the NIH facing sweeping budget cuts and DEI programs cancelled, Hercher makes a compelling case for why diversity isn’t just a social or moral issue—but a scientific imperative."What you're cutting is cancer funding. What you're cutting is Alzheimer's research. What you're

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5:31

Early Detection for Lung Cancer with Susan Tousi,...

Mendelspod Podcast ·

2025/02/06

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comLung cancer is the most deadly of all the cancers worldwide. Very few of those who should be— are getting screened. There is enormous medical need here, and early cancer detection through advanced liquid biopsy could be a tremendous part of the answer.Today, as part of our series on the future of genetic testing, we welcome Susan Tousi, CEO of Delfi Diagnostics, a company pioneering next-generation liquid biopsy

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6:13

Big RNA with Brendan Frey of Deep Genomics

Mendelspod Podcast ·

2025/01/30

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIn our first conversation with Deep Genomics, Theral sits down with Brendan Frey, the company's founder and Chief Innovation Officer, to explore the power of AI in RNA biology and drug discovery. Frey, a pioneer in deep learning who trained in the lab of AI luminary Geoffrey Hinton, shares how his personal experience in genetics back in 2002 led him to merge machine learning with genomic medicine. The company has a head

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31:04

Genome Informatics in the Age of AI With Ben Busby,...

Mendelspod Podcast ·

2025/01/23

In this Mendelspod episode, Theral explores the state of genome informatics with Ben Busby, principal scientist at DNAnexus.Busby reflects on his journey into the field, which was influenced by key projects and experiences during his time at the NCBI and his genomics hackathons. He outlines the current genome informatics landscape, emphasizing DNAnexus' role in fostering collaboration. Busby highlights transformative movements to refine disease subtyping based on haplotype data, underscoring their

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5:34

AI & the Future of Genetic Testing: Ezra Cohen, CMO...

Mendelspod Podcast ·

2025/01/16

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comAs 2025 begins, we are launching a new series The New Genetic Testing. To do that we’re welcoming today Dr. Ezra Cohen, Chief Medical Officer at Tempus to offer a behind-the-scenes look at how the company is transforming healthcare through cutting-edge AI. With its recent successful IPO, Tempus has firmly established itself as a leader in genomic testing and multimodal data integration and empowering providers and life

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5:26

PredxBio and the Promise of Spatially Intelligent...

Mendelspod Podcast ·

2025/01/10

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comThis week we welcome the innovative minds behind PredixBio, a new and groundbreaking company at the forefront of spatial biology. CEO Dusty Majumdar and co-founder Chakra Chennubhotla join us to discuss their mission to revolutionize cancer therapeutics through spatially intelligent biology. Founded in 2018 and supported by NIH grants, PredixBio focuses on unraveling the tumor microenvironment's heterogeneity using

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28:46

Surprise: Our Most Popular Show of 2024 Was on...

Mendelspod Podcast ·

2024/12/19

This year in a series co-produced with GenomeWeb we had an exclusive look into Illumina’s work in genomic AI with Kyle Farh, the VP and Distinguished Scientist leading the Illumina Artificial Intelligence Lab. "We lack a way of training genomic AI as readily as you would for natural language processing,” says Farh. "There are vast amounts of data, but there are no labels, no supervision. One of the most powerful tools that we’ve found is using clues from natural selection.”Farh says the company

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4:39

New Startup Launches Epigenetic Screening: Mohamad...

Mendelspod Podcast ·

2024/12/05

This is a free preview of a paid episode. To hear more, visit www.mendelspod.comIn this episode of Mendelspod, Theral sits down with Dr. Mohamad Takwa, co-founder and CEO of Epigenica, a Swedish startup revolutionizing epigenetic research. Epigenica is positioning itself at the forefront of this new and rapidly growing field with a mission to empower researchers through large-scale epigenetic profiling.

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