Bloody Minded

One step, two step, red step, blue step! Get stuck in to assessing factor levels in this episode looking at the differences between one and two step factor assays, the basis of chromogenic testing and how to resolve discrepancies between different methods. Timestamps:01:33 Intro to Factor Assays04:33 One-Stage Assays09:33 Historical Diversion - What's an IU?15:28 Factor VIII levels17:15 Two-Stage Assays21:31 Resolving Discrepancies25:24 FXIII Assays32:32 SummaryCheck out show notes, addi...

Finding your coagulation knowledge "LAC-ing"? Do you also hate things that were named terribly and thrive on pedantry? This week we pop the hood on that most mysterious of lab tests - the lupus anticoagulant. Listen to this episode again in 12 weeks time for an authentic lupus anticoagulant experience. Timestamps:02:10 - Introducing the LAC04:47 - What's in a name - nomenclature issues07:06 - LACs and the APTT11:31 - Testing for Lupus Anticoagulants16:55 - LAC testing and anticoagulation...

To infinXa and beyond! Let go of your veXation and eXalt our eXacting approach to coagulation testing. You'll know eXactly what you need for your eXams as long as they ask you about anti-Xa testing, thrombin times, fibrinogen and absolutely nothing else. Timestamps0:00 - Introductions2:40 - Thombin Time - Lab5:45 - Thrombin Time - Clinical9:24 - Thrombin Time - Variants11:06 - Anti-Xa Intro14:53 - Anti-Xa - Lab19:04 - Anti-Xa - Clinical25:21 - Santa-Clauss (Fibrinogen)30:20 - CasesCheck ...

Being alone can be difficult - and we would know! How should we think about a long aPTT when the rest of the coag screen looks normal? Join Bloody Minded crew as we learn how to tackle this surprisingly common (and surprisingly tricky) problem.Timestamps00:00 - Introductions02:21 - aPTT Revision03:59 - A case08:04 - Testing for heparins10:10 - Back to the case11:10 - DOACs and the aPTT12:34 - Mid Episode Recap13:32 - What if not heparin?16:56 - Mixing studies21:11 - PT Mixing23:01 - Cas...

“Have you not done tormenting me with your accursed time?“ Senior scientists Vladimir and Estragon are waiting quite a while for a clot to form in their tube. How should you react to prolonged clotting times? We cover an approach to prolonged PT and aPTT, as well as discuss the mechanism of common anticoagulants and their impact on these basic tests. Timestamps00:00 - Intro01:22 - Episode 2 Recap 03:13 - Why clotting times prolong 05:38 - Short clotting times 07:00 ...

It is a truth universally acknowledged that a JMO in possession of a coagulation tube will underfill it. But why should it matter?! In this episode, we review the principles behind the two most important coagulation screening tests (The PT and the aPTT) as well as follow the journey of that precious citrated sample through the lab. By the end, you’ll know enough to at least feel guilty when you still send that half filled tube down the chute at 3amTimestamps:00:00 - Introductions01:40 - Clini...

Optional Introductions - Skip to Episode 1 if you're after contentWe're excited to launch Bloody Minded - a haematology podcast for those who want an extra little drop of knowledge no matter where you are in your medical journey. Learn a little bit about your hosts and how we'll be formatting this show Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Surely it's just clot or no clot right? Join your intrepid guides Nick, Cale and Bashar as we help you master the med school coagulation cascade and its relevance (or lack of) to laboratory testing of haemostasis. Wait what’s that? Everything you’ve been taught so far is an irrelevant lie? Bring yourself up to speed with the cellular model of coagulation and learn what really happens to make that clot appearTimestamps00:00 - Introduction to Bloody Minded Podcast 02:57 - Episode Intr...