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PODCAST

Bloody Minded

Bloody Minded Crew

Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you"ve just finished haem block? Join the fellows of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs. Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au

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All Episodes

52:25

Episode 87 - Flitting About | In The Lab: FLT3 and NPM1

Bloody Minded ·

2026/04/21

“It’s pronounced nuc-ul-ophosmin” “Nucleophosmin”. “Noo-clee-o-phosmin”. FLT3-ITD got you In The Dumps? Have a Total Knowledge Deficit about TKD mutations? Struggling with the A-B-Cs of NPM1 mutations? Want to know how a cat sarcoma is somehow related to AML? Join the Bloody Minded Crew as they flit about the laboratory looking at the structure of FLT3 and NPM1, what these proteins usually do and how we test for mutations in the advanced myeloid episode. Timestamps 0:52 - Bloody Minded issues...

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37:27

Episode 86 - You Ugly | In The Lab: Bone Marrow...

Bloody Minded ·

2026/04/14

U-G-L-Y, you ain't got no alibi, you dysplastic yeah yeah you dysplastic. Apologies to all the ring sideroblasts out there, but this week the Bloody Minded crew is doing a Mean Girls and judging cells by their morphology. For now we’re deciding to ignore those that would argue that it’s what’s on the inside that counts (i.e. judging by NGS… that’ll come later). TIMESTAMPS 2:28 - For some reason, an audio podcast on visual dysplasia 5:05 - Normal erythroid morphology 7:17 - Dysplas...

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50:17

Episode 85 - Wake Me Up! | Acute Promyelocytic...

Bloody Minded ·

2026/04/07

What do arsenic, acne tablets and Jodi Picoult have in common? Why, it must be a deep dive with Nick, Bashar and Cale on acute promyelocytic leukaemia. From buzzwords to brain bleeds, the sweetest of translocations to the cruellest of coagulopathies... The yield is almost as high as the survival rates. TIMESTAMPS 00:57 - Bloody Minded Poetry Jam & Jodi Picoult 06:25 - APML Starts Here 08:02 - APML - Where does it fit in AML? 10:02 - Morphology & Flow 12:12 - PML::RARA - t(15;17) and r...

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58:14

Episode 84 - Chemotherapeutic Boogaloo | AML Part 2

Bloody Minded ·

2026/03/31

After our initial intro to AML back in ep 79, we are back to dig deeper into AML this week, from pathophysiology through to treatment overview. The boys are joined by final year registrar Dr Georgina Calov who is here to cut through our nonsense and deliver some actual high yield content. And thank goodness for that, otherwise it'd be an hour of us making bad April Fool's day jokes. Timestamps 2:09 - Introducing Dr Georgina Calov 3:34 - AML Refresher 7:12 - AML defined by recurrent genetic ab...

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54:39

Episode 83 - On The Wards: The NBM Transplant Patient

Bloody Minded ·

2026/03/24

Cat got your tongue? Or in this case - mucositis? Does converting the acute allogeneic transplant patient who can no longer eat's medications to IV fill you with dread? In this practical for once episode join consultant haematologist Dr Alison Chandler as well as haematology pharmacists Andriana Colic & Ariana McCauley as they take us through the how to of this challenging, but very common, clinical scenario. Timestamps 0:58 - Nick's literal nightmare 2:18 - Today's outline 3:38 - L...

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67:55

Episode 82 - MDS 102 | Much More on Myelodysplastic...

Bloody Minded ·

2026/03/17

Was episode 79 too light on MDS for you? “Amateurs” you said, adjusting your sellotaped glasses. If so, you’re in the right place today as we prepare to look at classification, risk stratification and treatment of myelodysplastic syndrome. You also should seek out psychiatric attention, or perhaps just go outside. But in the meantime, enjoy this episode where we’ll dig deeper into the nitty gritty of MDS! We’ve got a lot to cover so we float about between intermediate and advanced for this ep...

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38:41

Episode 81 - In the Beginning... | Myeloid Precursor...

Bloody Minded ·

2026/03/10

What if the prequel had a prequel? Join Bashar, Nick and Cale as they attempt to unpack the newfangled world of clonal haematopoeisis. Find out how CHIPs can kill and no, it’s not due to eating too many of them too fast. Though that might do it too. We’ve had one spectrum, but what about a second. We need to go deeper. TIMESTAMPS 0:56 - A classic chippy mixup 2:56 - Episode overview 3:54 - Where CHIP sits in haem 5:15 - Clonal haematopoiesis 11:21 - What gene...

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72:11

Episode 80 - GATTTACA | In The Lab: Introduction to...

Bloody Minded ·

2026/03/03

If we’re going to truly understand myeloid disease, we must dispense with the ward and journey to the dystopian heart that beats at the centre of each dysplastic cell. Learn what is valid and in-valid as we swim across an ocean of concepts - past the basic principles of DNA and RNA, Polymerase Chain Reaction and its many many variants, Fragment Analysis and Next Generation Sequencing. Just save a little something for the swim back to clinic next week. PS The Extra T is for TYOTT T...

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54:16

Episode 79 - Ghosts in the Machine | Basics of MDS &...

Bloody Minded ·

2026/02/24

Happy marrows are all alike; every unhappy marrow is unhappy in its own way. When haematopoiesis behaves itself, it’s frankly quite boring. When it goes rogue, it can get very creative. Join Cale, Bash and Nick as they attempt to walk through how this process goes off the rails, how MDS and AML are best understood and how dysplasia, cytopenias, blasts and clones all fit together. TIMESTAMPS 0:55 - Our serious introduction to counterbalance last week 1:58 - Episode overview 2...

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33:28

Episode 78 - All The Colours Of The Marrow | Overview...

Bloody Minded ·

2026/02/17

What’s a CHIP and why is it so delicious? Why do we still abbreviate myeodysplastic neoplasm to MDS? How did Bashar get his hands on the Necronomicon? These are questions that every budding haematologist asks themselves at some point and we will answer at least some of them here! Join us today for a birds-eye overview of the myeloid family of disorders before we dig into them more over the coming weeks. TIMESTAMPS 0:57 - Does anyone know a good priest? 3:17 - Myeloid conditions i...

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31:35

Episode 77 - The Factory Must Grow | Myelopoiesis

Bloody Minded ·

2026/02/10

Hi-ho, Hi-ho, it's off the myeloid factory we go. Grab your fastest belt, a spare inserter and all the iron plates you can get your hands on as the Bloody Minded Crew embark on their nerdiest references yet and learn all about the basic science behind myelopoiesis. You’d better hop on a train, because the only main bus here goes straight from the marrow out to the periphery carrying all sorts of myeloid cells. And some blue circuits. 0:52 - New year same us 2:44 - Season overview: myelo...

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66:58

Episode 76 - On the Wards: A Practical Guide to...

Bloody Minded ·

2026/01/27

So you’ve been asked to start a DOAC? How is that different from a NOAC? Is there a difference? Which one should you start? Is warfarin a WOAC? How do I initiate these drugs? Why is the dose weird at the beginning? Do I need to check my dose is appropriate? If oral anticoagulation has you discombobulated you are in the right place!! In part II on the practical management of anticoagulation we are here to clarify all your questions on the most common types of oral anticoagulation you wil...

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63:53

Episode 75 - On the Wards: A Practical Guide to...

Bloody Minded ·

2026/01/20

Does my blood look fat in this? Does the idea of heparin being a fraction make you wish you listened harder in maths? What is unfractionated heparin? Why are haematologists so judgmental and prefer their anticoagulation low molecular weight? Why does haematology frown when you use the term “blood thinners” ?!?! If injectable or parenteral anticoagulation feels confusing you have come to the right place! Today we look at unfractionated heparin and low molecular weight heparin, practical ...

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39:53

Episode 74 - Christmas Disease | A Bonus Beginners...

Bloody Minded ·

2025/12/23

Twas the night before Christmas, and all through the house, not a creature was stirring, particularly not a missing coagulation factor. Welcome to a very special present all wrapped and delivered by Santa and his Christmas elves and stuffed in your podcast queue in time to drive off for the holidays. Join Cale, a very dusty Bashar, Nick and Santa as we learn a little bit about Christmas Disease. We swear his jacket was that colour before we messed with his haemostatic pathways… CONTENT WARNIN...

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42:00

Episode 73 - What A Headache | CVST and Antithrombin...

Bloody Minded ·

2025/12/16

We’ve had one difficult coagulation topic yes, but what about second difficult coagulation topic? We are joined by the fantastic Dr Caroline Dix today to take us through not one but TWO challenging scenarios in thrombosis. First we’ll be revisiting Cerebral Venous Sinus Thrombosis but this time with someone who knows what they are doing. After that we’ll cover anticoagulating people when some very fundamental parts of the system are broken - the management of antithrombin deficiency. This epi...

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41:45

Episode 72 - How low can you go? | Thrombosis &...

Bloody Minded ·

2025/12/09

Sometimes something comes along that puts a chill down the spine of every doctor. Any conversation that starts with "Oh hey do you remember that patient you saw...?". Mystery meat day in the cafeteria. Dealing with hospital executives. For these times in life you need a guide. Today we'll be covering one of those spine-chilling clinical scenarios with our very apt guide consultant haematologist Dr Sara Ng. Over forty minutes Sara will un-chill your spine with her practical approach to managin...

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30:53

Episode 71 - Clotting For Good | In The Lab:...

Bloody Minded ·

2025/12/02

Come one come all to see the thinnest extended reference in the universe. Draped over not one but TWO episodes, the Bloody Minded Crew continue to make vaguely topical references to popular recent films. Look - we go outside and experience the full gamut of popular culture. Oh and we finish up our discussion of thrombophilia testing in the lab - looking this week at activated protein C resistance testing, molecular Factor V Leiden assessment and Prothrombin gene mutations. TIMESTAMPS 1:06 - P...

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37:31

Episode 70 - The Wizard of Clots | In the Lab:...

Bloody Minded ·

2025/11/25

Lions and tigers and… thrombosis? Oh my! Join the Bloody Minded Crew on the yellow brick road to visit the emerald laboratory and see the wonderful wizard of clots - your friendly laboratory coagulation scientist! Put on your blood red ruby slippers and join us for this bumper lab episode as we learn about how exactly we test for Protein C, S and antithrombin deficiencies as well as lupus anticoagulants. By the end of it you’ll have a brain for coags, a heart full of of love for thrombosis an...

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40:45

Episode 69 - I Have No Brain And I Must Test |...

Bloody Minded ·

2025/11/18

“HATE. LET ME TELL YOU HOW MUCH I'VE COME TO HATE YOU SINCE I BEGAN AS A HAEM REG. IF THE WORD HATE WAS ENGRAVED ON EACH NANO-ANGSTROM OF THE HUNDREDS OF MILLIONS OF CONSULT NOTES I HAVE WRITTEN IT WOULD NOT EQUAL ONE BILLIONTH OF THE HATE I FEEL FOR YOU ORDERING THROMBOPHILIA TESTING INAPPROPRIATELY.” Woah - Let’s calm down, that's a bit much. Cale and Bashar are exposed to Nick’s inner monologue as the Bloody Minded Crew learn about the what, when and when not of thrombophilia testing. ...

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50:35

Episode 68 - The Gut Brain Axis | CVST, CRVO,...

Bloody Minded ·

2025/11/11

We're nearly out of pipes to clean - Join us for the world's worst roadtrip we venture into the lesser known parts of human plumbing and tackle unusual site thromboembolism. From splanchnic clots, uterine and testicular thrombi it's clots as far as the eye can see (and those it can't like CRVO!) Timestamps: 0:58 - ROADTRIP 4:07 - CVST 11:07 - CVST - Treatment 15:36 - Lemierre's 17:50 - CRVO 24:36 - Splanchnic Thrombi 34:45 - Renal Vein Thrombi 39:41 - Uterine Vein Thrombus 42:09 - Ovarian Vei...

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