PODCAST

Immune

Vincent Racaniello

A podcast about the body"s defenders against disease.

science life sciences

All Episodes

01:35:18

Immune 40: COVID-19 nuances

Immune ·

2020/12/30

Immune reminisces about a year in COVID-19 immunology, Steph’s receiving the Pfizer vaccine, and answers to listener questions about a challenge study with common cold CoVs, T cell exhaustion, how CD4 T cells control infections, and more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Immune response during common cold CoV infection (Epidem Infect) Summary of

01:23:38

Immune 39: A Tonka Truck full of salt

Immune ·

2020/12/01

Immune catches up on COVID listener email, including discussions about long-term COVID, cross-reactive memory to SARS-CoV-2, common mucosal surfaces, the risky business of peptide mega-pools, immunodominant epitopes and much more. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Reflections of a COVID-19 long hauler (JAMA) Not a cytokine storm in COVID-19 (JCIO)

01:10:57

Immune 38: COVID-19 and kids with Sallie Permar

Immune ·

2020/11/28

Sallie joins Immune to discuss her career, emphasizing the importance of a good mentor and the ability to pivot, and her research, which has focused on mother to child transmission of infectious diseases including HIV/AIDS, CMV, and more recently, COVID-19/SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Sallie Permar Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Immune correlates of

02:00:55

Immune 37: Black in Immuno

Immune ·

2020/11/16

Alexis, Joel, Elaine, Justine, and Evonne join Immune to discuss their careers, their research, and a platform created by a collective of Black immunologists and allies aimed at amplifying, celebrating and supporting Black voices in immunology. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guests: Alexis Mobley, Joel Babdor, Elaine Kouame, Justine Noel, Evonne Jean Become a patron of Immune! Links for this episode Black in Immuno Black in Immuno week schedule

01:27:56

Immune 36: Aberrant immunity in COVID-19

Immune ·

2020/10/21

Immune describes the striking loss of germinal centers in lymph nodes and spleen in patients with severe COVID-19, providing an explanation for short-lived humoral immunity and limited somatic hypermutation of antibodies to SARS-CoV-2. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Guest: Alexander Dent Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Loss of germinal centers in severe COVID-19 patients (Cell)

01:20:11

Immune 35: SARS-CoV-2 antibodies

Immune ·

2020/09/23

Immune examines antibodies to SARS-CoV-2, including the relationship between severe COVID-19 and anti-spike antibodies, kinetics of production, and correlates of protection among coronaviruses. Hosts: Vincent Racaniello, Stephanie Langel, Cynthia Leifer, and Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode COVID-19 severity linked to antibody levels (bioRxiv) Review of antibody mediated immunity to coronaviruses (Nat Comm) Time

01:26:59

Immune 34: Coronavirus cross-reacting T cells

Immune ·

2020/08/25

Immune explains a study demonstrating T cells that react with SARS-CoV-2 epitopes in individuals who have never been infected with the virus, implying cross-reactivity with common cold coronaviruses. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Cross-reactive coronavirus CD4+ T cells (Science) Immune misfiring in severe COVID-19 (Nature) A COVID-19 riddle for the immune

01:23:57

Immune 33: COVID-19 immunotypes

Immune ·

2020/07/28

Immune explains a study of 125 COVID-19 patients by deep immune profiling, which revealed three immunotypes associated with poor clinical prognosis or recovery. Hosts: Vincent Racaniello and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CD8 cells defend against SARS-CoV (J Virol) Deep immune profiling of COVID-19 patients (Science) Letters read on Immune 33 Image credit Time stamps by Jolene. Thanks!

01:30:33

Immune 32: Immunology of COVID-19, part four

Immune ·

2020/06/05

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including inflammatory responses and disease, antibody and T-cell responses, and vaccines, and answers to listener questions. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Keep CoV off campus (NY Times) Inflammatory cytokines predict COVID-19 death (medRxiv) Imbalanced

01:30:05

Immune 31: Immunology of COVID-19, part three

Immune ·

2020/05/08

Immune continues a discussion of the immune response to infection with SARS-CoV-2, including vaccines and immunity, effects of BCG and OPV, immunity passports, and answers to listener questions. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode How long will a vaccine really take? (NYTimes) Humoral immunity in NYC COVID-19 patients (medRxiv) D614G is just a

01:23:27

Immune 30: Immunology of COVID-19, part two

Immune ·

2020/04/17

Brianne Barker returns to continue a discussion of the immune response to infection with SARS-CoV-2, including use of steroid, coagulation in some patients, cytokine storm, and vaccines. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode IL6 as COVID-19 marker for severity (Med Mal Infect) How does COVID-19 kill? (Nature) SARS-CoV-2 protective immunity in

01:26:56

Immune 29: Immunology of COVID-19

Immune ·

2020/03/31

Brianne Barker joins Immune to discuss the immune response to infection with SARS-CoV-2, including immune respones, pathogenesis, immunopathology and more. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Brianne Barker Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode ACE2 in oral mucosa (I J Oral Sci) IL6 predictor of COVID-19 death (Int Care Med) Protective immunity to SARS-CoV-2 in nonhuman primates (bioRxiv) Antibody

56:31

Immune 28: Fish immunology

Immune ·

2020/02/08

Irene Salinas joins Immune to reveal the work of her laboratory on the evolution of mucosal immune responses in teleost fish, the oldest living bony vertebrates. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Irene Salinas Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Evolution of mucosal Ig in rainbow trout (Sci Immunol) Fish olfactory neurons mediate rapid immune response (PNAS) Image credit Time stamps by Jolene

01:33:55

Immune 27: Trained immunity

Immune ·

2020/01/11

Steph explains how sepsis induces protective immune memory in NK cells, via histone methylation of the interferon gamma enhancer. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode H3K4me1 mark on memory-like NK cells (Cell Rep) Letters read on Immune 27 Time stamps by Jolene. Thanks! Music by Steve Neal. Immune logo image by Blausen Medical. Send your immunology questions and

01:37:33

Immune 26: Measles erases immune memory

Immune ·

2019/11/28

Michael Mina joins the Immune team to explain his findings that measles diminishes pre-existing antibodies that protect against infection with other pathogens. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Guest: Michael Mina Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Measles virus infection diminishes pre-existing antibodies (Science) Public epitope #1 (TWiV 342) Incomplete reconstitution of B cell pools after measles

01:22:29

Immune 25: Remembrance of antigen encounters past

Immune ·

2019/11/01

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode CD8+ T cell memory needs microbiome derived fatty acids (Immune) Image credit: Principles of Virology 4e Time stamps by Jolene. Thanks! Letters read on Immune 25 Weekly

01:29:23

Immune 24: Unlucky IL-13

Immune ·

2019/09/19

The Immune team reveals a new type of T helper cell that drives the production of IgE, leading to allergic responses. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode New type of T helper cell drives anaphylaxis (Science) Image credit Time stamps by Jolene. Thanks! Letters read on Immune 24 Weekly Science Picks Cindy- Lasker Award 2019 Vincent- Eleanor's Breakthrough video Music

01:27:12

Immune 23: How to tell a mouse from a mouse

Immune ·

2019/08/14

The immunosomes explain that widely used inbred laboratory mice are not identical, and how to tell them apart. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Genetic variation in laboratory mice (Immunity) Time stamps by Jolene. Thanks! Vaccines and Your Child Letters read on Immune 23 Weekly Science Picks Steph- University of Alaska budget crisis Cindy- 90% survival following

01:18:23

Immune 22: Engineering B cells

Immune ·

2019/07/31

Immune reveals an alternative to a protective vaccine, engineered B cells that produce antiviral antibodies. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Engineering B cells to produce antiviral antibodies (Sci Immun) Time stamps by Jolene. Thanks! Letters read on Immune 22 Weekly Science Picks Steph- Breath of fresh air Cindy- Biologist found dead Vincent- Nobel Prizes and

01:27:17

Immune 21: Islets of Langelhans

Immune ·

2019/06/12

Immune tackles the finding that patients with Type I diabetes have lymphocytes with both TCR and BCR that may drive the pathogenesis of the disease. Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer Subscribe (free): iTunes, Google Podcasts. RSS, email Become a patron of Immune! Links for this episode Dual receptor lymphocytes and type I diabetes (Cell) Image credit Time stamps by Jolene. Thanks! Weekly Science Picks Steph- Unique Scientists Cindy- Researcher app Vincent- STLR

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Immune

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