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PODCAST

The OptimalWork Podcast

Hosted by Dr. Kevin Majeres and Sharif Younes, co-founders of OptimalWork, The OptimalWork Podcast will help you learn to challenge yourself in each hour of work according to your highest ideals. We discuss all aspects of Dr. Majeres"s approach to work, which he developed in his private practice and teaches at Harvard Medical School, and show how it applies to everyday situations like professional work, study, sleep, and relationships. For personalized plans to help you put the ideas into practice,

education self-improvement

All Episodes

00:27:33

275. Engines of Enthusiasm III: Attention and the Cortex

The OptimalWork Podcast ·

2025/11/24

#275: In this episode, Sharif and Kevin explore how the cortex and attention form the capstone of motivation and enthusiasm. Together, they trace how meaning (the septum), willingness (the striatum), and focused presence (the cortex) work in harmony to create clarity, silence, and smoothness: the hallmarks of deep attention and flow. Kevin explains why distractions arise, what inner “friction” really signals, and how love and service fuel the brain’s attentional systems. This conversation offers a

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00:29:55

274. Engines of Enthusiasm II: Effort and the Striatum

The OptimalWork Podcast ·

2025/11/17

#274: In this follow-up to their discussion on meaning and the septum, Sharif and Kevin turn to the striatum—the brain’s engine of effort and challenge. Kevin explains how our willingness to act depends on dopamine, and how love, purpose, and embracing discomfort transform drudgery into freedom and flow. They contrast this neuroscience-based approach with Stoicism, showing how the key to persistence isn’t suppressing emotion but letting meaningful motivation drive every action.Find more at

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00:33:54

273. Engines of Enthusiasm I: Motivation and the Septum

The OptimalWork Podcast ·

2025/11/10

#273: In this conversation, Sharif Younes and Dr. Kevin Majeres explore the brain’s septum—the hidden center where love, meaning, and motivation converge. Kevin explains how “septal resonance” connects our sense of purpose to our relationships, and how practices like sincerity, gratitude, and loving-kindness can reawaken zeal in our daily work. Together, they unpack how reframing and genuine affection can shift us from threat mode into vitality mode, bringing new depth to both work and spiritual

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00:32:30

272. Understanding Depression VI: Ancient Wisdom and...

The OptimalWork Podcast ·

2025/11/03

#272: In this episode, Sharif and Kevin continue their exploration of depression, burnout, and low energy—this time uncovering a remarkable bridge between neuroscience and classical wisdom. Kevin reveals how adenosine’s “good tired” and “bad tired” states map directly onto Aquinas’ ideas of tristitia and acedia, showing that what medieval thinkers called “weariness of soul” may be the same state modern science calls burnout or depression. Together, they unpack Aquinas’ five treatments for

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00:30:04

271. Understanding Depression V: Good Tired and Good...

The OptimalWork Podcast ·

2025/10/27

#271: In this episode, Kevin and Sharif explore one of the most elegant parallels in psychiatry — the deep connection between anxiety and depression. Kevin explains how panic disorder can be seen as a phobia of adrenaline, while depression mirrors it as a phobia of adenosine, the brain’s “tiredness” signal. Together, they explore how unwillingness to feel these sensations fuels both disorders, and why willingness—even love—toward the very sensations we resist becomes the key to healing. With

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00:29:33

270. Understanding Depression IV: The Root Cause

The OptimalWork Podcast ·

2025/10/20

#270: In this episode, Kevin and Sharif explore a bold new way to understand depression—not as a simple chemical imbalance, but as what Kevin calls a “phobia of adenosine.” Drawing on neuroscience and behavioral psychology, Kevin explains how our brains rely on a natural rhythm of intensity and rest, and how losing that rhythm leads to burnout, lethargy, and despair. The discussion connects deep biological mechanisms—adenosine, dopamine, cortisol, and dynorphins—to everyday experiences of tiredness,

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00:33:46

269. Understanding Depression III: The Truth about...

The OptimalWork Podcast ·

2025/10/13

#269: Kevin and Sharif dive deep into the true biology and psychology of burnout — not as mere exhaustion, but as “bad tired on steroids.” Kevin explains how chronic threat mode floods the brain with cortisol, amplifying the “type two” tiredness that crushes motivation, focus, and connection. Together, they explore the three engines of vitality — meaning, effort, and attention — showing how burnout arises when these engines fall out of sync. Sharif presses on the dilemma of working hard without

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00:30:19

268. Understanding Depression II: Good and Bad Tired

The OptimalWork Podcast ·

2025/10/06

#268: Kevin and Sharif unpack why “good tired” and “bad tired” aren’t just degrees of fatigue but two distinct brain states tied to adenosine pathways—and how dopamine (and even caffeine) changes the experience. They translate cutting-edge neuroscience into practical steps you can test today: work from motives of love and service (to protect motivation), structure your day in focused sprints with real breaks (up to ~90 min work / ~15 min reset), and practice mindful unit-tasking to avoid the energy

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00:29:59

267. Understanding Depression I: The Role of Adenosine

The OptimalWork Podcast ·

2025/09/29

#267: Kevin and Sharif explore how depression connects to “bad tired,” the draining fatigue that comes from poor sleep, chronic stress, or unfinished effort. At the center is one molecule — adenosine — which can make us feel either “good tired” (satisfied, fulfilled) or “bad tired” (blue, demotivated). Kevin unpacks how adenosine builds up in the brain, how sleep and astrocytes clear it, and how simple practices — from morning light, hydration, and exercise to breathing, cold exposure, and creatine

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00:32:46

[Rebroadcast] Overcoming Anxiety I: Feel the Fear

The OptimalWork Podcast ·

2025/09/22

#266: Overcoming anxiety occurs in three successive stages. In this first installment of a three episode series, we discuss stage one: confronting the trigger of anxiety head-on, embracing the fear. Over time, the trigger will habituate; as you challenge yourself, the fear you experience will gradually diminish. You can then develop a sense of daring, which is the beginning of the second stage, the topic of next week’s episode.Find more at https://OptimalWork.com

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00:28:46

[Rebroadcast] How to Discipline Your Children While...

The OptimalWork Podcast ·

2025/09/15

#265: When a child does something wrong, your first instinct may be justice: to punish them. In this episode, we discuss “No-Drama Discipline,” by Daniel Siegal and Tina Bryson, exploring how to discipline children in a way that builds your bond with them and promotes their moral development. By connecting with your child, helping him or her gain insight into what went wrong, and look for ways to repair and reintegrate, discipline becomes a way of actually deepening your bond with them, rather than

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00:29:23

[Rebroadcast] Unleash the Power of Dynorphins

The OptimalWork Podcast ·

2025/09/08

#264: Difficult situations can feel intolerable. That intolerable feeling is produced by dynorphins and it makes us want to give up and abandon the difficulty we’re facing, whether it’s exercise, a difficult task, time in the sauna, or some small annoyance. But the more we embrace the dynorphin effect — the intolerable feeling — the more we develop a kind of inner strength. And, paradoxically, we end up unleashing a subsequent wave of endorphins, which cause feelings of wellbeing and improved mood

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00:27:53

[Rebroadcast] How to Get Energy from Tiredness

The OptimalWork Podcast ·

2025/09/01

#263: What do you do when you feel tired? Go back to sleep? Take a nap? Power through? In this episode, we discuss a number of approaches to overcoming tiredness, from tracking your levels of fatigue (not recommended) to changing up your diet. But the ultimate approach draws on all the principles of OptimalWork and will actually help you harness tiredness for increased energy! Find more at https://OptimalWork.com

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00:34:20

[Rebroadcast] The Paradoxes of Mindfulness

The OptimalWork Podcast ·

2025/08/25

#262: Mindfulness lies at the heart of OptimalWork’s approach. Living your highest ideals means being fully present, fully engaged with reality. Cultivating this habit is the work of mindfulness. But mindfulness rests on a set of apparent contradictions. Foremost among them is this: while mindfulness involves accepting reality as it is, it is often used as a way of achieving personal or behavioral change. In this episode, we discuss this apparent paradox and others, shedding light on the true nature

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00:29:45

[Rebroadcast] From Tolerance to Acceptance to Love

The OptimalWork Podcast ·

2025/08/18

#261: The two fundamental ways you can relate to challenge are approach and avoidance. Typically, approach leads to a virtuous cycle: the challenge gets easier and more enjoyable over time as you grow in mastery. Avoidance, on the other hand, often leads to a vicious cycle of increasing difficulty and pain. In this episode we further break down approach into three levels — tolerating, accepting, and loving the challenge — to show how to speed up the virtuous cycle and maximize your growth in the

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00:33:55

[Rebroadcast] Should You Be Doing Therapy at Work?

The OptimalWork Podcast ·

2025/08/11

#260: With rising rates of anxiety and depression, some have suggested that managers be trained to provide “mental-health first aid” to employees in distress. In this episode, we discuss the best ways managers can help employees thrive at work, how to help them grow, and how to balance the need to get results from their teams with the ideal of supporting and mentoring them.Find more at https://OptimalWork.com

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00:32:04

[Rebroadcast] How to Persuade Your Emotions

The OptimalWork Podcast ·

2025/08/04

#259: What’s the best way to prevent distractions? Are prevention techniques — like website blockers — effective? In this episode, we discuss different strategies aimed at behavior change. We argue that the source of the most sustainable behavior change is to build self-mastery through right action. By doing this, you’ll be laying the foundations for new predictions by your brain. Over time, it will come along and be no longer a source of friction, but a great help in pursuing meaningful action.Find

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00:27:08

[Rebroadcast] The True Value of Reframing

The OptimalWork Podcast ·

2025/07/28

#258: Reframing is a practice that developed from cognitive behavioral therapy. It means discovering the opportunity present within a challenge. If you face a challenge that causes anxiety, distraction, or burnout, reframing can help you approach it more effectively. But reframing can do more. It will also help you harmonize the different parts of your life so everything is working in the same direction: toward your highest ideals.Find more at https://OptimalWork.com

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00:33:30

[Rebroadcast] The Power of a Golden Hour

The OptimalWork Podcast ·

2025/07/21

#257: At the heart of our approach is the practice of a Golden Hour: preparing your mind for a time of work, focusing on one thing, and setting a stop time in advance. Doing a Golden Hour brings the key practices of psychology into your hour of work, so you not only do your best work, but you also practice bringing your highest ideals into your actions, which is the entire goal of OptimalWork. In this episode, we discuss the genesis of the Golden Hour, how to do it well, and some common questions

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00:28:55

[Rebroadcast] Why Embracing Shame Will Help You Thrive

The OptimalWork Podcast ·

2025/07/14

#256: Shame is the emotion we feel when we fear that our failures or weaknesses will become known. This fear can lead us to pursue certain outcomes as defenses — money, success, prestige, etc. — or to shy away from challenges that will expose us. In this episode, we discuss how to experience and accept shame, and why doing so gives us a profound freedom and unlocks the most meaningful forms of growth. Find more at https://OptimalWork.com

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275 results

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