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PODCAST

Extend Podcast with Darshan Shah, MD

Darshan Shah, MD

Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health

health & fitness medicine

All Episodes

58:57

144. Dr. Mao Shing Ni: Fertility Optimization, Egg...

Extend Podcast with Darshan Shah, MD ·

2026/03/05

Fertility is declining while menopausal symptoms are appearing earlier. Metabolic dysfunction, chronic stress, and environmental exposures are reshaping reproductive health for both women and men. In this episode of Extend, we sit down with Dr. Mao Shing Ni, co founder of Tao of Wellness and Yo San University of Traditional Chinese Medicine, to unpack how Eastern medicine and modern science can work together to optimize fertility, support egg freezing outcomes, and reframe menopause as a powerful

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51:14

143. The Teen Health Revolution: Raising Resilient...

Extend Podcast with Darshan Shah, MD ·

2026/03/03

Teen mental health is deteriorating in real time, fueled by ultra processed food, chronic stress, and constant screen exposure. The earlier we intervene, the more resilient the biology and brain become. In this episode of Extend, we sit down with Abdullah, Zain, Emaad, and Qasim Ansari, hosts of The Holistic Kids' Show and co authors of The Teen Health Revolution, to unpack how simple lifestyle shifts can radically improve youth mental, metabolic, and emotional health. We break down their REVOLUTION

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01:18:08

142. Dr. Tommy Wood: The Science of Brain Performance...

Extend Podcast with Darshan Shah, MD ·

2026/02/26

Most conversations about brain health focus on intelligence or genetics. True cognitive performance depends on how the brain is trained, supported, and allowed to recover across decades of life. In this episode of Extend, we sit down with Dr. Tommy Wood, neuroscientist and performance expert working at the intersection of elite motorsport and clinical brain research, to uncover how the brain adapts under extreme cognitive demand and how those same principles apply to long term brain health. We break

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01:08:45

141. Dr. Amy Shah: Hormone Havoc, Gut Health, and the...

Extend Podcast with Darshan Shah, MD ·

2026/02/24

Most women are taught to accept fatigue, weight gain, brain fog, and mood changes as a normal part of aging. What if the real issue has been overlooked gut health, muscle loss, and a medical system that failed to prioritize women's hormones. In this episode of Extend, we sit down with Dr. Amy Shah, MD, double board certified physician in internal medicine and immunology, to unpack the powerful connection between the gut microbiome, hormone balance, and long term health. We break down the

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01:27:51

140. Dr. Kelly Casperson: The Hormone Truth About...

Extend Podcast with Darshan Shah, MD ·

2026/02/19

Most women are taught that aging means decline, less energy, less strength, and less desire. What if the real problem has never been age itself, but untreated hormone loss and outdated medical narratives. In this episode of Extend, we sit down with Dr. Kelly Casperson, urologist, hormone expert, and leading voice in women's sexual health, to uncover how hormones shape longevity, muscle, brain health, and quality of life across midlife and beyond. We break down why estrogen, progesterone, and

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01:24:12

139. JJ Virgin: Muscle Over Weight Loss

Extend Podcast with Darshan Shah, MD ·

2026/02/17

Most people are told to lose weight to get healthy. What if that mindset is the reason metabolic health keeps getting worse, muscle keeps disappearing, and fat loss never lasts. In this episode of Extend, we sit down with JJ Virgin, triple board certified nutrition expert and Fitness Hall of Famer, to unpack why muscle, not weight loss, is the true driver of metabolic health and longevity. We break down why calorie counting and macro percentages fail, how protein first nutrition reshapes metabolism,

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01:06:49

138. Dr. Idrees Mughal: Why Most Viral Health Claims...

Extend Podcast with Darshan Shah, MD ·

2026/02/12

Most people assume viral health advice is backed by solid science. What if much of it is built on cherry-picked studies, misleading mechanisms, and narratives designed to sell certainty rather than protect long-term health. In this episode of Extend, we sit down with Dr. Idrees Mughal, UK-trained medical doctor and nutrition researcher, to unpack why so many viral health and nutrition claims fail under real scientific scrutiny. We break down how influencers misuse studies, why single papers rarely

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46:26

137. Ariana Thacker: Mold Toxicity, Treatment...

Extend Podcast with Darshan Shah, MD ·

2026/02/10

Most people assume mold exposure causes allergies or respiratory issues. What if it is actually driving chronic inflammation, hormone disruption, and neurological symptoms that standard labs fail to detect. In this episode of Extend, we sit down with Ariana Thacker, founder and CEO of Moldco, to uncover how mold toxicity operates as a systemic, cellular-level illness and why so many patients are misdiagnosed or dismissed. We break down how mold impacts mitochondrial energy, immune signaling, gut

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01:08:53

136. Dr. Goodenowe: Plasmalogens and the Hidden...

Extend Podcast with Darshan Shah, MD ·

2026/02/05

Most people think brain aging is inevitable. What if the real future of longevity is protecting cellular health long before symptoms appear. In this episode of Extend, we sit down with Dr. Dayan Goodenowe, neuroscientist and biochemist, to explore the hidden role of plasmalogens in brain health, aging, and all-cause mortality. Dr. Goodenowe shares how his work in advanced metabolomics revealed that declining plasmalogen levels can predict dementia, cancer recurrence, and shortened lifespan years

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01:08:05

135. Sarah Ann Macklin: Self-Compassion and...

Extend Podcast with Darshan Shah, MD ·

2026/02/03

Most people know what they should do to be healthy, yet still struggle to follow through. What if the real barrier is not discipline or knowledge, but mindset. In this episode of Extend, we sit down with Sarah Ann Macklin, a nutritionist and health educator who blends nutrition science with psychology and self-compassion. Sarah shares her journey from high fashion modeling to nutritional science, and how burnout, illness, and neurodiversity shaped her approach to sustainable health. We explore why

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51:02

134. Dr. Jessica Shepherd: Stop the Decline:...

Extend Podcast with Darshan Shah, MD ·

2026/01/29

Most people assume losing strength, energy, and bone health is inevitable as we age. But what if maintaining muscle, optimizing hormones, and protecting bone density were about targeting the right systems early rather than treating symptoms later? In this episode of Extend, we sit down with Dr. Jessica Shepherd, a board-certified OB/GYN and expert in midlife health and longevity. With years of experience merging clinical medicine with functional approaches, Dr. Shepherd shares how resistance

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01:02:18

133. Dr. Abid Husain: The Hidden Drivers of Heart...

Extend Podcast with Darshan Shah, MD ·

2026/01/27

Most people focus on cholesterol and plaque when thinking about heart health. The truth is, there are hidden drivers that can silently damage your arteries and increase cardiovascular risk. In this episode of Extend, we sit down with Dr. Abid Husain, cardiologist and expert in cardiometabolic health, to unpack how microvascular dysfunction, glycocalyx degradation, metabolic disease, and mental stress contribute to heart disease beyond traditional risk factors. We break down the role of nitric oxide,

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49:58

132. Nathalie Niddam: Reverse Aging Signals with...

Extend Podcast with Darshan Shah, MD ·

2026/01/22

Most people assume fatigue, low energy, and age-related decline are unavoidable. What if supporting your body, optimizing recovery, and enhancing longevity were about activating the right systems, rather than chasing symptoms? In this episode of Extend, we sit down with Nathalie Niddam, holistic nutritionist, longevity educator, and host of the Longevity Podcast with Nathalie Niddam, to unpack how bioregulators, mitochondrial peptides, and targeted nutritional strategies can support cellular health,

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01:04:27

131. Dr. Elizabeth Yurth: The Science of Ketones,...

Extend Podcast with Darshan Shah, MD ·

2026/01/20

Most people assume joint pain, fatigue, and limited mobility are inevitable with age. But what if protecting your joints, optimizing recovery, and maintaining energy were about targeting the right systems early, rather than treating symptoms later? In this episode of Extend, we sit down with Dr. Elizabeth Yurth, co-founder and chief medical officer of the Boulder Longevity Institute and a Stanford-trained sports and spine physician. With over 30 years of experience merging orthopedic expertise with

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25:39

130. Smarter Drinking: Cut Alcohol Without Sacrifice

Extend Podcast with Darshan Shah, MD ·

2026/01/15

How much control do you really have over your alcohol consumption and its effects on your health? Many people assume drinking is just part of social life, but science shows there are practical steps to reduce intake while still enjoying your routine. In this solo episode of Extend, Dr. Darshan Shah, longevity expert and founder of Next Health, breaks down why smarter drinking is a key strategy for improving sleep, metabolism, and long-term wellbeing. He explains how alcohol impacts the body, from

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01:01:48

129. Ashley Koff: The GLP-1 Conversation Most People...

Extend Podcast with Darshan Shah, MD ·

2026/01/13

Most people think weight loss is about discipline, calories, or finding the right medication. But what if the real issue is that we've misunderstood how hormones, digestion, and recovery actually regulate metabolism in the first place? In this episode of Extend, we sit down with registered dietitian Ashley Koff to unpack what GLP-1 medications are really doing in the body and why bariatric surgery revealed metabolic changes long before significant weight loss ever occurred. We explore incretin

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20:45

128. Hidden Environmental Toxins Are Destroying Your...

Extend Podcast with Darshan Shah, MD ·

2026/01/08

How much control do you actually have over the toxins in your daily environment? Most people assume chemical exposure is unavoidable, but the science shows there are practical steps that can significantly reduce your toxic load. In this solo episode, we break down why environmental detoxification is a key strategy for protecting your long-term health and longevity. We walk you through the main sources of exposure, from household cleaners and cookware to synthetic fragrances and clothing materials

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01:12:48

127. Allison Evans: Hidden Household Toxins That Are...

Extend Podcast with Darshan Shah, MD ·

2026/01/06

Toxin exposure rarely announces itself loudly, yet it quietly shapes hormone balance, immune resilience, mood, and neurological health long before a diagnosis appears. The real tension lies in the fact that these exposures are largely invisible, normalized, and happening inside the very spaces meant to keep us safe. We dive deeper into this in the Extend podcast with Allison Evans. We also chat about the "toxic bucket" concept, why synthetic fragrance and harsh disinfectants can act as endocrine

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28:42

126. How to Fix Your Metabolic Health at Any Age

Extend Podcast with Darshan Shah, MD ·

2026/01/01

Most people think they're doing "enough" for their health, yet nearly 90% of Americans are metabolically unhealthy and don't know it. In this episode, I challenge outdated metrics like BMI, explain why sleep quality matters more than hours slept, and break down what actually moves the needle when it comes to long-term health. In this solo episode of EXTEND, I outline my five core health frameworks for 2026. I also walk through what it means to become the CEO of your own health, how to use simple

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46:06

125. Best of Mental Health: The Foundation of Brain...

Extend Podcast with Darshan Shah, MD ·

2025/12/30

Mental health is shaped by how well the brain produces energy, how well the nervous system remains under stress, and how effectively the mind adapts over time. When these systems begin to break down, problems often appear years before a diagnosis, showing up as anxiety, brain fog, distraction, burnout, or emotional dysregulation that are frequently treated in isolation. This is a special Best Of episode of Extend, where I've compiled the most important insights from conversations with leaders

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145 results

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