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PODCAST

Extend Podcast with Darshan Shah, MD

Darshan Shah, MD

Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health

health & fitness medicine

All Episodes

53:48

206. Dr. Pamela Smith: The Truth About Hormone...

Extend Podcast with Darshan Shah, MD ·

2026/10/08

Hormones influence far more than reproductive health. They affect your sleep, mood, metabolism, muscle, bone health, brain function, stress response, and how you age—yet hormone health is still often reduced to a handful of numbers on a standard blood test. In this episode, I'm joined by Dr. Pamela Smith, a physician who has spent decades practicing and teaching personalized medicine, to break down what women and men need to understand about hormone replacement therapy, healthy aging, and disease

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01:03:27

205. Rajeev Kapur: How AI Is Transforming Healthcare

Extend Podcast with Darshan Shah, MD ·

2026/10/06

What if AI could change the way we understand, manage, and optimize our health? In today's episode, my guest is Rajeev Kapur, a leading AI advisor, educator, speaker, and author who helps non technical leaders understand how to turn artificial intelligence into practical, actionable results. We dive into AI in healthcare, personalized health, health optimization, and the ideas behind our co authored book, Your New Health OS. We explore how artificial intelligence could help move healthcare beyond

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55:47

204. Dr. Cassie Smith: Fix Your Gut, Fix Your...

Extend Podcast with Darshan Shah, MD ·

2026/10/01

What if your gut health is the missing piece behing your hormones, energy, metabolism, and how you feel every day? Today, I sit down with Dr. Cassie Smith, a double board-certiied endocrinologist and internal medicine physician who has taken a deeper look at the connection between gut health, hormones, thryoid function, metabolism, and overall health. We talk about why "normal" lab results don't always mean optimal health, how gut health can influence hormone metabolism, the role of stress and

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01:10:41

203. Sat Randhawa: Can You Train Your Brain? QEEG &...

Extend Podcast with Darshan Shah, MD ·

2026/09/29

What if we stopped guessing about the brain and started measuring it? In today's episode, my guest is Sat Randhawa of One-Hype Wellness, where he and his team are focused on using brain mapping and neurotechnology to better understand how each individual brain functions. We dive into QEEG brain mapping, neurofeedback, neuroplasticity, and brainwave analysis - and explore why there may not be a one-size-fits-all approach when it comes to the brain. Sat also shares insights into how technology is

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52:58

202. Dr. Colleen Cutcliffe: The Fiber-Gut Connection:...

Extend Podcast with Darshan Shah, MD ·

2026/09/24

Most people know they should eat more fiber. But what we're learning about fiber, gut health, and the microbiome goes far beyond digestion. Your gut contains trillions of microbes that depend on what you eat—and different types of fiber feed different bacteria. Those microbes can influence everything from blood sugar regulation and metabolic health to cholesterol and the way your digestive system functions. That means it's not just about getting more fiber. The diversity of the fiber you eat

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01:23:25

201: Joey Munoz: The Truth About Nutrition, Protein,...

Extend Podcast with Darshan Shah, MD ·

2026/09/22

What if the biggest mistake you're making with your health isn't what you're eating - but the way you're thinking about nutrition in the first place? In this episode, I'm joined by Dr. Joey Munoz, a PhD in Nutrition Science and an evidence-based nutrition and fitness educator. We have a fascinating conversation about why so many traditional approaches to dieting fail, what actually makes a healthy diet sustainablem, and how we can thing about nutrition in a way that supports long-term health rather

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01:09:59

200. Dr. Will Cole: How to Heal Your...

Extend Podcast with Darshan Shah, MD ·

2026/09/17

What if the fatigue, brain fog, low energy, and other symptoms we associate with getting older actually begin much deeper—at the level of our cells? I've followed Dr. Will Cole's work for years, and his approach to gut health and functional medicine played an important role in my own health journey. Now he's taking that conversation one step further with his new book, Heal Your Cells, exploring what's happening inside our cells as we age—and what we can do to support them. In this conversation, we

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01:10:25

199. Dr. Jeffrey Wiegers: Stem Cells Explained—What...

Extend Podcast with Darshan Shah, MD ·

2026/09/15

What if medicine could do more than manage disease—and actually help the body repair itself? Regenerative medicine is moving quickly, but the world of stem cells, PRP, exosomes, and cellular therapies can be incredibly confusing. In this conversation, I sit down with Dr. Wiggers to separate what we can do today from what may be coming next. We start with the basics: what stem cells actually are, how PRP and orthobiologics work, and the difference between using your own cells versus donor-derived

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58:59

198. Dr. Bryce Appelbaum: Your Eyes Are Connected to...

Extend Podcast with Darshan Shah, MD ·

2026/09/10

What if your eyesight is 20/20—but your vision still isn't working the way it should? Dr. Bryce Appelbaum specializes in functional vision and the connection between the eyes and the brain. In this conversation, he explains why seeing clearly is only one piece of vision—and how the brain's ability to process what we see can influence reading, focus, coordination, balance, motion sickness, athletic performance, and everyday life. We also explore what hours of daily screen time may be doing to our

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57:56

197. Ben Greenfield: When Biohacking Goes Too...

Extend Podcast with Darshan Shah, MD ·

2026/09/08

What happens when optimizing your health starts taking over your life? Ben Greenfield has spent decades at the forefront of biohacking, fitness, human performance, and longevity—testing the technologies, tracking the biomarkers, competing at an elite level, and pushing his body to its limits. But after years of relentless self-optimization, he realized something important: living longer means very little if the pursuit of longevity takes you away from the people and experiences you're trying to live

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54:09

196: Dr. Jill Carnahan: Is Mold Making You Sick?...

Extend Podcast with Darshan Shah, MD ·

2026/09/03

What if the fatigue, brain fog, inflammation, or unexplained symptoms you're experiencing aren't starting inside your body—but in the environment around you? Dr. Jill Carnahan knows this story from both sides of the exam room. At just 25, while still in medical school, she was diagnosed with breast cancer. Months after aggressive chemotherapy, she was diagnosed with Crohn's disease. Her search for answers ultimately transformed the way she practiced medicine and led her deep into the connections

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01:20:27

195: Jeff Byers: Inside the Supplement Industry: The...

Extend Podcast with Darshan Shah, MD ·

2026/09/01

Walk into any supplement aisle—or scroll through social media—and you'll find thousands of products promising better energy, performance, brain health, and longevity. But which supplements actually work? And how do you know what's really inside them? My guest is Jeff Byers, a former NFL athlete and the co-founder of Momentous, a performance nutrition company built around rigorous standards for supplement quality, sourcing, testing, and efficacy. His path into health and performance started long

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58:33

194: Dr. Mark Hyman: Why You're Still Sick—Finding...

Extend Podcast with Darshan Shah, MD ·

2026/08/27

What if the reason you're still sick isn't because there's no answer—but because no one has looked deeply enough for the root cause? My guest, Dr. Mark Hyman, is one of the world's leading voices in functional medicine, a bestselling author, physician, and founder of The UltraWellness Center. After navigating serious health challenges himself, he built his career around a different approach to chronic illness: stop simply naming the disease and start asking why it happened in the first place. We

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50:37

193: Dr. Sasha Hamdani: ADHD, Anxiety and How to...

Extend Podcast with Darshan Shah, MD ·

2026/08/25

What if ADHD isn't just an attention problem—but also a problem of emotional regulation? My guest, Dr. Sasha Hamdani, is a board-certified psychiatrist, ADHD specialist, author, and someone who has lived with ADHD herself. She brings a unique perspective to a part of ADHD that often gets overlooked: emotional sensitivity. We explore why some people feel emotions faster, more deeply, and for longer—and what's actually happening in the brain when a small trigger sends you into an emotional spiral. Dr

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01:09:12

192: Dr. Perlmutter: How to Protect Your Brain From...

Extend Podcast with Darshan Shah, MD ·

2026/08/20

What if your risk of Alzheimer's isn't predetermined by your genes—but influenced by the metabolic health of your brain? My guest, Dr. David Perlmutter, is a board-certified neurologist, six-time New York Times bestselling author, and one of the world's leading voices on brain health and neurodegenerative disease. His latest work reveals a fascinating shift in how we understand Alzheimer's and Parkinson's: the role of the brain's own immune cells. At the center of our conversation are

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01:11:52

191: Kiran Krishnan: How to Rebuild Your Gut...

Extend Podcast with Darshan Shah, MD ·

2026/08/18

What if the biggest mistake we're making with gut health is treating the microbiome like a list of bacteria instead of a living ecosystem? Your gut is home to trillions of microorganisms that influence inflammation, metabolism, immune function, hormones, brain health, and longevity. But modern life—from ultra-processed foods and antibiotics to pesticides, chronic stress, and inadequate fiber—may be systematically stripping away the microbial diversity we need to stay healthy. My guest, Kiran

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58:00

190. Dr. William Harris: 90% of Americans Are Low in...

Extend Podcast with Darshan Shah, MD ·

2026/08/13

What if one of the most important markers for your heart, brain, and longevity is something most people have never measured? AND roughly 90% of Americans aren't in the optimal range for? In this episode, I sit down with Dr. William Harris, one of the world's leading experts on Omega-3 fatty acids and the co-inventor of the Omega-3 Index, a test he helped develop more than 20 years ago. Dr. Harris has spent decades researching how omega-3s influence cardiovascular health, inflammation, cognitive

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35:34

189. Dr. Florence Comite: The 5 Biomarkers That...

Extend Podcast with Darshan Shah, MD ·

2026/08/11

What if aging isn't something you simply accept - but something you can measure, predict, and even reverse? Most of us are told our lab work is "normal," yet chronic disease often develops silently for years before symptoms appear. Dr. Florence Comite, one of the world's leading pioneers in precision medicine, is explaining why conventional medicine often misses the earliest signs of diesease- and how personalized data can completely change your health trajectory. Drawing from more than three

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01:06:57

188. James Beshara: How to Find Productivity Without...

Extend Podcast with Darshan Shah, MD ·

2026/08/06

We're living in a culture that celebrates being busy. More coffee. More hours. More hustle. But what if those things are actually making you less productive? The truth is, many high performers are stuck in a cycle of chasing energy instead of creating it. We rely on caffeine to wake up, push through stress, and squeeze more into each day - only to end up burned out, distracted, and wondering why success still feels exhausting. My guest James Beshara, is an entrepreneur, angel investor, and founder

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59:28

187. Dr. Izabella Wentz: 30+ Root Causes Behind An...

Extend Podcast with Darshan Shah, MD ·

2026/08/04

Hashimotos isn't just a thyroid disease-it may actually begin in the gut. If you've been told your thyroid labs are "normal" but you still struggle with fatigue, bloating, constipation, IBS, or autoimmune symptoms, this episode could change the way you think about your health. I sit down with Dr. Izabella Wentz, PharmD-better known as the Thyroid Pharmacist and one of the world's leading experts on Hashimoto's disease - to uncover the powerful connection between gut health, autoimmune disease, and

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