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PODCAST

Extend Podcast with Darshan Shah, MD

Darshan Shah, MD

Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health

health & fitness medicine

All Episodes

01:01:48

129. Ashley Koff: The GLP-1 Conversation Most People...

Extend Podcast with Darshan Shah, MD ·

2026/01/13

Most people think weight loss is about discipline, calories, or finding the right medication. But what if the real issue is that we've misunderstood how hormones, digestion, and recovery actually regulate metabolism in the first place? In this episode of Extend, we sit down with registered dietitian Ashley Koff to unpack what GLP-1 medications are really doing in the body and why bariatric surgery revealed metabolic changes long before significant weight loss ever occurred. We explore incretin

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20:45

128. Hidden Environmental Toxins Are Destroying Your...

Extend Podcast with Darshan Shah, MD ·

2026/01/08

How much control do you actually have over the toxins in your daily environment? Most people assume chemical exposure is unavoidable, but the science shows there are practical steps that can significantly reduce your toxic load. In this solo episode, we break down why environmental detoxification is a key strategy for protecting your long-term health and longevity. We walk you through the main sources of exposure, from household cleaners and cookware to synthetic fragrances and clothing materials

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01:12:48

127. Allison Evans: Hidden Household Toxins That Are...

Extend Podcast with Darshan Shah, MD ·

2026/01/06

Toxin exposure rarely announces itself loudly, yet it quietly shapes hormone balance, immune resilience, mood, and neurological health long before a diagnosis appears. The real tension lies in the fact that these exposures are largely invisible, normalized, and happening inside the very spaces meant to keep us safe. We dive deeper into this in the Extend podcast with Allison Evans. We also chat about the "toxic bucket" concept, why synthetic fragrance and harsh disinfectants can act as endocrine

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28:42

126. How to Fix Your Metabolic Health at Any Age

Extend Podcast with Darshan Shah, MD ·

2026/01/01

Most people think they're doing "enough" for their health, yet nearly 90% of Americans are metabolically unhealthy and don't know it. In this episode, I challenge outdated metrics like BMI, explain why sleep quality matters more than hours slept, and break down what actually moves the needle when it comes to long-term health. In this solo episode of EXTEND, I outline my five core health frameworks for 2026. I also walk through what it means to become the CEO of your own health, how to use simple

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46:06

125. Best of Mental Health: The Foundation of Brain...

Extend Podcast with Darshan Shah, MD ·

2025/12/30

Mental health is shaped by how well the brain produces energy, how well the nervous system remains under stress, and how effectively the mind adapts over time. When these systems begin to break down, problems often appear years before a diagnosis, showing up as anxiety, brain fog, distraction, burnout, or emotional dysregulation that are frequently treated in isolation. This is a special Best Of episode of Extend, where I've compiled the most important insights from conversations with leaders

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31:01

124. Best of Strength Training: Why Strength...

Extend Podcast with Darshan Shah, MD ·

2025/12/25

Over the past year on Extend, I've had powerful conversations with experts who all kept pointing back to the same foundation: strength training. So in this episode, I'm bringing together a Best Of compilation featuring key moments from Andy Galpin, Vonda Wright, JJ Virgin, Louisa Nicola, and Kelly and Juliet Starrett to highlight why strength matters far beyond the gym. This episode explores strength training from every angle that truly impacts longevity. I break down why muscle is a metabolic

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23:36

123. Best of Metabolic Health: Why Metabolic Health...

Extend Podcast with Darshan Shah, MD ·

2025/12/23

Metabolic health is the foundation that determines how your body produces energy, manages inflammation, regulates hormones, and protects you from chronic disease. When it breaks down, problems show up years later, long after the real warning signs were missed. This is a special Best Of episode of Extend, where I've compiled the most important insights from conversations with leaders in metabolic health and longevity, including Cynthia Thurlow, Ben Azadi, Dr. Mark Hyman, Casey Means, Josh Clemente,

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01:18:53

122. Dr. Mayim Bialik on Stress, Mental Health, and...

Extend Podcast with Darshan Shah, MD ·

2025/12/18

What if the stress you feel every day is not a personal failure, but a biological response to how modern life pulls at your nervous system? In this episode, I sit down with Dr. Mayim Bialik to explore why so many people feel overwhelmed, distracted, and disconnected, even when they are doing everything they were told should make them happy. We talk about how stress lives in the body, how technology quietly rewires attention and dopamine, and why mental health cannot be separated from gut health,

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36:16

121. How to Protect Your Brain at Every Age

Extend Podcast with Darshan Shah, MD ·

2025/12/16

How much control do you actually have over how your brain ages? Most people assume memory loss and cognitive decline are inevitable, but the science tells a very different story. In this solo episode, I break down why brain health is something you can actively protect decades before symptoms ever appear. I walk you through the core systems that shape how your brain functions over time, from blood sugar regulation and inflammation to sleep, stress, circulation, and daily movement. We explore how

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45:55

120. Jess Kane: Your Cells Are Leaking, Here's How to...

Extend Podcast with Darshan Shah, MD ·

2025/12/11

Have you ever wondered why you can be "doing everything right" with your health and still feel inflamed, foggy, or depleted? The more I study longevity, the more I am convinced this has less to do with the latest hack and more to do with something very basic that we almost never talk about: the integrity of the cell membrane. Every process in the human body begins at the level of the cell membrane, and in today's world, that membrane is under constant attack from toxins, infections, chemicals, and

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01:00:40

119. Dr. Rocio Salas Whalen: How To Lose Weight On...

Extend Podcast with Darshan Shah, MD ·

2025/12/09

Most people still think GLP-1s are "weight loss shots," but what we are really doing is changing biology at the level of appetite and inflammation, with ripple effects across future generations. In this conversation, I sit down with endocrinologist and obesity specialist Dr. Rocio Salas Whalen to unpack what these medications do inside the body and how to use them responsibly as part of a long-term health strategy. We get into why "eat less, exercise more" failed so many patients, how family

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54:37

118. Dr. Suzanne Steinbaum: A New Roadmap to Female...

Extend Podcast with Darshan Shah, MD ·

2025/12/04

Most people think heart disease is obvious and predictable, yet women often present with completely different warning signs that traditional testing fails to catch. We now have the tools to identify risk decades earlier and reverse disease before it becomes dangerous. In this episode of Extend, we sit down with Dr. Suzanne Steinbaum, cardiologist and leading voice in women's cardiovascular prevention, to uncover why standard testing misses female heart disease, how microvascular dysfunction develops

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01:11:13

117. Dr. Steven Gundry: The Microbiome War Shaping...

Extend Podcast with Darshan Shah, MD ·

2025/12/02

Most people think about the gut as a digestive system, yet emerging research shows it functions more like a command center shaping immunity, metabolism, mood, and even coronary artery calcification. The surprising twist is that your gut may be influencing your brain more than your brain influences your gut. In this episode of Extend, we sit down with Dr. Steven Gundry, cardiac surgeon and world leading expert on the microbiome, to uncover how gut bacteria communicate with your mitochondria and

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47:40

116. Dr. Stephanie Venn-Watson: The New Essential...

Extend Podcast with Darshan Shah, MD ·

2025/11/27

Most people hear "saturated fat" and think of something harmful, yet emerging research reveals that one specific fatty acid supports stronger cell membranes, healthier metabolic function, and better long-term resilience. C15 plays a unique role in the biology of aging and may help explain why certain populations experience longer, healthier lives. In this episode of Extend, we sit down with Dr. Stephanie Venn-Watson, veterinary epidemiologist and co-founder of Fatty15, to uncover how Navy dolphin

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01:06:17

115. Dr. Shivani Gupta: Heal Inflammation Through...

Extend Podcast with Darshan Shah, MD ·

2025/11/25

Most of us think inflammation is something we can fix with supplements, lab tests, or the latest diet trend. But what if the real solution comes from ancient wisdom that modern science is finally catching up to? In this episode of Extend, we sit down with Dr. Shivani Gupta, Ayurvedic practitioner, author, and founder of Fusionary Formulas, to explore how Ayurveda bridges timeless principles with modern longevity science. We break down how your dosha or "elemental design" shapes digestion, energy,

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44:50

114. Julia Putzeys: The App That Decodes Your Food Lies

Extend Podcast with Darshan Shah, MD ·

2025/11/20

Most of us grew up thinking anything sold at the grocery store was safe to eat. But behind every "heart healthy," "high protein," or "low fat" label lies a different truth one built on ultra-processed ingredients, chemical additives, and marketing tricks. In this episode of Extend, we sit down with Julia Putzeys, founder of the Trash Panda App, to uncover what's really in our food and how to make smarter choices that protect our long-term health. We break down what defines an ultra-processed food,

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01:12:09

113. Dr. Karan Rajan: Why Gut Health Shapes Your...

Extend Podcast with Darshan Shah, MD ·

2025/11/18

You can eat healthy, exercise daily, and still struggle with fatigue, inflammation, or brain fog. Why? Because every system in your body is connected. The gut, brain, and immune system are constantly communicating, and most health plans ignore that network. In this episode of Extend, I sit down with Dr. Karan Rajan to explore how the gut microbiome shapes everything from digestion and immunity to mood, skin, and longevity. We unpack the science behind leaky gut, fiber diversity, fermented foods, and

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01:29:14

112. Josh Clemente: Why Energy Crashes Keep Happening...

Extend Podcast with Darshan Shah, MD ·

2025/11/13

What if the future of medicine isn't about diagnosing disease, but preventing it entirely? For decades, our healthcare system has only reacted once things go wrong. We measure when there are symptoms. We intervene when there is a crisis. But what if we could see the shift before it becomes an illness? In this episode of EXTEND, I'm joined by Josh Clemente, founder of Levels and former SpaceX engineer, to explore how continuous health monitoring is about to change human health at scale. Josh shares

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01:14:50

111. Dr. Amir Vookshoor: Neurosurgeon Secrets For...

Extend Podcast with Darshan Shah, MD ·

2025/11/11

What if the real key to longevity has nothing to do with your workouts or supplements, but with how well your brain is wired to adapt, repair, and thrive? In this episode of EXTEND, I sit down with Dr. Amir Vookshoor, a board-certified neurosurgeon and founder of NeuroVella Brain Spa, to explore how modern neuroscience and biohacking are merging to shape the future of brain health. We dive into how trauma, inflammation, and stress rewire the nervous system and how to reset it. From neurofeedback and

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01:30:36

110. Dr. Josh Axe: The Hidden Connection Between...

Extend Podcast with Darshan Shah, MD ·

2025/11/06

What if the key to living longer and feeling younger has been hidden in ancient medicine all along? Long before supplements, peptides, or wearables, healing was about restoring balance through food, movement, belief, and nature. Today, those same principles are being shown by modern science to protect your cells, extend your healthspan, and reverse root causes of disease. In this episode of EXTEND, I'm joined by Dr. Josh Axe and we explore how ancient healing systems like Ayurveda and Traditional

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