MRC CTU Podcasts

00:30:01

PediCAP trial: Optimising treatment for children with...

MRC CTU Podcasts ·

2026/07/24

Children with community-acquired pneumonia are usually treated with an injectable antibiotic for five days. This often means staying in hospital for the full treatment period, even when they are well enough to go home earlier.The PediCAP trial tested a new approach designed to help children return home sooner while continuing to receive safe and effective care. In this episode, PediCAP team members Hilda Mujuru, Julia Bielicki and Michelle Clements discuss why the trial was needed, explain its

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00:25:46

The ACORD collaboration: Innovative Clinical Trials...

MRC CTU Podcasts ·

2026/06/30

ACORD is a pioneering collaboration that brings together experts from a wide range of disciplines to accelerate the development of treatments for neurodegenerative diseases. In this episode, we explore how ACORD works in practice, the innovative methodologies that underpin it, including the multi-arm, multi-stage trial design, and the opportunities it creates for researchers at different stages of their careers. We speak with James Carpenter, one of ACORD’s founders, and Ed Jabbari, an ACORD Fellow,

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00:25:09

International Clinical Trials Methodology Conference...

MRC CTU Podcasts ·

2024/10/30

At the start of October, lots of the Unit’s clinical trials methodology researchers travelled to Edinburgh, for the 7th International Clinical Trials Methodology Conference (ICTMC).ICTMC is the largest academic-led conference on clinical trials, bringing together trialists from across the globe to present their latest work in trials methodology. This year's conference featured a wide variety of workshops, talks and poster presentations from MRC Clinical Trials Unit researchers. In this latest

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00:26:57

Lessons from UKCTOCS, a large-scale trial in ovarian...

MRC CTU Podcasts ·

2024/02/05

UKCTOCS (UK Collaborative Trial of Ovarian Cancer Screening) is one of the largest screening trials in ovarian cancer. More than 200,000 women from England, Wales and Northern Ireland took part in it, and it ran for almost two decades. Designing and running such a large and lengthy trial came with its own challenges. In this episode, Professor Usha Menon discusses the key challenges that UKCTOCS faced in its design, conduct an analysis, and how the team addressed them.Further information is

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00:28:56

Careers in TB trials with Andrew Nunn and Sarah Meredith

MRC CTU Podcasts ·

2024/01/26

In the first episode of our new Trial Talk series, Hanif Esmail and Conor Tweed take over the microphones to interview Andrew Nunn and Sarah Meredith, who have both recently retired from the Unit, having spent a combined total of 92 years working in the field of tuberculosis (TB). As we celebrate Andrew and Sarah’s long and accomplished careers, we’ll dive into the history of TB clinical trials and muse on the future of TB research. For more information and to access the transcript:

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00:19:01

World AIDS Day (part 2): Bringing hope through...

MRC CTU Podcasts ·

2023/12/01

Every year on 1st December, we mark World AIDS Day to show solidarity in the fight against HIV and AIDS, and to remember those who have sadly lost their lives. Since the start of the global AIDS epidemic in the 1980s, researchers have made enormous progress towards preventing HIV transmission, and treating those who are living with HIV so that the virus remains suppressed. But while there have been marked improvements for adults, treatment coverage in children and adolescents is lagging behind

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00:24:04

World AIDS Day (part 1): Closing the gap between...

MRC CTU Podcasts ·

2023/12/01

Every year on 1st December, we mark World AIDS Day to show solidarity in the fight against HIV and AIDS, and to remember those who have sadly lost their lives. Since the start of the global AIDS epidemic in the 1980s, researchers have made enormous progress towards preventing HIV transmission, and treating those who are living with HIV so that the virus remains suppressed. But while there have been marked improvements for adults, treatment coverage in children and adolescents is lagging behind.

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00:20:02

Octopus (part 4): Involvement of people affected by...

MRC CTU Podcasts ·

2023/11/09

Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recruiting participants for the next few years. The podcast mini-series will explore the trial from different perspectives by talking to neurologists, MS

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00:24:04

Octopus (part 3): The patients’ experience with Dawn...

MRC CTU Podcasts ·

2023/11/02

Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recruiting participants for the next few years. The podcast mini-series will explore the trial from different perspectives by talking to neurologists, MS

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00:24:10

Octopus (part 2): Introducing the trial with Jeremy...

MRC CTU Podcasts ·

2023/10/26

Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC Clinical Trials Unit at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recruiting participants for the next few years. The podcast mini-series will explore the trial from different perspectives by talking to neurologists, MS

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00:17:20

Octopus (part 1): The MS landscape with Jeremy...

MRC CTU Podcasts ·

2023/10/19

Octopus is a new clinical trial for people living with progressive multiple sclerosis (MS), which is designed and run by the MRC CTU at UCL. Thanks to its multi-arm multi-stage platform design, Octopus has the potential to transform the way treatments for progressive MS are tested. The trial is now open in the UK and will be recruiting participants for the next few years. The podcast mini-series will explore the trial from different perspectives by talking to neurologists, MS experts and people

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00:24:28

Optimising treatments with the new MAMS-ROCI design

MRC CTU Podcasts ·

2023/09/21

Innovative platform designs present an opportunity to run faster and more efficient clinical trials. Clinical trials methodology is a research area that looks at how to improve the design, conduct, and analysis of clinical trials. It focuses on developing and implementing new methods to help run trials faster and more efficiently, that will ultimately accelerate the discovery of new treatments. In this episode, methodologist Matteo Quartagno tells us about a new clinical trial design called

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00:23:23

STAMPEDE (part 3): Impact and legacy with Max Parmar...

MRC CTU Podcasts ·

2023/08/24

STAMPEDE is a long-running trial in advanced prostate cancer, in which nearly 12,000 men have taken part. Thanks to its multi-arm multi-stage platform design, STAMPEDE has tested many different treatments and directly led to improvements in the standard of prostate cancer care several times. This Trial Talk podcast mini-series will explore the trial’s journey from its inception in the early 2000s to the end of patient recruitment in March 2023. In the final part, Max Parmar and Nick James look

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00:18:00

STAMPEDE (part 2): The role of the patient voice with...

MRC CTU Podcasts ·

2023/08/17

STAMPEDE is a long-running trial in advanced prostate cancer, in which nearly 12,000 men have taken part. Thanks to its multi-arm multi-stage platform design, STAMPEDE has tested many different treatments and directly led to improvements in the standard of prostate cancer care several times. This Trial Talk podcast mini-series will explore the trial’s journey from its inception in the early 2000s to the end of patient recruitment in March 2023. Part 2 is about patient and public involvement

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00:18:03

STAMPEDE (part 1): A new era for prostate cancer...

MRC CTU Podcasts ·

2023/08/10

STAMPEDE is a long-running trial in advanced prostate cancer, in which nearly 12,000 men have taken part. Thanks to its multi-arm multi-stage platform design, STAMPEDE has tested many different treatments and directly led to improvements in the standard of prostate cancer care several times. This Trial Talk podcast mini-series will explore the trial’s journey from its inception in the early 2000s to the end of patient recruitment in March 2023. Part 1 covers the landscape of prostate cancer

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00:16:57

The REFINE trial: How can we improve the way we give...

MRC CTU Podcasts ·

2023/07/18

Immunotherapy drugs fight cancer by helping the immune system recognise and attack cancer cells. These drugs have revolutionised cancer treatment over the last decade, improving survival for many people with different types of cancer. However, researchers are still unsure of the best way to give immunotherapy, which can come with unpredictable side effects. In this episode, Clinical Fellow Sophie Merrick discusses how the REFINE trial hopes to address this problem, by testing if giving

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00:25:39

How can clinical trials make the most of healthcare...

MRC CTU Podcasts ·

2023/06/26

Running a clinical trial means collecting a lot of data from the trial participants. But some of this data might be collected and stored in healthcare systems, as well as in clinical trial case report forms. What if we could avoid this doubling up, save time and resources, improve recruitment and reduce missing data? In this episode we explore the opportunities and challenges of using healthcare systems data in clinical trials, with Dr Macey Murray and Professor Matt Sydes. Resources:

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00:21:13

Neonatal infections (part 2): How the NeoSep1 trial...

MRC CTU Podcasts ·

2023/06/09

Neonatal sepsis is a life-threatening infection that affects up to 3 million babies per year globally. In an effort to identify better treatments, the NeoSep1 clinical trial evaluates new antibiotic combinations for newborn babies with sepsis. To learn more about the trial, we speak to Adrie Bekker and Cristina Obiero, principal investigators of the trial in South Africa and Kenya, Reenu Thomas, a neonatologist from South Africa, and Francesca Schiavone, the clinical project manager of the NeoSep1

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00:23:52

Neonatal infections (part 1): The NeoOBS study and...

MRC CTU Podcasts ·

2023/05/22

214,000 newborn babies die of sepsis caused by infections that are resistant to antibiotics every year. This is a major problem worldwide, but disproportionally affects low- and middle- income countries. Reenu Thomas and Adrie Bekker, two neonatologists from South Africa, and Francesca Schiavone, clinical project manager at the MRC CTU at UCL in London, discuss the challenges of treating neonatal sepsis and present the results from an observational study (NeoOBS), which assessed mortality rates of

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00:19:59

The STREAM2 trial: How should we treat multi-drug...

MRC CTU Podcasts ·

2023/03/24

For World TB Day, this episode explores the global burden of tuberculosis (TB) and how growing antibiotic resistance can complicate treatment options. Andrew Nunn, a Professor of Epidemiology, discusses his work on the STREAM2 trial, which investigated how treatment for multi-drug resistant TB could be shortened and made more acceptable for patients. Further information is available on the STREAM Stage 2 study page at www.mrcctu.ac.uk and results from STREAM2 are published open access in The

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