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Weight Loss And ...

Holly Wyatt & James Hill

Your go-to hangout for everything weight loss… and beyond! “Weight Loss and…” is brought to you by the University of Alabama at Birmingham (UAB) and hosted by seasoned experts in weight management, Dr. James Hill and Dr. Holly Wyatt. We’re your friendly guides through the maze of weight loss, but with a fun twist. We’re not here to preach the latest fad diet or promise a miracle workout. Instead, we’re all about embracing the journey, acknowledging there’s more than one way to hit your health

health & fitness nutrition

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45:39

Losing Weight on GLP-1s: Are You Moving More or Less...

Weight Loss And ... ·

2026/09/30

If losing weight made movement easier, wouldn’t you naturally start moving more? It’s the kind of assumption that feels almost too obvious to question: shed 40 or 50 pounds, and your knees stop aching, the stairs get easier, and you’re out there living more. Holly and Jim certainly believed it. But in the age of GLP-1 medications, where rapid, substantial weight loss is now common, does this assumption still hold up?In this episode, Holly and Jim put that belief to the test with real data

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45:20

Are You Eating Healthier While Eating Less on GLP-1...

Weight Loss And ... ·

2026/09/23

Everyone knows GLP-1 medications help people eat less. But does eating less actually mean eating better? It’s a question the weight loss field never really had to ask before, and the answer might surprise you.Join Holly and Jim as they dig into three GLP-1 studies looking at what people are actually eating. You’ll hear the real numbers behind diet quality, protein intake, and nutrient gaps on these medications, plus what it means for anyone currently taking (or considering) a GLP-1. Holly

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47:09

Pop Quiz: What Do You Really Know About Keeping...

Weight Loss And ... ·

2026/09/16

Think you know what it takes to keep weight off? Most people can tell you how to lose weight, but ask them what actually predicts keeping it off, and the answers get shaky fast. That’s a problem, because losing weight and maintaining weight loss are two completely different biological and behavioral games, and confusing the two is one of the biggest reasons people yo-yo.In this episode, Holly and Jim put their listeners to the test literally. They’ve built a 20-question pop quiz covering

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47:20

What Should We Eat? Evolution, Diet, and Eating Well...

Weight Loss And ... ·

2026/09/09

What did humans actually evolve to eat? With paleo, keto, vegan, Mediterranean, and a thousand other diets all claiming to be "the one," it's no wonder people feel whiplashed every time they walk into a grocery store. But what if the answer isn't found in the latest diet book, but in millions of years of human evolution?Join Holly and Jim as they welcome back Harvard evolutionary biologist Dan Lieberman for a second appearance on the show. This time, Dan isn't talking exercise. He's talking

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47:55

Ten Key Decisions That Shape Your Weight Loss Success

Weight Loss And ... ·

2026/09/02

Most people trying to lose weight obsess over the what: what diet, what medication, what workout plan. But according to Holly and Jim, the real key to long-term success isn't found in any of those choices. It's found in a set of decisions most people never even realize they're making.In this episode, Holly and Jim count down the 10 decisions that determine whether a weight loss journey actually sticks. Some are questions you'd expect. Others might catch you completely off guard, including

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46:17

Triple Agonists: Revolutionizing Weight Loss or Too...

Weight Loss And ... ·

2026/08/26

For years, the ceiling on medical weight loss was 15%, maybe 20% if you were lucky. Now a new triple-target medication is posting average results that flirt with 30% body weight loss in clinical trials, numbers once reserved for the operating room. Holly and Jim sat down to unpack what's driving these results, and found themselves asking a question neither expected to ask in their careers: how much weight loss is actually too much?Retatrutide, the drug at the center of this episode, adds a

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40:10

The Power of Mindfulness for Eating Habits and Weight...

Weight Loss And ... ·

2026/08/19

Can simply paying attention to your first bite of food change how much you eat? It sounds too simple to matter, but Holly and Jim are digging into a topic that might seem completely outside their lane: mindfulness and meditation.For years, mindfulness has been filed under "stress management," not "weight management." But a growing body of research is asking a bigger question: can training the mind actually change the way we eat, not by altering our biology, but by changing how we respond to

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46:14

The Five Minute Prescription: Online GLP-1 Meds and...

Weight Loss And ... ·

2026/08/12

A few clicks online. No exam, no phone call, no video visit. Minutes later, a GLP-1 prescription is headed to your door. It sounds like the future of healthcare: fast, easy, convenient. But is convenience the same thing as care?A Yale research team wanted to find out, so they built a fake patient, sent her to 49 different online GLP-1 providers, and tracked exactly what happened. What they found may change the way you think about getting these medications online and raise questions you

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42:39

The New Science of Food Noise and Its Impact on...

Weight Loss And ... ·

2026/08/05

For years, patients kept telling Holly the same strange thing: it wasn't the number on the scale that changed their life, it was something quieter, something they'd never had words for. They just didn't think about food anymore.Now that experience has a name, and for the first time, a way to measure it. Food noise has gone from an offhand comment on social media to one of the most talked-about concepts in obesity science, and Holly and Jim are back to unpack how far the research has come

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46:12

20 Questions That Will Change How You Think About GLP-1s

Weight Loss And ... ·

2026/07/29

GLP-1 medications are the single most requested topic on the show, no contest. But with so much noise on social media, in doctors' offices, and everywhere in between, sorting fact from fiction has never been trickier. Some of what's out there is spot-on. Some of it is dangerously wrong.So this week, Holly and Jim are flipping the format. Instead of another lecture, they're putting GLP-1 knowledge to the test with a 20-question quiz covering everything from the basic biology of these

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54:52

The More You Know, The More You Can Eat with Carolyn...

Weight Loss And ... ·

2026/07/22

We've all felt it: you decide to eat healthier, open social media, and within minutes, you're drowning in contradictory advice. Eggs are back. Butter's healthy. Seed oils are toxic. Never eat after 7pm. Wait, only eat between noon and 6pm? By the end, you're left wondering if anyone can just tell you what to eat.Join Holly and Jim as they sit down with award-winning food journalist and registered dietitian Carolyn O'Neil to unpack why nutrition advice feels so exhausting and contradictory

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50:56

The New Era of Weight Loss and Heart Health with...

Weight Loss And ... ·

2026/07/15

Cancer is the disease most people fear. But heart disease is the one that actually kills the most Americans, and most people never connect it to their weight. For decades, obesity was treated as a bystander to heart disease, a risk factor at best. That thinking has changed dramatically, and the data behind that shift is stunning: we now have a medication proven to cut major cardiovascular events by 20% in people with obesity.Join Holly and Jim as they sit down with an old friend and true

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42:33

How Many Steps Do You Really Need for Health and...

Weight Loss And ... ·

2026/07/08

For decades, one number has ruled the world of fitness: 10,000 steps. It's on your watch, your phone, maybe even tattooed into your daily to-do list. But what if that number was never based on science at all?Join Holly and Jim as they sit down with Dr. Amanda Paluch, Associate Professor of Kinesiology at the University of Massachusetts Amherst and leader of the Steps for Health Collaborative, an international research consortium pooling data from over 125,000 adults to answer one

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52:35

How Hype and Common Sense Shape Our Eating Choices...

Weight Loss And ... ·

2026/07/01

For 40 years, every time nutrition has found a new villain, the food industry has handed us a new label to go with it: non-fat, no GMOs, gluten-free, no seed oils, and now, non-ultra-processed. We have more experts, more studies, and more food rules than ever before, so why does standing in the grocery aisle still feel like such a guessing game?Join Holly and Jim as they sit down with Tamar Haspel, the James Beard Award-winning Washington Post columnist behind Unearthed and author of To

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50:15

The Science and Realities of Long-Term GLP-1 Use

Weight Loss And ... ·

2026/06/24

Losing weight on a GLP-1 medication can feel like magic until the scale stops moving. For almost everyone on these drugs, there comes a moment when the rapid progress slows, then stalls completely. Is the medication failing? Has your metabolism adapted? Did you do something wrong? For most people, that moment feels like a problem. It isn't.Join Holly and Jim as they unpack one of the most misunderstood parts of the GLP-1 journey: the shift from losing weight to keeping it off. You'll

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49:49

The Hidden Influence of Community and Environment...

Weight Loss And ... ·

2026/06/17

What if the biggest obstacle to your health isn't your willpower, it's your zip code? Most of us have been raised to believe that weight and health come down to personal choices: what you eat, how much you move, how disciplined you are. But what if the deck has been stacked against millions of Americans before they ever make a single decision?This week, Holly and Jim sit down with Dr. Christina Economos, Dean of the Friedman School of Nutrition Sciences and Policy at Tufts University, to

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46:39

The Rise and Fall of Popular Diets Over 100 Years

Weight Loss And ... ·

2026/06/10

If you've spent years hopping from one diet to the next: low fat, then low carb, then keto, then intermittent fasting, you're not alone, and you're not failing. The truth is, the diet world has been cycling through the same promises, the same villains, and the same disappointments for nearly a hundred years. And most of us never stop to ask why.Join Holly and Jim as they do something they've never done before on the show: step back and take a decade-by-decade look at almost 100 years of

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45:06

Why Dietitians Matter More Than Ever with Maha Tahiri

Weight Loss And ... ·

2026/06/03

Millions of people are now taking GLP-1 medications and losing weight, but is eating less the same as eating better? The answer, according to today's guest, is a resounding no. And almost nobody in medicine, food, or public health is talking seriously about what happens when appetite disappears, but nutritional needs don't.Join Holly and Jim as they sit down with Dr. Maha Tahiri, a nutrition scientist, food industry strategist, and founder of Nutrition Sustainability Strategies, for one of

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43:16

What Comes After GLP-1 Success with Ken Fujioka

Weight Loss And ... ·

2026/05/27

What if the medications changing everything about obesity treatment are also creating problems nobody saw coming? We’re living through a genuine before-and-after moment in obesity medicine. Drugs that once seemed like science fiction are now producing 20, even 25% weight loss in real patients. But the questions piling up are just as staggering as the results: What happens to your muscle? Your bone? Your sense of self? And what happens when the medication stops?Holly and Jim sit down with

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44:15

What the Nutrition Guidelines Still Haven't Caught Up...

Weight Loss And ... ·

2026/05/20

Everyone has been burned by nutrition advice that completely reversed itself a few years later. Eggs were dangerous, then essential. Butter was poison, then practically a health food. Fat was the enemy until we realized what replaced it might have been even worse. If you've ever thrown up your hands and wondered whether nutrition scientists agree on anything, you're not alone.What if the confusion isn't just about changing science but about how nutrition guidelines are made, who influences

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