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PODCAST

On the Edge of Breakthrough: Voices of Cancer Research

Welcome to On the Edge of Breakthrough: Voices of Cancer Research, your gateway to the latest in cancer care innovation. Hosted by Dr. Monty Pal, a medical oncologist and researcher at City of Hope, we’ll bring you inside one of the top 5 cancer research and treatment institutions in the U.S., where innovation and hope go hand-in-hand. Join Dr. Pal as he sits down with some of the world’s leading cancer experts as they explore some of the most pressing challenges and promising innovations in

health & fitness medicine

All Episodes

00:32:47

Bonus: The Future of Cancer Surgery: Innovations, AI...

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/12/23

This is an audience favorite episode. Dr. Monty Pal sits down with Yuman Fong, M.D., an internationally renowned surgical oncologist and Chair of Surgery at City of Hope, to explore the leading-edge innovations shaping the future of surgical oncology.Dr. Fong shares his incredible journey from studying medieval literature to being one of the first-ever surgeons to conduct surgery in space. They discuss the evolution of oncolytic viruses, the role of AI in cancer surgery, and how remote robotic

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00:39:04

The Quest to Cure: Exploring the Latest Frontiers in...

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/12/11

In this episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal welcomes Dr. Enrique Montero, research professor within the Arthur Riggs Diabetes & Metabolism Research Institute, to discuss his global journey in immunology and the pioneering work underway at City of Hope. Dr. Montero shares how early clinical experiences with lupus inspired his lifelong mission to bridge basic science and clinical application, leading to innovative therapies for cancer and autoimmune

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00:31:51

Translating Discovery: Shaping Tomorrow’s Prostate...

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/11/26

In this episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal welcomes Dr. Tanya Dorff, professor in the Department of Medical Oncology & Therapeutics Research and section chief of the Genitourinary Disease Program at City of Hope. Together they dive into Dorff’s pioneering work in immunotherapy for prostate cancer - from the challenges of moving treatments from bench to bedside, to the importance of collaborative team-science, and the role of deep biological

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00:51:26

Asking the Impossible: How Bold Questions are...

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/11/11

From a small Sicilian town to the forefront of diabetes research, Dr. Pugliese’s story is one of relentless curiosity and hope. He shares how early family experiences and clinical frustrations inspired his lifelong mission to improve outcomes type 1 diabetes.The conversation delves into the role of viruses and the microbiome in triggering type 1 diabetes. Dr. Pugliese describes his leadership in the Network for Pancreatic Organ Donors with Diabetes (nPOD), which has enabled collaborative studies

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00:55:41

Movement as Medicine: The Science Reshaping Oncology

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/10/28

In this episode of "On the Edge of Breakthrough: Voices of Cancer Research," host Dr. Monty Pal welcomes Dr. Lee Jones, Head of the Exercise Oncology Program in the Department of Medicine at City of Hope, to discuss how exercise science is helping reshape cancer treatment and care. Dr. Jones shares his journey from the UK to City of Hope, highlighting the challenges and breakthroughs in establishing exercise as a vital part of oncology research. He explains how the field of exercise oncology has

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00:32:05

How Team Science is Driving Lung Cancer Breakthroughs

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/08/20

In this episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal sits down with Dr. Loretta Erhunmwunsee, a thoracic surgeon and lung cancer researcher at City of Hope,.From her roots in underserved communities to today, where she is at the forefront of lung cancer research, Dr. Erhunmwunsee brings a unique perspective to understanding how environments and where we live can shape our health. Her latest groundbreaking research looks at how air pollution and neighborhood

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00:38:47

Expanding the Reach of TIL Therapy: What Will it Take?

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/08/05

What does it take to bring tumor-infiltrating lymphocyte (TIL) therapy to more patients and make the therapy more effective for those already eligible?In this episode of Edge of Breakthrough, Dr. Monty Pal sits down with Dr. Kelly Mahuron, a surgical oncologist at City of Hope, to unpack how TIL therapy is evolving. From identifying eligible patients and surgical harvesting of TILs to cell expansion and reinfusion, Dr. Mahuron breaks down the entire process of TIL therapy, highlighting how her

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00:47:37

Rewriting the Rules of Cellular Therapy

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/07/22

In this episode of On the Edge of Breakthrough, Dr. Monty Pal is joined by Dr. Stephen Forman, a giant of cancer care and hematologic malignancies and pioneer of cellular immunotherapy. Dr. Forman reflects on decades of progress in bone marrow transplantation, CAR T cell therapy, and the future of cellular therapies. But this conversation isn’t just about lab science. It’s about the human side of innovation: the infrastructure, access, and emotional support needed to truly care for patients through

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00:37:38

At the Crossroads of Cancer and Metabolism

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/07/08

In this episode of On the Edge of Breakthrough, host Dr. Monty Pal sits down with Dr. Charles Brenner, an internationally recognized expert in metabolism and the founding Chair of the Department of Diabetes & Cancer Metabolism at City of Hope. Together, they explore the metabolic links between diabetes, obesity, and cancer, and how understanding those connections could lead to new ways to prevent and treat multiple diseases.Dr. Brenner shares insights from his research into lean fatty liver disease

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00:43:59

Three Leaders, One Vision: Principles for...

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/06/24

In this special episode of On the Edge of Breakthrough, recorded live at the 2025 ASCO Annual Meeting, host Dr. Monty Pal sits down with two of City of Hope’s newest clinical leaders: Dr. Walter Stadler, Chief Clinical Officer at City of Hope Chicago, and Dr. Alan Bryce, Director of City of Hope Phoenix.Together, they explore what it takes to build a national model for research-driven care, from creating system-wide infrastructure for precision medicine to integrating AI across core services like

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00:47:08

How a Bold Yes Became a Scientific Breakthrough

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/06/10

Welcome back to Season 2 On the Edge of Breakthrough: Voices of Cancer Research. In this powerful episode, Dr. Monty Pal welcomes Dr. Linda Malkas, Dean of Translational Sciences at City of Hope, for a conversation that spans childhood stargazing in Queens to leading one of the most ambitious cancer drug developments in recent history.Dr. Malkas shares how a chance encounter with a grieving father sparked her quest to take on an “undruggable” target, resulting in AOH1996, a promising molecule

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00:49:09

Building the First AI Agent for Cancer Research

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/05/06

In this episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal sits down with Dr. Enrique Velazquez Villarreal, a physician-scientist in City of Hope’s Department of Integrative Translational Sciences, whose path into medicine and research is anything but typical.Dr. Velazquez Villarreal talks about growing up in Mexico, entering medical school at 17, and the many mentors—who shaped his decision to pursue oncology - three of whom he lost to colorectal cancer He shares how

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00:47:34

Humanizing Cancer Treatment Through Whole-Person Care

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/04/22

In this episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal sits down with Dr. Betty Ferrell, trailblazing nurse-scientist and director of the Division of Nursing Research and Education at City of Hope. Known globally for her foundational work in quality of life, pain management, and palliative care, Dr. Ferrell reflects on her nearly four decades of research, mentorship, and advocacy that have reshaped how we define patient-centered cancer care.Together they trace her

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00:38:55

Pushing the Limits of Cancer Research and Surgery

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/04/08

In this episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal talks with Mustafa Raoof, a leading surgical oncologist and physician-scientist at City of Hope, about the challenges and potential in treating some of the toughest cancers.Dr. Raoof reflects on his path - from boarding school in Pakistan to pioneering new techniques in peritoneal metastasis treatment at a world renowned cancer center, including the promising intraperitoneal therapy known as Pressurized

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00:33:09

Breaking Barriers in Cancer Care: Expanding Access,...

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/03/25

In this episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal speaks with Edward S. Kim, M.D., M.B.A., the physician-in-chief of City of Hope Orange County and Vice Physician-in-Chief of City of Hope National Medical Center. Dr. Kim shares his experience leading the transformation of leading U.S. cancer centers, and how City of Hope is using integrative oncology to reshape the patient experience. They discuss how innovative strategies, such as building a national clinical

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00:33:01

The Future of Cancer Surgery: Innovations, AI, and...

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/03/11

In this episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal sits down with Dr. Yuman Fong, an internationally renowned surgical oncologist and Chair of Surgery at City of Hope, to explore the leading-edge innovations shaping the future of surgical oncology.Dr. Fong shares his incredible journey from studying medieval literature to being one of the first-ever surgeons to conduct surgery in space. They discuss the evolution of oncolytic viruses, the role of AI in cancer

en

00:39:10

Advancing Cancer Survivorship and Cardio-Oncology

On the Edge of Breakthrough: Voices of Cancer Research ·

2025/02/25

In this episode of On the Edge of Breakthrough: Voices of Cancer Research, Dr. Monty Pal is joined by Dr. Saro Armenian, Chair of Pediatric Oncology at City of Hope, to discuss the latest innovative research driving advancements in cancer survivorship and cardio-oncology.Dr. Armenian shares his compelling journey into oncology, the challenges of addressing long-term treatment effects on patients, and the promising future of CHIP clinics and de-escalation of therapy. Learn how world-leading

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00:00:49

Exploring the Future of Cancer Care

On the Edge of Breakthrough: Voices of Cancer Research ·

2024/11/19

Welcome to On the Edge of Breakthrough: Voices of Cancer Research, your gateway to the latest in cancer care innovation. Hosted by Dr. Monty Pal, a medical oncologist and researcher at City of Hope, we’ll bring you inside one of the top 5 cancer research and treatment institutions in the U.S., where innovation and hope go hand-in-hand.Join Dr. Pal as he sits down with some of the world’s leading cancer experts as they explore some of the most pressing challenges and promising innovations in oncology

en

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