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PODCAST

Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge.Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an

health & fitness alternative health

All Episodes

25:29

60. The Gut and Immune System: The Histamine Connection

Histamine Well Podcast: Exploring Histamine,... ·

2026/10/05

Could your gut help explain why you’re reacting to foods you once tolerated? In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explaining how the microbiome, intestinal lining, immune system, and nervous system interact. A low histamine diet may help reduce symptoms, but what happens when the gut itself is contributing to your histamine burden? Joanne discusses SIBO, dysbiosis, histamine-producing bacteria, mast cells, and the ...

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3:57

Q&A. Why Do I Feel More Bloated on a Low FODMAP Diet?

Histamine Well Podcast: Exploring Histamine,... ·

2026/09/30

A low FODMAP diet is often used to reduce bloating, so why might your symptoms get worse after starting one? In this short Q&A episode, Joanne explores three possibilities: eating more sulfur-rich foods, replacing wheat with higher-oxalate ingredients, and changes in gut motility, including the migrating motor complex. She explains why it’s worth looking at what has changed in your diet instead of simply pushing through worsening bloating. In this episode: How food swaps on a low FODMAP d...

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36:42

59. Circadian Rhythm: How Your Body Clock Affects...

Histamine Well Podcast: Exploring Histamine,... ·

2026/09/28

In this episode of The Histamine Well, Joanne is joined by clinical nutritionist Melanie Peers to explore circadian rhythm: the daily cycle that helps coordinate sleep, energy, hormones, digestion and immune activity. They also discuss why histamine symptoms may feel worse at certain times of the day or night. Joanne and Melanie talk about the signals that can disrupt your body clock, from spending the day indoors to bright lights, screens and late meals at night. They share practical ways to...

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5:19

Q&A. Why Do I Feel Sick from Taking N-Acetylcysteine?

Histamine Well Podcast: Exploring Histamine,... ·

2026/09/23

NAC can support glutathione production, respiratory health and biofilm disruption—but some people experience nausea, headaches, brain fog, fatigue or bloating after taking it. In this Q&A episode, Joanne explains how reactions to NAC may be connected to sulfur intolerance, hydrogen sulfide production, gut dysbiosis, biofilm disruption and sensitivity to its mucolytic effects. You’ll also learn why feeling worse doesn’t necessarily mean NAC is working—and why a lower dose, slower introdu...

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18:09

58. Biofilms: Why SIBO, Candida & Gut Infections Keep...

Histamine Well Podcast: Exploring Histamine,... ·

2026/09/21

Why do SIBO, Candida, and other gut infections sometimes return—even after treatment initially seems successful? In this episode of The Histamine Well Podcast, Joanne explains how biofilms may contribute to persistent bacterial and fungal overgrowths. Biofilms are organised microbial communities surrounded by a protective matrix that can help microorganisms survive antimicrobial treatment and resist immune defences. Joanne explores the role biofilms may play in recurring SIBO, Candida overgro...

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3:49

Q&A. Why Do I Feel Sick From Having an Epsom Salt bath?

Histamine Well Podcast: Exploring Histamine,... ·

2026/09/16

Do you feel nauseous, dizzy, exhausted, or brain foggy after an Epsom salt bath? If a bath you hoped would help you relax leaves you feeling worse, you might wonder whether you’re experiencing a “detox reaction,” reacting to the heat or struggling to tolerate the Epsom salts themselves. In this short Q&A episode of The Histamine Well Podcast, Joanne explores possible reasons for feeling sick after an Epsom salt bath, including bath temperature, changes in blood pressure, histamine intoler...

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15:23

57. Gut Microbiome & Hydrogen Sulfide SIBO |...

Histamine Well Podcast: Exploring Histamine,... ·

2026/09/14

Do eggs, garlic, onions or broccoli leave you feeling bloated, fatigued or foggy-headed? In episode 57 of The Histamine Well Podcast, Joanne explores hydrogen sulfide SIBO and intestinal sulfide overproduction (ISO), discussing how sulfur-producing gut bacteria may contribute to these symptoms. Discover: The connection between sulfur intolerance and the gut microbiome.Why hydrogen sulfide production and clearance both matter.The uses and limitations of stool and breath testing.Joanne’s clinic...

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3:10

Q&A. What should I do if I'm Constipated on the...

Histamine Well Podcast: Exploring Histamine,... ·

2026/09/09

Struggling with constipation on the low-FODMAP diet? If your bloating has improved but your bowel movements have slowed down, what should you consider next? In this short Q&A episode of The Histamine Well Podcast, naturopath Joanne Kennedy shares how she approaches constipation in patients following a low-FODMAP diet. She discusses fibre intake, hydration, digestive support, and the role of the nervous system in bowel regularity. If you’re navigating constipation, SIBO, bloating or hist...

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15:15

56. Can Gut Dysbiosis Cause Anxiety & Depression?...

Histamine Well Podcast: Exploring Histamine,... ·

2026/09/07

Can an imbalanced gut microbiome contribute to anxiety and depression? We often think of mental health conditions as beginning solely in the brain. However, growing research suggests that the gut microbiome may also influence mood through the gut–brain axis. In this episode of The Histamine Well, Joanne explores what gut dysbiosis is and how the gut communicates with the brain through the vagus nerve, immune signalling, inflammation, stress hormones, short-chain fatty acids and neurotransmitt...

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18:10

55. Bile & Digestion: Ox Bile, TUDCA, Taurine &...

Histamine Well Podcast: Exploring Histamine,... ·

2026/08/31

Could sluggish bile be affecting your digestion, gut health and histamine symptoms? In this episode of The Histamine Well Podcast, Joanne Kennedy explains the essential role bile plays in fat digestion, nutrient absorption, liver detoxification and microbial balance. She also explores how poor bile flow may contribute to SIBO, histamine intolerance and increased oxalate absorption. Joanne breaks down four popular bile-support supplements—ox bile, TUDCA, taurine and phosphatidylcholine—includi...

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14:42

54. Stress, Cortisol & Histamine: The Hidden Loop

Histamine Well Podcast: Exploring Histamine,... ·

2026/08/24

In this episode of The Histamine Well, Joanne explores the powerful connection between stress, cortisol, mast cell activation, and histamine intolerance. She explains how chronic stress can keep the nervous system trapped in fight-or-flight mode, trigger histamine release, and contribute to symptoms such as itching, flushing, headaches, sinus congestion, digestive issues, and skin reactions. You’ll learn how the HPA axis responds to stress, why cortisol is helpful in the short term, and what ...

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79:22

Are Oxalates Fueling Your Histamine Intolerance?...

Histamine Well Podcast: Exploring Histamine,... ·

2026/08/17

Could oxalates be the hidden reason your histamine intolerance symptoms aren’t improving? In this popular podcast replay, Joanne is joined by Melanie Peers to explore the often-overlooked connection between oxalates, histamine intolerance, inflammation, gut health, and nervous system dysregulation. Oxalates are naturally occurring compounds found in many foods—including some commonly considered healthy. For sensitive individuals, a high oxalate load may contribute to pain, digestive problems,...

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36:06

How Histamine Works (and What Happens When It's Too...

Histamine Well Podcast: Exploring Histamine,... ·

2026/08/11

What is histamine, and why does it cause so many frustrating symptoms? In this replay of one of our most popular episodes, Joanne explains the science of histamine intolerance in a simple, practical way. Learn how histamine affects your immune system, gut health, hormones, brain, and skin, why histamine levels become too high, and the common symptoms of histamine intolerance—including migraines, anxiety, insomnia, hives, eczema, reflux, bloating, and more. Discover why a low-his...

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65:42

Histamine Intolerance: What Actually Causes It [Replay]

Histamine Well Podcast: Exploring Histamine,... ·

2026/08/04

One of our most downloaded episodes is back. If you've been diagnosed with histamine intolerance, MCAS, or unexplained food sensitivities, this replay is one you won't want to miss. In this listener-favorite episode, Joanne Kennedy explains why histamine intolerance is not a diagnosis—it's a symptom of deeper underlying health issues. While many people rely on a low histamine diet to manage symptoms, lasting improvement comes from identifying and treating the root causes driving excess histam...

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16:14

53. Histamine Intolerance vs MCAS: How To Tell The...

Histamine Well Podcast: Exploring Histamine,... ·

2026/07/06

Many people with flushing, hives, anxiety, brain fog, digestive issues, food sensitivities, and heart palpitations are told they have either histamine intolerance or Mast Cell Activation Syndrome (MCAS). While these conditions can look remarkably similar, they have very different underlying mechanisms—and understanding those differences is often the key to finding the right treatment. In this episode, Joanne explains the difference between histamine intolerance and MCAS, why symptoms overlap,...

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26:15

52. Clinical Experience Of Working With Women On...

Histamine Well Podcast: Exploring Histamine,... ·

2026/06/29

Many women enter their 40s expecting a few hormonal changes, but are often unprepared for the anxiety, sleep disturbances, fatigue, low mood, histamine symptoms, weight changes, and nervous system shifts that can accompany perimenopause. In this episode, Joanne shares her clinical and personal experience working with women through perimenopause and menopause, including her own journey with bioidentical oestrogen and progesterone. She discusses the signs of low oestrogen and progesterone, the ...

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11:50

51. Methylation Optimisation: What The Biohacking...

Histamine Well Podcast: Exploring Histamine,... ·

2026/06/22

Methylation has become one of the hottest topics in functional medicine, biohacking, and wellness. From MTHFR testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity. But what if more methylation isn't always better? In this episode, Joanne explores the science behind methylation, the roles of MTHFR and COMT, and why relying solely on genetic reports can lead to inappropriate supp...

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23:01

50. Is PMDD a Histamine Problem? H1 and H2 Blockers...

Histamine Well Podcast: Exploring Histamine,... ·

2026/06/15

Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)? In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing piece of the PMDD puzzle? Joanne breaks down the science behind the estrogen-histamine feedback lo...

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11:53

49. Mould & Mitochondria: Why You're Still Exhausted...

Histamine Well Podcast: Exploring Histamine,... ·

2026/06/08

Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve. In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould illness and mitochondrial dysfunction, revealing why fatigue can persist long after mould exposure has been identified. You'll learn how three...

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15:05

48. How Mould Mycotoxins Cause SIBO

Histamine Well Podcast: Exploring Histamine,... ·

2026/06/01

In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction. If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea, fatigue, or recurring SIBO that never fully resolves, this episode explains how mould exposure m...

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79 results

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