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PODCAST

This Week in Startups

Jason Calacanis

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

technology

All Episodes

01:21:54

Bittensor Drama! TAO down 15%! | E2274

This Week in Startups ·

2026/04/11

This Week In Startups is made possible by:Pilot - https://pilot.com/TWISTSquarespace -https://squarespace.com/TWISTNorthwest Registered Agent - https://northwestregisteredagent.com/TWISTPlaud - https://Plaud.ai/twistCrowdHealth - ⁠https://JoinCrowdHealth.com/twist⁠Today’s show:TAO, the token associated with the Bittensor network, fell sharply last night after a major project declared it was taking its business elsewhere. Covenant AI had used Bittensor subnets 3, 39, and 89 before its abrupt and

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01:16:48

Anthropic’s Mythos is a cyber-weapon, so you can’t...

This Week in Startups ·

2026/04/09

Anthropic just built a model so dangerous, they’re not even going to release it (for now). On TWiST, Jason, Alex, and Neurometric CEO Rob May discuss whether or not this is just another frontier model or a potential weapon of mass internet destruction.Claude Mythos Preview is already in the hands of over 40 Anthropic partners — including Nvidia, Apple, Amazon, Microsoft, and Google — as part of its “Project Glasswing” security council.Together, they’ll test how quickly and easily the model can

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01:19:09

3 AI Agents That Actually Replaced Human Jobs | E2272

This Week in Startups ·

2026/04/07

Anthropic just pulled the plug on Claude subscriptions for OpenClaw and every third party agentic tool. So Jason and Lon welcome back three of our top TWiST OpenClaw experts to break down what it means, how much it’s going to cost now, and whether this is truly the end of the subsidized AI era.And they all brought demos! We’re checking out ClawChief from Ryan Carson, Alex Finn’s agent Henry, and Yazin Alirhayim’s Sidecast protocol, inspired by a special request from JCal!HostsJason Calacanis:

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01:20:52

AI Rebuilt Every YC W26 Startup. Should Founders Be...

This Week in Startups ·

2026/04/03

This Week In Startups is made possible by:Deel - deel.com/twistGrasshopper Bank - grasshopper.bank/twistRender - render.com/twistPlaud - Plaud.ai/twistAn AI “holding company” rebuilt dozens of YC Winter ‘26 startups in one weekend. Now we’re bringing the founder responsible into Jason’s Courtroom to defend himself.PLUS a live demo of Boardy, the AI that acts like a virtual board member and makes crucial introductions. Find out why he gets to have so much agency, how creator Andrew D’Souza used him

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00:30:10

How 3 CEOs Use AI to Run $10B in Companies | This...

This Week in Startups ·

2026/04/02

This Week in AI, JCal sits down with three CEOs building the infrastructure, intelligence, and interfaces for the next era of AI: Jeremy Fraenkel (CEO, Fundamental), Victor Riparbelli (CEO, Synthesia), and Nick Harris (CEO, Lightmatter). We break down what's actually happening beneath the AI hype: the data modality LLMs completely missed, why copper is the real bottleneck in AI data centers, OpenAI shutting down Sora, the build vs. buy debate for AI tools, and how close we really are to

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01:28:07

Venture Roundtable: SpaceX IPO, AI's PR Crisis, and...

This Week in Startups ·

2026/04/01

This Week In Startups is made possible by:PaperOS - https://PaperOS.com/twistNorthwest Registered Agent- https://northwestregisteredagent.com/twistEvery.io - https://Every.ioPlaud - https://Plaud.ai/twistToday’s show:Silicon Valley just lined up its biggest liquidity event in years: SpaceX filed confidentially for an IPO that could target a $1.75 trillion valuation — potentially the largest public offering in history. Meanwhile, a new Quinnipiac poll shows that 62% of Americans aren't excited

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01:27:14

The 5-Step Framework for AI Agents That Improve While...

This Week in Startups ·

2026/03/31

This Week In Startups is made possible by:Quo - https://quo.com/TWiSTLinkedIn Jobs - https://LinkedIn.com/twistIru - https://iru.com/twistPlaud - https://Plaud.ai/twistToday’s show:Google project manager Shubham Saboo is running 6 AI agents on a Mac Mini that handle all of his side business autonomously, from research, to social posts, to newsletters.He joins Jason and Lon to walk us through his 5-step framework for designing an efficient AI agent team:Start with one agent and onboard them like a

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01:39:16

The $60 billion resource hiding in space, and the...

This Week in Startups ·

2026/03/27

This Week In Startups is made possible by:Wispr Flow - https://wisprflow.ai/twistCircle - http://circle.so/twistDeel - http://deel.com/twistToday’s show:AstroForge is building low-cost, replicable spacecraft to mine platinum group metals from near-Earth asteroids — a $60 billion annual market for materials that are running out on Earth. Founder and CEO Matt Gialich joins the show to talk about the company's ambitious mission, what went wrong on their first two flights, and why Mission 3 could

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01:12:53

This Bittensor Subnet Could Cut Drug Discovery Costs...

This Week in Startups ·

2026/03/26

This Week In Startups is made possible by:Luma AI - https://lumalabs.ai/twistEvery.io - https://every.ioLemon.io - https://Lemon.io/twistPlaud - https://Plaud.ai/twistToday’s show:What do drug discovery, the creator economy, and AI vision models have in common? In the case of Metanova, Bitcast, and Score, the answer is Bittensor. Yes, each of the three companies leverages the Bittensor network to get more work done, more quickly, in a completely decentralized fashion.Metanova uses its subnet to run

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01:15:24

$2.5B Chip Heist, The Future of American AI, and...

This Week in Startups ·

2026/03/25

This Week in AI sneak peak! If you enjoy the episode find us on Spotify, Apple podcasts and YouTube by looking up "This Week in AI" or by going to thisweekinai.aiThis week Jason sat down with Jake Loosararian and Chris Lattner on Episode 6 of This Week in AI. Jake is the CEO and co-founder of Gecko Robotics, a company deploying purpose-built robots and AI for mission-critical infrastructure inspection across energy, defense, and manufacturing. Chris is the CEO and co-founder of Modular,

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01:26:44

Compliance Startup Scandal... Is Delve Guilty? | E2266

This Week in Startups ·

2026/03/24

This Week In Startups is made possible by:Northwest Registered Agent - https://northwestregisteredagent.com/twistLinkedIn Jobs - https://linkedIn.com/twistSentry - https://sentry.io/twistPlaud - http://Plaud.ai/twistRo.co - http://Ro.co/TwistToday’s show:Hustle Fund general partner Elizabeth Yin joined Jason and Alex to discuss how rapid advances in AI have changed the venture capital game, and how the same AI updates are changing how founders build. Founders may need less capital than before, which

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01:38:38

The Drone Company Everyone Thought Was Illegal (Now...

This Week in Startups ·

2026/03/20

This Week In Startups is made possible by:Northwest Registered Agent - https://www.northwestregisteredagent.com/twistCircle - https://circle.so/twistNetsuite - https://www.netsuite.com/twistToday’s show:Zipline founder Keller Cliffton started his company with a simple premise: build automated logistics that serve everyone equally. The only problem? It was literally illegal in the US.In this live recording from LaunchFest in San Francisco, Keller shares how Zipline went from a 20-person team working

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00:49:41

How Robinhood became a $68B company w/ Vlad Tenev

This Week in Startups ·

2026/03/18

This Week In Startups is made possible by:Deel - https://deel.com/twistLinkedIn Jobs - https://LinkedIn.com/twist.Iru - https://iru.com/twistToday’s show:We’ve got a treat for you today on TWiST! Jason is live from LAUNCH Fest in San Francisco, where he’s joined by Robinhood founder Vlad Tenev.The era of AI is here. Robinhood found success in the midst of the last great technological shift. What lessons did Vlad take from this, and how can founders apply these to this next transformative period

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01:13:45

Are Brain-Computer Interfaces Actually Ready for Humans?

This Week in Startups ·

2026/03/16

This Week In Startups is made possible by:Caldera + Lab - https://CalderaLab.com/TWISTNorthwest Registered Agent - https://northwestregisteredagent.com/twistLemon - https://Lemon.io/twistToday’s show:Computers that read your mind? Jets that are all wings? Continuously tracking your body’s vital signs to live longer? We’ve got all that and more on the show today.First, we sat down with the CEO of Paradromics, Matt Angle, to dig into the progress that his brain-computer interface startup has made

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01:30:27

One Genius Rule That Made This Coffee Brand Famous |...

This Week in Startups ·

2026/03/14

Legendary British ad man Rory Sutherland invented a fake business on a podcast, a coffee shop appealing to the busy commuter called “Flat White or F**k Off.”But it’s one thing to have a post go big on TikTok or Instagram… but to turn that viral moment into an actual COMPANY is a very different challenge.On TWiST, Jason and Lon chat with Charlie Hurst, Tom Noble, and Will Sudlow, founders of the online brand “Flat White or F**k Off,” about how they took a funny little slogan and turned it into a

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01:09:18

The Global Expansion of Self-Driving Vehicles

This Week in Startups ·

2026/03/11

This Week In Startups is made possible by:Circle - http://circle.so/twistSentry - http://Sentry.ioDeel - http://deel.com/twistPlaud - http://Plaud.ai/twistToday’s show:It’s self-driving time! We’re going deep on one of the most exciting spaces developing in the world, autonomous vehicles! We’ve got 3 experts on the show to talk to us enlighten us, Ben Seidl of Autolane, Ming Maa of Moove, and Nathan Parker of EdgeCase.What’s going on in the world of self-driving? How has the reliability of

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01:00:38

How agents will change banking forever | E2260

This Week in Startups ·

2026/03/10

This Week In Startups is made possible by:Northwest Registered Agent - ⁠⁠northwestregisteredagent.com/twist⁠⁠Quo - ⁠⁠quo.com/TWiST⁠⁠Gusto - ⁠⁠Gusto.com/twist⁠⁠Plaud - http://Plaud.ai/twistAthena - https://www.athena.com/jcalToday’s show:How long until AI models can improve AI models? Once possible, recursive self-improvement by AI technology could accelerate — forever. Thus far, humans (and their coding agents) are still driving AI progress. But a recent project by AI developer extraordinare Andrej

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01:08:26

Wisdom of the $TAO: the future is decentralized AI

This Week in Startups ·

2026/03/06

This Week In Startups is made possible by:Every Banking - https://Every.iohttps://Lemon.io - Lemon.io/twistWispr Flow - https://wisprflow.ai/twistPlaud - https://plaud.ai/twistRo.co - https://Ro.co/TwistToday’s show:*Sure, we all love open source models, but what about completely decentralized AI? Rather than leaving the big decision-making in the hands of a few elite CEOs, shouldn’t users have a say — and potentially even a stake — in how this incredible technology develops?On TWiST, we welcome Ala

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01:20:55

Is Anthropic Making the Biggest Mistake in AI History...

This Week in Startups ·

2026/03/05

This Week In Startups is made possible by:Plaud - Plaud.ai/twistLinkedIn Jobs - https://LinkedIn.com/twist.Deel - https://deel.com/twistIru - https://iru.com/twist!Today’s show:It’s a packed TWiST Today! WITH US, we’ve got Erik Voorhees of VeniceAI and Logan Allin of Fin Capital on to talk agents, crypto, and… you guessed it, OPENCLAW!Where does agentic AI meet the financial system? How will agents transact? And what does privacy look like in a world with omnipresent AI?Stick around for some demos

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01:14:43

How the OpenClaw foundation bullet-proofed its future...

This Week in Startups ·

2026/03/03

This Week In Startups is made possible by:Circle — http://circle.so/twistHubspot Creators — http://clickhubspot.com/twist2Uber AI Solutions — http://uber.com/ai-solutionsToday’s show: *Dave Morin joined the show today to explain how the OpenClaw Foundation came into existence, and what its goals are. Fear not, Peter Steinberger retains directional control of the project. But if you want to sustain an open-source project over time, you need a corporate entity, well-heeled sponsors, maintainers and

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1,264 results

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