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PODCAST

Ninja Nerd

Welcome to the official Ninja Nerd Podcast! Brought to you by Zach and Rob, we will be presenting on board exam content and highlighting the most important information you need in order to crush your exams and apply these concepts clinically.

health & fitness medicine

All Episodes

36:59

Pancreatic and Hepatobiliary Cancer

Ninja Nerd ·

2025/11/06

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob explore pancreatic and hepatobiliary cancers through four patient cases packed with clinical pearls. We begin with a 63-year-old man presenting with painless jaundice, pruritus, and weight loss. Zach walks through the differential for obstructive cholestasis, covering malignant (pancreatic head cancer, cholangiocarcinoma, ampullary tumors) and benign (stones, strictures) causes. We emphasize RUQ ultrasound's role in assessi...

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28:56

Esophageal & Gastric Cancer

Ninja Nerd ·

2025/10/23

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob discuss two high-yield, board-relevant cases highlighting the diagnosis, staging, and treatment of esophageal adenocarcinoma and intestinal-type gastric adenocarcinoma. We begin with a 56-year-old man presenting with progressive dysphagia and unintentional weight loss. Zach breaks down the concern for distal esophageal adenocarcinoma in the long-standing GERD and Barrett's esophagus setting. We walk through the stepwise di...

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20:36

Testicular Cancer

Ninja Nerd ·

2025/10/09

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob discuss testicular cancer, one of the most common solid tumors in young adult men. We begin with a classic clinical vignette of a young male presenting with a painless testicular mass. From there, we explore the epidemiology and key risk factors for testicular germ cell tumors, including cryptorchidism, family history, and Klinefelter syndrome (in rare cases of nonseminomatous tumors like mediastinal choriocarcinoma). We th...

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29:41

Urinary Tract Malignancies

Ninja Nerd ·

2025/09/25

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob dive into the essential clinical and pathophysiologic features of urinary tract malignancies, beginning with renal cell carcinoma (RCC) and followed by urothelial carcinoma of the bladder. We start with a patient case of renal cell carcinoma, exploring the epidemiology and risk factors such as smoking, obesity, hypertension, and inherited syndromes like von Hippel-Lindau disease. The discussion focuses on the pathophysiolog...

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34:59

Prostate Cancer

Ninja Nerd ·

2025/09/11

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob break down the essential clinical and pathophysiologic features of Prostate Cancer, one of the most common malignancies affecting men worldwide. We begin with the epidemiology and risk factors, highlighting age, race, family history, and androgen exposure. From there, we explore the pathogenesis of prostate cancer, focusing on the role of androgen receptor signaling. The discussion covers clinical manifestations, including u...

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37:25

Colorectal Cancer

Ninja Nerd ·

2025/09/04

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob discuss Colorectal Cancer. This comprehensive discussion focuses on the clinical presentation, pathogenesis, and management of one of the most common malignancies encountered in clinical practice. We start by breaking down the epidemiology and risk factors, covering both sporadic and inherited forms—highlighting Lynch syndrome and familial adenomatous polyposis (FAP). From there, we analyze the adenoma-carcinoma sequenc...

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35:15

Brain Tumors

Ninja Nerd ·

2025/05/08

Ninja Nerds! In this episode of the Ninja Nerd Podcast, Zach and Rob explore the complex world of Brain Tumors. We explore the key types of brain tumors—both primary and metastatic—and examine their clinical implications through high-yield pathophysiology, neuroanatomy, and diagnostic principles. The discussion begins with an overview of tumor classification, distinguishing between supratentorial and infratentorial masses, and covers the most common tumors seen in adults versus children. Zach...

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46:06

Lung Cancer

Ninja Nerd ·

2025/04/04

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Lung Cancer, a leading cause of cancer-related mortality worldwide. We explore the pathophysiology, risk factors, and key differences between non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) to help you master this complex topic. Our discussion covers the clinical presentation of lung cancer, including subtle early symptoms like cough, hemoptysis, and chest pain, as well as advan...

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26:35

Myelodysplastic Syndrome (MDS)

Ninja Nerd ·

2025/03/28

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myelodysplastic Syndrome (MDS), a group of hematologic disorders characterized by ineffective hematopoiesis and a risk of progression to acute myeloid leukemia (AML). We also discuss the pathophysiology of MDS, highlighting the clonal stem cell mutations that lead to dysplastic bone marrow changes and peripheral blood cytopenias. Our discussion explores the clinical presentation of MDS, from common ...

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44:06

Breast Cancer

Ninja Nerd ·

2025/03/21

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Breast Cancer's pathogenesis, risk factors, and the latest advancements in screening, diagnosis, and treatment. We break down the molecular subtypes of breast cancer, including hormone receptor-positive, HER2-positive, and triple-negative disease, and discuss their clinical implications and targeted therapies. Our discussion covers essential diagnostic tools, such as mammography, breast ultrasound, M...

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30:35

Amyloidosis

Ninja Nerd ·

2025/03/14

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Amyloidosis, a complex disorder characterized by the misfolding and deposition of insoluble amyloid fibrils in tissues. We break down the different subtypes, including AL (light chain), AA (secondary), ATTR (transthyretin), and Aβ2M (β2 microglobulin), highlighting their unique pathogenesis, clinical manifestations, and diagnostic approaches. Our discussion covers the systemic vs. localized forms of ...

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34:14

Lymphoma

Ninja Nerd ·

2025/03/07

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Lymphoma, breaking down its pathogenesis, clinical presentation, and the latest advancements in treatment. We explore the key differences between Hodgkin and Non-Hodgkin Lymphoma, examining the role of Reed-Sternberg cells, CD markers, and genetic mutations that define these malignancies. Our discussion includes high-yield diagnostic tools like lymph node biopsy, flow cytometry, PET/CT imaging...

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35:23

Chronic Leukemias

Ninja Nerd ·

2025/02/28

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Chronic Leukemias, focusing on their pathogenesis, clinical features, and modern treatment strategies. We compare Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL), discussing the role of BCR-ABL in CML and the implications of smudge cells and monoclonal B-cell proliferation in CLL. Our conversation covers key diagnostic tools such as PCR, flow cytometry, and blood smear findings,...

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45:29

Acute Leukemias

Ninja Nerd ·

2025/02/21

Ninja Nerds, Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Acute Leukemias, breaking down their pathophysiology, clinical presentation, and management. We explore the key differences between Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL), focusing on the genetic mutations, risk factors, and cellular mechanisms driving these malignancies. Our discussion includes high-yield diagnostic approaches such as peripheral blood smear, bone ...

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37:25

Myeloproliferative Neoplasia

Ninja Nerd ·

2025/02/14

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Myeloproliferative Neoplasms, covering their pathophysiology, clinical presentation, and management. We discuss Polycythemia Vera, Essential Thrombocythemia, Chronic Myeloid Leukemia, and Primary Myelofibrosis, focusing on key mutations like JAK2, CALR, and BCR-ABL. Our discussion includes diagnostic tools such as peripheral blood smear, bone marrow biopsy, and laboratory markers like erythropoietin ...

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28:11

Plasma Cell Disorders

Ninja Nerd ·

2025/02/07

Ninja Nerds! Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we take a closer look at Plasma Cell Disorders, focusing on their pathophysiology, clinical features, and management. Topics include the mechanisms behind multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), and Waldenström macroglobulinemia, as well as the role of paraproteins and their clinical implications. We discuss diagnostic approaches such as serum protein electrophoresis (SPEP),...

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47:19

Antiplatelets, Anticoagulants, and Thrombolytics

Ninja Nerd ·

2025/01/31

Ninja Nerds!Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Antiplatelets, Anticoagulants, and Thrombolytics, focusing on their mechanisms and clinical uses. Topics include the pharmacology of antiplatelet agents such as aspirin and P2Y12 inhibitors, the role of anticoagulants like heparins, direct oral anticoagulants (DOACs), and warfarin in preventing thromboembolic events, and the use of thrombolytics like tPA in acute ischemic stroke and myocardial infarct...

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39:33

Hypercoagulable States

Ninja Nerd ·

2025/01/24

Ninja Nerds!Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we discuss Hypercoagulable States, covering key disorders and their clinical significance. Topics include Antiphospholipid Syndrome (APLS), its role in thrombosis and pregnancy loss; Factor V Leiden Mutation, the most common inherited thrombophilia; and Prothrombin Gene Mutation and its increased clotting risk. We also explore Protein C and S Deficiency, Antithrombin Deficiency, and acquired states like Cancer-A...

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39:33

Coagulopathy

Ninja Nerd ·

2025/01/17

Ninja Nerds!Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Coagulopathy, focusing on key bleeding and clotting disorders. Topics include Hemophilia A and B, their genetic causes, and modern treatments; Von Willebrand Disease (vWD), the most common inherited bleeding disorder; and Heparin-Induced Coagulopathy, with its paradoxical effects. We also cover Acquired Factor VIII Inhibitors in autoimmune and malignancy settings, Vitamin K Deficiency as a cause of bl...

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58:22

Platelet Disorders

Ninja Nerd ·

2024/11/29

Ninja Nerds!Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Platelet Disorders, breaking down the essential concepts and clinical applications. We will discuss Heparin-Induced Thrombocytopenia (HIT), focusing on its pathophysiology and management. Learn about Antiphospholipid Syndrome (APLS) and its role in thrombosis and pregnancy complications. We’ll also cover Disseminated Intravascular Coagulation (DIC), including its triggers and treatment strategies, and...

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87 results

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