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PODCAST

The Cancer Letter

The Cancer Letter

The Cancer Letter, an independent weekly news publication, has been the leading source for information on the issues that shape oncology since 1973. With a dedicated audience of oncology’s leaders, The Cancer Letter stays on top of breaking news and advances in oncology, providing authoritative, award-winning coverage of the development of cancer therapies, drug regulation, legislation, cancer research funding, health care finance, and public health. This weekly podcast features interviews,

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All Episodes

00:36:54

One result, two reactions: GRAIL’s Hall and NCI’s...

The Cancer Letter ·

2026/03/11

On Feb. 19, GRAIL Inc. announced that its pivotal NHS-Galleri trial failed to meet its primary endpoint of reduction in advanced stage cancers. The media and the market reacted as one would expect: GRAIL’s stock price halved the day after the announcement and at least three law firms said that they are conducting investigations in preparation for filing investor suits.Despite this, GRAIL has been doggedly positive in its press about the results. In this episode of The Cancer Letter Podcast, GRAIL’s

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00:23:39

Lawsuits brought against Tempus AI raise more...

The Cancer Letter ·

2026/03/04

Two lawsuits filed within days of each other in the U.S. District Court for the Northern District of Illinois claimed that Tempus AI Inc., an AI-driven precision and genomic testing company, had violated the Illinois Genetic Information Privacy Act when it acquired Ambry Genetics and started to integrate its genetics data into its predictive models.“Ambry contained genetic information from a lot of people,” Paul Goldberg, editor and publisher of The Cancer Letter, said. “And the question is, were

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00:32:27

Joni Nelson tells us how her background led her to...

The Cancer Letter ·

2026/02/27

One of Joni D. Nelson’s biggest influences growing up was her maternal grandmother, or Màma, as Nelson would affectionately call her. Despite a third grade education and limited literacy, Màma showed her “there is an opportunity to change what’s possible” no matter the barriers life sets in front of you.Now, Nelson is the assistant director for the Office of Workforce Development at The Medical University of South Carolina Hollings Cancer Center. Nelson’s mother also helped her find her path. She

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00:46:46

The Directors: Yolanda Sanchez and Kelvin Lee talk...

The Cancer Letter ·

2026/02/27

In an era of uncertainty around funding for academic research, Yolanda Sanchez and Kelvin Lee are thinking about how to build the next generation of scientists in spite of these challenges. “Certainty is not there anymore. So, what do you do?” said Sanchez, director of the University of New Mexico Comprehensive Cancer Center. “Because we’re not stopping. We’re not telling students that they can’t be graduate students, they can’t be postdocs anymore. We are continuing the work. We just have to shift

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00:27:18

Fires, F-bombs, and facemasks—Study results show...

The Cancer Letter ·

2026/02/25

“About a year ago, in January, were these two massive fires in Los Angeles: the Palisades fire, and the Eaton Fire,” Sara Willa Ernst, reporter with The Cancer Letter, said on The Cancer Letter Podcast. On this week's episode, Sara and Jacquelyn Cobb, associate editor with The Cancer Letter, talk about their experience working as writer-and-editor duo on The Cancer Letter’s most recent cover story, which featured emerging data about the toxic exposure and cancer risk caused by the Eaton and

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00:43:07

Malcolm V. Brock on his journey from Bermuda to Japan...

The Cancer Letter ·

2026/02/20

Malcolm V. Brock, director of Clinical and Translational Research in Thoracic Surgery at Johns Hopkins Kimmel Comprehensive Cancer Center, grew up on the island of Bermuda. His father insisted that his children branch outside the island’s small footprint—the country has a population of just over 60,000 people—and challenge themselves abroad.“My father said to me, ‘Look, you're not going to do much sitting here in a 20-square-mile place,’” Brock said. “He had a plan. [To] all of us, at about

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00:26:18

Lowy fields questions about peer review at inaugural...

The Cancer Letter ·

2026/02/18

With NCI Director Anthony Letai in Milan supporting his daughter, Julie, at the 2026 Winter Olympics, Douglas R. Lowy, principal deputy director of NCI, took on the job of delivering detailed remarks and fielding questions at the inaugural meeting of the NCAB’s ad hoc working group on Extramural Research Concepts and Programs.The meeting was the first time the field was able to publicly communicate with NCI leadership since President Trump signed the FY26 funding bill.On this week’s episode, Paul

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00:22:25

One year of The Cancer Letter Podcast: “When you...

The Cancer Letter ·

2026/02/11

When The Cancer Letter founder Jerry Boyd carried the first print run of his little eight page oncology newsletter into an NCAB meeting in 1973, he certainly could not have predicted that, half a century later, his experiment would branch out into this thing called “podcasts.”On this week's episode, Paul Goldberg, editor and publisher of The Cancer Letter, and Jacquelyn Cobb, associate editor, celebrate the one year anniversary of The Cancer Letter Podcast.Boyd understood that oncology was a

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00:43:25

Black History Month: Otis Brawley shares how lessons...

The Cancer Letter ·

2026/02/06

Growing up in inner-city Detroit, Otis Brawley had a thriving community made up of his parents, Jesuit priests, friends, and neighbors encouraging him that he could do anything he put his mind to. Brawley’s parents worked at the local Veteran’s Hospital, his father in janitorial services and his mother in food services. Neither graduated from high school, but they had high aspirations for their son, and would not take no for an answer. “I can remember in 1970, when I was 11 years old, the census

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00:22:29

The soul of oncology: Centering patient stories amid...

The Cancer Letter ·

2026/02/04

Last week’s issue of The Cancer Letter included an obituary that the entire staff at The Cancer Letter had been dreading for years: Abdallah Abou Zahr, an oncologist at Roger Maris Cancer Center in Fargo, ND, died Jan. 23 of a liposarcoma after a five-year battle with the disease. Abou Zahr’s story had become personal for The Cancer Letter. In February 2024, an intimate story of how cancer hijacked his family’s future—and of how his colleagues and community rallied around him—became one of the

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00:47:28

The Directors: Gary Schwartz and Ramon Parsons on the...

The Cancer Letter ·

2026/01/30

As NCI paylines drop to 4%, cancer centers are tapping into their institutional funds to provide “bridge funding,” typically in $50,000 to $100,000 increments, to enable investigators to keep their labs open until better times return—next year God willing. “It’s sort of starvation wages in terms of the grant funding,” said Ramon E. Parsons, director of Tisch Cancer Institute & Mount Sinai Cancer at Icahn School of Medicine at Mount Sinai. “And so, how do we pay for salaries for research

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00:24:44

“There is no safe harbor:” FY26 funding bill...

The Cancer Letter ·

2026/01/28

In last week’s issue of The Cancer Letter, Jacquelyn Cobb, associate editor, wrote a story about the then-promising legislative package that was passed by the U.S. House of Representatives Jan. 22. At the time, the package was expected to pass in the Senate, provide funding for the federal government through fiscal year 2026, and prevent a government shutdown that looms Jan. 30. Then, on Jan. 24, 37-year-old ICU nurse Alex Pretti was shot in Minneapolis while trying to document the actions of U.S

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00:27:36

With five-year cancer survival at an all-time high,...

The Cancer Letter ·

2026/01/21

“It's really, really important that every year since 1991, cancer mortality has dropped by a little bit, and it did again!” said Paul Goldberg, editor and publisher of The Cancer Letter. “Now, mortality is a good metric, age-adjusted mortality. As far as survival, well, that's not so good.”In last week’s cover story in The Cancer Letter, Paul and Jacquelyn Cobb, associate editor of The Cancer Letter, wrote about the annual cancer statistics report by the American Cancer Society. The

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00:37:02

Could mRNA vaccines hold the key to building an...

The Cancer Letter ·

2026/01/14

“I believe in the concept of a universal cancer vaccine,” said Elias Sayour, a pediatric oncologist at the University of Florida. “I think if this fails in a prospective phase III trial, I still believe we can engineer a vaccine that works prospectively.”The cover story of last week’s issue of The Cancer Letter was about the potential of COVID-19 mRNA vaccines to improve response to checkpoint inhibitor therapies in patients with lung cancer and melanoma. The finding was published by Sayour and his

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00:27:28

Nancy Goodman: “Sen. Sanders says he cares about kids...

The Cancer Letter ·

2026/01/07

On Dec. 19, the Mikaela Naylon Give Kids a Chance Act was blocked in the Senate by Sen. Bernie Sanders (I-VT) after receiving unanimous approval from the U.S. House of Representatives Dec. 1. On this episode of The Cancer Letter Podcast, Nancy Goodman, founder and executive director of Kids v. Cancer, joins Jacquelyn Cobb, associate editor with The Cancer Letter, and Claire Marie Porter, reporter. Goodman walks Jacquelyn and Claire through the emotional highs and lows that have characterized the

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01:04:20

Otis Brawley looks back on a year of great science...

The Cancer Letter ·

2025/12/31

In a year that brought us new KRAS-inhibiting drugs, deepened our understanding of HER2 in breast cancer, and highlighted new potential for mRNA vaccines, the cancer field was also rocked by uncertainty of the future of research funding, equity in cancer delivery, and the integrity of review at FDA. In a lively conversation with The Cancer Letter’s Paul Goldberg, Brawley, who is the Bloomberg Distinguished Professor of Oncology and Epidemiology at Johns Hopkins University and co-editor of the Cancer

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00:39:55

2025 in review: In a mess, there is movement—and...

The Cancer Letter ·

2025/12/24

A year like 2025 has demanded a lot from all of us, between the Trump administration’s flooding of the zone, the impact of DOGE and MAHA initiatives on the National Cancer Program, and the personal toll of living amidst uncertainty. In many ways, 2025 was a test. Did the field of oncology pass? Did The Cancer Letter? Reflecting on a year of cancer news coverage and our readers’ most-read stories, Paul Goldberg, editor and publisher of The Cancer Letter, and Jacquelyn Cobb, associate editor, talk

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00:45:36

The Directors: Joann Sweasy and Robert Winn reflect...

The Cancer Letter ·

2025/12/19

As trust in scientific and regulatory institutions frays and the meaning of “gold standard science” is increasingly contested, cancer research faces a credibility test of its own. “Cancer research is apolitical,” Joann Sweasy, director of the Fred & Pamela Buffett Cancer Center, and president of the Association of American Cancer Institutes, said. “Everyone is impacted by cancer. I don't know any family that's not impacted by cancer.”Sweasy said since the Trump administration took over

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00:21:47

Testing for asbestos in talc-based cosmetics seems...

The Cancer Letter ·

2025/12/17

Last month, FDA withdrew a proposed rule for standardized asbestos testing in talc-based cosmetics. The proposed rule, introduced in Nov. 2024 and withdrawn Nov. 2025, was mandated by the Modernization of Cosmetics Regulation Act of 2022 or MoCRA.Following an open comment period, FDA decided to withdraw the rule—citing significant public opposition and unintended consequences.“When you read the headline: ‘They're withdrawing a proposed rule that would regulate asbestos,’ it's hard to see how

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00:27:29

Richard Pazdur left FDA to avoid being part of “the...

The Cancer Letter ·

2025/12/10

Last week’s issue of The Cancer Letter featured great news and terrible news. On the one hand, Anthony G. Letai, the new director of the National Cancer Institute who has been regarded as a great choice for the position by oncology leaders, has stepped into the public sphere and has been spreading a message of stability and continuity. On the other hand, Richard Pazdur retired from his position as director of FDA’s Center for Drugs Evaluation and Research after a nearly three-decade career shaping

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