PODCAST

The Pauling Principle

PAULING.AI

AI and drug discovery to extend healthy human lifespan. Sponsored by https://www.pauling.ai

science life sciences

All Episodes

01:01:22

The Pauling Principle Episode 22 - Bolz-2, Boltzgen...

The Pauling Principle ·

2025/11/03

Is protein folding solved? Not quite, even though the progress has been tremendous since the first AlphaFold and up to last year's Nobel prize. The team behind Boltz and Boltz-2, from MIT CSAIL and Jameel Clinic, just released Boltzgen, a state of the art model for protein design. In this chat with Gabriele Corso I review the progress in the field and whats next.

01:00:04

The Pauling Principle Episode 18 - Taking photos of...

The Pauling Principle ·

2025/10/22

Shantanu Singh is one of the principal investigators at the celebrated Broad Institute of MIT and Harvard. His research is centered around finding “fingerprints” of genes, chemicals and diseases from microscopy images of cells. Which has tremendous applications for drug discovery and curing diseases. I hope you enjoy this episode!Also check out some more links about his work below:About the Lab:- Carpenter-Singh Lab: https://carpenter-singh-lab.broadinstitute.org/- MIT Technology Review article on

01:02:14

The Pauling Principle Episode 18 - Can we fix...

The Pauling Principle ·

2025/10/14

Andy and his team at Vincere have been doing amazing work over years to figure out the mitochondrial mechanisms that may contribute to Parkinson's and other neurodegenerative diseases. Listen in as we discuss curing Parkinson's, using AI to find new molecules and broader drug discovery.

00:58:50

The Pauling Principle Episode 16 - Building an AI...

The Pauling Principle ·

2025/09/18

Andrew White and his team at Future House have one of the most ambitious missions. I'll quote here because I couldn't say it better myself: Our mission is to build an AI scientist, or AI systems, that can automate scientific research and accelerate the pace of discovery, so humanity can find cures for disease, solutions for climate change, and other species-accelerating technologies. Must watch! 👀

01:01:57

The Pauling Principle - Episode 15 - Rethinking...

The Pauling Principle ·

2025/09/02

What if the biggest breakthroughs in health and biotechnology aren’t waiting on new ideas but on better experiments? In this episode, Michael Florea joins Javier to expose the hidden bottlenecks in animal research, the quiet revolution of automation in the lab, and the radical possibilities of treating DNA itself as medicine. This conversation peels back the curtain on how science really moves forward and why the future of drug development may look nothing like today.

01:04:19

The Pauling Principle Episode14 - Curing...

The Pauling Principle ·

2025/08/20

Join my conversation with Matthew "Oki" O'Connor Co-CEO of Cyclarity Therapeutics. We talk about curing cardiovascular disease, radically extending healthy longevity and the drug discovery journey.

00:58:47

The Pauling Principle Episode 13 - Can language...

The Pauling Principle ·

2025/08/05

Nicholas Runcie of Oxford University and I discuss whether large language models such as ChatGPT can really understand chemistry. Which of course will be essential as we try to use them to find new medicines and materials.

00:58:01

The Pauling Principle Episode 12 - The future of...

The Pauling Principle ·

2025/07/21

Eva Smorodina, researcher at the University of Oslo and expert in Computational Chemistry, joins me for an interesting conversation about designing antibodies, tools for biology and the future of AI and drug discovery. I hope you will enjoy!

01:02:17

The Pauling Principle Episode 11 - Curing...

The Pauling Principle ·

2025/07/01

In this episode I talk with the amazing Reason and Mourad from Repair Bio about a cure for cardiovascular disease. Reason serves as CEO and is also a legend in the world of longevity, having run https://www.fightaging.org for a couple of decades. Mourad serves as CSO and is a celebrated researcher with stints at Harvard Medical School and Pfizer.

00:56:25

The Pauling Principle Episode 10 - The Google AI...

The Pauling Principle ·

2025/06/16

Google recently announced AI Co-Scientist, a state-of-the-art AI agent turbo-charging research. The Co-Scientist team has already uncovered new liver-fibrosis targets and repurposed drugs for cancer. Don't miss this episode with Vivek Natarajan, Research Lead for Google’s AI Co-Scientist!

01:09:45

The Pauling Principle Episode 8 - From LLMs to...

The Pauling Principle ·

2025/06/04

From AI and language models to robots, agents and using AI to automate medicine and software engineering. And even beyond: human consciousness and space exploration. This was one of the most fascinating conversations with Massimo Mascaro, AI expert and part of the CTO Office at Google.

01:04:28

The Pauling Principle Episode 9 - Worms for longevity

The Pauling Principle ·

2025/05/27

I discuss longevity, AI drug discovery and using worms to test longevity therapeutics with Ben Blue, CTO of Ora Biomedical. I hope you enjoy the podcast, remember to like and subscribe!

00:48:13

The Pauling Principle Episode 7 - Improving Genomic...

The Pauling Principle ·

2025/05/07

If we want to live over 150 years and avoid cancer we will need better mechanisms to preserve our genomic integrity. Join my conversation with Benjamin Arya to learn more!

01:11:21

The Pauling Principle Episode 6 - Finding new...

The Pauling Principle ·

2025/04/21

We have not found new antibiotics for decades, even while the world struggles with new strains of bacteria. What can we do about it?

01:03:26

The Pauling Principle Ep 5 with Trishan Panch -...

The Pauling Principle ·

2025/04/07

I welcome my good friend Trishan in a fascinating conversation about making healthcare accessible through technology and in particular AI.

00:59:35

The Pauling Principle - Episode 4 - How to find new...

The Pauling Principle ·

2025/03/24

A conversation with Dr. Andrii Buvailo, an expert on AI for drug discovery, on how AI can help us find new medicines.

00:54:38

The Pauling Principle - Episode 3 - Brain health

The Pauling Principle ·

2025/03/11

What should we do to prevent Alzheimer's and other neurodegenerative diseases as we age?

00:45:17

The Pauling Principle - Episode 2

The Pauling Principle ·

2025/03/04

Dan and I talk about the history of artificial intelligence, AI, ML, DL, LLMs what are all those and what they have to do with each other? Listen in to find out.

00:46:34

Welcome to The Pauling Principle

The Pauling Principle ·

2025/02/20

We will talk about AI and drug discovery. Welcome to our new podcast!

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