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PODCAST

Speaking of Mol Bio

Thermo Fisher Scientific

Speaking of Mol Bio, a podcast series from Thermo Fisher Scientific, discusses trending applications in science and the molecular biology aspects of those applications. Our host delves in to deep discussion with CEOs, R&D scientists, researchers, and key opinion leaders across the globe. Speaking of Mol Bio helps scientific curious people - from all scientific and non-scientific backgrounds - understand how modern molecular biology applications can help push the boundaries in medicine, science, drug

science life sciences

All Episodes

00:14:50

No lyophilizer? No problem. Dry-Ready reagents...

Speaking of Mol Bio ·

2025/10/22

In this Mol Bio Minutes episode, Thermo Fisher Scientific's Dr. Agnė Alminaitė unveils an exciting new approach for assay developers: Dry-Ready™ reagents for RT-LAMP and RT-qPCR. These innovations eliminate the need for lyophilizers by enabling air drying of molecular assays in a standard heating oven, producing room temperature-stable assays in under two hours.Agnė walks listeners through how Dry-Ready differs from traditional Lyo-Ready™ and lyophilization methods, while delivering similar

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00:33:28

Unlocking phagocytosis―a look at advanced cancer...

Speaking of Mol Bio ·

2025/10/08

In this inspiring episode, Dr. Felipe Gálvez-Cancino, group leader at Oxford's Center for Immuno-Oncology, walks us through his team’s groundbreaking research on macrophages, T cells, and immune regulation in solid tumors. Tracing his path from early cancer vaccine work to advanced antibody-dependent cellular phagocytosis (ADCP), Felipe shares how his team is working to reprogram tumor-associated macrophages to more efficiently eliminate cancer cells.He explains how regulatory CD4+ T cells suppress

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00:19:35

From seed to cDNA―lessons learned from plant RNA...

Speaking of Mol Bio ·

2025/09/24

In this Mol Bio Minutes episode, Dr. Will Barnes, a plant biologist turned senior sales training specialist at Thermo Fisher Scientific, reflects on his time at the bench and the molecular lessons learned along the way. Will dives deep into the difficulties of RNA work in plant systems—carbohydrate contamination, genomic DNA carryover, secondary structure—and how these hindered everything from cloning and expression analysis to sequencing and qPCR.Through real-world anecdotes, he explains how

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00:37:02

Seeding scientific equity through access

Speaking of Mol Bio ·

2025/09/10

In this episode of Speaking of Mol Bio, host Steve Lewis speaks with Dr. Melissa Wu, co-founder and CEO of Seeding Labs, a nonprofit that’s redefining global scientific access. Dr. Wu shares the inspiring story of how Seeding Labs helps institutions in developing nations build research infrastructure by redistributing surplus laboratory equipment from partners like Thermo Fisher Scientific.With an innovative model that connects equipment donors in the global North with universities and institutes

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00:14:45

Customization is key―tailoring RT-qPCR for modern assays

Speaking of Mol Bio ·

2025/08/20

In this Mol Bio Minutes mini-episode, Thermo Fisher Scientific’s Agnė Žiupkaitė takes listeners on a journey through the evolving world of RNA assay development—focusing specifically on 1-Step RT-qPCR. She outlines the critical considerations for assay developers, including enzyme speed, robustness, and the growing demand for customizable reagents that meet both technical and regulatory needs.Highlighting Thermo Fisher’s SuperScript reverse transcriptase family—particularly the Lyo-ready SuperScript

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00:35:21

Quantum barcoding and the future of single-cell...

Speaking of Mol Bio ·

2025/08/06

In this episode, host Steve Lewis sits down with Giovanna Prout, President and CEO of Scale Biosciences, to explore how Scale is pushing the boundaries of single-cell omics. With a career that spans roles with big players and entrepreneurial ventures, Giovanna brings a unique perspective to the world of genomics innovation.Giovanna dives into Scale's patented Quantum Barcoding technology—a high-throughput, combinatorial indexing approach that allows researchers to process millions of cells and

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00:11:24

Simplify your science ― why 1-step RT-PCR is a game...

Speaking of Mol Bio ·

2025/07/23

In this episode of Speaking of Mol Bio, Aistė Serapinaite, an experienced R&D scientist, shares her insights into the world of 1-Step RT-PCR—a method that simplifies RNA analysis by combining reverse transcription and PCR amplification in a single reaction. She explains how traditional RNA workflows once lengthy, multi-step processes were prone to errors and contamination, and how 1-Step RT-PCR has transformed this landscape with speed, efficiency, and fewer handling steps.Listeners learn about the

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00:30:12

No nucleus, no problem – platelet biology and...

Speaking of Mol Bio ·

2025/07/09

In this episode of Speaking of Mol Bio, Dr. Beth Webb takes us deep into the world of platelets, often misunderstood components of blood that punch far above their weight in both physiological and pathological processes. As a postdoctoral researcher at the University of Leeds, Dr. Webb explores how endothelial signals influence platelet activity, and how these anucleate cell fragments play roles not only in clotting, but also in immune responses, inflammation, and diseases like cardiovascular

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00:18:41

Boosting PCR accuracy – tips for maximizing...

Speaking of Mol Bio ·

2025/06/25

In this Mol Bio Minutes episode, Laurynas Alijošius shares a personal story that every molecular biologist can relate to—running PCR, cloning, and sequencing, only to discover frustrating errors in the DNA. This episode dives deep into PCR accuracy and why it matters for everything from sequencing to cloning and long-read library prep. Laurynas breaks down the major contributors to PCR error, including the fidelity of DNA polymerase, primer design flaws, template impurities, and suboptimal cycling

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00:33:16

Multiomics, systems biology, and the future of...

Speaking of Mol Bio ·

2025/06/11

In this episode of Speaking of Mol Bio, Dr. Cath Moore of the Australian Genome Research Facility (AGRF) discusses how molecular biology technologies are helping to shape Australia’s scientific landscape—from clinical genomics and conservation to bioremediation and agriculture. With over 20 years of experience in both academia and industry, Dr. Moore reflects on the remarkable evolution of genomic tools, from Sanger sequencing to high-resolution spatial multiomics.She unpacks AGRF’s mission to

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00:16:40

Fast PCR fundamentals – from instruments to enzymes

Speaking of Mol Bio ·

2025/05/28

In this Mol Bio Minutes episode, Laurynas Alijošius breaks down how to run fast PCR to save time and increase lab efficiency. He explains how to choose the right thermal cycler with fast ramp speeds, select low-volume and thin-walled PCR plastics, and use engineered DNA polymerases that offer rapid elongation and hot-start capability. Laurynas also covers practical tips for optimizing reaction components, shortening cycling protocols, and reducing waste. Whether you’re aiming to finish your

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00:31:51

The hidden language of RNA – how epigenetics is...

Speaking of Mol Bio ·

2025/05/14

This episode teaches that innovation is born at the intersection of curiosity and persistence. Dr. Gudrun Stengel, co-founder and CEO of Alida Biosciences, reveals how her startup is transforming the landscape of RNA research through a novel technology called proximity barcoding. Dr. Stengel’s story exemplifies the power of entrepreneurial spirit in driving scientific discovery, offering a glimpse into how one idea can reshape an entire field.At Alida Biosciences, Dr. Stengel and her team are

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00:10:21

Sustainability Made Simple: Greener Choices in...

Speaking of Mol Bio ·

2025/04/22

Sustainability in the lab isn't just a trend—it's a responsibility. In this quick but powerful Mol Bio Minutes episode, sustainability expert Sune Lund Sporring shares actionable tips to reduce energy use, manage lab waste, and transition to greener materials like Thermo Fisher’s Sustain Series bio-based plastics.Discover the difference between bio-based and biodegradable, why second-generation feedstocks are a game-changer, and how to make low-impact changes without compromising performance. Learn

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00:33:53

From bats to cancer – the power of gene regulation

Speaking of Mol Bio ·

2025/04/09

Join us for an insightful conversation with Dr. Nadav Ahituv, a leader in human genetics and gene regulation at UCSF. He shares his personal journey from scoliosis patient to genetic researcher, exploring the mysteries of non-coding DNA, massively parallel reporter assays, and CRISPR-based therapeutic innovations.We dive into his lab’s diverse projects, from decoding bat wing development and diet adaptation to tackling complex diseases like scoliosis and cancer through gene modulation. Learn how

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00:09:05

No more smears – expert tips for electrophoresis success

Speaking of Mol Bio ·

2025/03/26

With prior Mol Bio Minutes episodes covering DNA form migration and staining considerations for nucleic acid gel electrophoresis, we tie it all together with this great set of overall tips, tricks and resources for the topic. Anyone that’s ever run a gel has undoubtedly produced gels with smeared, faint or poorly separated bands. What causes these and how can you avoid them? Well, Aistė Polikaitytė, Scientist at Thermo Fisher Scientific is here to cover the likely causes and troubleshooting tips to

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00:32:00

Biologically removing the forever from “forever...

Speaking of Mol Bio ·

2025/03/12

It could be argued that biology has always boiled down to chemistry, and that chemistry has always boiled down to physics. However, not many would deny that the fields of biology and chemistry are overlapping more than ever, with both leveraging computing methods, also more than ever. This conversation with Dr. Ramesh Jha, Technical Staff Member at Los Alamos National Laboratory (LANL), crosses biology, chemistry, and computing methods. The work of his biome team at LANL uses computational tools to

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00:10:17

A clear picture – staining tips for gel electrophoresis

Speaking of Mol Bio ·

2025/02/26

You can run the perfect agarose gel to separate your nucleic acid fragments but if you don’t stain and image the gel properly, it’s all for not. In this second installment of Mol Bio Minutes we take a look at the staining considerations for nucleic acid gel electrophoresis with Paulius Palaima, Product Manager at Thermo Fisher Scientific. He covers the range of stains and staining approaches available while calling out pros, cons and considerations for each. How these recommendations change,

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00:35:37

With knowledge comes great responsibility

Speaking of Mol Bio ·

2025/02/12

Topics and terms such as biosafety, biosecurity, containment, and contamination are things most of us have heard of and think about at some level, but with the pace of molecular biology moving faster than ever, these are topics with implications that are reaching farther than ever. We’re joined by Dr. Ryan Burnette and Dr. Lauren Richardson from Merrick and company for this episode, and they’re ace communicators that help walk us through the expanding horizon and implications of these topics.This

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00:09:19

DNA on the move – the influence of form on gel migration

Speaking of Mol Bio ·

2025/01/29

Agarose gel electrophoresis is a staple method in almost all biology and biochemistry lab where separation and analysis of nucleic acids is needed. In this Mol Bio Minutes mini episode Augustė Užuotaitė, Scientist III at Thermo Fisher Scientific, covers the basics of electrophoresis with a spotlight on how different forms of DNA migrate differently in agarose gel electrophoresis.In less than 10 quick minutes, you’ll learn about the many factors that affect DNA migration rate. Augustė reviews how DNA

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00:31:37

The genetics and neuroendocrinology of obesity

Speaking of Mol Bio ·

2025/01/15

Obesity is one of the most pressing health challenges of our time, with genetic and molecular factors playing a crucial role in how our bodies regulate weight. In this season opener, we explore the science behind obesity, focusing on how hormones, genetics, and brain circuits influence feeding behavior and body weight. Join us for a fascinating discussion about the interplay between molecular biology and real-world health outcomes.Our guest, Dr. Giles Yeo, is a professor of molecular

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42 results

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