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PODCAST

Biomedical Frontiers: Stories with Innovators in Healthcare

Welcome to "Biomedical Frontiers: Stories with Innovators in Healthcare," a podcast produced by the University of Virginia"s Wallace H. Coulter Center for Translational Research.Biomedical Frontiers is a forum for in-depth discussions at the intersection of healthcare technology and translational research. We feature leading voices from the University of Virginia community and the broader biomedical industry. Each episode explores pivotal research projects and disruptive innovations aimed at

science life sciences

All Episodes

81:31

Time to Critical Care: How AI Can Cut Patient Wait...

Biomedical Frontiers: Stories with Innovators in... ·

2025/10/06

When every minute counts, inefficiencies in communication and data flow can cost lives. In this episode of Biomedical Frontiers, trauma surgeon Dr. Jamie Wisser and entrepreneur Robert Holton share how they’re using AI and interoperability to accelerate time to critical care.Dr. Wisser, founder of Actual Healthcare Solutions, describes how his experience performing 26-hour reconstructive surgeries exposed the limits of today’s electronic medical records. Together with Holton, he’s building a

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72:48

Reversing Diabetes: The Promise of Lifestyle Medicine...

Biomedical Frontiers: Stories with Innovators in... ·

2025/08/26

Type 2 diabetes affects over 37 million Americans — but what if our standard treatment paradigm is all wrong?In this episode, Dr. Meagan Grega shares the science and strategy behind lifestyle medicine, a fast-growing movement that uses food, sleep, movement, stress reduction, and social connection to treat and even reverse chronic disease.Dr. Grega is the co-author of the first-ever Clinical Practice Guideline on Lifestyle Interventions for Type 2 Diabetes and a lead author of ACLM’s Expert

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69:56

Personalized Drug Design: New Therapies for Rare...

Biomedical Frontiers: Stories with Innovators in... ·

2025/08/01

Dr. Stanley Crooke pioneered a new class of medicine—antisense oligonucleotides—and built a $5B biotech company, Ionis Pharmaceuticals, to prove it could work. Then he walked away to found a nonprofit, n-Lorem, to treat patients with one-in-a-billion genetic mutations—people no one else would help. In this episode, we explore:What nano-rare diseases are, and why they represent medicine’s next great frontier.The promise of antisense therapy for individualized, mutation-specific treatment.The 30-year

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46:33

Pharmacists + Doctors: Partnerships That Make...

Biomedical Frontiers: Stories with Innovators in... ·

2025/06/26

Why Is Your Prescription So Expensive? How Pharmacists Can Help Fix Healthcare 💊 Featuring: Vinay Patel, Pharmacist & Founder of MakoRxDid you know that prescription drugs now account for 40% of healthcare spending on many employer plans? Or that pharmacists were once forbidden from telling you about cheaper alternatives to the medications you take?In this eye-opening episode, pharmacist and healthcare entrepreneur Vinay Patel joins host Dasha Tyshlek to expose the tangled web of middlemen,

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56:10

Genetic Disorders of the Eye: Living with Vision...

Biomedical Frontiers: Stories with Innovators in... ·

2025/06/03

What is it like to live with a rare genetic eye disorder? Join Dr. Abigail Fahim and Dr. Chris Moen as they discuss choroideremia—a progressive retinal disease—and how research, advocacy, and patient experience intersect to push for treatments and improve quality of life.Dr. Fahim shares her cutting-edge research into the cellular mechanisms driving this progressive condition, while Dr. Moen—a physician, patient, and advocate—shares his personal experience with vision loss and the systemic gaps that

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71:05

Digital Mental Health - the Future of Managing...

Biomedical Frontiers: Stories with Innovators in... ·

2025/04/24

How do we tackle the rising epidemic of anxiety with tools that actually scale? Why aren’t traditional therapy models enough? And how can digital technologies like mobile sensing and cognitive bias modification help close the treatment gap in mental health?In this episode of Biomedical Frontiers, host Dasha Tyshlek sits down with Dr. Bethany Teachman, Professor of Psychology and Director of Clinical Training at the University of Virginia, to explore how digital mental health tools are being designed

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69:38

Improving Rural Health: Medical Devices That Increase...

Biomedical Frontiers: Stories with Innovators in... ·

2025/03/27

Can medical devices improve patient care in rural healthcare systems? In this episode, Dr. Aileen Helsel, Director of Innovation at Carilion Clinic, shares how her team of engineers works with Carilion’s clinical teams to develop new medical devices that solve unique challenges in rural settings.Rural patients often travel long distances for care - making management of time sensitive emergencies and recurring visits for chronic conditions particularly challenging. Dr. Helsel highlights three

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66:01

Tech Transfer, navigating the healthcare system and...

Biomedical Frontiers: Stories with Innovators in... ·

2025/03/04

How do groundbreaking biomedical innovations move from research labs to real-world applications? What challenges make healthcare such a complex industry for startups? What risks are worth taking when translating science into impactful solutions?In this episode host Dasha Tyshlek sits down with David Chen, Assistant Dean of Entrepreneurship and Innovation Partnerships, and Lisa Bowers, Director of UVA’s Enterprise Studio and former biotech executive, to explore tech transfer in healthcare. We

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58:39

Dr. Ben Holmes on Regenerating Cartilage: A 3D...

Biomedical Frontiers: Stories with Innovators in... ·

2024/12/03

Cartilage doesn’t heal easily—but what if it could? In this episode, we sit down with Ben Holmes Ph.D, CEO of Nanochon, to explore how his team is revolutionizing cartilage repair with 3D printing technology. Learn how Nanochon’s innovative material mimics natural cartilage and stimulates proper healing and repair. It may one day make knee replacements obsolete. Ben also shares his leadership journey, how he conducted over 100 physician interviews to help him understand the pain points in

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46:20

Dr. Jonathon Hill on Gene Sequencing: How Epigenetics...

Biomedical Frontiers: Stories with Innovators in... ·

2024/11/08

Genetic sequencing is the process of determining the exact order of the nucleotides in a DNA or RNA molecule. Sequencing provides the complete "blueprint" of an organism's genetic code, and it's a critical tool in genetics, molecular biology, and medical research. Dr. Jonathon Hill develops innovative genomic and bioinformatic methods for gene expression analysis which has tremendous applications in cancer, early detection of chronic diseases, and personalized medicineLove this podcast? Write to us

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68:02

Dr. Andrew DiMeo on Repeatable Innovation: Frameworks...

Biomedical Frontiers: Stories with Innovators in... ·

2024/10/23

What is innovation and why is it important to teach in an engineering program? Innovation has been defined as increasing value, which is increasing the benefits to cost ratio. Because innovation can be an ambiguous concept, it is important to develop a framework to guide the process. Since 2006, Dr. DiMeo has been coaching, consulting, and training processes of innovation, design thinking, and entrepreneurship for medical device innovation and healthcare impact.Love this podcast? Write to us with

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51:18

Dr. Shayn Peirce-Cottler on Alzheimer's and Diabetes,...

Biomedical Frontiers: Stories with Innovators in... ·

2024/09/11

Microvessels are a crucial part of our body’s circulatory system. They're responsible for delivering the oxygen and nutrients to every cell in your body and are often devastated by diseases like Diabetes and Alzheimer's. Dr. Peirce-Cottler develops computational models and combines them with wet lab experiments to study how tissues heal after injury and to develop therapies for inducing tissue regeneration.Love this podcast? Write to us with ideas, feedback, and guest recommendations at

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73:27

Dr. Tom Skalak on the Value of Research, Emerging...

Biomedical Frontiers: Stories with Innovators in... ·

2024/08/29

Investment is critical for advancing promising biomedical research out of the lab and into the hospital. Dr. Tom Skalak has worked widely on innovation ecosystems with the White House, U.S. Congress, and Fortune 500 CEOs and C-suites seeking cultures to advance creative ideation and implementation of innovations. He urges VCs to invest locally with research universities and shares his perspective of some of the most exciting, emerging fields of research.Love this podcast? Write to us with ideas,

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74:29

Dr. Mark Hanson on the Evolution of Healthcare...

Biomedical Frontiers: Stories with Innovators in... ·

2024/06/26

Heart disease is the leading cause of death for men and women in the United States. Mark Hanson co-founded Heartbeat Health to make heart care more consistent and to ensure the patient gets the care when they need it, wherever they are. By transforming how heart care is delivered through technology, the Heartbeat Health team is accelerating access to quality cardiovascular care and improving patient outcomes. In this episode of Biomedical Frontiers, we explore how telemedicine can be a solution to

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36:38

Dr. Jennifer West on the Future of Tissue Engineering...

Biomedical Frontiers: Stories with Innovators in... ·

2024/05/30

Tissue engineering is an exciting field that promises to solve many health conditions, but there are several fundamental challenges that remain unsolved. Dr. Jennifer West is leading the field with research on novel techniques that promote vascularization (tissue blood supply) and mimic the extracellular matrix (ECM) for tissue engineering applications. Dr. West’s lab focuses on biomaterials, nanotechnology, and tissue engineering, applying engineering approaches to study biological problems and

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46:52

Dr. Daniero and Dr. Griffin on Regenerating Vocal...

Biomedical Frontiers: Stories with Innovators in... ·

2024/05/02

The human voice box is a delicate, complex and highly specialized structure that enables the fine control and wondrous beauty of speech and song. When vocal cords are damaged, recovery and healing are difficult and lengthy. At UVA, Dr. James Daniero established the Interdisciplinary Voice and Swallowing Clinic, specializing in surgeries of the airways and the vocal cords. He met Dr. Donald Griffin, professor of Biomedical Engineering, and together they developed a plan to design new materials to

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67:32

Dr. Slivia Blemker on Modeling Muscles with MRI and...

Biomedical Frontiers: Stories with Innovators in... ·

2024/03/20

Muscles play a pivotal role throughout our bodies, not just in our day-to-day functions but also as foundational elements in our journey towards healthy aging. At the forefront of exploring this intricate system is Dr. Silvia Blemker and her dedicated team at the M3 Lab at the University of Virginia. Their innovative approach weaves together advanced imaging, hands-on experimentation, and sophisticated computational methods to delve deep into the anatomy and mechanics of muscles, shedding light on

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63:13

Dr. Natasha Sheybani on Precision Cancer Treatments...

Biomedical Frontiers: Stories with Innovators in... ·

2024/03/14

An in-depth discussion with Dr. Natasha Sheybani, who is pioneering the use of Focused Ultrasound (FUS) in precision cancer treatment at the University of Virginia. Dr. Sheybani's research focuses on enhancing immunotherapy for brain and breast cancers through innovative, non-invasive techniques. Her efforts to improve glioblastoma patient outcomes by overcoming major treatment barriers, such as the blood-brain barrier, have earned her recognition by the Forbes 30 under 30 in Science Award and many

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98:42

Dr. Nathan Price on Alzheimers, Digital Twins, and...

Biomedical Frontiers: Stories with Innovators in... ·

2024/03/13

In this episode we delve into the future of medicine with Dr. Nathan Price, Chief Science Officer at Thorne HealthTech and co-author of "The Age of Scientific Wellness." Dr. Price shares his visionary insights on the transformation of medicine through systems biology approaches, modeling and analytics, and practices centered in prevention. He shares how his research uses digital twins in predicting and preventing the progression of Alzheimer’s diseases and how other AI developments are impacting

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