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PODCAST

Dr. GPCR Podcast

Dr. Yamina Berchiche

We bring you closer to dedicated scientists who work tirelessly to help understand GPCR pathophysiology.

science life sciences

All Episodes

00:54:48

Can Simulations Predict GPCR Ligand Bias?

Dr. GPCR Podcast ·

2026/03/18

How does ligand binding at the extracellular pocket of a GPCR reshape signaling on the intracellular side?Biased agonism is often measured through pathway activation assays, but the structural origin of ligand bias remains difficult to trace. Can molecular simulations reveal the communication routes that link ligand binding to G protein or arrestin signaling?In this conversation, computational biologist Anita Niveda explores how molecular dynamics and network analysis can map allosteric

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00:51:05

Why Mosquitoes Hunt You: The GPCR Behind the Bite

Dr. GPCR Podcast ·

2026/03/04

Conserved neuropeptide Y GPCRs orchestrate both feeding and mating behaviors in mosquitoes, with direct translational parallels to human gut-brain signaling.Quick SummaryLearn how receptor internalization and neuropeptide GPCR signaling underlie the regulation of mosquito host-seeking and reproduction. Dr. Laura Duvall details the use of CRISPR-based assay development and fluorescence-driven phenotyping to connect molecular manipulation to whole-animal behavior. Her approach provides actionable

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00:37:01

GPCR Location and Lipid Raft Signaling

Dr. GPCR Podcast ·

2026/02/18

Key TakeawaysHow does the precise localization of GPCRs in lipid rafts reshape drug discovery strategy? Examine implications for functional assays and therapeutic innovation.Explore the pivotal role of GPCR-lipid raft compartmentalization in receptor signaling, desensitization, and pharmacology research. Dr. Keyvan Sedaghat discusses assay approaches, regulatory mechanisms, and the translational impact of bitter taste receptors beyond sensory biology. Leveraging decades of experience in assay

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00:51:00

Choosing the Right GPCR Assays for Translational Drug...

Dr. GPCR Podcast ·

2026/02/04

Episode SummaryPotent in vitro hits often fail in vivo—Martin Marro details how robust assay choice and pathway deconvolution can revive GPCR drug discovery programs.Listeners will learn practical approaches to assay development for GPCR drug discovery, the pitfalls of calcium readouts, and how identifying pathway bias impacts translational success. Dr. Marro shares his experience bridging in vitro–in vivo gaps, refining selection flowcharts, and leveraging pharmacology research to drive clinical

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00:55:06

How Academia–Industry Collaboration Is Scaling GLP-1...

Dr. GPCR Podcast ·

2025/12/17

GPCR tools don’t move the field forward unless researchers can actually use them. This episode breaks down how collaboration turns probes into progress.SummaryIn the final episode of this series, David Hodson, Johannes Broichhagen, and Maria Majellaro unpack how academic labs and Celtarys Research partnered to scale fluorescent probes, improve assay development, and support gpcr drug discovery. The conversation spans receptor internalization, fluorescence assays, tech transfer realities, and why

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00:38:58

Imaging GPCRs in Action: Chemical Probes for...

Dr. GPCR Podcast ·

2025/12/03

Chemical probes are reshaping how we map GLP-1R in real time — revealing receptor pools antibodies can’t reliably capture.This is Episode 2 of a 3-part GPCR tool-development series created in partnership with Celtarys Research.Summary:Dr. Johannes Broichhagen aka JB breaks down the design logic behind fluorophore-linked peptides, assay trade-offs, and what true receptor internalization looks like in live tissue. A concise masterclass in assay development and GPCR drug discovery.What you’ll learn:•

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00:55:06

Mapping GLP-1 & GIP Receptors in Metabolic Disease...

Dr. GPCR Podcast ·

2025/11/19

Precise receptor mapping is reshaping how we understand incretin biology. David Hodson explains how GPCR-targeted chemical probes reveal where GLP-1 and GIP receptors actually signal across pancreas and brain—and what this means for metabolic drug design.Learn how these tools refine gpcr drug discovery, clarify receptor internalization, and guide next-gen therapeutics.🎓 Join Dr. GPCR Premium for exclusive episodes + research tools → https://www.ecosystem.drgpcr.com/

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00:47:20

Inside Monash: Organized Signaling, Real Impact

Dr. GPCR Podcast ·

2025/11/12

What makes Monash a model for modern pharmacology? Dr. Michelle Halls reveals how collaboration, mentorship, and receptor organization shape today’s GPCR breakthroughs — from femtomolar signaling to cancer biology. A look inside a lab culture built on precision, openness, and impact.👉 Watch the complete episode: https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/leadership-luck-and-gpcr-signaling🎓 Join Dr. GPCR Premium for exclusive episodes + research tools → https://www.drgpcr.com/premium

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00:44:55

Model. Predict. Discover. with Dr. Jens Carlsson |...

Dr. GPCR Podcast ·

2025/10/22

Predicting, not just explaining, can change how we design GPCR-targeted drugs. Jens Carlsson reveals how modeling bridges structure, function, and pharmacology.Hear how predictive simulations shape assay development, GPCR drug discovery, and collaborations across disciplines.🎓 Join Dr. GPCR Premium for exclusive episodes + research tools → https://www.ecosystem.drgpcr.com/gpcr-university-pricing Watch the complete episode at

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00:42:12

From Rare Earth Probes to Internalization Assays: The...

Dr. GPCR Podcast ·

2025/09/22

🔬 What if you could track GPCR internalization—no wash, high-throughput, and in endogenous systems?Discover how Dr. Eric Trinquet and Revvity built pH Sense, a next-gen fluorescence assay that redefines receptor internalization workflows. Learn assay trade-offs, tool design, and how to decode GPCR behavior with precision.🎓 Join Dr. GPCR Premium for exclusive episodes + research tools → https://www.ecosystem.drgpcr.com/gpcr-university-pricingWatch the complete episode at

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01:03:26

From Curiosity to Breakthrough: Ajay Yekkirala on...

Dr. GPCR Podcast ·

2025/09/02

What if a failed med school plan led to a biotech breakthrough?Ajay Yekkirala shares how GPCRs, AI, and scientific curiosity are reshaping pain therapeutics — and what it really takes to build better medicines.Watch the video version of this podcast episode: What if a failed med school plan led to a biotech breakthrough?Ajay Yekkirala shares how GPCRs, AI, and scientific curiosity are reshaping pain therapeutics — and what it really takes to build better medicines.Watch the video version of this

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01:00:56

Xylazine, Fentanyl, and the Fight for Breath with...

Dr. GPCR Podcast ·

2025/08/19

When fentanyl slows your breath and xylazine traps it, the clock starts ticking.PhD candidate Catherine Demery takes us inside her fight to understand how fentanyl and xylazine shut down breathing in different ways—work that blends GPCR pharmacology, animal models, and real-time street data to combat the opioid crisis.Watch the video version of this podcast episode: Ep 172 with Catherine Demery

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00:34:29

Smells Like GPCR Spirit: Cracking Olfactory Codes...

Dr. GPCR Podcast ·

2025/08/05

Watch the video version of this podcast episode.https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-171-with-alessandro-nicoli---------------------------------Become a #DrGPCR Ecosystem Member---------------------------------Imagine a world in which the vast majority of us are healthy.The #DrGPCR Ecosystem is all about dynamic interactions between us working towards exploiting the druggability of #GPCRs. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and

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01:02:27

GPCRs and the Science Behind Pain & Recovery with Dr....

Dr. GPCR Podcast ·

2025/07/22

Watch the video version of this podcast episode.https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-170-with-dr-alex-serafini---------------------------------Become a #DrGPCR Ecosystem Member---------------------------------Imagine a world in which the vast majority of us are healthy.The #DrGPCR Ecosystem is all about dynamic interactions between us working towards exploiting the druggability of #GPCRs. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and

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00:56:54

GPCR Pharmacology, Career Twists & Serendipity with...

Dr. GPCR Podcast ·

2025/07/08

Watch the video version of this podcast episode.https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-169-with-dr-sokhom-pin---------------------------------Become a #DrGPCR Ecosystem Member---------------------------------Imagine a world in which the vast majority of us are healthy.The #DrGPCR Ecosystem is all about dynamic interactions between us working towards exploiting the druggability of #GPCRs. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive

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01:05:41

Baking Molecules, Building Probes: When Chemists...

Dr. GPCR Podcast ·

2025/06/10

Watch the video version of this podcast episode:https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-168-with-dr.-maria-majellaro-from-celtarysVisit Celtarys' website in the Ecosystem: https://www.ecosystem.drgpcr.com/celtarys-research-dr-gpcr-ecosystemRead the DrGPCR x Celtarys Partnership Press Release: https://www.ecosystem.drgpcr.com/post/dr-gpcr-and-celtarys-research-join-forces-to-expand-access-to-innovative-gpcr-toolsLearn more about Celtarys Research:

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00:39:01

Hacking GPCRs: Tools, Tech & Drug Discovery w/ Drs....

Dr. GPCR Podcast ·

2025/05/27

Watch the video version of this podcast episode.https://www.ecosystem.drgpcr.com/dr-gpcr-podcast/ep-167-with-tom-sakmar-%26-ilana-kotliar---------------------------------Become a #DrGPCR Ecosystem Member---------------------------------Imagine a world in which the vast majority of us are healthy.The #DrGPCR Ecosystem is all about dynamic interactions between us working towards exploiting the druggability of #GPCRs. We aspire to provide opportunities to connect, share, form trusting partnerships,

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00:49:49

When to Walk, When to Run: Lessons from the GPCR...

Dr. GPCR Podcast ·

2025/05/13

Episode 166 of the Dr. GPCR Podcast features Benjamin Clements, a postdoctoral fellow at the University of Michigan, who brings fresh insight into the therapeutic promise of GPCRs — particularly in the context of opioid pharmacology. With a background in pharmaceutical sciences and neuroscience, Ben now focuses on positive allosteric modulators (PAMs) targeting the mu-opioid receptor, aiming to preserve opioid analgesia while reducing harmful side effects like respiratory depression and addiction.In

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00:49:44

Finance is Science too with Chuck DeWeese & Joe St....

Dr. GPCR Podcast ·

2025/04/29

In this episode of the Dr. GPCR Podcast, we step outside the lab to talk about what keeps research-driven organizations running behind the scenes: finance and operations. Yamina Berchiche is joined by Joe St. Germain and Chuck DeWeese from Company Launch Partners to discuss the real-world challenges of building startups and nonprofits—including Dr. GPCR itself. Joe shares his leap from corporate finance to launching a firm that supports early-stage ventures, while Chuck explains his journey from

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00:49:33

Signals, pH, and Discovery: Cracking GPCR Mysteries...

Dr. GPCR Podcast ·

2025/04/15

In this science-focused episode of the Dr. GPCR podcast, we meet Dr. Ian Chronis, a freshly minted PhD from the University of Michigan. While his academic roots started in classical history and ancient Greek, Ian’s curiosity pulled him toward chemistry, then pharmacology, and eventually into the complex world of GPCR signaling. His story is a testament to the power of staying open to change and following emerging scientific questions wherever they lead.Ian’s doctoral work focused on two key GPCR

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222 results

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