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PODCAST

Longevity Optimization with Kayla Barnes-Lentz

Kayla Barnes-Lentz

Maximizing Human Health and Performance. We discuss: optimal health, nutrition, high-performance, cognitive excellence, biohacking, longevity and more with top experts around the world. Hosted by Kayla Barnes-Lentz.

health & fitness

All Episodes

01:13:03

GLP-1 Crisis for Women, Gut Health, Bone Loss with...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/04/16

We're back with Dr. Szal! Today we are discussing a variety of topics: Gut health, peptides, hormone health , GLP-1's, bone health and so much more!In this conversation, Dr. Sara G dives into the gut-brain connection and explains how disrupting the microbiome can directly affect mood, anxiety, and overall mental resilience. She breaks down why even a single course of antibiotics can shift the balance of your gut in ways most people never consider, and what that means for how you feel day to

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01:32:32

Dr. Bérénice Benayoun, PhD: Why Your Ovaries Age (And...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/04/09

Bérénice Benayoun, PhD, explains why ovarian aging may be one of the earliest and most important drivers of female aging, influencing the brain, immune system, metabolism, and long-term disease risk far beyond reproduction. She breaks down what we actually know so far, including DNA damage, mitochondrial dysfunction, fibrosis, hormonal signaling, and why the ovary appears to age faster than other tissues.We also get into one of the most surprising findings in the field right now: a brand new study

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01:32:51

Dr. Deb Rivera, PhD: The Missing Link Between Stress,...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/04/02

Most people can feel when stress is affecting them. Far fewer know whether their body is adapting well or quietly being pushed toward dysfunction.In this episode, Dr. Deb Rivera, PhD in neuroengineering, explains the hidden biological system that helps determine how well your body handles stress. Her research focuses on redox balance and the glutathione ratio, a biomarker that may reveal whether your body is adapting to stress or slowly moving toward dysfunction.Join the most comprehensive

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01:39:12

Dr. Eboni Cornish, MD: Brain Longevity,...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/03/26

Brain health problems rarely begin where most people look. Memory issues, low mood, poor focus, anxiety, and even early cognitive decline can be driven by hidden inflammation and root-cause imbalances long before they show up the way most people expect.In this episode, Dr. Eboni Cornish explains how chronic infections, mold, toxins, hormones, gut dysfunction, and oral or nasal microbial imbalances can all affect the brain, and why “mental health” often needs to be approached as brain health

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00:51:25

Jessie Inchauspé Glucose Goddess on CGMs, Crashes &...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/03/19

Blood sugar stability may be one of the most important levers for long term health, yet most people never look at it.In this episode, I am joined by Jessie Inchauspé, widely known as the Glucose Goddess, to examine what glucose spikes are actually doing inside the body and why they matter even if you are not diabetic.We unpack how glucose spikes can influence your mood, focus, cravings, and energy levels, why blood sugar stability matters even if you are not diabetic, and how seeing your own

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01:45:36

Dr. Deanna Minich, PhD: How Women Should Structure...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/03/12

Women are told to fast, cut carbs, eat high protein, avoid seed oils, and track macros, but most of that advice ignores female physiology.In this episode, I’m joined by Dr. Deanna Minich, PhD, certified functional medicine practitioner and nutrition scientist. We walk through the Female Longevity Nutrition Protocol she created, including circadian timing, macro ranges by life stage, and how to stop getting whiplash from internet nutrition trends.Join the most comprehensive *female-specific community

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01:21:09

Dr. Susanna Søberg, PhD: The Science of Cold Plunges...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/03/05

Cold exposure is not a badge of toughness. It’s a stressor.And if you do it wrong, you can absolutely overdo it.In this episode, I’m joined by Dr. Susanna Søberg, PhD, scientist and educator specializing in metabolism, cold and heat exposure, and longevity. We break down what cold exposure is actually doing in the body, why brown fat matters for metabolic health, and how women should think about timing cold exposure around PMS, luteal phase, and menstruation.Join the most comprehensive

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01:35:53

Dr. Stephanie Riley Hahn: Pelvic Floor Optimization,...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/02/26

Pelvic floor problems are not a “just do more kegels” issue.For a lot of women, kegels are either not specific enough, or they make symptoms worse.In this episode, Dr. Stephanie Riley Hahn, pelvic floor physical therapist and founder of Longevity and Pilates, breaks down what pelvic floor dysfunction actually is, how to tell weakness from tightness, and why pressure management and breathing mechanics often matter more than squeezing harder.Join the most comprehensive *female-specific community for

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01:54:54

Dr. Aimie Apigian, MD: The Biology of Trauma +...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/02/19

Longevity isn’t just workouts, supplements, and recovery tools, it starts with nervous system health. In this episode, Dr. Aimie Apigian explains what trauma actually is (not a label, but a measurable physiological response), how the body shifts from stress into overwhelm, and why “pushing through” often turns into years of avoidance, numbing, and hidden internal strain.She breaks down the biology behind the trauma response, including the role of adrenaline, cortisol timing, and how mitochondrial

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00:18:48

I Became the First Woman in the World to Test Her...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/02/14

For the first time in history, ovarian biological age can be measured, and I became the first woman in the world to take the test.Until now, women have had no real way to understand how their ovaries are aging beyond rough estimates like AMH. But this new machine-learning algorithm, trained on over 40,000 real women across different life stages, analyzes hormone biomarkers, body composition, and reproductive history to estimate ovarian age relative to chronological age.This is a massive step forward

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00:58:49

Cynthia Thurlow, NP: Perimenopause, Insulin...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/02/12

Perimenopause is not just about hormones, it’s a metabolic transition that affects insulin sensitivity, gut health, stress tolerance, and long-term disease risk.In this episode, Cynthia Thurlow, board-certified nurse practitioner and functional medicine expert, explains how women’s metabolism changes in midlife and why insulin resistance, poor stress resilience, and gut dysfunction often appear years before menopause.She breaks down how perimenopause can begin earlier than most women expect, why

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02:39:42

Dr. Chris Masterjohn, PhD - Mitochondria,...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/02/05

When cellular energy production is impaired, no diet, supplement, or health protocol can work as intended.In this episode, Dr. Chris Masterjohn, nutrition scientist and expert in micronutrients and metabolism, explains why mitochondrial function is the limiting factor behind stalled progress, persistent fatigue, and supplements that stop working over time.He breaks down why vitamin D supplementation often creates new problems when it is taken without proper nutrient balance, how high doses can

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00:49:13

Dr. Jessica Shepherd, MD – Menopause, Hormone Therapy...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/01/29

In this episode, Dr. Jessica Shepard, board-certified OB/GYN and Chief Medical Officer of Hers, shares that the FDA just removed the black box warning on hormone replacement therapy after 23 years. We discuss what actually happened with the WHI study that created all the fear around estrogen and breast cancer, and why the research never actually supported that narrative.Dr. Shepard explains why you shouldn't wait until menopause to start the HRT conversation and how starting in your

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01:09:08

Dr. Khanh Nguyen - The Blood Swap: Why Doctors Are...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/01/22

What if your blood is what’s making you sick and the key to reversing it is removing it?In this episode, I sit down with Dr. Khanh Nguyen, a regenerative and anti-aging physician, to explore therapeutic plasma exchange and the rising use of young plasma. We talk detox, autoimmune disease, aging, peptides, and why your blood might be holding you back.Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and

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01:01:40

Dr. Ann Shippy, MD - The Fertility Alarm: Why 1 in 31...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/01/15

Is your environment silently sabotaging your fertility? Dr. Ann Shippy joins the show to reveal how hidden toxins, mold, and overlooked cellular damage may be accelerating ovarian aging and how to reclaim your fertility before it’s too late. From infertility misdiagnoses to rising autism rates, we dive deep into the tests most doctors never run, and the real impact your body’s toxic load has on future generations. Kayla's social + website:Instagram: kaylabarnesTikTok: femalelongevityTwitter:

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01:15:40

Ashley Koff, RD - Dietitian Reveals: The Hormone...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/01/08

Ashley Koff is a registered dietitian and author who spent 20 years discovering that weight and health aren't separate issues, they're connected through "weight health hormones." After her own struggles with restrictive eating despite doing everything "right," a functional medicine doctor helped her understand what was actually broken, and that was, her body's natural hormone function.In this episode, Ashley explains why GLP-1 medications like Ozempic work, who

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01:38:37

Dr. Will Bulsiewicz, MD - The #1 Nutrient for...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/01/01

In this video, Dr. Will Bulsiewicz shares his transformation from an overweight, depressed gastroenterologist to a gut health expert after meeting his now-wife changed his entire approach to food. He reveals why 95% of Americans are fiber deficient and how this single nutrient could be the key to longevity. Dr. B breaks down the science of the gut microbiome, explains why hyperpalatable foods force us to overeat 500 extra calories per day, and shares actionable strategies for rebuilding your gut

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00:25:04

How to Make 2026 Your Healthiest Year Ever (Complete...

Longevity Optimization with Kayla Barnes-Lentz ·

2026/01/01

Women don’t fail January — January fails women. Nearly 80% of New Year health goals are abandoned within weeks, not because of discipline, but because most plans ignore female biology. That’s why I created the 30-Day Female Longevity Challenge — a physiology-first way to prepare calmly and build health that actually lasts. Save $50 with code 2026. https://kayla-barnes-lentz.circle.so/checkout/female-longevity-challenge-2026?coupon_code=2026When you join, you also get one full year access to my

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01:16:02

Dr. Sarah E. Hill, PhD - PMS Expert: Get Through Your...

Longevity Optimization with Kayla Barnes-Lentz ·

2025/12/18

In this conversation, Kayla sits down with Dr. Sarah E. Hill, PhD to talk about the science behind PMS, cycle syncing, and why most health advice completely fails women. Dr. Hill explains the three main causes of PMS symptoms, natural hormonal shifts, one-size-fits-all protocols designed for men, and lack of cellular resilience.Join the most comprehensive female-specific community for health and longevity optimization. After over a decade dedicated to human performance and women’s health, I created

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01:52:54

Deanna Minich, PhD - Doctor Shares: 5 Superfoods...

Longevity Optimization with Kayla Barnes-Lentz ·

2025/12/11

For years, functional medicine has focused on lab results and supplement protocols. Dr. Deanna Minich knows there's a deeper layer most practitioners miss. As a nutrition scientist who worked under Dr. Jeffrey Bland and educated for the Institute for Functional Medicine, she's witnessed how artificial light at night disrupts women's hormones more than almost any other factor, yet it's completely ignored.In this episode, Dr. Minich reveals why 85% of people are Omega-3 deficient

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