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Journal of Neurophysiology

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Podcasts created by the Journal of Neurophysiology community

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All Episodes

13:45

Deep brain stimulation of A13 region evokes robust...

Journal of Neurophysiology ·

2025/10/29

In this episode, coauthors Anupam Bisht and Cecilia Badenhorst discuss their study, “Deep brain stimulation of A13 region evokes robust locomotory response in rats.” Their research demonstrates that deep brain stimulation (DBS) of the A13 region in rats robustly increases locomotor activity without inducing anxiety using a novel wireless stimulation approach, suggesting that A13 may be a promising therapeutic target for gait dysfunction in Parkinson’s disease. Deep brain stimulation of A13 region

9:09

Pharmacological modulation of the M-current shapes...

Journal of Neurophysiology ·

2025/10/03

In this episode, coauthors Stephanie Gaudreau and Tuan Bui discuss their recently published research, “Pharmacological modulation of the M-current shapes locomotor function in developing zebrafish.” For the first time, they show that the M-current influences escape responses and swimming in larval zebrafish, with experiments in isolated spinal preparations revealing its presence in spinal circuits.Pharmacological modulation of the M-current shapes locomotor function in developing

34:12

Legacy of Dr. Joseph Erlanger: A Conversation with...

Journal of Neurophysiology ·

2025/09/12

In our latest episode, Journal of Neurophysiology Editor-in-Chief Dr. Nino Ramirez discusses the life and scientific legacy of Dr. Joseph Erlanger with Dr. Erlanger’s granddaughter, Dorothy Erlanger. While the world knows Dr. Joseph Erlanger as a scientific pioneer in the fields of neuroscience and cardiovascular science, Dorothy Erlanger remembers her grandfather as a humble person who enjoyed weekly dinners and playing cards with his family. His work as an experimental pioneer led Dr. Erlanger,

6:02

Higher hyperpolarization activated current (Ih) in a...

Journal of Neurophysiology ·

2025/09/03

In this episode, coauthor Lauren Hewitt discusses her recently published study, “Higher hyperpolarization activated current (Ih) in a subpopulation of interneurons in stratum oriens of area CA1 in the hippocampus of Fragile X mice.” The research examines how inhibitory interneurons are altered in a fragile X mouse model, revealing that increased Ih current reduces the excitability of a specific interneuron subtype. These findings highlight how changes in voltage-gated ion channel function can

05:26

Emerging evidence on the effects of electrode...

Journal of Neurophysiology ·

2025/08/22

In this episode of the Journal of Neurophysiology’s podcast series, coauthor Andrea Gigliotti discusses the newly published review, “Emerging evidence on the effects of electrode arrangements and other parameters on the application of transcutaneous spinal direct current stimulation.” Gigliotti explains how computer simulations are helping researchers understand the role of electrode placement, polarity, and tissue properties in shaping tsDCS outcomes. He also describes why dosage may matter less

07:43

Motor Unit Firing Rates During Arm Cycling vs....

Journal of Neurophysiology ·

2025/07/29

In this episode, coauthor Daniel C. Basile discusses the team’s newly published research, "Investigating motor unit firing rates during arm cycling compared with intensity-matched isometric contractions in humans." Until now, motor unit firing rates (MUFRs) during upper-limb locomotor tasks had not been recorded in humans, leaving gaps in our understanding of how motor units behave during dynamic, CPG-mediated activity. Using indwelling fine-wire electrodes, the study reveals that MUFRs are

05:00

Alpha Rhythms and Occluded Motion in Natural Scenes

Journal of Neurophysiology ·

2025/07/29

In this episode, coauthors Lu-Chun Yeh and Daniel Kaiser discuss their recently published Short Report, "Cortical alpha rhythms interpolate occluded motion from natural scene context." When objects or people become temporarily hidden from view, our brains rely on environmental cues to predict their motion. This study shows that cortical alpha oscillations play a key role in this process, tracking not only visible movement but also anticipating whether motion continues or stops based on obstacles in

05:47

Uncovering Perceptual Templates with Natural Statistics

Journal of Neurophysiology ·

2025/07/29

In this episode of the Journal of Neurophysiology’s podcast series, coauthor Lorenzo Landolfi joins us to discuss the newly published research titled "Reverse correlation of natural statistics for ecologically relevant characterization of human perceptual templates." Reverse correlation remains a cornerstone technique for probing neuronal and perceptual receptive fields, yet its application to naturalistic behavior is complicated by the complex structure of real-world stimuli. While advances in

07:29

H-Reflex as a Biomarker: Insights from ALS Research

Journal of Neurophysiology ·

2025/07/03

In this episode of the Journal of Neurophysiology’s podcast series, coauthor Véronique Marchand-Pauvert discusses key findings from the team's published study, "Synaptic dynamics linked to widespread elevation of H-reflex before peripheral denervation in amyotrophic lateral sclerosis." The episode explores how an increased H-reflex—observed even without clear evidence of peripheral denervation—may reflect early synaptic changes in ALS. Marchand-Pauvert explains how this phenomenon appears widespread

10:20

Uncovering a New Aβ Receptor: A Key to Controlling...

Journal of Neurophysiology ·

2025/07/03

In this episode of the Journal of Neurophysiology's podcast series, we spotlight the research titled “Discovery of the Aβ receptor that controls the voltage-gated sodium channel activity: unraveling mechanisms underlying neuronal hyperexcitability.”Alzheimer’s disease is well known for memory loss and cognitive decline—but behind these symptoms lies a web of complex neuronal dysfunction. This study reveals that amyloid beta peptides (Aβs), known to enhance sodium channel activity and drive

06:20

How Visual Feedback Shapes Muscle Control: Insights...

Journal of Neurophysiology ·

2025/07/03

In this episode, lead author Alexander M. Zero highlights their newly published research, “Without visual feedback voluntary torque is overestimated during muscle potentiation despite similar motor unit firing rate and perception of exertion.” Alexander Zero breaks down their findings on how visual feedback — or the lack of it — influences voluntary torque control during muscle potentiation. Despite changes in muscle state, the study reveals that motor unit firing rates and perceived exertion remain

03:26

Exploring Angiogenesis and Cerebral Blood Flow in...

Journal of Neurophysiology ·

2025/07/03

In this episode, coauthors Dr. Bing Xin Song and Dr. Krista L. Lanctôt give a snapshot of their recently published manuscript, "Vascular Endothelial Growth Factor and Regional Cerebral Blood Flow in Early Alzheimer’s Disease." Building on past in vitro and in vivo studies, their work highlights a compelling link between angiogenesis and cerebral blood flow (CBF) in individuals with early-stage Alzheimer’s disease. Using a combination of neuroimaging and neurophysiology techniques, the study reveals

06:15

Aging, Force, and Feedback: Rethinking Proprioception...

Journal of Neurophysiology ·

2025/05/15

In this episode, coauthor Mélanie Henry highlights the findings of the newly published study, “Influence of Age and Feedback Modality on the Proprioceptive Sense of Force: Insights from Motor Unit Recordings.” She discusses how different types of feedback—auditory vs. visual—affect force-reproduction accuracy across age groups. Surprisingly, middle-aged and older adults performed better with auditory feedback, an improvement linked to increased motor unit coherence in the beta band. Tune in to

06:53

Unlocking the Spine: Exploring the Neurophysiology of...

Journal of Neurophysiology ·

2025/05/15

In this episode, coauthor Gretchen Seif discusses her recently published study, “Neurophysiological Effects of Latent Trigger Point Dry Needling on Spinal Reflexes.” Dive into the fascinating world of deep dry needling (DDN) as she highlights its impact on spinal reflexes in the triceps surae. Dr. Seif breaks down the study's key findings—including unchanged H reflex responses and increased soleus inhibition immediately and 72 hours post-DDN—along with the observed gains in ankle range of motion

08:05

JNP Podcasts: Unlocking Insulin's Mechanism:...

Journal of Neurophysiology ·

2025/03/07

In this episode, coauthor Karoline Martins dos Santos discusses the recently published research, "Insulin activates parasympathetic hepatic-related neurons of the paraventricular nucleus of the hypothalamus through mTOR signaling." The study investigates the complex role of insulin in regulating hepatic glucose production, focusing on how insulin influences specific brain regions. While it's known that insulin reduces liver glucose production, the precise mechanisms and brain areas involved have

05:40

JNP Podcasts: Decoding Motor Control - Estimating...

Journal of Neurophysiology ·

2025/03/07

In this episode, coauthor Lei Zhang explores the research titled "Estimating descending activation patterns from EMG in fast and slow movements using a model of the stretch reflex." Lei introduces a novel method that directly estimates descending activation from electromyographic (EMG) signals and arm kinematics by inverting a model of the spinal stretch reflex—without relying on muscle models or an arm dynamics model. This innovative approach uncovers how movement speed influences the time

10:02

JNP Podcasts: The Power of Light Touch: How Fingertip...

Journal of Neurophysiology ·

2025/03/07

In this episode, coauthor Megan Goar discusses the recently published research titled "Light touch alters vestibular-evoked balance responses: insights into dynamics of sensorimotor reweighting." The research uncovers how minimal fingertip contact (light touch) during balance tasks can reduce the impact of electrical vestibular stimulation (EVS) on body sway. Not only does this touch alter sway magnitude, but it also reveals a high-frequency center of pressure element, tied to vestibular inputs,

06:01

JNP Podcasts: Improving localization and measurements...

Journal of Neurophysiology ·

2025/02/14

In this episode, coauthor Ernesto Bedoy discusses their recently published research, "Improving Localization and Measurements of M-Waves Using High-Density Surface Electromyography." The study presents an innovative approach to enhancing the measurement of evoked potentials through high-density surface electromyography (HD-sEMG). By incorporating spatial filters and ultrasound imaging, the research significantly improves the precision and localization of evoked potentials, providing a more accurate

10:39

JNP Podcasts: Hypercapnia elicits changes in...

Journal of Neurophysiology ·

2025/02/14

In this episode, coauthor Obaid U. Khurram discusses their recently published research, "Hypercapnia Impacts Neural Drive and Timing of Diaphragm Neuromotor Control." The study explores the complex neuromotor control of the diaphragm muscle (DIAm) under hypercapnic conditions, an area that has not been fully understood. Dr. Khurram explains how hypercapnia increases motor unit recruitment and discharge rates, indicating an enhanced respiratory drive. The research also reveals how hypercapnia affects

04:59

JNP Micro Podcasts: Flexion reflexes during...

Journal of Neurophysiology ·

2025/01/31

In this episode, coauthors Maria Knikou and Abdullah M. Sayed Ahmad discuss their research on "Transspinal stimulation downregulates flexion reflex pathways during walking in healthy humans." The study investigates how transspinal stimulation over the thoracolumbar region affects reflex pathways during walking, revealing its ability to suppress the tibialis anterior flexion reflex at varying frequencies (15, 30, and 50 Hz).Transspinal stimulation downregulates flexion reflex pathways during walking

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