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Xio Talks(乾科學)

台灣活性脂質股份有限公司

Xio Talks（乾科學）——不乾的科學，只給你乾貨。脂質很難懂？RNA又在幹嘛？保健品到底補不補？別怕，這裡沒有艱深的科學語言，只有用聽得懂的方式，聊你該知道的那些生醫大小事。適合生技從業者、創新創業者、醫藥營養學者與對科學有好奇心的你，一起聽見科學與產業的真實聲音。 🎧 科學其實不無聊，無聊的是沒聽Xio Talks。

health & fitness alternative health

All Episodes

00:08:37

EP19｜🍳 為什麼有些人怎麼吃都不飽？答案可能藏在蛋白質

Xio Talks(乾科學) ·

2025/11/26

你有沒有過這種經驗：吃了一堆東西，還是覺得餓？研究發現，當食物中蛋白質不足，我們的身體會「強迫」我們吃更多。從紅毛猩猩的覓食行為談起，我們來聊聊你日常飲食中可能忽略的營養秘密。Ever feel full but still hungry? Turns out, when there’s not enough protein in your food, your body keeps asking for more. Starting with how orangutans manage their meals in the wild, this episode brings nutrition science into your everyday choices—no PhD required.📝https://www.science.org/doi/10.1126/sciadv.adv7613--TBAL

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00:09:59

EP18｜從分子失衡到髓鞘修復停滯：UBE3A 如何改寫 MS 的神經再生劇本？

Xio Talks(乾科學) ·

2025/11/14

在多發性硬化症的病理進程中，少突膠質細胞的成熟與髓鞘重建是一項關鍵挑戰。本集深入探討UBE3A的上調表現如何影響細胞命運決定與髓鞘形成，連結小鼠模型與人類資料，試圖釐清UBE3A是否為限制神經修復的核心節點，並探討其作為治療靶點的可能性。Myelin repair is a cornerstone challenge in MS.This deep-dive explores how UBE3A upregulation disrupts oligodendrocyte lineage progression and impairs remyelination. Drawing from both mouse models and human studies, we examine whether UBE3A represents a central molecular brake—and a viable therapeutic target—for neuroregeneration.-📝https://doi.org/10.1038/s41467-025-62053-w-TBAL

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00:09:18

EP17｜🔬 SFA 與心血管健康：乳製品中的基質效應新解讀

Xio Talks(乾科學) ·

2025/10/30

飽和脂肪酸（SFA）一向被視為心血管健康的風險因子，但近期法國研究指出，來自奶油與優格等乳製品中的 SFA，可能因食物基質效應產生不同的代謝結果。本集帶你深入解析「基質效應」如何重塑我們對脂肪與健康的理解，並探討公共營養建議是否應重新修正。Saturated fats (SFA) have long been associated with cardiovascular risk—but new French research suggests that the SFA in dairy foods like butter and yogurt may behave differently due to the food matrix effect. In this episode, we unpack the science behind this paradigm shift and explore whether current dietary guidelines need a

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00:06:53

EP16｜🍷 喝一杯真的比較好過嗎？你以為的「借酒澆愁」其實只是腦補

Xio Talks(乾科學) ·

2025/10/14

壞心情來襲，你會選擇來一杯紅酒嗎？科學研究告訴我們——心情差不一定就會讓你喝更多！本集用輕鬆語氣聊聊心理學家怎麼破解「喝酒動機的錯覺」，讓你重新認識自己拿酒杯的那一刻，其實可能一點都不關心緒。Think sadness equals more drinking? Not so fast! In this fun episode, we bust the myth of “drinking your feelings away” and explore what science really says about why people drink. Spoiler: It’s not always about the mood. Tune in for quirky insights, real data, and maybe a few surprises about that after-work glass of wine.-📝https://doi.org/10.3390/bs15080998-TBAL

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00:09:43

EP15｜😱 肝癌背後的微脂肪陰謀？你從沒聽過的「乙醚脂質」與隱形開關 TRPV2！

Xio Talks(乾科學) ·

2025/10/07

癌症會操控脂肪？是的！而且還是你從沒聽過的乙醚脂質。這集揭開一場看不見的「脂質內戰」：一個關鍵基因（PPARα）失能，一個鈣離子通道（TRPV2）開關錯亂，就可能讓肝癌細胞加速轉移！一場細胞內的化學間諜戰，就此揭幕。Could cancer hijack your fat metabolism? Shocking new research says yes—with ether lipids acting as the secret messengers. In this mind-blowing episode, we uncover how silent switches like TRPV2 and PPARα can unleash a metabolic conspiracy that accelerates liver cancer progression.-📝https://doi.org/10.1186/s12929-025-01178-y-TBAL

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00:16:48

EP14｜🥛 牛奶界的雙打冠軍：LF 和 OPN 怎麼打贏寶寶腸道保衛戰？

Xio Talks(乾科學) ·

2025/09/25

寶寶的第一場腸道戰役，竟然靠牛奶裡的「雙蛋白神隊友」打贏？本集用輕鬆方式告訴你什麼是LF（乳鐵蛋白）和OPN（骨橋蛋白），它們怎麼攜手打怪、顧腸道、養免疫！你會驚訝這杯牛奶比你想像的還猛。Who knew yourbaby’s gut had superhero backup from milk proteins? Meet LF and OPN—the tagteam that fights off pathogens, balances microbiota, and builds strongimmunity. In this fun episode, we break down how these milk-born allies worktheir magic (and why your milk powder might just be next-gen tech).📝https://doi.org/10.1038/s42003-025-08460-7-TBAL

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00:08:43

EP13｜🔍 從失敗中找解方：阿茲海默症與多體學的交錯路徑

Xio Talks(乾科學) ·

2025/08/08

阿茲海默症臨床試驗長年處於高失敗率、低回報的泥沼。本集邀請你從科學的根本重新審視：透過整合基因體、蛋白體、代謝體等多體學資料，科學家如何重建疾病機制地圖，並意外發現可重定位的癌症藥物組合，有望為退化性神經疾病注入新曙光。Alzheimer’s trials have long suffered from high failure rates. In this deep-dive episode of XioTalks, we explore how multi-omics is reshaping our understanding of disease pathways—and how it’s leading researchers to unexpected therapeutic combinations, including repurposed oncology drugs.-📝https://doi.org/10.1016/j.cell.2025.06.035-TBAL

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00:09:35

EP12｜威而鋼抗癌？這次不是開玩笑

Xio Talks(乾科學) ·

2025/08/01

你沒聽錯，威而鋼真的有可能成為抗癌幫手！本集我們揭開這項令人驚訝的研究發現：威而鋼可以活化樹突細胞、調節免疫反應，甚至強化免疫療法的效果。從熟悉的藥物到前沿研究，讓我們一起重新認識它的第二人生！Viagra vs. Cancer? This Time It’s Not a JokeYes—you read that right. Recent studies show that sildenafil (Viagra) mayenhance immune responses by boosting dendritic cell activity. In this episode,we unpack the unexpected science behind this repurposed drug and explore itssurprising potential in cancer therapy.📝https://doi.org/10.1038/s41586-025-09202-9-TBAL

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00:09:34

EP11｜為什麼我們無法再生？答案藏在一個關掉的基因裡

Xio Talks(乾科學) ·

2025/07/22

小時候擦破皮會自動癒合，但為什麼我們不能長出一隻新手指？原來，哺乳動物體內真的有「再生開關」，只是演化中被關掉了。本集用生活化語言帶你認識最新研究成果，解釋為何科學家相信，我們或許能再次「學會再生」。Why Can’t We Regrow? A Genetic Switch Might Be the KeyWhy can kids heal scrapes but not regrow limbs? Turns out mammals carry the genetic machinery for regeneration—it’s just switched off. In this episode, we explain the fascinating science behind a recent discovery that could one day change how we recover from injuries.📝https://www.science.org/doi/10.1126/science.adp0176-📣【TBAL展場限定・破盤優惠】只在 2025

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00:07:45

EP10｜尿液代謝體學：非侵入性樣本在疾病預測中的新角色

Xio Talks(乾科學) ·

2025/07/18

本集深入探討尿液作為代謝體學樣本的研究進展與臨床應用價值。從慢性腎病、代謝症候群到癌症風險評估，尿液中所蘊含的代謝物資訊，正為無創預測工具開啟新契機。探討技術平台、資料解析與未來整合趨勢，適合關注精準醫學的研究與產業界聽眾。This episode explores the evolving role of urine-basedmetabolomics in biomedical research. From kidney disease to metabolic disordersand early cancer detection, urine provides a rich, non-invasive matrix forpredictive biomarker discovery. We delve into its analytical strengths,limitations, and translational potential in precision

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00:07:09

EP9｜慢性病不是突然來的：代謝體教你提早看見警訊

Xio Talks(乾科學) ·

2025/07/10

高血壓、糖尿病、甚至癌症，都不是突然發生的。現在有一種方法叫做代謝體檢測，可以提早發現你身體的風險訊號。本集用簡單語言帶你認識這項新科技，幫助你提早佈局自己的健康未來。Chronic diseases like diabetes and heart disease often build silently over time. In this episode, we explain how metabolomics can detect subtle changes in your body long before symptoms appear—helping you make smarter health choices today, for a better tomorrow.📝https://www.nature.com/articles/s41591-022-01980-3-📣【TBAL展場限定・破盤優惠】只在 2025 亞洲生技大展！Nightingale 全方位血液代謝體檢測🔬一次解析250+項健康指標 📌 原價 NT$8,000👉 展場價

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00:06:50

EP8｜代謝體學與風險預測：精準醫學在心血管疾病的應用前線

Xio Talks(乾科學) ·

2025/06/24

心血管疾病預測仍以膽固醇與血壓為主？其實風險遠不止於此。本集深入探討代謝體學（Metabolomics）如何突破傳統框架，透過數百種代謝物數據描繪更精準的個人健康風險，成為未來預防醫學的重要工具。科學與臨床正在接軌，這場預測革命，正在展開。Can we go beyond cholesterol to predict heart disease? In this episode, we explore how metabolomics is reshaping cardiovascular risk assessment—leveraging hundreds of metabolic markers to improve accuracy and guide personalized prevention strategies. The future of predictive medicine is already

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00:08:34

EP7｜Microfluidic mRNA製程革新：實現疫苗量產與品質雙贏

Xio Talks(乾科學) ·

2025/06/18

Significance 研究意義本研究提出以矽-玻璃製成的 SCALAR ( Silicon Calable ALipid RNP) 微流體晶片，將單一混合單元無縫擴增至 1×、10×、256×，使 mRNA-LNP 產量從 0.1 L /hr 躍升至 17 L /hr，同時保持粒徑 (~70 nm)、封裝效率 (>85 %) 及體內免疫效力一致。在 COVID-19 疫情中，LNP 配製是疫苗產線瓶頸；該平台證明可在不改變配方參數的情況下，直接由實驗室規模過渡到臨床與商業量產，顯著縮短反應新興病原的時程。The study introduces a silicon–glass SCALARmicrofluidic platform that parallelizes identical mixing units (1×, 10×, 256×),boosting mRNA-LNP output from 0.1 L /hr to 17 L /hr while preserving particlesize (~70 nm), encapsulation efficiency

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00:07:57

EP6｜癌細胞的「脂質防護罩」：解密化療抗藥性的新發現

Xio Talks(乾科學) ·

2025/06/13

為何有些上皮性卵巢癌細胞能逃過化療？一項發表在《細胞與分子醫學》期刊的研究揭示，一種名為 PEO 的特定脂質分子，特別是透過細胞內 AGPS 酵素合成的這類 PEO，就像為癌細胞穿上了一層「保護罩」。研究人員分析大型資料庫 (如 CCLEC, GDSC) 與實驗室數據，發現甘油磷脂代謝，尤其是 PEO 的含量，與癌細胞對常用化療藥物紫杉醇 (Paclitaxel) 和鉑類藥物 (Cisplatin) 的不敏感性有顯著的正相關。透過補充 PEO、抑制 AGPS 等實驗，證實細胞自身合成的 PEO 是導致抗藥性的關鍵因素。本集將深入解析這個「脂質防護罩」的秘密，以及它如何影響癌症治療效果。Why do some epithelial ovariancancer cells evade chemotherapy? A study published in the journal Cell & Molecular Medicine reveals that a specific lipid molecule called PEO,particularly the type

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00:08:22

EP5｜你吃的那口油，可能讓癌細胞跑更快？

Xio Talks(乾科學) ·

2025/06/09

你可能沒想過，一塊炸雞裡的油脂，竟然可能加快癌細胞的轉移速度？棕櫚酸這個在日常飲食中無所不在的脂肪酸，正被科學家點名為「癌症潛在幫兇」。本集以淺顯方式揭開脂肪與癌細胞的複雜關係，也許會讓你重新審視冰箱裡的食材。Sounds wild, but it's true—palmitic acid,found in everyday foods, may help cancer cells move faster. This episode unpacksthe science in simple terms, exploring how one common fat could change the waywe think about food, health, and cancer. 📝https://www.nature.com/articles/s43018-023-00513-2TBAL

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00:08:16

EP4｜脂肪無罪？重新認識油脂與你的代謝風險

Xio Talks(乾科學) ·

2025/06/06

油吃多真的會「堵住血管」嗎？還是我們誤會脂肪太久了？本集帶你釐清不同脂肪（飽和、不飽和、反式脂肪）對心血管代謝的影響，結合最新脂質體學與營養標記分析，提供科學角度的健康建議。從飲食習慣到精準預防，掌握脂肪與代謝風險的關鍵知識，你一定要聽懂！Is fat clogging your arteries—or have wemisunderstood it all along?In this episode, we explore the complex relationship between dietary fats and cardiovascular metabolism. Learn how different fats (saturated, unsaturated,trans) influence your health, and how lipidomics and nutritional biomarkers are reshaping how we assess risk. From daily habits to future diagnostics, this is your

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00:09:51

EP3｜下一波疫苗革命？Mildronate × 脂質體的臨床潛能

Xio Talks(乾科學) ·

2025/06/03

疫苗技術正在加速演化，mRNA只是開始。這一集聚焦一個被低估的小分子：Mildronate，在新一代脂質體配方中的策略角色。它如何影響劑量設計、安全性與製程效率？這場看不見的藥物遞送革命，或許將重塑疫苗市場版圖。The mRNA wave was just the beginning. This episode examines how Mildronate—an often-overlooked small molecule—might play a strategic role in next-gen liposomal vaccines. We dive into formulation insights, delivery precision, and clinical implications that could reshape the future of immunization tech.📝https://pubmed.ncbi.nlm.nih.gov/38798555/https://pubmed.ncbi.nlm.nih.gov/39151414/ TBAL

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00:10:10

EP2｜為什麼頂尖藥廠都盯上『胞外囊泡』？

Xio Talks(乾科學) ·

2025/05/28

你知道嗎？細胞釋放出來的「胞外囊泡」（Extracellular Vesicles, EVs），不只是垃圾袋，更可能是下一代藥物傳輸的關鍵武器！本集將帶你深入了解這項新興技術：如何強化囊泡的載貨能力、提升穩定性與靶向性，並應用於癌症治療、神經疾病、疫苗載體等前沿醫療領域。從脂質體到EV，藥物運輸的科技革命正在悄悄進行。你準備好迎接這場細胞層級的未來變革了嗎？Did you know your cells naturally produce nanoscopic vesicles that might carry the next generation of therapies? In this episode, we unpack the science behind Extracellular Vesicles (EVs), how they’re being engineered for better cargo delivery, and why they’re gaining attention as the future of precision drug delivery—from

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00:07:48

EP1｜醫療用大麻不是夢？脂肪肝的新療法你敢試嗎？

Xio Talks(乾科學) ·

2025/05/20

#TBAL與您分享---Two non-psychoactive cannabinoids reduce intracellular lipid levels and inhibit hepatosteatosis. J Hepatol. 2015 Jun;62(6):1382-90..📌Significance :The significance of this study lies in exploration of potential therapeutic agents for non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome, that are increasingly prevalent due to rising obesity rates. The study investigates the effects of cannabinoids, specifically THCV and CBD, for their potential to improve insulin sensitivity

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