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PODCAST

The Health Edge: translating the science of self-care

Mark Pettus MD and John Bagnulo PhD, MPH

“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”.Will RogersWe believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from the debate

health & fitness medicine

All Episodes

55:53

A 15-Year Study Linking Unprocessed Red Meat To Lower...

The Health Edge: translating the science of self-care ·

2026/04/08

Send us Fan Mail A 15-year follow-up study out of Sweden forces an uncomfortable question: what if unprocessed red meat isn’t a brain-health villain at all, and the real risk sits upstream in metabolic dysfunction and refined carbs? Mark Pettis and John Bagnulo dig into the data on red meat consumption, cognitive decline, and dementia risk, with a special focus on the highest-concern group: people with the APOE4 genotype. If you’ve ever seen a genetic test result and felt like Alzheimer’s dis...

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54:03

Fear of Skin Cancer Will Reduce Your Lifespan

The Health Edge: translating the science of self-care ·

2026/04/01

Send us Fan Mail Sunlight has been framed as a problem to avoid, but the data keeps pointing in the opposite direction: people who get more natural light tend to live longer and carry a lower risk of chronic disease. We take a hard look at why this topic still feels controversial, and how fear based messaging can flatten a complex risk-benefit reality into a single command: stay out of the sun. We walk through a powerful new UK Biobank analysis on habitual ultraviolet exposure and mortality,...

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57:40

How Food And Cold Exposure Can Raise Daily Calorie Burn

The Health Edge: translating the science of self-care ·

2026/03/25

Send us Fan Mail Thermogenesis is one of the most ignored levers in weight loss and metabolic health, and it changes the way we think about “calories out”. We talk through how your body generates heat all day long, why resting energy expenditure and basal metabolic rate are not fixed, and how small choices can compound into meaningful differences over months. We start with diet-induced thermogenesis and the thermic effect of food, including why protein burns more energy during digestion and ...

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33:46

How Positive Age Beliefs Improve Cognitive Function...

The Health Edge: translating the science of self-care ·

2026/03/18

Send a text If you’ve ever caught yourself thinking that aging automatically means pain, weakness, or losing your independence, this conversation is a reset. We dig into a Yale study published in *Geriatrics* showing that beliefs about aging are not just “nice ideas” but measurable predictors of how well we think and move as the years pass. When you treat mindset as part of health science, the story of getting older starts to look far more hopeful and far more actionable. We walk throu...

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42:54

Statins, Muscle Mass and Strength: A long-term trade...

The Health Edge: translating the science of self-care ·

2026/03/11

Send a text What if a lower LDL comes with a quiet cost to your strength and resilience? We dig into a massive biobank analysis linking long-term statin use with declines in grip strength and appendicular lean mass, then connect the dots to sarcopenia, mitochondrial function, and the daily choices that shape metabolic health. Strength is more than performance; it predicts independence, glucose control, and longevity, which is why any therapy that erodes muscle demands a closer look. We walk ...

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36:03

Pasteurized Akermansia and Metabolic Health

The Health Edge: translating the science of self-care ·

2026/03/04

Send a text What if the most effective probiotic isn’t alive? We dive into the surprising science of pasteurized Akkermansia muciniphila—how a heat-treated microbe can tighten the gut barrier, steady blood sugar, and spark fat oxidation without needing to survive your stomach. Drawing on recent human trials and compelling mechanistic insights, we unpack why preserving cell-wall signals and membrane proteins may matter more than colony counts, and why autoclaving destroys the very benefits pas...

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48:53

Finding The Sweet Spot For Iron And Health

The Health Edge: translating the science of self-care ·

2026/02/04

Send us a text Iron can be the spark for energy or the fuel for oxidative fire—and most lab reports don’t tell you which side you’re on. We dig into what really matters: tighter ferritin targets, how genetics and food shape absorption, and why the “normal range” can still mean higher risk for stroke, atherosclerosis, heart failure, and insulin resistance. We start with the fundamentals—heme vs non‑heme iron, why absorption is so uneven, and how early CBC clues like a low MCV can flag deficie...

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45:48

The Quality of Darkness at Night: a major disruptor...

The Health Edge: translating the science of self-care ·

2026/01/28

Send us a text A quiet glow at midnight can echo through your biology like a shout. We dig into new research showing that even modest night light is tied to higher risks of heart failure, atrial fibrillation, stroke, and coronary disease—and we connect the dots to circadian rhythm, metabolism, and the choices we make at home every evening. This isn’t fearmongering; it’s a roadmap for reclaiming sleep, stabilizing blood pressure, and improving insulin sensitivity with tools you already have. ...

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60:29

Rethinking Alkaline Eating: What Really Drives...

The Health Edge: translating the science of self-care ·

2026/01/14

Send us a text Forget the hype about a food’s pH in your glass. What shapes your health is the acid produced after digestion—and how your kidneys manage it all day, every day. We unpack the science behind dietary acid load, explain the difference between DAL, PRAL, and NEAP, and show how a modern, grain-heavy pattern quietly raises acid burden while delivering minimal nutrients. The goal isn’t to fear protein; it’s to pair it with the right plants so bones, muscles, and metabolism get stronge...

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41:55

Hidden Metabolic Danger In “Healthy” Adults

The Health Edge: translating the science of self-care ·

2026/01/09

Send us a text Feeling “fine” with normal labs can hide the earliest signs of metabolic trouble. We dive into a revealing study of young adults that compares sedentary people to those who simply meet activity guidelines, and what it uncovers inside their muscle cells is hard to ignore: lower mitochondrial respiration, poorer cardiolipin quality, higher lactate production, and a tilt toward glycolysis that predicts insulin resistance and chronic disease years before a diagnosis. We walk throu...

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46:58

Uric Acid, The Hidden Metabolic Signal

The Health Edge: translating the science of self-care ·

2025/12/31

Send us a text A quiet lab number is telling a loud story about modern health. We dig into uric acid as a powerful signal of metabolic strain, connecting the dots between rising sugar intake, sodium overload, dehydration, and that stubborn fatigue and weight gain so many of us feel. Drawing on pioneering research from Richard Johnson and Robert Lustig, we break down how fructose doesn’t just sweeten food; it drains cellular energy, elevates uric acid, and flips an ancient “fat switch” designe...

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53:48

How Exercise Intensity Shapes Longevity, Heart...

The Health Edge: translating the science of self-care ·

2025/12/17

Send us a text A minute that leaves you breathless can rival eight minutes of comfortable effort. That’s the eye-opening takeaway we unpack as we dive into fresh UK Biobank data showing how vigorous activity dramatically outperforms moderate and light movement for reducing all-cause mortality, cardiovascular events, diabetes, and even cancer risk. We strip away jargon and use the talk test—can you sing, speak, or barely get a sentence out?—so anyone can gauge intensity without a lab or a smar...

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35:04

Coffee, AFib, And What The Science Says

The Health Edge: translating the science of self-care ·

2025/12/11

Send us a text Coffee and heart rhythm don’t have to be enemies. We dig into a new randomized trial across the US, Canada, and Australia suggesting that caffeinated coffee may lower the risk of recurrent atrial fibrillation compared with abstaining, then connect the dots with real-world monitoring, ablation strategy, and day-to-day choices that influence heart health. We start by grounding AFib in plain terms: what it is, why so many people never feel it, and how stroke risk rises when the a...

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52:25

The Delicate Balance Between Oxidative Stress And...

The Health Edge: translating the science of self-care ·

2025/12/03

Send us a text Most wellness advice tries to stamp out oxidative stress. We make a different case: the right dose of stress is the signal that builds resilience. From the first snowfall chat to a deep dive on electrons, mitochondria, and energy flow, we walk through how redox balance—reduction and oxidation—is the unseen driver of better fitness, metabolism, and healthy aging. Rather than drowning your cells in pharmacologic antioxidant doses, we show why whole foods, intelligent training, an...

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28:43

How To Love Holiday Food That Loves You Back

The Health Edge: translating the science of self-care ·

2025/11/26

Send us a text The table can be joyful and nourishing at the same time. We open the season with a simple promise: keep the flavors you love, swap the parts that don’t love you back. From a resistant starch gravy that boosts your microbiome to a mushroom-forward, breadless stuffing that hits all the nostalgic notes, we map a path to a Thanksgiving that tastes great and leaves you energized. We rethink side dishes through a health-first lens without losing comfort: slow-roasted sweet potatoes ...

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49:48

If Light Is A Language, What Is Your Body Hearing?

The Health Edge: translating the science of self-care ·

2025/11/19

Send us a text What if your lighting is sending the wrong message to your biology? We dig into the science of light as information, showing how specific wavelengths trigger opsins in the eyes and skin to set circadian rhythm, shape metabolism, and influence mood, sleep, and aging. From violet and sky-blue that kick-start morning alertness to red and near-infrared that support mitochondrial function, collagen, and nitric oxide, we connect the dots between spectrum quality and everyday health. ...

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42:56

Is Coconut Oil A Villain Or Just Misunderstood?...

The Health Edge: translating the science of self-care ·

2025/10/22

Send us a text Curious why coconut oil can raise LDL for some people yet still show up in diets that improve metabolic health, cognition, and body composition? We get clear on what coconut oil actually is—a family of saturated fats with a rare abundance of medium-chain triglycerides—and why MCTs create ketones that the brain and mitochondria can use even without fasting. Instead of stopping at cholesterol, we look at the fuller picture: insulin resistance, inflammation, triglycerides, and rea...

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39:37

Your gut can turn ellagic acid into urolithin A—and...

The Health Edge: translating the science of self-care ·

2025/10/15

Send us a text If pomegranates, raspberries, and walnuts could whisper a secret to your cells, it might be this: the right microbes can turn plant defense into human resilience. We dive into the journey from ellagic acid to urolithin A, mapping how polyphenols meet the microbiome to support mitochondrial function, muscle strength, and brain health. Along the way, we unpack the science of mitophagy, inflammation control, and metabolic signaling that ties colorful foods to better performance an...

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30:45

Four Days to Metabolic Flexibility: What a Danish...

The Health Edge: translating the science of self-care ·

2025/10/08

Send us a text A 35% drop in liver fat in under a week sounds impossible—until you see how a simple macro shift can redirect your metabolism. We dive into a Danish crossover study where calories stayed equal, protein held steady, and the only real change was carbohydrates versus fat. The result: rapid reductions in hepatic fat, lower triglycerides, improved insulin sensitivity, and clear signs of metabolic flexibility, all in four to five days. We unpack what that means for everyday eating, h...

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37:10

Childhood Night Light Exposure and the Hidden Cost of...

The Health Edge: translating the science of self-care ·

2025/10/01

Send us a text The clock isn’t just on your wall—it’s in your cells. As autumn settles in and daylight wanes, we dig into how light acts as information for your biology, shaping sleep depth, hormone timing, and metabolic health. A standout 15-year cohort of 200,000+ children links persistent artificial light at night to higher obesity risk, and it pairs with wearable data from tens of thousands of people that reveals how little real sunlight most of us get—even at the height of summer. We br...

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64 results

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